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- The crosstalk between bacteria and host autophagy: host defense or bacteria offense
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Lin Zheng , Fang Wei , Guolin Li
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J. Microbiol. 2022;60(5):451-460. Published online April 29, 2022
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DOI: https://doi.org/10.1007/s12275-022-2009-z
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Abstract
- Xenophagy is a specific selective autophagy for the elimination
of intracellular bacteria. Current evidence suggests that the
processes for host autophagy system to recognize and eliminate
invading bacteria are complex, and vary according to
different pathogens. Although both ubiquitin-dependent and
ubiquitin-independent autophagy exist in host to defense invading
bacteria, successful pathogens have evolved diverse
strategies to escape from or paralyze host autophagy system.
In this review, we discuss the mechanisms of host autophagy
system to recognize and eliminate intracellular pathogens and
the mechanisms of different pathogens to escape from or paralyze
host autophagy system, with a particular focus on the
most extensively studied bacteria.
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