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Astragaloside IV reversed the autophagy and oxidative stress induced by the intestinal microbiota of AIS in mice
Nan Xu , Pengcheng Kan , Xiuhua Yao , Ping Yang , Jiwei Wang , Lei Xiang , Yu Zhu
J. Microbiol. 2018;56(11):838-846.   Published online October 24, 2018
DOI: https://doi.org/10.1007/s12275-018-8327-5
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AbstractAbstract
Acute ischaemic stroke (AIS) seriously affects patient quality of life. We explored the role of the intestinal microbiota on oxidative stress and autophagy in stroke, and Astragaloside IV (AS-IV) reversed the changes induced by intestinal microbiota. We determined the characteristics of the intestinal microbiota of AIS and transient ischaemic attack (TIA) patients by 16S sequencing and found that the structure and diversity of the intestinal microbiota in patients with AIS and TIA were significantly different from those in healthy subjects. Specifically, the abundance of genus Bifidobacterium, Megamonas, Blautia, Holdemanella, and Clostridium, content of homocysteine and triglyceride was increased significantly, thus it may be as a potential mechanism of AIS and TIA. Furthermore, germ-free mice were infused intracolonically with fecal supernatants of TIA and AIS with/without feed AS-IV for 12 weeks, and we found that the feces of AIS up-regulated the autophagy markers Beclin-1, light chain 3 (LC3)-II and autophagy-related gene (Atg)12, and the expression of reactive oxygen species (ROS) and NADPH oxidase 2/4 (NOX2/4), malondialdehyde (MDA), however, the expression of total antioxidant capacity (T-AOC) and activity of superoxide dismutase (SOD) and glutathione (GSH) was down-regulated in brain tissue, the content of homocysteine and free fatty acids (FFA) in serum of the mice. Meanwhile, AS-IV could reverse the above phenomenon, however, it does not affect the motor function of mice. AS-IV reversed these changes and it may be a potential drug for AIS therapeutics.

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  • New insight into gut microbiota and their metabolites in ischemic stroke: A promising therapeutic target
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    Biomedicine & Pharmacotherapy.2023; 162: 114559.     CrossRef
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    Journal of Neurochemistry.2023; 166(2): 328.     CrossRef
  • Dissecting Causal Relationships Between Gut Microbiota, Blood Metabolites, and Stroke: A Mendelian Randomization Study
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    Journal of Stroke.2023; 25(3): 350.     CrossRef
  • Progress on traditional Chinese medicine in treatment of ischemic stroke via the gut-brain axis
    Zhe Zhai, Pei-Wei Su, Lan-ying Ma, Hui Yang, Tong Wang, Zheng-Gen Fei, Ya-Nan Zhang, Yuan Wang, Ke Ma, Bing-Bing Han, Zhi-Chun Wu, Hua-Yun Yu, Hai-Jun Zhao
    Biomedicine & Pharmacotherapy.2023; 157: 114056.     CrossRef
  • Gut microbiota, a hidden protagonist of traditional Chinese medicine for acute ischemic stroke
    Lin Gao, Xiuwen Xia, Yinqi Shuai, Hong Zhang, Wei Jin, Xiaoyun Zhang, Yi Zhang
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • The mechanism of intestinal microbiota regulating immunity and inflammation in ischemic stroke and the role of natural botanical active ingredients in regulating intestinal microbiota: A review
    Jinsong Zeng, Kailin Yang, Huifang Nie, Le Yuan, Shanshan Wang, Liuting Zeng, Anqi Ge, Jinwen Ge
    Biomedicine & Pharmacotherapy.2023; 157: 114026.     CrossRef
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    Biomedicine & Pharmacotherapy.2023; 159: 114229.     CrossRef
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    Phytomedicine.2023; 121: 155086.     CrossRef
  • CONSORT-Characteristics and metabolic phenotype of gut microbiota in NAFLD patients
    Haize Ge, Wei Wei, Liang Tang, Yaqiong Tian, Yu Zhu, Yan Luo, Shuye Liu
    Medicine.2022; 101(25): e29347.     CrossRef
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    Man Li, Bing Han, Huan Zhao, Chongyi Xu, Daokun Xu, Elwira Sieniawska, Xianming Lin, Guoyin Kai
    Phytomedicine.2022; 98: 153918.     CrossRef
  • Gut microbes in cerebrovascular diseases: Gut flora imbalance, potential impact mechanisms and promising treatment strategies
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    Manjunath Kalyan, Ahmed Hediyal Tousif, Sharma Sonali, Chandrasekaran Vichitra, Tuladhar Sunanda, Sankar Simla Praveenraj, Bipul Ray, Vasavi Rakesh Gorantla, Wiramon Rungratanawanich, Arehally M. Mahalakshmi, M. Walid Qoronfleh, Tanya M. Monaghan, Byoung-
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