MSK
Search
- Page Path
- HOME > Search
Journal Articles
- Increased susceptibility against Cryptococcus neoformans of lupus mouse models (pristane-induction and FcGRIIb deficiency) is associated with activated macrophage, regardless of genetic background
- Saowapha Surawut , Jiradej Makjaroen , Arthid Thim-uam , Jutamas Wongphoom , Tanapat Palaga , Prapaporn Pisitkun , Ariya Chindamporn , Asada Leelahavanichkul
- J. Microbiol. 2019;57(1):45-53. Published online November 19, 2018
- DOI: https://doi.org/10.1007/s12275-019-8311-8
- 69 View
- 0 Download
- 16 Web of Science
- 13 Crossref
-
Abstract
- The severity of cryptococcosis in lupus from varying geneticbackgrounds might be different due to the heterogeneity of lupus-pathogenesis. This study explored cryptococcosis in lupus mouse models of pristane-induction (normal geneticbackground) and FcGRIIb deficiency (genetic defect). Because the severity of lupus nephritis, as determined by proteinuria and serum creatinine, between pristane and FcGRIIb-/- mice were similar at 6-month-old, Cryptococcus neoformans was intravenously administered in 6-month-old mice and were age-matched with wild-type. Indeed, the cryptococcosis disease severity, as evaluated by mortality rate, internal-organ fungal burdens and serum cytokines, between pristane and FcGRIIb-/- mice was not different. However, the severity of cryptococcosis in wild-type was less severe than the lupus mice. On the other hand, phagocytosis activity of peritoneal macrophages from lupus mice (pristane and FcGRIIb-/-) was more predominant than the wild-type without the difference in macrophage killing-activity among these groups. In addition, the number of active T helper cells (Th-cell) in the spleen, including Th-cells with intracellular IFN-γ, from lupus mice (pristane and FcGRIIb-/-) was higher than wildtype. Moreover, these active Th-cells were even higher after 2 weeks of cryptococcal infection. These data support enhanced macrophage activation through prominent Th-cells in both lupus models. In conclusion, an increased susceptibility of cryptococcosis in both lupus models was independent to genetic background. This might due to Th-cell enhanced macrophage phagocytosis with the interference of macrophage killing activity from Cryptococcal immune-evasion properties.
-
Citations
Citations to this article as recorded by
- Comparative time-series analyses of gut microbiome profiles in genetically and chemically induced lupus-prone mice and the impacts of fecal transplantation
Piraya Chatthanathon, Asada Leelahavanichkul, Thanya Cheibchalard, Alisa Wilantho, Nattiya Hirankarn, Naraporn Somboonna
Scientific Reports.2024;[Epub] CrossRef - Fungal microbiome in gut of systemic lupus erythematosus (SLE)-prone mice (pristane and FCGRIIb deficiency), a possible impact of fungi in lupus
Thanya Cheibchalard, Asada Leelahavanichkul, Piraya Chatthanathon, Piriya Klankeo, Nattiya Hirankarn, Naraporn Somboonna, Veena Taneja
PLOS ONE.2024; 19(12): e0314662. CrossRef - Obesity Exacerbates Lupus Activity in Fc Gamma Receptor IIb Deficient Lupus Mice Partly through Saturated Fatty Acid-Induced Gut Barrier Defect and Systemic Inflammation
Kanyarat Udompornpitak, Awirut Charoensappakit, Kritsanawan Sae-Khow, Thansita Bhunyakarnjanarat, Cong Phi Dang, Wilasinee Saisorn, Peerapat Visitchanakun, Pornpimol Phuengmaung, Tanapat Palaga, Patcharee Ritprajak, Somkanya Tungsanga, Asada Leelahavanich
