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- REVIEW] Hgc1-Cdc28–how much does a single protein kinase do in the regulation of hyphal development in Candida albicans?
- Yue Wang
- J. Microbiol. 2016;54(3):170-177. Published online February 27, 2016
- DOI: https://doi.org/10.1007/s12275-016-5550-9
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- 18 Crossref
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Abstract
- The fungal human pathogen Candida albicans can cause invasive infection with high mortality rates. A key virulence factor is its ability to switch between three morphologies: yeast, pseudohyphae and hyphae. In contrast to the ovalshaped unicellular yeast cells, hyphae are highly elongated, tube-like, and multicellular. A long-standing question is what coordinates all the cellular machines to construct cells with distinct shapes. Hyphal-specific genes (HSGs) are thought to hold the answer. Among the numerous HSGs found, only UME6 and HGC1 are required for hyphal development. UME6 encodes a transcription factor that regulates many HSGs including HGC1. HGC1 encodes a G1 cyclin which partners with the Cdc28 cyclin-dependent kinase. Hgc1- Cdc28 simultaneously phosphorylates and regulates multiple substrates, thus controlling multiple cellular apparatuses for morphogenesis. This review is focused on major progresses made in the past decade on Hgc1’s roles and regulation in C. albicans hyphal development and other traits important for infection.
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Citations
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Systematic analysis of the
Candida albicans
kinome reveals environmentally contingent protein kinase-mediated regulation of filamentation and biofilm formation
in vitro
and
in vivo
Juraj Kramara, Min-Ju Kim, Tomye L. Ollinger, Laura C. Ristow, Rohan S. Wakade, Robert Zarnowski, Melanie Wellington, David R. Andes, Aaron G. Mitchell, Damian J. Krysan, Judith Berman
mBio.2024;[Epub] CrossRef - Hgc1 Independence of Biofilm Hyphae in Candida albicans
Anupam Sharma, Norma V. Solis, Manning Y. Huang, Frederick Lanni, Scott G. Filler, Aaron P. Mitchell, Yong-Sun Bahn
mBio.2023;[Epub] CrossRef - Strain variation in gene expression impact of hyphal cyclin Hgc1 in Candida albicans
Anupam Sharma, Aaron P Mitchell, J Berman
G3: Genes, Genomes, Genetics.2023;[Epub] CrossRef -
Use of the Iron-Responsive
RBT5
Promoter for Regulated Expression in Candida albicans
Yinhe Mao, Norma V. Solis, Anupam Sharma, Max V. Cravener, Scott G. Filler, Aaron P. Mitchell, Michael Lorenz
mSphere.2022;[Epub] CrossRef -
Systematic Metabolic Profiling Identifies
De Novo
Sphingolipid Synthesis as Hypha Associated and Essential for Candida albicans Filamentation
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Antibiotics.2022; 11(11): 1474. CrossRef - Integrative multi-omics profiling reveals cAMP-independent mechanisms regulating hyphal morphogenesis in Candida albicans
Kyunghun Min, Thomas F. Jannace, Haoyu Si, Krishna R. Veeramah, John D. Haley, James B. Konopka, Joachim Morschhäuser
PLOS Pathogens.2021; 17(8): e1009861. CrossRef - The Ndr/LATS Kinase Cbk1 Regulates a Specific Subset of Ace2 Functions and Suppresses the Hypha-to-Yeast Transition in Candida albicans
Rohan S. Wakade, Laura C. Ristow, Mark A. Stamnes, Anuj Kumar, Damian J. Krysan, James W. Kronstad
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Applied Microbiology and Biotechnology.2018; 102(23): 9873. CrossRef - A comprehensive analysis of Candida albicans phosphoproteome reveals dynamic changes in phosphoprotein abundance during hyphal morphogenesis
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Applied Microbiology and Biotechnology.2018; 102(22): 9731. CrossRef - A phenotypic small-molecule screen identifies halogenated salicylanilides as inhibitors of fungal morphogenesis, biofilm formation and host cell invasion
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Scientific Reports.2018;[Epub] CrossRef - Candida albicans morphology: still in focus
Ilse D. Jacobsen, Bernhard Hube
Expert Review of Anti-infective Therapy.2017; 15(4): 327. CrossRef - Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef - CDK phosphorylates the polarisome scaffold Spa2 to maintain its localization at the site of cell growth
Haitao Wang, Zhen‐Xing Huang, Jie Ying Au Yong, Hao Zou, Guisheng Zeng, Jiaxin Gao, Yanming Wang, Ada Hang‐Heng Wong, Yue Wang
Molecular Microbiology.2016; 101(2): 250. CrossRef
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Systematic analysis of the
Candida albicans
kinome reveals environmentally contingent protein kinase-mediated regulation of filamentation and biofilm formation
in vitro
and
in vivo
- Isolation and Characterization of Bud6p, an Actin Interacting Protein, from Yarrowia lipolytica
- Yunkyoung Song , Seon Ah Cheon , So-Yeon Lee , Ji-Sook Hwang , Jeong-Yoon Kim
- J. Microbiol. 2003;41(2):121-128.
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Abstract
- The identification of genes involved in true hypha formation is important in the study of mechanisms underlying the morphogenetic switch in yeast. We isolated a gene responsible for the morphogenetic switch in Yarrowia lipolytica, which forms true hyphae in response to serum or N-acetylglucosamine. The isolated gene, encoding 847 amino acids, had sequence identities of 27% and 25% with the Bud6 (Aip3) proteins of Saccharomyces cerevisiae and Schizosaccharomyces pombe, respectively. Disruption of this gene, designated YlBUD6, in haploid and diploid strains significantly reduced the ability of Y. lipolytica to switch from the yeast form to the hyphal form in hypha-inducing media. It was also found that YlBud6 mutants were rounder than the wild type when grown in the yeast form. These results indicate that the YlBud6 protein is necessary for hyphal growth and cell polarity in both haploid and diploid Y. lipolytica cells.
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