Journal Article
- Lactobacillus curvatus WiKim38 isolated from kimchi induces IL-10 production in dendritic cells and alleviates DSS-induced colitis in mice
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Sung-Gang Jo , Eui-Jeong Noh , Jun-Young Lee , Green Kim , Joo-Hee Choi , Mo-Eun Lee , Jung-Hee Song , Ji-Yoon Chang , Jong-Hwan Park
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J. Microbiol. 2016;54(7):503-509. Published online June 28, 2016
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DOI: https://doi.org/10.1007/s12275-016-6160-2
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Abstract
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Probiotics such as lactobacilli and bifidobacteria have healthpromoting
effects by immune modulation. In the present
study, we examined the immunomodulatory properties of
Lactobacillus curvatus WiKim38, which was newly isolated
from baechu (Chinese cabbage) kimchi. The ability of L.
curvatus WiKim38 to induce cytokine production in bone
marrow-derived dendritic cells (BMDCs) was determined by
enzyme-linked immunosorbent assay. To evaluate the molecular
mechanisms underlying L. curvatus Wikim38-mediated
IL-10 production, Western blot analyses and inhibitor
assays were performed. Moreover, the in vivo anti-inflammatory
effects of L. curvatus WiKim38 were examined in a dextran
sodium sulfate (DSS)-induced colitis mouse model. L.
curvatus WiKim38 induced significantly higher levels of IL-
10 in BMDCs compared with that induced by LPS. NF-κB
and ERK were activated by L. curvatus WiKim38, and an
inhibitor assay revealed that these pathways were required
for L. curvatus WiKim38-induced production of IL-10 in
BMDCs. An in vivo experiment showed that oral administration
of L. curvatus WiKim38 increased the survival rate
of mice with DSS-induced colitis and improved clinical signs
and histopathological severity in colon tissues. Taken together,
these results indicate that L. curvatus Wikim38 may
have health-promoting effects via immune modulation, and
may thus be applicable for therapy of various inflammatory
diseases.
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Citations
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Nutrients.2023; 15(6): 1388. CrossRef - Distribution, inducibility, and characteristics of Latilactobacillus curvatus temperate phages
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Microbiome Research Reports.2023;[Epub] CrossRef - A Review of the Health Benefits of Kimchi Functional Compounds and Metabolites
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LWT.2022; 169: 113915. CrossRef - Immunomodulatory Activity of Extracellular Vesicles of Kimchi-Derived Lactic Acid Bacteria (Leuconostoc mesenteroides, Latilactobacillus curvatus, and Lactiplantibacillus plantarum)
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Ziqi Shi, Naiyu Guan, Weijiao Sun, Tianzhi Sun, Lingdi Niu, Jinyu Li, Junwei Ge
Probiotics and Antimicrobial Proteins.2022; 14(5): 830. CrossRef - Lactobacillus plantarum strains attenuated DSS-induced colitis in mice by modulating the gut microbiota and immune response
Israr Khan, Junshu Wei, Anping Li, Zhirong Liu, Pingrong Yang, Yaping Jing, Xinjun Chen, Tang Zhao, Yanrui Bai, Lajia Zha, Chenhui Li, Naeem Ullah, Tuanjie Che, Chunjiang Zhang
International Microbiology.2022; 25(3): 587. CrossRef - Phenotype-genotype analysis of Latilactobacills curvatus from different niches: Carbohydrate metabolism, antibiotic resistance, bacteriocin, phage fragments and linkages with CRISPR-Cas systems
Leilei Yu, Xiaojie Zang, Ying Chen, Yuhang Gao, Zhangming Pei, Bo Yang, Hao Zhang, Arjan Narbad, Fengwei Tian, Qixiao Zhai, Wei Chen
