Research Support, Non-U.S. Gov't
- Lactobacillus paracasei subsp. paracasei LC01 Positively Modulates Intestinal Microflora in Healthy Young Adults
-
Hao Zhang , Jing Sun , Xianting Liu , Chuan Hong , Yuanbo Zhu , Aiping Liu , Siqi Li , Huiyuan Guo , Fazheng Ren
-
J. Microbiol. 2013;51(6):777-782. Published online December 19, 2013
-
DOI: https://doi.org/10.1007/s12275-013-3279-2
-
-
50
View
-
0
Download
-
21
Crossref
-
Abstract
-
Lactobacillus paracasei subsp. paracasei LC01 (LC01) can
tolerate intestinal stresses and has antioxidant activity. To
evaluate the effect of the bacterium on human intestinal microflora,
a randomized, double-blind, placebo-controlled
human trial was carried out. Fifty-two healthy adult volunteers
were randomized equally to two groups. One group
consumed 12% (wt/vol) skimmed milk supplemented with
1010 CFU of LC01 each day for the 4-week treatment period,
and then consumed placebo in the next treatment period,
separated by a 2-week washout. The other group followed
the reverse order. Group-specific real-time PCR and biochemical
analyses was used to determine the intestinal bacterial
composition of fecal samples collected at the end of
every period, and the concentration of short-chain fatty acids
and ammonia. A significant inhibition in fecal Escherichia
coli and increase in Lactobacillus, Bifidobacterium, and Roseburia
intestinalis were observed after consumption of LC01.
Acetic acid and butyric acid were significantly higher in the
probiotic stage and fecal ammonia was significantly lower.
The results indicated a modulation effect of LC01 on the
intestinal microflora of young adults, suggesting a beneficial
effect on bowel health. LC01 may have potential value as a
probiotic.
-
Citations
Citations to this article as recorded by

- Targeting maternal gut microbiome to improve mental health outcomes—a pilot feasibility trial
Faith Gallant, Kieran Cooley, Sophie Grigoriadis, Neda Ebrahimi
Frontiers in Psychiatry.2024;[Epub] CrossRef - Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease
Zhi Zhang, Jiajia Sun, Yanxia Li, Kexin Yang, Gang Wei, Shenglong Zhang
Experimental Gerontology.2023; 183: 112308. CrossRef - Dietary Lactobacillus fermentum and Lactobacillus paracasei improve the intestinal health of broilers challenged with coccidia and Clostridium perfringens
Peng Li, Liyun Zheng, Ya Qi, Zhipeng Liu, Encun Du, Jintao Wei, Zhengfan Zhang, Shuangshuang Guo, Binying Ding
Frontiers in Veterinary Science.2022;[Epub] CrossRef - Chemical composition and sensory properties of fermented citrus juice using probiotic lactic acid bacteria
Masahiro Yuasa, Ami Shimada, Ayumi Matsuzaki, Ayaka Eguchi, Mihoko Tominaga
Food Bioscience.2021; 39: 100810. CrossRef - The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health
Ana Nogal, Ana M. Valdes, Cristina Menni
Gut Microbes.2021;[Epub] CrossRef - Differences in Manifestations and Gut Microbiota Composition Between Patients With Different Henoch-Schonlein Purpura Phenotypes
Yuanzhen Zhang, Guizhi Xia, Xiaojing Nie, Yugui Zeng, Yi Chen, Yifang Qian, Guangming Chen, Jun Huang, Chengfeng Wang, Chuanyin Zhang, Xiaoli Huang, Yuen Yang, Xiaojian Qiu, Fang Yang, Jie Chen, Jun Hu
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef - Lactobacillus casei LC01 Regulates Intestinal Epithelial Permeability through miR-144 Targeting of OCLN and ZO1
Qiuke Hou, Yongquan Huang, Yan Wang, Liu Liao, Zhaoyang Zhu, Wenjie Zhang, Yongshang Liu, Peiwu Li, Xinlin Chen, Fengbin Liu