Journal of Innate Immunity.2023; 15(1): 240. CrossRef - Myracrodruon urundeuva lectins present anticancer and anticryptococcal activities with low cytotoxic or genotoxic effects
Larissa Cardoso Corrêa de Araújo Videres, Matheus Cavalcanti de Barros, Thamara Figueiredo Procópio, Gustavo Ramos Salles Ferreira, Pollyanna Michelle da Silva, André Mariano Batista, Maria Madalena Pessoa Guerra, Marilene Henning Vainstein, Jaciana dos S
South African Journal of Botany.2023; 157: 614. CrossRef - Enhanced lupus progression in alcohol‐administered Fc gamma receptor‐IIb–deficiency lupus mice, partly through leaky gut‐induced inflammation
Wiwat Chancharoenthana, Supitcha Kamolratanakul, Phatcharapon Yiengwattananon, Pornpimol Phuengmaung, Kanyarat Udompornpitak, Wilasinee Saisorn, Pratsanee Hiengrach, Peerapat Visitchanakun, Marcus J Schultz, Asada Leelahavanichkul
Immunology & Cell Biology.2023; 101(8): 746. CrossRef - A Comparison Between 1 Day versus 7 Days of Sepsis in Mice with the Experiments on LPS-Activated Macrophages Support the Use of Intravenous Immunoglobulin for Sepsis Attenuation
Jiradej Makjaroen, Arthid Thim-Uam, Cong Phi Dang, Trairak Pisitkun, Poorichaya Somparn, Asada Leelahavanichkul
Journal of Inflammation Research.2021; Volume 14: 7243. CrossRef - Quantum dots conjugated to lectins from Schinus terebinthifolia leaves (SteLL) and Punica granatum sarcotesta (PgTeL) as potential fluorescent nanotools for investigating Cryptococcus neoformans
Abdênego Rodrigues da Silva, Weslley Felix de Oliveira, Pollyanna Michelle da Silva, Leydianne Leite de Siqueira Patriota, Robson Raion de Vasconcelos Alves, Ana Patrícia Silva de Oliveira, Maria Tereza dos Santos Correia, Patrícia Maria Guedes Paiva, Mar
International Journal of Biological Macromolecules.2021; 192: 232. CrossRef - Lipopolysaccharide-Enhanced Responses against Aryl Hydrocarbon Receptor in FcgRIIb-Deficient Macrophages, a Profound Impact of an Environmental Toxin on a Lupus-Like Mouse Model
Kanyarat Udompornpitak, Thansita Bhunyakarnjanarat, Awirut Charoensappakit, Cong Phi Dang, Wilasinee Saisorn, Asada Leelahavanichkul
International Journal of Molecular Sciences.2021; 22(8): 4199. CrossRef - Prominent Indomethacin-Induced Enteropathy in Fcgriib Defi-cient lupus Mice: An Impact of Macrophage Responses and Immune Deposition in Gut
Thansita Bhunyakarnjanarat, Kanyarat Udompornpitak, Wilasinee Saisorn, Bhumdhanin Chantraprapawat, Peerapat Visitchanakun, Cong Phi Dang, Jiraphorn Issara-Amphorn, Asada Leelahavanichkul
International Journal of Molecular Sciences.2021; 22(3): 1377. CrossRef - A Synergy Between Endotoxin and (1→3)-Beta-D-Glucan Enhanced Neutrophil Extracellular Traps in Candida Administered Dextran Sulfate Solution Induced Colitis in FcGRIIB-/- Lupus Mice, an Impact of Intestinal Fungi in Lupus
Supichcha Saithong, Wilasinee Saisorn, Peerapat Visitchanakun, Kritsanawan Sae-khow, Direkrit Chiewchengchol, Asada Leelahavanichkul
Journal of Inflammation Research.2021; Volume 14: 2333. CrossRef - A1 and A2A adenosine receptors play a protective role to reduce prevalence of autoimmunity following tissue damage
Reut Riff, Oshri Naamani, Julia Mazar, Yosef S Haviv, Cidio Chaimovitz, Amos Douvdevani
Clinical & Experimental Immunology.2021; 205(3): 278. CrossRef - Acute Kidney Injury Induced Lupus Exacerbation Through the Enhanced Neutrophil Extracellular Traps (and Apoptosis) in Fcgr2b Deficient Lupus Mice With Renal Ischemia Reperfusion Injury
