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- [Minireview] Primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas
- Sangmin Kang , Jinjong Myoung
- J. Microbiol. 2017;55(5):319-329. Published online April 29, 2017
- DOI: https://doi.org/10.1007/s12275-017-7075-2
- 55 View
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- 12 Crossref
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Abstract
- Kaposi’s sarcoma-associated herpesvirus (KSHV) is the latest addition to the human herpesvirus family. Unlike alpha- and beta-herpesvirus subfamily members, gamma-herpesviruses, including Epstein-Barr virus (EBV) and KSHV, cause vari-ous tumors in humans. KSHV primarily infects endothelial and B cells in vivo, and is associated with at least three malig-nancies: Kaposi’s sarcoma and two B cell lymphomas, res-pectively. Although KSHV readily infects endothelial cells in vitro and thus its pathogenic mechanisms have been exten-sively studied, B cells had been refractory to KSHV infection. As such, functions of KSHV genes have mostly been eluci-dated in endothelial cells in the context of viral infection but not in B cells. Whether KSHV oncogenes, defined in endo-thelial cells, play the same roles in the tumorigenesis of B cells remains an open question. Only recently, through a few ground-breaking studies, B cell infection models have been established. In this review, those models will be compared and contrasted and putative mechanisms of KSHV-induced B cell transformation will be discussed.
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Citations
Citations to this article as recorded by
- Folate-Targeted Nanocarriers Co-Deliver Ganciclovir and miR-34a-5p for Combined Anti-KSHV Therapy
Fangling Li, Dongdong Cao, Wenyi Gu, Dongmei Li, Zhiyong Liu, Lin Cui
International Journal of Molecular Sciences.2024; 25(5): 2932. CrossRef - Structural aspects of hepatitis E virus
Florencia Cancela, Ofelia Noceti, Juan Arbiza, Santiago Mirazo
Archives of Virology.2022; 167(12): 2457. CrossRef - iTIME.219: An Immortalized KSHV Infected Endothelial Cell Line Inducible by a KSHV-Specific Stimulus to Transition From Latency to Lytic Replication and Infectious Virus Release
Stephen J. Dollery, Tania D. Maldonado, Eric A. Brenner, Edward A. Berger
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef - Analysis of KSHV B lymphocyte lineage tropism in human tonsil reveals efficient infection of CD138+ plasma cells
Farizeh Aalam, Romina Nabiee, Jesus Ramirez Castano, Jennifer Totonchy, Vera L. Tarakanova
PLOS Pathogens.2020; 16(10): e1008968. CrossRef - Molecular Virology of KSHV in the Lymphocyte Compartment—Insights From Patient Samples and De Novo Infection Models
Farizeh Aalam, Jennifer Totonchy
Frontiers in Cellular and Infection Microbiology.2020;[Epub] CrossRef - Molecular and cellular interplay in virus-induced tumors in solid organ recipients
Alessia Gallo, Monica Miele, Ester Badami, Pier Giulio Conaldi
Cellular Immunology.2019; 343: 103770. CrossRef - Middle East respiratory syndrome coronavirus-encoded ORF8b strongly antagonizes IFN-β promoter activation: its implication for vaccine design
Jeong Yoon Lee, Sojung Bae, Jinjong Myoung
Journal of Microbiology.2019; 57(9): 803. CrossRef - Methyltransferase of a cell culture-adapted hepatitis E inhibits the MDA5 receptor signaling pathway
Jinjong Myoung, Jeong Yoon Lee, Kang Sang Min
Journal of Microbiology.2019; 57(12): 1126. CrossRef - Cell Type-Specific Interferon-γ-mediated Antagonism of KSHV Lytic Replication
Mi-Kyung Park, Hyejeong Cho, Seong Woon Roh, Seong-Jun Kim, Jinjong Myoung
Scientific Reports.2019;[Epub] CrossRef - Comment on primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas (Journal of Microbiology 2017, 55(5): 319-329)
Giovanna Rappocciolo, Frank Jenkins, Charles R. Rinaldo
Journal of Microbiology.2017; 55(7): 592. CrossRef - Lipids, lipid metabolism and Kaposi’s sarcoma-associated
herpesvirus pathogenesis
Lu Dai, Zhen Lin, Wei Jiang, Erik K. Flemington, Zhiqiang Qin
Virologica Sinica.2017; 32(5): 369. CrossRef - The Roles of Matricellular Proteins in Oncogenic Virus-Induced Cancers and Their Potential Utilities as Therapeutic Targets
Naoyoshi Maeda, Katsumi Maenaka
International Journal of Molecular Sciences.2017; 18(10): 2198. CrossRef
- Folate-Targeted Nanocarriers Co-Deliver Ganciclovir and miR-34a-5p for Combined Anti-KSHV Therapy
Research Support, Non-U.S. Gov't
- Comparative Analysis of Immune Responses to Mycobacterium abscessus Infection and Its Antigens in Two Murine Models
- Bo-Young Jeon , Jeongyeon Kwak , Seung-Sub Lee , SangNae Cho , Chul Jae Won , Jin Man Kim , Sung Jae Shin
- J. Microbiol. 2009;47(5):633-640. Published online October 24, 2009
- DOI: https://doi.org/10.1007/s12275-009-0139-1
- 30 View
- 0 Download
- 9 Scopus
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Abstract
- Mycobacterium abscessus has been identified as an emerging pulmonary pathogen in humans. Because little is known regarding immune responses elicited by M. abscessus or its antigens, immunological responses were studied in two murine models subjected to intravenous (high-dose or systemic infection) or pulmonary (low-dose or local infection) inoculation with M. abscessus ATCC 19977. An overall comparison between the two models showed similar patterns of bacterial survival and host immune responses. The colonization of M. abscessus was the highest at 5 days post-infection (dpi) and its elimination was positively correlated with cell-mediated immunity in both challenges. However, an inverse relationship was observed between progressive inflammation and mycobacterial colonization levels in mice infected with a high dose at 14 dpi. Regarding antigens, culture filtrate (CF) of M. abscessus strongly induced IFN-γ secretion, whereas cellular extract (CE) antigen elicited strong antibody responses. The antibody response to M. abscessus antigens in mice subjected to low-dose infection increased when the cellular immune response decreased over 14 dpi. However, the antibody response for the high-dose infection increased promptly after the infection. In comparison of cytokine expression in lung homogenates after M. abscessus infection, Th1 and Th2 cytokines increased simultaneously in the high-dose infection, whereas only cell-mediated immunity developed in the low-dose pulmonary infection. These findings not only enhance our understanding of the immune response to M. abscessus infection according to systemic or pulmonary infection, but may also aid in immunological diagnosis and vaccine development.
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