Journal of Microbiology and Biotechnology.2020; 30(10): 1480. CrossRef - Gut microbiota is associated with adiposity markers and probiotics may impact specific genera
Aline Corado Gomes, Christian Hoffmann, João Felipe Mota
European Journal of Nutrition.2020; 59(4): 1751. CrossRef - Microbiota and Lifestyle: A Special Focus on Diet
Noemí Redondo-Useros, Esther Nova, Natalia González-Zancada, Ligia E. Díaz, Sonia Gómez-Martínez, Ascensión Marcos
Nutrients.2020; 12(6): 1776. CrossRef - Hematobiochemical and Immunological Responses of Rats Treated with Multi-strain Probiotics and Infected with Trypanosoma brucei
Chukwuemeka Calistus Okolo, Nwakaego Ernestina Nweze, Ifeanyi James Eze
Probiotics and Antimicrobial Proteins.2020; 12(3): 952. CrossRef - Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study
Ezgi BELLIKCI-KOYU, Banu Pınar SARER-YUREKLI, Yakut AKYON, Fadime AYDIN-KOSE, Cem KARAGOZLU, Ahmet Gokhan OZGEN, Annika BRINKMANN, Andreas NITSCHE, Koray ERGUNAY, Engin YILMAZ, Zehra BUYUKTUNCER
Nutrients.2019; 11(9): 2089. CrossRef - “Physicochemical, immunomodulatory and safety aspects of milks fermented with Lactobacillus paracasei isolated from kefir”
Ana A. Bengoa, Carolina Iraporda, Leonardo B. Acurcio, Sávio H. de Cicco Sandes, Karen Costa, Gabriele Moreira Guimarães, Rosa M. Esteves Arantes, Elisabeth Neumann, Álvaro Cantini Nunes, Jaques R. Nicoli, Graciela L. Garrote, Analía G. Abraham
Food Research International.2019; 123: 48. CrossRef - Use of Gas Chromatography to Quantify Short Chain Fatty Acids in the Serum, Colonic Luminal Content and Feces of Mice
Willian Ribeiro, Marco Vinolo, Leandro Calixto, Caroline Ferreira
BIO-PROTOCOL.2018;[Epub] CrossRef -
Roseburia
Spp.: A Marker of Health?
Zohreh Tamanai-Shacoori, Imen Smida, Latifa Bousarghin, Olivier Loreal, Vincent Meuric, Shao Bing Fong, Martine Bonnaure-Mallet, Anne Jolivet-Gougeon
Future Microbiology.2017; 12(2): 157. CrossRef - An overview of advanced technologies for selection of probiotics and their expediency: A review
Ruby Yadav, Pratyoosh Shukla
Critical Reviews in Food Science and Nutrition.2017; 57(15): 3233. CrossRef - RNA and a cell wall component of Enterococcus faecalis IC-1 are required for phagocytosis and interleukin 12 production by the mouse macrophage cell line J774.1
Junpei Nakase, Yuuichi Ukawa, Syoji Takemoto, Takayoshi Kubo, Yuko M Sagesaka, Ayako Aoki-Yoshida, Mamoru Totsuka
Bioscience, Biotechnology, and Biochemistry.2017; 81(6): 1099. CrossRef - The Role of Probiotics on the Microbiota
Esther Nova, Fátima Pérez de Heredia, Sonia Gómez‐Martínez, Ascensión Marcos
Nutrition in Clinical Practice.2016; 31(3): 387. CrossRef - The growth potential for dairy probiotics
Gregor Reid
International Dairy Journal.2015; 49: 16. CrossRef - Fate, activity, and impact of ingested bacteria within the human gut microbiota
Muriel Derrien, Johan E.T. van Hylckama Vlieg
Trends in Microbiology.2015; 23(6): 354. CrossRef - Cellular model to assess the antioxidant activity of lactobacilli
Jiali Xing, Gang Wang, Zhennan Gu, Xiaoming Liu, Qiuxiang Zhang, Jianxin Zhao, Hao Zhang, Yong Q. Chen, Wei Chen
RSC Advances.2015; 5(47): 37626. CrossRef - Antiviral effects of Lactobacillus ruminis SPM0211 and Bifidobacterium longum SPM1205 and SPM1206 on rotavirus-infected Caco-2 cells and a neonatal mouse model
Joo Yeon Kang, Do Kyung Lee, Nam Joo Ha, Hea Soon Shin
Journal of Microbiology.2015; 53(11): 796. CrossRef