Food Research International.2022; 160: 111640. CrossRef - Latilactobacillus curvatus BYB3 Isolated from Kimchi Alleviates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice by Inhibiting IL-6 and TNF-R1 Production
Xing Wang, Dingyun Li, Ziyao Meng, Kiyeop Kim, Sejong Oh
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Wei-Feng Wang, Feng Zhou, Shan Xu, Yu-Liang Feng, Xiao-Yan Zhang, Qin Zhu, Qiao-Na He, Pei-Fen Zheng
Biologia.2022; 77(9): 2667. CrossRef - Immunomodulation of dendritic cells byLactobacillus reuterisurface components and metabolites
Melinda A. Engevik, Wenly Ruan, Magdalena Esparza, Robert Fultz, Zhongcheng Shi, Kristen A. Engevik, Amy C. Engevik, Faith D. Ihekweazu, Chonnikant Visuthranukul, Susan Venable, Deborah A. Schady, James Versalovic
Physiological Reports.2021;[Epub] CrossRef -
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A.‐R. Jang, J.‐S. Park, D.‐K. Kim, J.‐Y. Park, J.‐H. Ahn, D.‐Y. Kim, T.‐S. Lee, J.‐Y. Chang, J.‐H. Choi, J.‐H. Park
Letters in Applied Microbiology.2021; 73(3): 383. CrossRef - Genotoxicity and subchronic general toxicity assessments of Lactobacillus curvatus WiKim 38 using Sprague-Dawley rats
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Open Life Sciences.2021; 16(1): 1122. CrossRef -
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Scientific Reports.2021;[Epub] CrossRef - Alleviating Gut Inflammation with Latilactobacillus
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Subin Kim, Xing Wang, Sejong Oh
Trends in Agriculture & Life Sciences.2021; 59: 29. CrossRef - Latilactobacillus curvatus: A Candidate Probiotic with Excellent Fermentation Properties and Health Benefits
Ying Chen, Leilei Yu, Nanzhen Qiao, Yue Xiao, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai
Foods.2020; 9(10): 1366. CrossRef - Beneficial effect of immunobiotic strains on attenuation of Salmonella induced inflammatory response in human intestinal epithelial cells
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PLOS ONE.2020; 15(3): e0229647. CrossRef - Weissella paramesenteroides WpK4 plays an immunobiotic role in gut-brain axis, reducing gut permeability, anxiety-like and depressive-like behaviors in murine models of colitis and chronic stress
Sávio Sandes, Naiara Figueiredo, Sílvia Pedroso, Felipe Sant'Anna, Leonardo Acurcio, Mário Abatemarco Junior, Patrícia Barros, Fabrício Oliveira, Valbert Cardoso, Simone Generoso, Marcelo Caliari, Jacques Nicoli, Elisabeth Neumann, Álvaro Nunes
Food Research International.2020; 137: 109741. CrossRef - Unraveling microbial fermentation features in kimchi: from classical to meta-omics approaches
Se Hee Lee, Tae Woong Whon, Seong Woon Roh, Che Ok Jeon
Applied Microbiology and Biotechnology.2020; 104(18): 7731. CrossRef - Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates microbiota dysbiosis in an experimental model of sepsis
Lufang Chen, Hanyu Li, Jinyou Li, Yue Chen, Yunmei Yang
International Journal of Molecular Medicine.2019;[Epub] CrossRef - Anticariogenic and antibiofilm of purified bacteriocin of Lactobacillus curvatus and immunomodulatory effect of L. curvatus in streptococcal bacteremia
Likaa H. Mahdi, Nada Z. Mahdi, Rasha M. Sajet, Ibtesam G. Auda, Haifa N. Mater, Luma A.H. Zwain, Bushra M. Kadhem, Luma G. Alsaadi
Reviews in Medical Microbiology.2019; 30(1): 26. CrossRef - Lactobacillus brevis 23017 Relieves Mercury Toxicity in the Colon by Modulation of Oxidative Stress and Inflammation Through the Interplay of MAPK and NF-κB Signaling Cascades
Xinpeng Jiang, Shanshan Gu, Di Liu, Lili Zhao, Shuang Xia, Xinmiao He, Hongyan Chen, Junwei Ge