Wilasinee Saisorn, Supichcha Saithong, Pornpimol Phuengmaung, Kanyarat Udompornpitak, Thansita Bhunyakarnjanarat, Peerapat Visitchanakun, Awirut Chareonsappakit, Prapaporn Pisitkun, Direkrit Chiewchengchol, Asada Leelahavanichkul
Frontiers in Immunology.2021;[Epub] CrossRef - Syk inhibitor attenuates inflammation in lupus mice from FcgRIIb deficiency but not in pristane induction: the influence of lupus pathogenesis on the therapeutic effect
Jiraphorn Issara-Amphorn, Naraporn Somboonna, Prapaporn Pisitkun, Nattiya Hirankarn, Asada Leelahavanichkul
Lupus.2020; 29(10): 1248. CrossRef
- Comparative time-series analyses of gut microbiome profiles in genetically and chemically induced lupus-prone mice and the impacts of fecal transplantation
- The in vitro and in vivo efficacy of fluconazole in combination with farnesol against Candida albicans isolates using a murine vulvovaginitis model
- Aliz Bozó , Marianna Domán , László Majoros , Gábor Kardos , István Varga , Renátó Kovács
- J. Microbiol. 2016;54(11):753-760. Published online October 29, 2016
- DOI: https://doi.org/10.1007/s12275-016-6298-y
- 63 View
- 0 Download
- 27 Crossref
-
Abstract
- Farnesol is a quorum-sensing molecule that inhibits biofilm formation in Candida albicans. Previous in vitro data suggest that, in combination with certain antifungals, farnesol may have an adjuvant anti-biofilm agent. However, the in vivo efficacy of farnesol is very questionable. Therefore, the in vitro and in vivo activity of fluconazole combined with farnesol was evaluated against C. albicans biofilms using fractional inhibitory concentration index (FICI) determination, time-kill experiments and a murine vulvovaginitis model. The median biofilm MICs of fluconazole-sensitive C. albicans isolates ranged between 4 -> 512 mg/L and 150–300 μM for fluconazole and farnesol, respectively. These values were 512 -> 512 mg/L and > 300 μM for fluconazole-resistant clinical isolates. Farnesol decreased the median MICs of fluconazole by 2-64-fold for biofilms. Based on FICI, synergistic interaction was observed only in the case of the sessile SC5314 reference strain (FICIs: 0.16–0.27). In time-kill studies, only the 512 mg/L fluconazole and 512 mg/L fluconazole + 75 μM farnesol reduced biofilm mass significantly at each time point in the case of all isolates. The combination reduced the metabolic activity of biofilms for all isolates in a concentration- and time-dependent manner. Our findings revealed that farnesol alone was not protective in a murine vulvovaginitis model. Farnesol was not beneficial in combination with fluconazole for fluconazole-susceptible isolates, but partially increased fluconazole activity against one fluconazole- resistant isolate, but not the other one.
-
Citations
Citations to this article as recorded by- Exploring the Potential of Farnesol as a Novel Antifungal Drug and Related Challenges
Dongming Zheng, Linlan Yang, Yuxin Bai, Jiangyan Yong, Yan Li
Current Infectious Disease Reports.2024; 26(4): 123. CrossRef - Total transcriptome response for tyrosol exposure in Aspergillus nidulans
Ágnes Jakab, Kinga Csillag, Károly Antal, Imre Boczonádi, Renátó Kovács, István Pócsi, Tamás Emri
Fungal Biology.2024; 128(2): 1664. CrossRef - Combination of Farnesol with Common Antifungal Drugs: Inhibitory Effect against Candida Species Isolated from Women with RVVC
