Journal of Microbiology

Review

MINIREVIEW] The Role of MicroRNAs in Hepatitis C Virus Replication and Related Liver Diseases: Chang Ho Lee , Ji Hyun Kim , Seong-Wook Lee; J. Microbiol. 2014;52(6):445-451. Published online May 29, 2014; DOI: https://doi.org/10.1007/s12275-014-4267-x

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Hepatitis C virus (HCV) infection is a worldwide health problem and is one of the main causes of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). However, only limited therapeutic options and no vaccines are currently available against HCV infection. Recent studies of microRNAs (miRNAs), which are able to regulate HCV replication and its related liver diseases by directly interacting with the HCV genome or indirectly controlling virus-associated host pathways, have broadened our understanding of the HCV life cycle. HCV utilizes host cellular miRNAs and modulates expression of miRNAs in infected hepatocytes for its infection and propagation. Moreover, such miRNAs directly or indirectly alter HCV replication efficiency and induce liver diseases including liver fibrosis, cirrhosis, or HCC. Representatively, miR-122 directly modulates the HCV life cycle by increasing HCV translation and genomic RNA stability. Recently, a phase IIa clinical trial with miravirsen, an LNA form of antimiR-122 oligonucleotides, showed significant reduction in serum HCV levels in patients chronically infected with HCV with no detectible evidence of resistance. In addition to miR-122, other miRNAs involved in the regulation of HCV propagation could be targeted in strategies to modulate HCV replication and pathogenesis. In this review, we summarize the features of miRNAs critical for HCV replication and HCV-mediated liver abnormalities and briefly discuss their potential application as therapeutic reagents for the treatment of HCV infection and its related diseases.