Frontiers in Microbiology.2018;[Epub] CrossRef - Acute infection with Strongyloides venezuelensis increases intestine production IL-10, reduces Th1/Th2/Th17 induction in colon and attenuates Dextran Sulfate Sodium-induced colitis in BALB/c mice
Vanessa Fernandes Rodrigues, Márcia Paulliny Soares Bahia, Núbia Rangel Cândido, João Marcelo Peixoto Moreira, Vinicius Gustavo Oliveira, Emília Souza Araújo, Jailza Lima Rodrigues Oliveira, Michelle de Carvalho Rezende, Ary Correa, Deborah Negrão-Corrêa
Cytokine.2018; 111: 72. CrossRef - Targeted Synthesis and Characterization of a Gene Cluster Encoding NAD(P)H-Dependent 3α-, 3β-, and 12α-Hydroxysteroid Dehydrogenases from Eggerthella CAG:298, a Gut Metagenomic Sequence
Sean M. Mythen, Saravanan Devendran, Celia Méndez-García, Isaac Cann, Jason M. Ridlon, Claire Vieille
Applied and Environmental Microbiology.2018;[Epub] CrossRef - Comparative genomics of Lactobacillus curvatus enables prediction of traits relating to adaptation and strategies of assertiveness in sausage fermentation
Lara Eisenbach, Dorothee Janßen, Matthias A. Ehrmann, Rudi F. Vogel
International Journal of Food Microbiology.2018; 286: 37. CrossRef - A survey of research papers on the health benefits of kimchi and kimchi lactic acid bacteria
Bohkyung Kim, Eun-Gyung Mun, Doyeon Kim, Young Kim, Yongsoon Park, Hae-Jeung Lee, Youn-Soo Cha
Journal of Nutrition and Health.2018; 51(1): 1. CrossRef - Potential of Lactobacillus plantarum ZDY2013 and Bifidobacterium bifidum WBIN03 in relieving colitis by gut microbiota, immune, and anti-oxidative stress
Yuanyuan Wang, Yilin Guo, Hui Chen, Hua Wei, Cuixiang Wan
Canadian Journal of Microbiology.2018; 64(5): 327. CrossRef - Bacterial community analysis in three types of the fermented seafood, jeotgal, produced in South Korea
Eun-Ji Song, Eun-Sook Lee, So-Lim Park, Hak-Jong Choi, Seong Woon Roh, Young-Do Nam
Bioscience, Biotechnology, and Biochemistry.2018; 82(8): 1444. CrossRef - Probiotic Characteristics of Lactobacillus curvatus DN317, a Strain Isolated from Chicken Ceca
Mohamed Zommiti, Nathalie Connil, Jeannette Ben Hamida, Mounir Ferchichi
Probiotics and Antimicrobial Proteins.2017; 9(4): 415. CrossRef - Effect of a probiotic beverage consumption (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) in rats with chemically induced colitis
Larissa Sbaglia Celiberto, Raquel Bedani, Naiara Naiana Dejani, Alexandra Ivo de Medeiros, José Antonio Sampaio Zuanon, Luis Carlos Spolidorio, Maria Angela Tallarico Adorno, Maria Bernadete Amâncio Varesche, Fábio Carrilho Galvão, Sandro Roberto Valentin
PLOS ONE.2017; 12(4): e0175935. CrossRef - Draft Genome Sequence of Lactobacillus curvatus FLEC03, a Meat-Borne Isolate from Beef Carpaccio Packaged in a Modified Atmosphere
Lucrecia C. Terán, Gwendoline Coeuret, Raúl Raya, Marie-Christine Champomier-Vergès, Stéphane Chaillou
Genome Announcements.2017;[Epub] CrossRef - A lactic acid bacterium isolated from kimchi ameliorates intestinal inflammation in DSS-induced colitis
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Journal of Microbiology.2017; 55(4): 304. CrossRef - Complete Genome Sequence of Lactobacillus curvatus Strain WiKim38 Isolated from Kimchi
Se Hee Lee, Min Young Jung, Jung-Hee Song, Moeun Lee, Ji Yoon Chang
Genome Announcements.2017;[Epub] CrossRef - Using murine colitis models to analyze probiotics–host interactions
Rebeca Martín, Florian Chain, Sylvie Miquel, Jean-Paul Motta, Nathalie Vergnolle, Harry Sokol, Philippe Langella
FEMS Microbiology Reviews.2017; 41(Supp_1): S49. CrossRef
Research Support, Non-U.S. Gov't
- Modulation of Immune Response by Interleukin-10 in Systemic Corynebacterium kutscheri Infection in Mice
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Eui-Suk Jeong , Kyoung-Sun Lee , Seung-Ho Heo , Jin-Hee Seo , Yang-Kyu Choi
