Journal of Microbiology

Journal Articles

Correlation between fat accumulation and fecal microbiota in crossbred pigs: Xin Li , Mengyu Li , Jinyi Han , Chuang Liu , Xuelei Han , Kejun Wang , Ruimin Qiao , Xiu-Ling Li , Xin-Jian Li; J. Microbiol. 2022;60(11):1077-1085. Published online September 9, 2022; DOI: https://doi.org/10.1007/s12275-022-2218-5

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Backfat thickness (BF) is an important indicator of fat deposition capacity and lean meat rate in pigs and is very important in porcine genetics and breeding. Intestinal microbiota plays a key role in nutrient digestion and utilization with a profound impact on fat deposition of livestock animals. To investigate the relationship between the pig gut microbiome and BF, 20 low-BF (L-BF) and 20 high-BF (H-BF) pigs were selected as two groups from Yunong Black pigs in the present study. Fecal samples from pigs were analyzed for microbial diversity, composition, and predicted functionality using 16S rRNA gene sequencing. The results showed that there were significant differences in microbial β diversity between the two groups. LEfSe analysis revealed a number of bacterial features being differentially enriched in either L-BF or H-BF pigs. Spearman correlation analysis identified the abundance of Oscillospira, Peptococcus, and Bulleidia were significantly positive correlations with BF (P < 0.05), while Sutterella and Bifidobacterium were significantly negatively correlated with BF (P < 0.05). Importantly, the bacteria significantly positively correlated with BF mainly belong to Clostridium, which can ferment host-indigestible plant polysaccharides into shortchain fatty acid (SCFA) and promote fat synthesis and deposition. Predictive functional analysis indicated that the pathway abundance of cell motility and glycan biosynthesis were significantly widespread in the microbiota of the H-BF group. The results of this study will be useful for the development of microbial biomarkers for predicting and improving porcine BF, as well as for the investigation of targets for dietary strategies.

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Carboxymethyl chitosan-dialdehyde glucan/polydopamine carrier targeted delivery Bacillus subtilis on enhancing oral utilization and intestinal colonization in mice
Lulu Chu, Luyu Xie, Bingzhi Chen, Yuji Jiang, Wenjie Wang
International Journal of Biological Macromolecules.2024; 280: 135574. CrossRef
Impact of Early Weaning on Development of the Swine Gut Microbiome
Benoit St-Pierre, Jorge Yair Perez Palencia, Ryan S. Samuel
Microorganisms.2023; 11(7): 1753. CrossRef
Comparison of Conjunctival Sac Microbiome between Low and High Myopic Eyes
Kang Xiao, Zhengyu Chen, Qin Long
Journal of Microbiology.2023; 61(5): 571. CrossRef

Vibrio vulnificus PlpA facilitates necrotic host cell death induced by the pore forming MARTX toxin: Changyi Cho , Sanghyeon Choi , Myung Hee Kim , Byoung Sik Kim; J. Microbiol. 2022;60(2):224-233. Published online February 1, 2022; DOI: https://doi.org/10.1007/s12275-022-1448-x

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Abstract

Opportunistic pathogen Vibrio vulnificus causes severe systemic infection in humans with high mortality. Although multiple exotoxins have been characterized in V. vulnificus, their interactions and potential synergistic roles in pathogen-induced host cell death have not been investigated previously. By employing a series of multiple exotoxin deletion mutants, we investigated whether specific exotoxins of the pathogen functioned together to achieve severe and rapid necrotic cell death. Human epithelial cells treated with V. vulnificus with a plpA deletion background exhibited an unusually prolonged cell blebbing, suggesting the importance of PlpA, a phospholipase A2, in rapid necrotic cell death by this pathogen. Additional deletion of the rtxA gene encoding the multifunctional autoprocessing repeats-in-toxin (MARTX) toxin did not result in necrotic cell blebs. However, if the rtxA gene was engineered to produce an effector-free MARTX toxin, the cell blebbing was observed, indicating that the pore forming activity of the MARTX toxin is sufficient, but the MARTX toxin effector domains are not necessary, for the blebbing. When a recombinant PlpA was treated on the blebbed cells, the blebs were completely disrupted. Consistent with this, MARTX toxin-pendent rapid release of cytosolic lactate dehydrogenase was significantly delayed in the plpA deletion background. Mutations in other exotoxins such as elastase, cytolysin/hemolysin, and/or extracellular metalloprotease did not affect the bleb formation or disruption. Together, these findings indicate that the pore forming MARTX toxin and the phospholipase A2, PlpA, cooperate sequentially to achieve rapid necrotic cell death by inducing cell blebbing and disrupting the blebs, respectively.