Fatemeh Nikoomanesh, Mahsa Falahatinejad, Lucia Černáková, André Luis Souza dos Santos, Shahla Roudbar Mohammadi, Mitra Rafiee, Célia Fortuna Rodrigues, Maryam Roudbary
Medicina.2023; 59(4): 743. CrossRef - Antifungal Activity and Type of Interaction of Melissa officinalis Essential Oil with Antimycotics against Biofilms of Multidrug-Resistant Candida Isolates from Vulvovaginal Mucosa
Marina Ranđelović, Marina Dimitrijević, Suzana Otašević, Ljiljana Stanojević, Milica Išljamović, Aleksandra Ignjatović, Valentina Arsić-Arsenijević, Zorica Stojanović-Radić
Journal of Fungi.2023; 9(11): 1080. CrossRef - Application of natamycin and farnesol as bioprotection agents to inhibit biofilm formation of yeasts and foodborne bacterial pathogens in apple juice processing lines
María del Rosario Agustín, María Clara Tarifa, María Soledad Vela-Gurovic, Lorena Inés Brugnoni
Food Microbiology.2023; 109: 104123. CrossRef - Hexyl-Aminolevulinate Ethosomes: a Novel Antibiofilm Agent Targeting Zinc Homeostasis in Candida albicans
Yingzhe Wang, Wei Long, Feiyin Zhang, Meimei Zhang, Kang Zeng, Xiaoliang Zhu, Gustavo H. Goldman
Microbiology Spectrum.2022;[Epub] CrossRef - Farnesol Boosts the Antifungal Effect of Fluconazole and Modulates Resistance in Candida auris through Regulation of the CDR1 and ERG11 Genes
Jaroslava Dekkerová, Lucia Černáková, Samuel Kendra, Elisa Borghi, Emerenziana Ottaviano, Birgit Willinger, Helena Bujdáková
Journal of Fungi.2022; 8(8): 783. CrossRef - Application of Natamycin and Farnesol as Biocontrol Agents of Multi-Species Biofilms on Industrial Surfaces in Apple Juice
María del Rosario Agustín, Maria Clara Tarifa, Maria Soledad Vela-Gurovic, Lorena Ines Brugnoni
SSRN Electronic Journal .2022;[Epub] CrossRef - Transcriptional Profiling of the Candida auris Response to Exogenous Farnesol Exposure
Ágnes Jakab, Noémi Balla, Ágota Ragyák, Fruzsina Nagy, Fruzsina Kovács, Zsófi Sajtos, Zoltán Tóth, Andrew M. Borman, István Pócsi, Edina Baranyai, László Majoros, Renátó Kovács, Aaron P. Mitchell
mSphere.2021;[Epub] CrossRef - Farnesol: An approach on biofilms and nanotechnology
Adelaide Fernandes Costa, Lívia do Carmo Silva, Andre Correa Amaral
Medical Mycology.2021; 59(10): 958. CrossRef - Modulating the Antifungal Activity of Antimycotic Drugs with Farnesol
N. P. Sachivkina, A. N. Senyagin, I. V. Podoprigora, D. G. Brown, V. V. Vissarionova
Drug development & registration.2021; 10(4): 162. CrossRef - In vivo antifungal activities of farnesol combined with antifungal drugs against murine oral mucosal candidiasis
Chengxi Li, Zheng Xu, Siqi Liu, Yun Huang, Wei Duan, Xin Wei
Biofouling.2021; 37(8): 818. CrossRef - Analysis of biofilm formation bySporothrix schenckii
Rocío Sánchez-Herrera, Lérida Liss Flores-Villavicencio, Juan Luis Pichardo-Molina, José Pedro Castruita-Domínguez, Xochilt Aparicio-Fernández, Myrna Sabanero López, Julio Cesar Villagómez-Castro
Medical Mycology.2021; 59(1): 31. CrossRef - Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole
Camila Fonseca Bezerra, José Geraldo de Alencar Júnior, Rosilaine de Lima Honorato, Antonia Thassya Lucas dos Santos, Josefa Carolaine Pereira da Silva, Taís Gusmão da Silva, Antonio Linkoln Alves Borges Leal, Janaína Esmeraldo Rocha, Thiago Sampaio de Fr
Chemistry and Physics of Lipids.2020; 233: 104987. CrossRef - Optimum Inhibition of Amphotericin-B-Resistant Candida albicans Strain in Single- and Mixed-Species Biofilms by Candida and Non-Candida Terpenoids