Citations

Citations to this article as recorded by

MiR-130c-5p targets the SHVV n gene and upregulates immune cytokines (IL-6, IL-22, IL-1β) to inhibit viral replication
Jin Wei, Yan Ji, Yaqian Bai, Rui Cheng, Jiaqi Zhang, Xianqin Hu, Chi Zhang
Frontiers in Immunology.2024;[Epub] CrossRef
Research advances in serum chitinase-3-like protein 1 in liver fibrosis
Xingwei Hu, Wenhan Liu, Jianhua Liu, Bojian Wang, Xiaosong Qin
Frontiers in Medicine.2024;[Epub] CrossRef
A Review of miRNA Regulation in Japanese Encephalitis (JEV) Virus Infection
Maneesh Kumar, Ganesh Chandra Sahoo, Vidya Nand Rabi Das, Kamal Singh, Krishna Pandey
Current Pharmaceutical Biotechnology.2024; 25(5): 521. CrossRef
Cold exposure impairs extracellular vesicle swarm–mediated nasal antiviral immunity
Di Huang, Maie S. Taha, Angela L. Nocera, Alan D. Workman, Mansoor M. Amiji, Benjamin S. Bleier
Journal of Allergy and Clinical Immunology.2023; 151(2): 509. CrossRef
Circulating miRNA-192 and miR-29a as Disease Progression Biomarkers in Hepatitis C Patients with a Prevalence of HCV Genotype 3
Amin Ullah, Irshad Ur Rehman, Katharina Ommer, Nadeem Ahmed, Margarete Odenthal, Xiaojie Yu, Jamshaid Ahmad, Tariq Nadeem, Qurban Ali, Bashir Ahmad
Genes.2023; 14(5): 1056. CrossRef
Hepatocellular carcinoma, hepatitis C virus infection and miRNA involvement: Perspectives for new therapeutic approaches
Ester Badami, Rosalia Busà, Bruno Douradinha, Giovanna Russelli, Vitale Miceli, Alessia Gallo, Giovanni Zito, Pier Giulio Conaldi, Gioacchin Iannolo
World Journal of Gastroenterology.2022; 28(22): 2417. CrossRef
Host Epigenetic Alterations and Hepatitis B Virus-Associated Hepatocellular Carcinoma
Mirjam B. Zeisel, Francesca Guerrieri, Massimo Levrero
Journal of Clinical Medicine.2021; 10(8): 1715. CrossRef
MiRNAs and Cancer: Key Link in Diagnosis and Therapy
Yu Shi, Zihao Liu, Qun Lin, Qing Luo, Yinghuan Cen, Juanmei Li, Xiaolin Fang, Chang Gong
Genes.2021; 12(8): 1289. CrossRef
Circulating microRNA-155 is associated with insulin resistance in chronic hepatitis C patients
Nourhan M. El Samaloty, Zeinab A. Hassan, Zeinab M. Hefny, Dalia H.A. Abdelaziz
Arab Journal of Gastroenterology.2019; 20(1): 1. CrossRef
Integrated Analysis of miRNA and mRNA Expression Profiles in Spleen of Specific Pathogen-Free Chicken Infected with Avian Reticuloendotheliosis Virus Strain SNV
Shuo Gao, Hao Jiang, Jie Sun, Youxiang Diao, Yi Tang, Jingdong Hu
International Journal of Molecular Sciences.2019; 20(5): 1041. CrossRef
Molecular mechanisms of circular RNAs, transforming growth factor‐β, and long noncoding RNAs in hepatocellular carcinoma
Wenkang Shang, Gabriel Komla Adzika, Yujie Li, Qike Huang, Ningding Ding, Bianca Chinembiri, Mohammad Sajjad Ibn Rashid, Jeremiah Ong'achwa Machuki
Cancer Medicine.2019; 8(15): 6684. CrossRef
MicroRNA Expression in Focal Nodular Hyperplasia in Comparison with Cirrhosis and Hepatocellular Carcinoma
Gábor Lendvai, Tímea Szekerczés, Benedek Gyöngyösi, Krisztina Schlachter, Endre Kontsek, Adrián Pesti, Attila Patonai, Klára Werling, Ilona Kovalszky, Zsuzsa Schaff, András Kiss
Pathology & Oncology Research.2019; 25(3): 1103. CrossRef
gga-miR-21 modulates Mycoplasma gallisepticum (HS strain)-Induced inflammation via targeting MAP3K1 and activating MAPKs and NF-κB pathways
Yabo Zhao, Mengyun Zou, Yingfei Sun, Kang Zhang, Xiuli Peng
Veterinary Microbiology.2019; 237: 108407. CrossRef
miR-27b-mediated suppression of aquaporin-11 expression in hepatocytes reduces HCV genomic RNA levels but not viral titers
Fuminori Sakurai, Rina Hashimoto, Chieko Inoue, Keisaku Wakabayashi, Tomohito Tsukamoto, Tsutomu Imaizumi, Taracena Gandara Marcos Andres, Eiko Sakai, Kanae Itsuki, Naoya Sakamoto, Takaji Wakita, Hiroyuki Mizuguchi
Virology Journal.2019;[Epub] CrossRef
Novel Insights on Notch signaling pathways in liver fibrosis
Ming-ming Ni, Ya-rui Wang, Wen-wen Wu, Chong-cai Xia, Yi-he Zhang, Jing Xu, Tao Xu, Jun Li
European Journal of Pharmacology.2018; 826: 66. CrossRef
Non-Coding RNAs and Hepatitis C Virus-Induced Hepatocellular Carcinoma
Marie-Laure Plissonnier, Katharina Herzog, Massimo Levrero, Mirjam B. Zeisel
Viruses.2018; 10(11): 591. CrossRef
Circular RNAs: Characteristics, Function and Clinical Significance in Hepatocellular Carcinoma
Man Wang, Fei Yu, Peifeng Li
Cancers.2018; 10(8): 258. CrossRef
Upregulated microRNA-429 inhibits the migration of HCC cells by targeting TRAF6 through the NF-κB pathway
Peng Wang, Jia Cao, Shihai Liu, Huazheng Pan, Xiangping Liu, Aihua Sui, Liping Wang, Ruyong Yao, Zimin Liu, Jun Liang
Oncology Reports.2017; 37(5): 2883. CrossRef
Hepatitis C virus and atherosclerosis: A legacy after virologic cure?
M.F. Bassendine, S.U. Nielsen, S.H. Bridge, D.J. Felmlee, D.A. Sheridan, C.J. Packard, R.D. Neely
Clinics and Research in Hepatology and Gastroenterology.2017; 41(1): 25. CrossRef
The Potential of MicroRNAs as Novel Biomarkers for Transplant Rejection
Matthias Hamdorf, Satoru Kawakita, Matthew Everly
Journal of Immunology Research.2017; 2017: 1. CrossRef
The notorious R.N.A. in the spotlight - drug or target for the treatment of disease
Philipp Reautschnig, Paul Vogel, Thorsten Stafforst
RNA Biology.2017; 14(5): 651. CrossRef
Decline of miR‐124 in myeloid cells promotes regulatory T‐cell development in hepatitis C virus infection
Jun P. Ren, Lin Wang, Juan Zhao, Ling Wang, Shun B. Ning, Mohamed El Gazzar, Jonathan P. Moorman, Zhi Q. Yao
Immunology.2017; 150(2): 213. CrossRef
Protection of CD4+ T cells from hepatitis C virus infection-associated senescence via ΔNp63–miR-181a–Sirt1 pathway
Yun Zhou, Guang Y Li, Jun P Ren, Ling Wang, Juan Zhao, Shun B Ning, Ying Zhang, Jian Q Lian, Chang X Huang, Zhan S Jia, Jonathan P Moorman, Zhi Q Yao
Journal of Leukocyte Biology.2016; 100(5): 1201. CrossRef
Achieving sustained virologic response after interferon‐free hepatitis C virus treatment correlates with hepatic interferon gene expression changes independent of cirrhosis
E. G. Meissner, A. Kohli, K. Virtaneva, D. Sturdevant, C. Martens, S. F. Porcella, J. G. McHutchison, H. Masur, S. Kottilil
Journal of Viral Hepatitis.2016; 23(7): 496. CrossRef
MicroRNA-mediated interactions between host and hepatitis C virus
Hu Li
World Journal of Gastroenterology.2016; 22(4): 1487. CrossRef
Hepatitis C virus infection stimulates transforming growth factor-β1 expression through up-regulating miR-192
Ji Hyun Kim, Chang Ho Lee, Seong-Wook Lee
Journal of Microbiology.2016; 54(7): 520. CrossRef
MicroRNA-33a-5p Modulates Japanese Encephalitis Virus Replication by Targeting Eukaryotic Translation Elongation Factor 1A1
Zheng Chen, Jing Ye, Usama Ashraf, Yunchuan Li, Siqi Wei, Shengfeng Wan, Ali Zohaib, Yunfeng Song, Huanchun Chen, Shengbo Cao, R. M. Sandri-Goldin
Journal of Virology.2016; 90(7): 3722. CrossRef
Circulating MiRNA-122 Levels Are Associated with Hepatic Necroinflammation and Portal Hypertension in HIV/HCV Coinfection
Christian Jansen, Thomas Reiberger, Jia Huang, Hannah Eischeid, Robert Schierwagen, Mattias Mandorfer, Evrim Anadol, Philipp Schwabl, Carolynne Schwarze-Zander, Ute Warnecke-Eberz, Christian P. Strassburg, Jürgen K. Rockstroh, Markus Peck-Radosavljevic, M
PLOS ONE.2015; 10(2): e0116768. CrossRef
Advances, Nuances, and Potential Pitfalls When Exploiting the Therapeutic Potential of RNA Interference
M Battistella, PA Marsden
Clinical Pharmacology & Therapeutics.2015; 97(1): 79. CrossRef
Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases
Jason Lamontagne
World Journal of Gastroenterology.2015; 21(24): 7375. CrossRef
Hepatitis C virus–induced reduction in miR‐181a impairs CD4+ T‐cell responses through overexpression of DUSP6
Guang Y. Li, Yun Zhou, Ruo S. Ying, Lei Shi, Yong Q. Cheng, Jun P. Ren, Jeddidiah W.D. Griffin, Zhan S. Jia, Chuan F. Li, Jonathan P. Moorman, Zhi Q. Yao
Hepatology.2015; 61(4): 1163. CrossRef
miR-141 targets ZEB2 to suppress HCC progression
Shi-Min Wu, Hong-Wu Ai, Ding-Yu Zhang, Xiao-Qun Han, Qin Pan, Feng-Ling Luo, Xiao-Lian Zhang
Tumor Biology.2014; 35(10): 9993. CrossRef