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Genome-wide phenotypic profiling of transcription factors and identification of novel targets to control the virulence of Vibrio vulnificus
Dayoung Sung, Garam Choi, Minji Ahn, Hokyung Byun, Tae Young Kim, Hojun Lee, Zee-Won Lee, Ji Yong Park, Young Hyun Jung, Ho Jae Han, Sang Ho Choi
Nucleic Acids Research.2024;[Epub] CrossRef
Vibrio-infecting bacteriophages and their potential to control biofilm
Ana Cevallos-Urena, Jeong Yeon Kim, Byoung Sik Kim
Food Science and Biotechnology.2023; 32(12): 1719. CrossRef
Pathogenic Mechanism of Vibrio Vulnificus Infection
Kun Lu, Yang Li, Rui Chen, Hua Yang, Yong Wang, Wei Xiong, Fang Xu, Qijun Yuan, Haihui Liang, Xian Xiao, Renqiang Huang, Zhipeng Chen, Chunou Tian, Songqing Wang
Future Microbiology.2023; 18(6): 373. CrossRef
Functional conservation of specialized ribosomes bearing genome-encoded variant rRNAs in Vibrio species
Younkyung Choi, Eunkyoung Shin, Minho Lee, Ji-Hyun Yeom, Kangseok Lee, Bashir Sajo Mienda
PLOS ONE.2023; 18(12): e0289072. CrossRef
Complex regulatory networks of virulence factors in Vibrio vulnificus
Garam Choi, Sang Ho Choi
Trends in Microbiology.2022; 30(12): 1205. CrossRef
MARTX toxin of Vibrio vulnificus induces RBC phosphatidylserine exposure that can contribute to thrombosis
Han Young Chung, Yiying Bian, Kyung-Min Lim, Byoung Sik Kim, Sang Ho Choi
Nature Communications.2022;[Epub] CrossRef

Comparison of anti-influenza virus activity and pharmacokinetics of oseltamivir free base and oseltamivir phosphate: Jin Soo Shin , Keun Bon Ku , Yejin Jang , Yi-Seul Yoon , Daeho Shin , Oh Seung Kwon , Yun Young Go , Seong Soon Kim , Myoung Ae Bae , Meehyein Kim; J. Microbiol. 2017;55(12):979-983. Published online December 7, 2017; DOI: https://doi.org/10.1007/s12275-017-7371-x

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Abstract

Influenza viruses are major human respiratory pathogens that cause high morbidity and mortality worldwide. Currently, prophylactic vaccines and therapeutic antiviral agents are used to prevent and control influenza virus infection. Oseltamivir free base (OSV-FB), a modified generic antiviral drug of Tamiflu (oseltamivir phosphate, OSV-P), was launched in the Republic of Korea last year. Here, we examine the bioequivalence of these two compounds by assessing their antiviral efficacy in infected cells and in a mouse model. It was observed that both antivirals showed comparable efficacy against 11 different influenza A and B viruses in vitro. Moreover, in mice infected with influenza A virus (mouse-adapted A/Puerto Rico/8/34), they showed a dose-dependent therapeutic activity and alleviated infection-mediated reductions in body weight, leading to significantly better survival. There was histopathological disappearance of virus-induced inflammatory cell infiltration of the lung after oral treatment with either antiviral agent (at 10 mg/kg). Pharmacokinetic analysis also exhibited similar plasma concentrations of the active drug, oseltamivir carboxylate, metabolised from both OSVB and OSV-P. This is the first report showing bioequivalence of OSV-FB to its phosphate salt form in the mouse system. The free base drug has some beneficial points including simple drug formulation process and reduced risk of undesirable cation-phosphate precipitation within solution. The long term stability of OSV-FB requires further monitoring when it is provided as a national stock in readiness for an influenza pandemic.

