Journal Articles
- Correlation between fat accumulation and fecal microbiota in crossbred pigs
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Xin Li , Mengyu Li , Jinyi Han , Chuang Liu , Xuelei Han , Kejun Wang , Ruimin Qiao , Xiu-Ling Li , Xin-Jian Li
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J. Microbiol. 2022;60(11):1077-1085. Published online September 9, 2022
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DOI: https://doi.org/10.1007/s12275-022-2218-5
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Abstract
- Backfat thickness (BF) is an important indicator of fat deposition
capacity and lean meat rate in pigs and is very important
in porcine genetics and breeding. Intestinal microbiota
plays a key role in nutrient digestion and utilization with a
profound impact on fat deposition of livestock animals. To
investigate the relationship between the pig gut microbiome
and BF, 20 low-BF (L-BF) and 20 high-BF (H-BF) pigs were
selected as two groups from Yunong Black pigs in the present
study. Fecal samples from pigs were analyzed for microbial
diversity, composition, and predicted functionality using 16S
rRNA gene sequencing. The results showed that there were
significant differences in microbial β diversity between the
two groups. LEfSe analysis revealed a number of bacterial features
being differentially enriched in either L-BF or H-BF pigs.
Spearman correlation analysis identified the abundance of
Oscillospira, Peptococcus, and Bulleidia were significantly
positive correlations with BF (P < 0.05), while Sutterella and
Bifidobacterium were significantly negatively correlated with
BF (P < 0.05). Importantly, the bacteria significantly positively
correlated with BF mainly belong to Clostridium, which can
ferment host-indigestible plant polysaccharides into shortchain
fatty acid (SCFA) and promote fat synthesis and deposition.
Predictive functional analysis indicated that the pathway
abundance of cell motility and glycan biosynthesis were
significantly widespread in the microbiota of the H-BF group.
The results of this study will be useful for the development of
microbial biomarkers for predicting and improving porcine
BF, as well as for the investigation of targets for dietary strategies.
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- Carboxymethyl chitosan-dialdehyde glucan/polydopamine carrier targeted delivery Bacillus subtilis on enhancing oral utilization and intestinal colonization in mice
Lulu Chu, Luyu Xie, Bingzhi Chen, Yuji Jiang, Wenjie Wang
International Journal of Biological Macromolecules.2024; 280: 135574. CrossRef - Impact of Early Weaning on Development of the Swine Gut Microbiome
Benoit St-Pierre, Jorge Yair Perez Palencia, Ryan S. Samuel
Microorganisms.2023; 11(7): 1753. CrossRef - Comparison of Conjunctival Sac Microbiome between Low and High Myopic Eyes
Kang Xiao, Zhengyu Chen, Qin Long
Journal of Microbiology.2023; 61(5): 571. CrossRef
- Vibrio vulnificus PlpA facilitates necrotic host cell death induced by the pore forming MARTX toxin
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Changyi Cho , Sanghyeon Choi , Myung Hee Kim , Byoung Sik Kim
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J. Microbiol. 2022;60(2):224-233. Published online February 1, 2022
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DOI: https://doi.org/10.1007/s12275-022-1448-x
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53
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7
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Abstract
- Opportunistic pathogen Vibrio vulnificus causes severe systemic
infection in humans with high mortality. Although multiple
exotoxins have been characterized in V. vulnificus, their
interactions and potential synergistic roles in pathogen-induced
host cell death have not been investigated previously.
By employing a series of multiple exotoxin deletion mutants,
we investigated whether specific exotoxins of the pathogen
functioned together to achieve severe and rapid necrotic cell
death. Human epithelial cells treated with V. vulnificus with
a plpA deletion background exhibited an unusually prolonged
cell blebbing, suggesting the importance of PlpA, a phospholipase
A2, in rapid necrotic cell death by this pathogen. Additional
deletion of the rtxA gene encoding the multifunctional
autoprocessing repeats-in-toxin (MARTX) toxin did not result
in necrotic cell blebs. However, if the rtxA gene was engineered
to produce an effector-free MARTX toxin, the cell
blebbing was observed, indicating that the pore forming activity
of the MARTX toxin is sufficient, but the MARTX toxin
effector domains are not necessary, for the blebbing. When
a recombinant PlpA was treated on the blebbed cells, the blebs
were completely disrupted. Consistent with this, MARTX
toxin-pendent rapid release of cytosolic lactate dehydrogenase
was significantly delayed in the plpA deletion background.