Research Support, Non-U.S. Gov't

Prediction of Bacterial microRNAs and Possible Targets in Human Cell Transcriptome: Amir Shmaryahu , Margarita Carrasco , Pablo D.T. Valenzuela; J. Microbiol. 2014;52(6):482-489. Published online May 29, 2014; DOI: https://doi.org/10.1007/s12275-014-3658-3

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Abstract

Recent studies have examined gene transfer from bacteria to humans that would result in vertical inheritance. Bacterial DNA appears to integrate into the human somatic genome through an RNA intermediate, and such integrations are detected more frequently in tumors than normal samples and in RNA than DNA samples. Also, vertebrate viruses encode products that interfere with the RNA silencing machinery, suggesting that RNA silencing may indeed be important for antiviral responses in vertebrates. RNA silencing in response to virus infection could be due to microRNAs encoded by either the virus or the host. We hypothesized that bacterial expression of RNA molecules with secondary structures is potentially able to generate miRNA molecules that can interact with the human host mRNA during bacterial infection. To test this hypothesis, we developed a pipelinebased bioinformatics approach to identify putative micro-RNAs derived from bacterial RNAs that may have the potential to regulate gene expression of the human host cell. Our results suggest that 68 bacterial RNAs predicted from 37 different bacterial genomes have predicted secondary structures potentially able to generate putative microRNAs that may interact with messenger RNAs of genes involved in 47 different human diseases. As an example, we examined the effect of transfecting three putative microRNAs into human embryonic kidney 293 (HEK293) cells. The results show that the bacterially derived microRNA sequence can significantly regulate the expression of the respective target human gene. We suggest that the study of these predicted microRNAs may yield important clues as to how the human host cell processes involved in human diseases like cancer, diabetes, rheumatoid arthritis, and others may respond to a particular bacterial environment.