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Interaction mechanism of oseltamivir phosphate with bovine serum albumin: multispectroscopic and molecular docking study
Jing Yu, Jian-Ming Liu, Hui-Yi Chen, Wei-Ming Xiong
BMC Chemistry.2024;[Epub] CrossRef
A Lysosome-Targeting hNEU1 Inhibitor Treats Myocardial Infarction: A Potential Therapeutic Breakthrough
Wen Zhou, Wanxiang Yang, Ping Jiang, Shaohua Gou
Journal of Medicinal Chemistry.2024; 67(18): 16899. CrossRef
The possible techniques that used to improve the bioavailablity, pharmacological activity, solubility and permeability of anti-viral drugs: Insight for COVID-19 antiviral drugs
Ghassan Mudher Hashim , Ghaidaa S. Hameed , Dalya Basil Hanna
Al Mustansiriyah Journal of Pharmaceutical Sciences.2023; 23(3): 231. CrossRef
Antiviral Drug Delivery System for Enhanced Bioactivity, Better Metabolism and Pharmacokinetic Characteristics
Ran Chen, Tingting Wang, Jie Song, Daojun Pu, Dan He, Jianjun Li, Jie Yang, Kailing Li, Cailing Zhong, Jingqing Zhang
International Journal of Nanomedicine.2021; Volume 16: 4959. CrossRef
Multistage Extraction of Star Anise and Black Pepper Derivatives for Antibacterial, Antioxidant, and Anticancer Activity
Helin Li, Xiaoyu Wu, Xin Li, Xiaobing Cao, Yanjun Li, Huaru Cao, Yongzhi Men
Frontiers in Chemistry.2021;[Epub] CrossRef
Development of Sustained Release Oseltamivir Phosphate Dry Powder Inhaler: In-Vitro Characterization and In-Vivo Toxicological Studies
Harshal Sahastrabudhe, Prathmesh Kenjale, Varsha Pokharkar
Current Drug Delivery.2020; 17(8): 703. CrossRef
In Vitro and In Vivo Antiviral Activity of Nylidrin by Targeting the Hemagglutinin 2-Mediated Membrane Fusion of Influenza A Virus
Yejin Jang, Jin Soo Shin, Joo-Youn Lee, Heegwon Shin, Sang Jick Kim, Meehyein Kim
Viruses.2020; 12(5): 581. CrossRef
A new naphthoquinone analogue and antiviral constituents from the root of Rhinacanthus nasutus
Tran Minh Ngoc, Nguyen Thi Thanh Phuong, Nguyen Minh Khoi, SeonJu Park, Hee Jae Kwak, Nguyen Xuan Nhiem, Bui Thi Thu Trang, Bui Huu Tai, Jae-Hyoung Song, Hyun-Jeong Ko, Seung Hyun Kim
Natural Product Research.2019; 33(3): 360. CrossRef
Salinomycin Inhibits Influenza Virus Infection by Disrupting Endosomal Acidification and Viral Matrix Protein 2 Function
Yejin Jang, Jin Soo Shin, Yi-Seul Yoon, Yun Young Go, Hye Won Lee, Oh Seung Kwon, Sehee Park, Man-Seong Park, Meehyein Kim, Jae U. Jung
Journal of Virology.2018;[Epub] CrossRef
The Cranberry Extract Oximacro® Exerts in vitro Virucidal Activity Against Influenza Virus by Interfering With Hemagglutinin
Anna Luganini, Maria E. Terlizzi, Gianluca Catucci, Gianfranco Gilardi, Massimo E. Maffei, Giorgio Gribaudo
Frontiers in Microbiology.2018;[Epub] CrossRef