Mutations in other exotoxins such as elastase, cytolysin/hemolysin,
and/or extracellular metalloprotease did not affect
the bleb formation or disruption. Together, these findings indicate
that the pore forming MARTX toxin and the phospholipase
A2, PlpA, cooperate sequentially to achieve rapid necrotic
cell death by inducing cell blebbing and disrupting the
blebs, respectively.
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Citations
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- Genome-wide phenotypic profiling of transcription factors and identification of novel targets to control the virulence of Vibrio vulnificus
Dayoung Sung, Garam Choi, Minji Ahn, Hokyung Byun, Tae Young Kim, Hojun Lee, Zee-Won Lee, Ji Yong Park, Young Hyun Jung, Ho Jae Han, Sang Ho Choi
Nucleic Acids Research.2024;[Epub] CrossRef - Vibrio-infecting bacteriophages and their potential to control biofilm
Ana Cevallos-Urena, Jeong Yeon Kim, Byoung Sik Kim
Food Science and Biotechnology.2023; 32(12): 1719. CrossRef -
Pathogenic Mechanism of
Vibrio Vulnificus
Infection
Kun Lu, Yang Li, Rui Chen, Hua Yang, Yong Wang, Wei Xiong, Fang Xu, Qijun Yuan, Haihui Liang, Xian Xiao, Renqiang Huang, Zhipeng Chen, Chunou Tian, Songqing Wang
Future Microbiology.2023; 18(6): 373. CrossRef - Functional conservation of specialized ribosomes bearing genome-encoded variant rRNAs in Vibrio species
Younkyung Choi, Eunkyoung Shin, Minho Lee, Ji-Hyun Yeom, Kangseok Lee, Bashir Sajo Mienda
PLOS ONE.2023; 18(12): e0289072. CrossRef - Complex regulatory networks of virulence factors in Vibrio vulnificus
Garam Choi, Sang Ho Choi
Trends in Microbiology.2022; 30(12): 1205. CrossRef - MARTX toxin of Vibrio vulnificus induces RBC phosphatidylserine exposure that can contribute to thrombosis
Han Young Chung, Yiying Bian, Kyung-Min Lim, Byoung Sik Kim, Sang Ho Choi
Nature Communications.2022;[Epub] CrossRef
- Comparison of anti-influenza virus activity and pharmacokinetics of oseltamivir free base and oseltamivir phosphate
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Jin Soo Shin , Keun Bon Ku , Yejin Jang , Yi-Seul Yoon , Daeho Shin , Oh Seung Kwon , Yun Young Go , Seong Soon Kim , Myoung Ae Bae , Meehyein Kim
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J. Microbiol. 2017;55(12):979-983. Published online December 7, 2017
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DOI: https://doi.org/10.1007/s12275-017-7371-x
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Abstract
- Influenza viruses are major human respiratory pathogens that
cause high morbidity and mortality worldwide. Currently,
prophylactic vaccines and therapeutic antiviral agents are used
to prevent and control influenza virus infection. Oseltamivir
free base (OSV-FB), a modified generic antiviral drug of
Tamiflu (oseltamivir phosphate, OSV-P), was launched in
the Republic of Korea last year. Here, we examine the bioequivalence
of these two compounds by assessing their antiviral
efficacy in infected cells and in a mouse model. It was
observed that both antivirals showed comparable efficacy
against 11 different influenza A and B viruses in vitro. Moreover,
in mice infected with influenza A virus (mouse-adapted
A/Puerto Rico/8/34), they showed a dose-dependent therapeutic
activity and alleviated infection-mediated reductions
in body weight, leading to significantly better survival. There
was histopathological disappearance of virus-induced inflammatory
cell infiltration of the lung after oral treatment with
either antiviral agent (at 10 mg/kg). Pharmacokinetic analysis
also exhibited similar plasma concentrations of the active
drug, oseltamivir carboxylate, metabolised from both OSVB
and OSV-P. This is the first report showing bioequivalence
of OSV-FB to its phosphate salt form in the mouse system.