Citations

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Microbial Pathogenesis.2024; 188: 106562. CrossRef
Selective extracellular secretion of small double-stranded RNA by Tetragenococcus halophilus
Imrat, Rajendra Kumar Labala, Abhisek Kumar Behara, Kumaraswamy Jeyaram
Functional & Integrative Genomics.2023;[Epub] CrossRef
Identification of putative microRNAs in the complete genome of Mycobacterium avium and their possible interaction with human transcripts
Durbba Nath, Supriyo Chakraborty
Journal of Applied Genetics.2022; 63(1): 169. CrossRef
Biological Functions and Cross-Kingdom Host Gene Regulation of Small RNAs in Lactobacillus plantarum-Derived Extracellular Vesicles
Siran Yu, Zhehao Zhao, Piliang Hao, Yan Qiu, Meiyi Zhao, Gang Zhou, Chengqian Zhang, Jiuhong Kang, Ping Li
Frontiers in Microbiology.2022;[Epub] CrossRef
The neglected nutrigenomics of milk: What is the role of inter-species transfer of small non-coding RNA?
Laura Bordoni, Rosita Gabbianelli
Food Bioscience.2021; 39: 100796. CrossRef
Prediction of microRNAs in Pseudomonas syringae pv. tomato DC3000 and their potential target prediction in Solanum lycopersicum
Yengkhom Sophiarani, Supriyo Chakraborty
Gene Reports.2021; 25: 101360. CrossRef
Small RNAs Asserting Big Roles in Mycobacteria
Fatma S. Coskun, Przemysław Płociński, Nicolai S. C. van Oers
Non-Coding RNA.2021; 7(4): 69. CrossRef
Genome wide analysis of Mycobacterium leprae for identification of putative microRNAs and their possible targets in human
Durbba Nath, Supriyo Chakraborty
Biologia.2021; 76(8): 2437. CrossRef
Potential Mechanisms Linking Food-Derived MicroRNAs, Gut Microbiota and Intestinal Barrier Functions in the Context of Nutrition and Human Health
Ester Díez-Sainz, Silvia Lorente-Cebrián, Paula Aranaz, José I. Riezu-Boj, J. Alfredo Martínez, Fermín I. Milagro
Frontiers in Nutrition.2021;[Epub] CrossRef
From Gene to Protein—How Bacterial Virulence Factors Manipulate Host Gene Expression During Infection
Lea Denzer, Horst Schroten, Christian Schwerk
International Journal of Molecular Sciences.2020; 21(10): 3730. CrossRef
Editorial commentary: Wanted: MicroRNAs to the aid of the diabetic foot
Louise T. Dalgaard, Eugenia Carvalho
Trends in Cardiovascular Medicine.2019; 29(3): 138. CrossRef
MicroRNA expression profiles of bovine monocyte-derived macrophages infected in vitro with two strains of Streptococcus agalactiae
Anna Monika Lewandowska-Sabat, Silje Furre Hansen, Trygve Roger Solberg, Olav Østerås, Bjørg Heringstad, Preben Boysen, Ingrid Olsaker
BMC Genomics.2018;[Epub] CrossRef
Core non-coding RNAs of Piscirickettsia salmonis
Cristopher Segovia, Raul Arias-Carrasco, Alejandro J. Yañez, Vinicius Maracaja-Coutinho, Javier Santander, Igor B. Rogozin
PLOS ONE.2018; 13(5): e0197206. CrossRef
Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk
Mélodie Duval, Pascale Cossart, Alice Lebreton
Seminars in Cell & Developmental Biology.2017; 65: 11. CrossRef
A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles
Katja Koeppen, Thomas H. Hampton, Michael Jarek, Maren Scharfe, Scott A. Gerber, Daniel W. Mielcarz, Elora G. Demers, Emily L. Dolben, John H. Hammond, Deborah A. Hogan, Bruce A. Stanton, Marvin Whiteley
PLOS Pathogens.2016; 12(6): e1005672. CrossRef
Regulatory role of cellular and viral microRNAs in insect–virus interactions
Sassan Asgari
Current Opinion in Insect Science.2015; 8: 104. CrossRef
Wolbachia small noncoding RNAs and their role in cross-kingdom communications
Jaime G. Mayoral, Mazhar Hussain, D. Albert Joubert, Iñaki Iturbe-Ormaetxe, Scott L. O’Neill, Sassan Asgari
Proceedings of the National Academy of Sciences.2014; 111(52): 18721. CrossRef

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