Research Support, Non-U.S. Gov'ts

Antiviral Activity of 3,4'-Dihydroxyflavone on Influenza A Virus: Mohammed Kawser Hossain , Hye Yeon Choi , Jae-Seon Hwang , Ahmed Abdal Dayem , Jung-Hyun Kim , Young Bong Kim , Haryoung Poo , Ssang-Goo Cho; J. Microbiol. 2014;52(6):521-526. Published online May 29, 2014; DOI: https://doi.org/10.1007/s12275-014-4212-z

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Abstract

Influenza virus infection causes thousands of deaths and millions of hospitalizations worldwide every year and the emergence of resistance to anti-influenza drugs has prompted scientists to seek new natural antiviral materials. In this study, we screened 13 different flavonoids from various flavonoid groups to identify the most potent antiviral flavonoid against human influenza A/PR/8/34 (H1N1). The 3-hydroxyl group flavonoids, including 3,2'-dihydroxyflavone (3,2'-DHF) and 3,4'-dihydroxyflavone (3,4'-DHF), showed potent anti-influenza activity. They inhibited viral neuraminidase activity and viral adsorption onto cells. To confirm the anti-influenza activity of these flavonoids, we used an in vivo mouse model. In mice infected with human influenza, oral administration of 3,4'-DHF significantly decreased virus titers and pathological changes in the lung and reduced body weight loss and death. Our data suggest that 3-hydroxyl group flavonoids, particularly 3,4'-DHF, have potent antiviral activity against human influenza A/PR/8/34 (H1N1) in vitro and in vivo. Further clinical studies are needed to investigate the therapeutic and prophylactic potential of the 3-hydroxyl group flavonoids in treating influenza pandemics.