The free base drug has some beneficial points including simple
drug formulation process and reduced risk of undesirable
cation-phosphate precipitation within solution. The long term
stability of OSV-FB requires further monitoring when it is
provided as a national stock in readiness for an influenza
pandemic.
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Citations
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Jing Yu, Jian-Ming Liu, Hui-Yi Chen, Wei-Ming Xiong
BMC Chemistry.2024;[Epub] CrossRef - A Lysosome-Targeting hNEU1 Inhibitor Treats Myocardial Infarction: A Potential Therapeutic Breakthrough
Wen Zhou, Wanxiang Yang, Ping Jiang, Shaohua Gou
Journal of Medicinal Chemistry.2024; 67(18): 16899. CrossRef - The possible techniques that used to improve the bioavailablity, pharmacological activity, solubility and permeability of anti-viral drugs: Insight for COVID-19 antiviral drugs
Ghassan Mudher Hashim , Ghaidaa S. Hameed , Dalya Basil Hanna
Al Mustansiriyah Journal of Pharmaceutical Sciences.2023; 23(3): 231. CrossRef - Antiviral Drug Delivery System for Enhanced Bioactivity, Better Metabolism and Pharmacokinetic Characteristics
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Helin Li, Xiaoyu Wu, Xin Li, Xiaobing Cao, Yanjun Li, Huaru Cao, Yongzhi Men
Frontiers in Chemistry.2021;[Epub] CrossRef - Development of Sustained Release Oseltamivir Phosphate Dry Powder Inhaler: In-Vitro Characterization and In-Vivo Toxicological Studies
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Frontiers in Microbiology.2018;[Epub] CrossRef
Research Support, Non-U.S. Gov'ts
- Antiviral Activity of 3,4'-Dihydroxyflavone on Influenza A Virus
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Mohammed Kawser Hossain , Hye Yeon Choi , Jae-Seon Hwang , Ahmed Abdal Dayem , Jung-Hyun Kim , Young Bong Kim , Haryoung Poo , Ssang-Goo Cho
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J. Microbiol. 2014;52(6):521-526. Published online May 29, 2014
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DOI: https://doi.org/10.1007/s12275-014-4212-z
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Abstract
- Influenza virus infection causes thousands of deaths and millions of hospitalizations worldwide every year and the emergence of resistance to anti-influenza drugs has prompted scientists to seek new natural antiviral materials. In this study, we screened 13 different flavonoids from various flavonoid groups to identify the most potent antiviral flavonoid against human influenza A/PR/8/34 (H1N1). The 3-hydroxyl group flavonoids, including 3,2'-dihydroxyflavone (3,2'-DHF) and 3,4'-dihydroxyflavone (3,4'-DHF), showed potent anti-influenza activity. They inhibited viral neuraminidase activity and viral adsorption onto cells. To confirm the anti-influenza activity of these flavonoids, we used an in vivo mouse model. In mice infected with human influenza, oral administration of 3,4'-DHF significantly decreased virus titers and pathological changes in the lung and reduced body weight loss and death. Our data suggest that 3-hydroxyl group flavonoids,
particularly 3,4'-DHF, have potent antiviral activity against human influenza A/PR/8/34 (H1N1) in vitro and in vivo. Further clinical studies are needed to investigate the therapeutic and prophylactic potential of the 3-hydroxyl group flavonoids in treating influenza pandemics.