Hidaya F. Z. Touil, Kebir Boucherit, Zahia Boucherit-Otmani, Ghalia Kohder, Mohamed Madkour, Sameh S. M. Soliman
Biomolecules.2020; 10(2): 342. CrossRef - In vitro and in vivo Effect of Exogenous Farnesol Exposure Against Candida auris
Fruzsina Nagy, Eszter Vitális, Ágnes Jakab, Andrew M. Borman, Lajos Forgács, Zoltán Tóth, László Majoros, Renátó Kovács
Frontiers in Microbiology.2020;[Epub] CrossRef - Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms
Renátó Kovács, László Majoros
Journal of Fungi.2020; 6(3): 99. CrossRef - Fungal infection models: Current progress ofex vivomethods
Priscilla Maciel Quatrin, Daiane Flores Dalla Lana, Taís Fernanda Andrzejewski Kaminski, Alexandre Meneghello Fuentefria
Mycoses.2019; 62(10): 860. CrossRef -
Effect of quorum sensing molecules and natamycin on biofilms of
Candida tropicalis
and other yeasts isolated from industrial juice filtration membranes
M.d.R. Agustín, F.R. Viceconte, M.S. Vela Gurovic, A. Costantino, L.I. Brugnoni
Journal of Applied Microbiology.2019; 126(6): 1808. CrossRef - Farnesol inhibits planktonic cells and antifungal-tolerant biofilms of Trichosporon asahii and Trichosporon inkin
Rossana de Aguiar Cordeiro, Lívia Maria Galdino Pereira, José Kleybson de Sousa, Rosana Serpa, Ana Raquel Colares Andrade, Fernando Victor Monteiro Portela, Antônio José de Jesus Evangelista, Jamille Alencar Sales, Ana Luiza Ribeiro Aguiar, Patrícia Bruna
Medical Mycology.2019; 57(8): 1038. CrossRef -
In Vivo
Applicability of Neosartorya fischeri Antifungal Protein 2 (NFAP2) in Treatment of Vulvovaginal Candidiasis
Renátó Kovács, Jeanett Holzknecht, Zoltán Hargitai, Csaba Papp, Attila Farkas, Attila Borics, Lilána Tóth, Györgyi Váradi, Gábor K. Tóth, Ilona Kovács, Sandrine Dubrac, László Majoros, Florentine Marx, László Galgóczy
Antimicrobial Agents and Chemotherapy.2019;[Epub] CrossRef - Biofilms and vulvovaginal candidiasis
Carmen Rodríguez-Cerdeira, Miguel Carnero Gregorio, Alberto Molares-Vila, Adriana López-Barcenas, Gabriella Fabbrocini, Brunilda Bardhi, Ardiana Sinani, Elena Sánchez-Blanco, Roberto Arenas-Guzmán, Rigoberto Hernandez-Castro
Colloids and Surfaces B: Biointerfaces.2019; 174: 110. CrossRef - Photodynamic Inactivation Potentiates the Susceptibility of Antifungal Agents against the Planktonic and Biofilm Cells of Candida albicans
Mu-Ching Huang, Mandy Shen, Yi-Jhen Huang, Hsiao-Chi Lin, Chin-Tin Chen
International Journal of Molecular Sciences.2018; 19(2): 434. CrossRef - Antimicrobial photodynamic therapy as a new approach for the treatment of vulvovaginal candidiasis: preliminary results
Maria Eugênia Simões Onofre de Santi, Renato Araujo Prates, Cristiane Miranda França, Rúbia Garcia Lopes, Aline Silva Sousa, Luis Rodolfo Ferreira, Sandra Kalil Bussadori, Adjaci Uchoa Fernandes, Alessandro Melo Deana
Lasers in Medical Science.2018; 33(9): 1925. CrossRef -
In vitro antifungal susceptibility patterns of planktonic and sessile Candida kefyr clinical isolates
Fruzsina Nagy, Aliz Bozó, Zoltán Tóth, Lajos Daróczi, László Majoros, Renátó Kovács
Medical Mycology.2018; 56(4): 493. CrossRef - The Structure-Activity Relationship of Pterostilbene Against Candida albicans Biofilms
Dan-Dan Hu, Ri-Li Zhang, Yong Zou, Hua Zhong, En-Sheng Zhang, Xiang Luo, Yan Wang, Yuan-Ying Jiang