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Antifungal and antibiofilm activities of flavonoids against Candida albicans: Focus on 3,2′-dihydroxyflavone as a potential therapeutic agent
Jin-Hyung Lee, Yong-Guy Kim, Inji Park, Jintae Lee
Biofilm.2024; 8: 100218. CrossRef
Selected flavonoids exhibit antibiofilm and antibacterial effects against Vibrio by disrupting membrane integrity, virulence and metabolic activities
Olajide Sunday Faleye, Jin-Hyung Lee, Jintae Lee
Biofilm.2023; 6: 100165. CrossRef
Specialized metabolites from plants as a source of new multi-target antiviral drugs: a systematic review
Maria Ponticelli, Maria Laura Bellone, Valentina Parisi, Annamaria Iannuzzi, Alessandra Braca, Nunziatina de Tommasi, Daniela Russo, Annalisa Sileo, Paola Quaranta, Giulia Freer, Mauro Pistello, Luigi Milella
Phytochemistry Reviews.2023; 22(3): 615. CrossRef
Technological Maturity and Systematic Review of Medicinal Plants with Pharmacological Activity in the Central Nervous System
Eduardo M.S. Bastos, Victor D.A. da Silva, Silvia L. Costa, Samira A. Hanna
Recent Patents on Biotechnology.2021; 15(2): 89. CrossRef
Hypoglycemic Effects of Plant Flavonoids: A Review
Foo Sok Yen, Chan Shu Qin, Sharryl Tan Shi Xuan, Puah Jia Ying, Hong Yi Le, Thiviya Darmarajan, Baskaran Gunasekaran, Shamala Salvamani, Huijun Wang
Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1. CrossRef
3,2′-Dihydroxyflavone Improves the Proliferation and Survival of Human Pluripotent Stem Cells and Their Differentiation into Hematopoietic Progenitor Cells
Kyeongseok Kim, Ahmed Abdal Dayem, Minchan Gil, Gwang-Mo Yang, Soo Bin Lee, Oh-Hyung Kwon, Sangbaek Choi, Geun-Ho Kang, Kyung Min Lim, Dongho Kim, Ssang-Goo Cho
Journal of Clinical Medicine.2020; 9(3): 669. CrossRef
pH dependency of the structural and photophysical properties of the atypical 2′,3-dihydroxyflavone
Luc Labarrière, Aurélien Moncomble, Jean-Paul Cornard
RSC Advances.2020; 10(58): 35017. CrossRef
Improved Isolation and Culture of Urine-Derived Stem Cells (USCs) and Enhanced Production of Immune Cells from the USC-Derived Induced Pluripotent Stem Cells
Kyeongseok Kim, Minchan Gil, Ahmed Dayem, Sangbaek Choi, Geun-Ho Kang, Gwang-Mo Yang, Sungha Cho, Yeojin Jeong, Se Kim, Jaekwon Seok, Hee Kwak, Subbroto Kumar Saha, Aram Kim, Ssang-Goo Cho
Journal of Clinical Medicine.2020; 9(3): 827. CrossRef
Xanthohumol inhibits PRRSV proliferation and alleviates oxidative stress induced by PRRSV via the Nrf2–HMOX1 axis
Xuewei Liu, Zhongbao Song, Juan Bai, Hans Nauwynck, Yongxiang Zhao, Ping Jiang
Veterinary Research.2019;[Epub] CrossRef
Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels
Raghad Khalid AL-Ishaq, Mariam Abotaleb, Peter Kubatka, Karol Kajo, Dietrich Büsselberg
Biomolecules.2019; 9(9): 430. CrossRef
Experimental validation and computational modeling of anti-influenza effects of quercetin-3-O-α-L-rhamnopyranoside from indigenous south African medicinal plant Rapanea melanophloeos
Parvaneh Mehrbod, Samad Nejad Ebrahimi, Fatemeh Fotouhi, Fatemeh Eskandari, Jacobus N. Eloff, Lyndy J. McGaw, Folorunso O. Fasina
BMC Complementary and Alternative Medicine.2019;[Epub] CrossRef
Bax Inhibitor-1 Acts as an Anti-Influenza Factor by Inhibiting ROS Mediated Cell Death and Augmenting Heme-Oxygenase 1 Expression in Influenza Virus Infected Cells
Mohammed Hossain, Subbroto Saha, Ahmed Abdal Dayem, Jung-Hyun Kim, Kyeongseok Kim, Gwang-Mo Yang, Hye Choi, Ssang-Goo Cho
International Journal of Molecular Sciences.2018; 19(3): 712. CrossRef
Antiviral activity of Poncirus trifoliata seed extract against oseltamivir-resistant influenza virus
Yoonki Heo, Yeondong Cho, Kwon sung Ju, Hansam Cho, Ki Hoon Park, Hanul Choi, Jong Kwang Yoon, Chiung Moon, Young Bong Kim
Journal of Microbiology.2018; 56(8): 586. CrossRef
Immunomodulatory properties of quercetin-3-O-α-L-rhamnopyranoside from Rapanea melanophloeos against influenza a virus
Parvaneh Mehrbod, Muna Ali Abdalla, Fatemeh Fotouhi, Masoumeh Heidarzadeh, Abimbola O. Aro, Jacobus N. Eloff, Lyndy J. McGaw, Folorunso O. Fasina
BMC Complementary and Alternative Medicine.2018;[Epub] CrossRef
Seasonal variation of pheophorbide a and flavonoid in different organs of two Carpinus species and its correlation with immunosuppressive activity
Qianqian Sheng, Xianying Fang, Zunling Zhu, Wei Xiao, Zhenzhong Wang, Gang Ding, Linguo Zhao, Yujian Li, Ping Yu, Zhibin Ding, Qinru Sun
In Vitro Cellular & Developmental Biology - Animal.2016; 52(6): 654. CrossRef
Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids
Mohammed Kawser Hossain, Ahmed Abdal Dayem, Jihae Han, Yingfu Yin, Kyeongseok Kim, Subbroto Kumar Saha, Gwang-Mo Yang, Hye Choi, Ssang-Goo Cho
International Journal of Molecular Sciences.2016; 17(4): 569. CrossRef
Antiviral Effect of Methylated Flavonol Isorhamnetin against Influenza
Ahmed Abdal Dayem, Hye Yeon Choi, Young Bong Kim, Ssang-Goo Cho, Luis Menéndez-Arias
PLOS ONE.2015; 10(3): e0121610. CrossRef

