Zika virus (ZIKV) is a previously little-known flavivirus closely
related to Japanese encephalitis, West Nile, dengue, and
yellow fever viruses, all of which are primarily transmitted
by blood-sucking mosquitoes. Since its discovery in Uganda
in 1947, ZIKV has continued to expand its geographic range,
from equatorial Africa and Asia to the Pacific Islands, then
further afield to South and Central America and the Caribbean.
Currently, ZIKV is actively circulating not only in much
of Latin America and its neighbors but also in parts of the
Pacific Islands and Southeast Asia. Although ZIKV infection
generally causes only mild symptoms in some infected individuals,
it is associated with a range of neuroimmunological
disorders, including Guillain-Barré syndrome, meningoencephalitis,
and myelitis. Recently, maternal ZIKV infection during
pregnancy has been linked to neonatal malformations, result ing in various degrees of congenital abnormalities, microcephaly,
and even abortion. Despite its emergence as an
important public health problem, however, little is known
about ZIKV biology, and neither vaccine nor drug is available
to control ZIKV infection. This article provides a brief
introduction to ZIKV with a major emphasis on its molecular
virology, in order to help facilitate the development of diagnostics,
therapeutics, and vaccines.
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Brain grants permission of access to Zika virus but denies entry to drugs: a molecular modeling perspective to infiltrate the boundary Nikita Devnarain, Pritika Ramharack, Mahmoud E. Soliman RSC Adv..2017; 7(75): 47416. CrossRef
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The currently spreading arbovirus epidemic is having a severe
impact on human health worldwide. The two most common
flaviviruses, dengue virus (DENV) and Zika virus (ZIKV), are
transmitted through the same viral vector, Aedes spp. mosquitoes.
Since the discovery of DENV in 1943, this virus has
been reported to cause around 390 million human infections
per year, approximately 500,000 of which require hospitalization
and over 20,000 of which are lethal. The present
DENV epidemic is primarily concentrated in Southeast Asia.
ZIKV, which was discovered in 1952, is another important
arthropod-borne flavivirus. The neurotropic role of ZIKV
has been reported in infected newborns with microcephaly
and in adults with Guillain-Barre syndrome. Despite DENV
and ZIKV sharing the same viral vector, their complex pathogenic
natures are poorly understood, and the infections they
cause do not have specific treatments or effective vaccines.
Therefore, this review will describe what is currently known
about the clinical characteristics, pathogenesis mechanisms,
and transmission of these two viruses. Better understanding
of the interrelationships between DENV and ZIKV will provide
a useful perspective for developing an effective strategy
for controlling both viruses in the future.
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SARS-CoV-2 and arbovirus infection: a rapid systematic review Keilla Martins Milby, Alvaro Nagib Atallah, César Ramos Rocha-Filho, Ana Carolina Pereira Nunes Pinto, Aline Pereira da Rocha, Felipe Sebastião de Assis Reis, Nelson Carvas Junior, Vinicius Tassoni Civile, Rodolfo Rodrigo Pereira Santos, Laura Jantsch Fer Sao Paulo Medical Journal.2020; 138(6): 498. CrossRef
Clinical relevance of Zika symptoms in the context of a Zika Dengue epidemic Humberto Guanche Garcell, Francisco Gutiérrez García, Manuel Ramirez Nodal, Alfredo Ruiz Lozano, Carlos R. Pérez Díaz, Anaika González Valdés, Luis Gonzalez Alvarez Journal of Infection and Public Health.2020; 13(2): 173. CrossRef
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7X multiplexed, optofluidic detection of nucleic acids for antibiotic-resistance bacterial screening G. G. Meena, T. A. Wall, M. A. Stott, O. Brown, R. Robison, A. R. Hawkins, H. Schmidt Optics Express.2020; 28(22): 33019. CrossRef
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