Molecules.2017; 22(3): 360. CrossRef - Antifungal activity of tyrosol and farnesol used in combination against Candida
species in the planktonic state or forming biofilms
D.R. Monteiro, L.S. Arias, R.A. Fernandes, L.F. Deszo da Silva, M.O.V.F. de Castilho, T.O. da Rosa, A.P.M. Vieira, F.G. Straioto, D.B. Barbosa, A.C.B. Delbem
Journal of Applied Microbiology.2017; 123(2): 392. CrossRef
- Exploring the Potential of Farnesol as a Novel Antifungal Drug and Related Challenges
Research Support, Non-U.S. Gov'ts
- Newly Identified CpG ODNs, M5-30 and M6-395, Stimulate MouseNewly Identified CpG ODNs, M5-30 and M6-395, Stimulate Mouse Immune Cells to Secrete TNF-α and Enhance Th1-Mediated Immunity
- Sun-Shim Choi , Eunkyung Chung , Yu-Jin Jung
- J. Microbiol. 2010;48(4):512-517. Published online August 20, 2010
- DOI: https://doi.org/10.1007/s12275-010-0053-6
- 54 View
- 0 Download
- 13 Scopus
-
Abstract
- Bacterial CpG motifs are known to induce both innate and adaptive immunity in infected hosts via toll-like receptor 9 (TLR9). Because small oligonucleotides (ODNs) mimicking bacterial CpG motifs are easily synthesized, they have found use as immunomodulatory agents in a number of disease models. We have developed a novel bioinformatics approach to identify effective CpG ODN sequences and evaluate their function as TLR9 ligands in a murine system. Among the CpG ODNs we identified, M5-30 and M6-395 showed significant ability to stimulate TNF-α and IFN-γ production in a mouse macrophage cell line and mouse splenocytes, respectively. We also found that these CpG ODNs activated cells through the canonical NF-κB signaling pathway. Moreover, both CpG ODNs were able to induce Th1-mediated immunity in Mycobacterium tuberculosis (Mtb)-infected mice. Our results demonstrate that M5-30 and M6-395 function as TLR9-specific ligands, making them useful in the study of TLR9 functionality and signaling in mice.
- In Vivo Studies with a Candida tropicalis Isolate Exhibiting Paradoxical Growth In Vitro in the Presence of High Concentration of Caspofungin
- Sedigh Bayegan , Laszlo Majoros , Gabor Kardos , Adam Kemény-Beke , Cecilia Miszti , Renato Kovacs , Rudolf Gesztelyi
- J. Microbiol. 2010;48(2):170-173. Published online May 1, 2010
- DOI: https://doi.org/10.1007/s12275-010-9221-y
- 57 View
- 0 Download
- 18 Crossref
-
Abstract
- We investigated the activity of caspofungin against a Candida tropicalis clinical isolate showing paradoxical growth in vitro. BALB/c mice immunosuppressed by cyclophosphamide were infected intraperitoneally using 107 CFU/mouse. Caspofungin was administered intraperitoneally once daily for 5 days or as a single dose using the following doses: 0.12, 0.25, 1, 2, 3, 5, and 15 mg/kg. The single dose of caspofungin was effective only at 5 and 15 mg/kg concentrations (100% survival). Five-day caspofungin treatment led to 100% survival at doses of 1 mg/kg or higher. Caspofungin treatment significantly decreased the number of viable yeasts in the peritoneal lavage samples as well as in the infected abscesses at doses 1, 3, 5, and 15 mg/kg caspofungin as compared to the untreated control (P<0.001 in all cases), and even to the group treated with 0.12 mg/kg caspofungin (P<0.05 in all cases). At 2 mg/kg caspofungin dose, sterilization of the internal organs was reproducibly incomplete, suggesting that the role of paradoxical growth in the late clinical failure cannot be excluded.