DBA/2 Mouse as an Animal Model for Anti-influenza Drug Efficacy Evaluation: Jin Il Kim , Sehee Park , Sangmoo Lee , Ilseob Lee , Jun Heo , Min-Woong Hwang , Joon-Yong Bae , Donghwan Kim , Seok-Il Jang , Mee Sook Park , Man-Seong Park; J. Microbiol. 2013;51(6):866-871. Published online December 19, 2013; DOI: https://doi.org/10.1007/s12275-013-3428-7

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Abstract

Influenza viruses are seasonally recurring human pathogens. Vaccines and antiviral drugs are available for influenza. However, the viruses, which often change themselves via antigenic drift and shift, demand constant efforts to update vaccine antigens every year and develop new agents with broad-spectrum antiviral efficacy. An animal model is critical for such efforts. While most human influenza viruses are unable to kill BALB/c mice, some strains have been shown to kill DBA/2 mice without prior adaptation. Therefore, in this study, we explored the feasibility of employing DBA/2 mice as a model in the development of anti-influenza drugs. Unlike the BALB/c strain, DBA/2 mice were highly susceptible and could be killed with a relatively low titer (50% DBA/2 lethal dose = 102.83 plaque-forming units) of the A/ Korea/01/2009 virus (2009 pandemic H1N1 virus). When treated with a neuraminidase inhibitor, oseltamivir phosphate, infected DBA/2 mice survived until 14 days postinfection. The reduced morbidity of the infected DBA/2 mice was also consistent with the oseltamivir treatment. Taking these data into consideration, we propose that the DBA/2 mouse is an excellent animal model to evaluate antiviral efficacy against influenza infection and can be further utilized for combination therapies or bioactivity models of existing and newly developed anti-influenza drugs.