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J. Microbiol. 2012;50(2):301-310. Published online April 27, 2012
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DOI: https://doi.org/10.1007/s12275-012-1298-z
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Abstract
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Interleukin (IL)-10 is an anti-inflammatory cytokine that
modulates sepsis by decreasing pro-inflammatory cytokine
production and chemokine expression. In this study, IL-
10-deficient and wild-type (WT) mice were infected with
Corynebacterium kutscheri to determine if the absence of
IL-10 altered the protective immunity and pathogenesis.
After infection, IL-10 knockout (KO) mice had a higher
survival rate than WT mice. The decrease of body weight
and the increased weight of organs such as liver and spleen
were greater in WT mice. Bacterial counts were significantly
increased after inoculation in WT mice over those in
IL-10 KO mice. WT mice had more granulomatous inflammation
and coagulative necrosis in the liver and spleen,
lymphocyte depletion in lymphoid follicles, and apoptosis
of immune cells in the spleen. WT mice had significantly
higher plasma concentrations of aspartate aminotransferase
and alanine aminotransferase. Furthermore, more upregulation
of tumor necrosis factor-α and IL-4 in the plasma,
macrophage inflammatory protein-2, keratinocyte-derived
chemokine, inducible nitric oxide synthase, and interferoninducible
protein 10 mRNA in the spleen were observed in
WT mice after inoculation. These results suggest that the
lack of IL-10 contributes to an increase in the systemic
clearance of C. kutscheri, and that IL-10 plays a detrimental
role in controlling systemic C. kutscheri infection.
- In situ Delivery of Therapeutic Proteins by Recombinant Lactococcus lactis
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Lothar Steidler , Sabine Neirynck
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J. Microbiol. 2003;41(2):63-72.
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Abstract
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Chronic inflammatory bowel disease (IBD) such as Crohn’s disease or ulcerative colitis, affects around 2 in every 1000 individuals in western countries and its incidence, particularly amongst children, is increasing. IBD shows extreme morbidity with impact on all aspects of quality of life. If left untreated, IBD can lead to death. Conventional treatment of IBD involves powerful immunosuppressive chemotherapies and surgical intervention. Long-term anti-inflammatory medication is required and so patients are often subject to a spectrum of unpleasant side effects. Interleukin-10 (IL-10) is a cytokine that acts to suppress inflammation. When however administered by injection, the high levels of IL-10 that are distributed throughout the body also lead to side effects. Lactococcus lactis can be genetically engineered to secrete biologically active cytokines. When applied to the mucosa, these L. lactis can actively deliver such cytokines. By use of this principle we developed a new therapeutic approach for IBD. Administration of L. lactis that secretes murine IL-10 cures and prevents IBD in mice. The use of the engineered L. lactis gets around the problem of delivering IL-10, allowing dramatic reduction of the effective dose. A sincere concern exists about the possible dangers of uncontrolled, deliberate release of genetically modified microorganisms, such as could occur following application in healthcare. We engaged in the establishment of adequate means for biological growth control of engineered L. lactis by targeted