-
Citations
Citations to this article as recorded by- Adaptation of the emerging pathogenic yeast Candida auris to high caspofungin concentrations correlates with cell wall changes
Violeta Lara-Aguilar, Cristina Rueda, Irene García-Barbazán, Sarai Varona, Sara Monzón, Pilar Jiménez, Isabel Cuesta, Ángel Zaballos, Óscar Zaragoza
Virulence.2021; 12(1): 1400. CrossRef - Relative Frequency of Paradoxical Growth and Trailing Effect with Caspofungin, Micafungin, Anidulafungin, and the Novel Echinocandin Rezafungin against Candida Species
Zoltán Tóth, Lajos Forgács, Tamás Kardos, Renátó Kovács, Jeffrey B. Locke, Gábor Kardos, Fruzsina Nagy, Andrew M. Borman, Awid Adnan, László Majoros
Journal of Fungi.2020; 6(3): 136. CrossRef - Minimal Inhibitory Concentration (MIC)-Phenomena in Candida albicans and Their Impact on the Diagnosis of Antifungal Resistance
Ulrike Binder, Maria Aigner, Brigitte Risslegger, Caroline Hörtnagl, Cornelia Lass-Flörl, Michaela Lackner
Journal of Fungi.2019; 5(3): 83. CrossRef - Treatment of Invasive Candidiasis: A Narrative Review
Ronen Ben-Ami
Journal of Fungi.2018; 4(3): 97. CrossRef - Pharmacokinetics of extended dose intervals of micafungin in haematology patients: optimizing antifungal prophylaxis
E W Muilwijk, J A Maertens, W J F M van der Velden, R ter Heine, A Colbers, D M Burger, D Andes, K Theunissen, N M A Blijlevens, R J M Brüggemann
Journal of Antimicrobial Chemotherapy.2018; 73(11): 3095. CrossRef - An Update on Candida tropicalis Based on Basic and Clinical Approaches
Diana L. Zuza-Alves, Walicyranison P. Silva-Rocha, Guilherme M. Chaves
Frontiers in Microbiology.2017;[Epub] CrossRef - Recent Insights into the Paradoxical Effect of Echinocandins
Johannes Wagener, Veronika Loiko
Journal of Fungi.2017; 4(1): 5. CrossRef - Drug resistance mechanisms and their regulation in non-albicans Candidaspecies
Anna Kołaczkowska, Marcin Kołaczkowski
Journal of Antimicrobial Chemotherapy.2016; 71(6): 1438. CrossRef - The Eagle-Like Effect of the Echinocandins: Is It Relevant for Clinical Decisions?
Kayla R. Stover, John D. Cleary
Current Fungal Infection Reports.2015; 9(2): 88. CrossRef - Paradoxical Growth of Candida albicans in the Presence of Caspofungin Is Associated with Multiple Cell Wall Rearrangements and Decreased Virulence
Cristina Rueda, Manuel Cuenca-Estrella, Oscar Zaragoza
Antimicrobial Agents and Chemotherapy.2014; 58(2): 1071. CrossRef - The Eagle-like effect of echinocandins: what’s in a name?
Kim Vanstraelen, Katrien Lagrou, Johan Maertens, Joost Wauters, Ludo Willems, Isabel Spriet
Expert Review of Anti-infective Therapy.2013; 11(11): 1179. CrossRef -
The Postantifungal and Paradoxical Effects of Echinocandins Against
Candida
spp.
Brad Moriyama, Stacey A Henning, Scott R Penzak, Thomas J Walsh
Future Microbiology.2012; 7(5): 565. CrossRef - Echinocandin Resistance in Candida Species: Mechanisms of Reduced Susceptibility and Therapeutic Approaches
Nicholas D Beyda, Russell E Lewis, Kevin W Garey
Annals of Pharmacotherapy.2012; 46(7-8): 1086. CrossRef - The potential impact of antifungal drug resistance mechanisms on the host immune response to Candida
Russell E. Lewis, Pierluigi Viale, Dimitrios P Kontoyiannis
Virulence.2012; 3(4): 368. CrossRef - Candida glabrata, Candida parapsilosisandCandida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance
Sónia Silva, Melyssa Negri, Mariana Henriques, Rosário Oliveira, David W. Williams, Joana Azeredo
FEMS Microbiology Reviews.2012; 36(2): 288. CrossRef - Effect of nikkomycin Z and 50% human serum on the killing activity of high-concentration caspofungin againstCandida speciesusing time-kill methodology
Judit Szilágyi, Richárd Földi, Sedigh Bayegan, Gábor Kardos, László Majoros
Journal of Chemotherapy.2012; 24(1): 18. CrossRef - Echinocandins: Are They All The Same?