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Citations
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- Antifungal and antibiofilm activities of flavonoids against Candida albicans: Focus on 3,2′-dihydroxyflavone as a potential therapeutic agent
Jin-Hyung Lee, Yong-Guy Kim, Inji Park, Jintae Lee
Biofilm.2024; 8: 100218. CrossRef - Selected flavonoids exhibit antibiofilm and antibacterial effects against Vibrio by disrupting membrane integrity, virulence and metabolic activities
Olajide Sunday Faleye, Jin-Hyung Lee, Jintae Lee
Biofilm.2023; 6: 100165. CrossRef - Specialized metabolites from plants as a source of new multi-target antiviral drugs: a systematic review
Maria Ponticelli, Maria Laura Bellone, Valentina Parisi, Annamaria Iannuzzi, Alessandra Braca, Nunziatina de Tommasi, Daniela Russo, Annalisa Sileo, Paola Quaranta, Giulia Freer, Mauro Pistello, Luigi Milella
Phytochemistry Reviews.2023; 22(3): 615. CrossRef - Technological Maturity and Systematic Review of Medicinal Plants with Pharmacological Activity in the Central Nervous System
Eduardo M.S. Bastos, Victor D.A. da Silva, Silvia L. Costa, Samira A. Hanna
Recent Patents on Biotechnology.2021; 15(2): 89. CrossRef - Hypoglycemic Effects of Plant Flavonoids: A Review
Foo Sok Yen, Chan Shu Qin, Sharryl Tan Shi Xuan, Puah Jia Ying, Hong Yi Le, Thiviya Darmarajan, Baskaran Gunasekaran, Shamala Salvamani, Huijun Wang
Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1. CrossRef - 3,2′-Dihydroxyflavone Improves the Proliferation and Survival of Human Pluripotent Stem Cells and Their Differentiation into Hematopoietic Progenitor Cells
Kyeongseok Kim, Ahmed Abdal Dayem, Minchan Gil, Gwang-Mo Yang, Soo Bin Lee, Oh-Hyung Kwon, Sangbaek Choi, Geun-Ho Kang, Kyung Min Lim, Dongho Kim, Ssang-Goo Cho
Journal of Clinical Medicine.2020; 9(3): 669. CrossRef - pH dependency of the structural and photophysical properties of the atypical 2′,3-dihydroxyflavone
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Parvaneh Mehrbod, Samad Nejad Ebrahimi, Fatemeh Fotouhi, Fatemeh Eskandari, Jacobus N. Eloff, Lyndy J. McGaw, Folorunso O. Fasina
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- DBA/2 Mouse as an Animal Model for Anti-influenza Drug Efficacy Evaluation
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Jin Il Kim , Sehee Park , Sangmoo Lee , Ilseob Lee , Jun Heo , Min-Woong Hwang , Joon-Yong Bae , Donghwan Kim , Seok-Il Jang , Mee Sook Park , Man-Seong Park
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J. Microbiol. 2013;51(6):866-871. Published online December 19, 2013
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DOI: https://doi.org/10.1007/s12275-013-3428-7
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Abstract
- Influenza viruses are seasonally recurring human pathogens.
Vaccines and antiviral drugs are available for influenza.
However, the viruses, which often change themselves via
antigenic drift and shift, demand constant efforts to update
vaccine antigens every year and develop new agents with
broad-spectrum antiviral efficacy. An animal model is critical
for such efforts. While most human influenza viruses are
unable to kill BALB/c mice, some strains have been shown
to kill DBA/2 mice without prior adaptation. Therefore, in
this study, we explored the feasibility of employing DBA/2
mice as a model in the development of anti-influenza drugs.
Unlike the BALB/c strain, DBA/2 mice were highly susceptible
and could be killed with a relatively low titer (50%
DBA/2 lethal dose = 102.83 plaque-forming units) of the A/
Korea/01/2009 virus (2009 pandemic H1N1 virus). When
treated with a neuraminidase inhibitor, oseltamivir phosphate,
infected DBA/2 mice survived until 14 days postinfection.
The reduced morbidity of the infected DBA/2
mice was also consistent with the oseltamivir treatment.
Taking these data into consideration, we propose that the
DBA/2 mouse is an excellent animal model to evaluate antiviral
efficacy against influenza infection and can be further
utilized for combination therapies or bioactivity models of
existing and newly developed anti-influenza drugs.
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Citations
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- Swine influenza A virus isolates containing the pandemic H1N1 origin matrix gene elicit greater disease in the murine model
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- Cells in the Respiratory and Intestinal Tracts of Chickens Have Different Proportions of both Human and Avian Influenza Virus Receptors
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Jin A Kim , Si Yun Ryu , Sang Heui Seo
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J. Microbiol. 2005;43(4):366-369.
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DOI: https://doi.org/2252 [pii]
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Abstract
- Avian influenza viruses play a crucial role in the creation of human pandemic viruses. In this study, we have demonstrated that both human and avian influenza receptors exist in cells in the respiratory and intestinal tracts of chickens. We have also determined that primarily cultured chicken lung cells can support the replication of both avian and human influenza viruses.