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Swine influenza A virus isolates containing the pandemic H1N1 origin matrix gene elicit greater disease in the murine model
Shelly J. Curran, Emily F. Griffin, Lucas M. Ferreri, Constantinos S. Kyriakis, Elizabeth W. Howerth, Daniel R. Perez, S. Mark Tompkins, Robert Paul de Vries
Microbiology Spectrum.2024;[Epub] CrossRef
Kinetic of the Antibody Response Following AddaVax-Adjuvanted Immunization with Recombinant Influenza Antigens
Ted. M. Ross, Naveen Gokanapudi, Pan Ge, Hua Shi, Robert A. Richardson, Spencer R. Pierce, Pedro Sanchez, Subhan Ullah, Eliana De Luca, Giuseppe A. Sautto
Vaccines.2022; 10(8): 1315. CrossRef
Peptidylarginine Deiminase 2 in Murine Antiviral and Autoimmune Antibody Responses
Aisha M. Mergaert, Michael F. Denny, Brock Kingstad-Bakke, Mandar Bawadekar, S. Janna Bashar, Thomas F. Warner, Marulasiddappa Suresh, Miriam A. Shelef, Baohui Xu
Journal of Immunology Research.2022; 2022: 1. CrossRef
The morphine/heroin vaccine decreased the heroin-induced antinociceptive and reinforcing effects in three inbred strains mouse
Susana Barbosa-Méndez, Maura Matus-Ortega, Ricardo Hernández-Miramontes, Alberto Salazar-Juárez
International Immunopharmacology.2021; 98: 107887. CrossRef
Animal models for the risk assessment of viral pandemic potential
Mee Sook Park, Jin Il Kim, Joon-Yong Bae, Man-Seong Park
Laboratory Animal Research.2020;[Epub] CrossRef
In Vivo Assessment of Antibody-Dependent Enhancement of Influenza B Infection
Gautham K Rao, Rodney A Prell, Steven T Laing, Stefanie C M Burleson, Allen Nguyen, Jacqueline M McBride, Crystal Zhang, Daniel Sheinson, Wendy G Halpern
Toxicological Sciences.2019; 169(2): 409. CrossRef
Targeting the proviral host kinase, FAK, limits influenza a virus pathogenesis and NFkB-regulated pro-inflammatory responses
Silke Bergmann, Husni Elbahesh
Virology.2019; 534: 54. CrossRef
Effects of heat-killed Lactobacillus plantarum against influenza viruses in mice
Sehee Park, Jin Il Kim, Joon-Yong Bae, Kirim Yoo, Hyunung Kim, In-Ho Kim, Man-Seong Park, Ilseob Lee
Journal of Microbiology.2018; 56(2): 145. CrossRef
Alternative Strategy for a Quadrivalent Live Attenuated Influenza Virus Vaccine
Zhimin Wan, Stivalis Cardenas Garcia, Jing Liu, Jefferson Santos, Silvia Carnaccini, Ginger Geiger, Lucas Ferreri, Daniela Rajao, Daniel R. Perez, Adolfo García-Sastre
Journal of Virology.2018;[Epub] CrossRef
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David Ernszt, Krisztina Banfai, Zoltan Kellermayer, Attila Pap, Janet M. Lord, Judit E. Pongracz, Krisztian Kvell
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Yufeng Song, Xiang Wang, Hongbo Zhang, Xinying Tang, Min Li, Jufang Yao, Xia Jin, Hildegund C. J. Ertl, Dongming Zhou, D. S. Lyles
Journal of Virology.2015; 89(15): 7841. CrossRef
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Kannan Tharakaraman, Vidya Subramanian, Karthik Viswanathan, Susan Sloan, Hui-Ling Yen, Dale L. Barnard, Y. H. Connie Leung, Kristy J. Szretter, Tyree J. Koch, James C. Delaney, Gregory J. Babcock, Gerald N. Wogan, Ram Sasisekharan, Zachary Shriver
Proceedings of the National Academy of Sciences.2015; 112(35): 10890. CrossRef
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Hwan Hee Lee, Heejin Park, Gi-Ho Sung, Kanghyo Lee, Taeho Lee, Ilseob Lee, Man-seong Park, Yong Woo Jung, Yu Su Shin, Hyojeung Kang, Hyosun Cho
Journal of Microbiology.2014; 52(8): 696. CrossRef
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Sehee Park, Jin Il Kim, Ilseob Lee, Sangmoo Lee, Min-Woong Hwang, Joon-Yong Bae, Jun Heo, Donghwan Kim, Seok-Il Jang, Hyejin Kim, Hee Jin Cheong, Jin-Won Song, Ki-Joon Song, Luck Ju Baek, Man-Seong Park, Balaji Manicassamy
PLoS ONE.2014; 9(7): e101325. CrossRef

Cells in the Respiratory and Intestinal Tracts of Chickens Have Different Proportions of both Human and Avian Influenza Virus Receptors: Jin A Kim , Si Yun Ryu , Sang Heui Seo; J. Microbiol. 2005;43(4):366-369.; DOI: https://doi.org/2252 [pii]

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Abstract: Avian influenza viruses play a crucial role in the creation of human pandemic viruses. In this study, we have demonstrated that both human and avian influenza receptors exist in cells in the respiratory and intestinal tracts of chickens. We have also determined that primarily cultured chicken lung cells can support the replication of both avian and human influenza viruses.

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