PK Mukherjee, D Sheehan, L Puzniak, H Schlamm, MA Ghannoum
Journal of Chemotherapy.2011; 23(6): 319. CrossRef - Paradoxical Effect of Caspofungin against Candida Bloodstream Isolates Is Mediated by Multiple Pathways but Eliminated in Human Serum
Ryan K. Shields, M. Hong Nguyen, Chen Du, Ellen Press, Shaoji Cheng, Cornelius J. Clancy
Antimicrobial Agents and Chemotherapy.2011; 55(6): 2641. CrossRef
- Adaptation of the emerging pathogenic yeast Candida auris to high caspofungin concentrations correlates with cell wall changes
- Comparative Analysis of Immune Responses to Mycobacterium abscessus Infection and Its Antigens in Two Murine Models
- Bo-Young Jeon , Jeongyeon Kwak , Seung-Sub Lee , SangNae Cho , Chul Jae Won , Jin Man Kim , Sung Jae Shin
- J. Microbiol. 2009;47(5):633-640. Published online October 24, 2009
- DOI: https://doi.org/10.1007/s12275-009-0139-1
- 44 View
- 0 Download
- 10 Crossref
-
Abstract
- Mycobacterium abscessus has been identified as an emerging pulmonary pathogen in humans. Because little is known regarding immune responses elicited by M. abscessus or its antigens, immunological responses were studied in two murine models subjected to intravenous (high-dose or systemic infection) or pulmonary (low-dose or local infection) inoculation with M. abscessus ATCC 19977. An overall comparison between the two models showed similar patterns of bacterial survival and host immune responses. The colonization of M. abscessus was the highest at 5 days post-infection (dpi) and its elimination was positively correlated with cell-mediated immunity in both challenges. However, an inverse relationship was observed between progressive inflammation and mycobacterial colonization levels in mice infected with a high dose at 14 dpi. Regarding antigens, culture filtrate (CF) of M. abscessus strongly induced IFN-γ secretion, whereas cellular extract (CE) antigen elicited strong antibody responses. The antibody response to M. abscessus antigens in mice subjected to low-dose infection increased when the cellular immune response decreased over 14 dpi. However, the antibody response for the high-dose infection increased promptly after the infection. In comparison of cytokine expression in lung homogenates after M. abscessus infection, Th1 and Th2 cytokines increased simultaneously in the high-dose infection, whereas only cell-mediated immunity developed in the low-dose pulmonary infection. These findings not only enhance our understanding of the immune response to M. abscessus infection according to systemic or pulmonary infection, but may also aid in immunological diagnosis and vaccine development.
-
Citations
Citations to this article as recorded by- Mycobacterium abscessus biofilm cleared from murine lung by monoclonal antibody against bacterial DNABII proteins
Joseph A. Jurcisek, Nikola Kurbatfinski, Kathryn Q. Wilbanks, Jaime D. Rhodes, Steven D. Goodman, Lauren O. Bakaletz
Journal of Cystic Fibrosis.2025; 24(2): 374. CrossRef - Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design
Kia C. Ferrell, Matt D. Johansen, James A. Triccas, Claudio Counoupas
Frontiers in Microbiology.2022;[Epub] CrossRef - Vaccination inducing durable and robust antigen-specific Th1/Th17 immune responses contributes to prophylactic protection against Mycobacterium avium infection but is ineffective as an adjunct to antibiotic treatment in chronic disease
Ju Mi Lee, Jiyun Park, Steven G Reed, Rhea N Coler, Jung Joo Hong, Lee-Han Kim, Wonsik Lee, Kee Woong Kwon, Sung Jae Shin
Virulence.2022; 13(1): 808. CrossRef - Species-Specific Interferon-Gamma Release Assay for the Diagnosis of Mycobacterium abscessus Complex Infection
Mathis Steindor, Florian Stehling, Margarete Olivier, Jan Kehrmann, Margo Diricks, Florian P. Maurer, Peter A. Horn, Svenja Straßburg, Matthias Welsner, Sivagurunathan Sutharsan, Monika Lindemann
Frontiers in Microbiology.2021;[Epub] CrossRef - A New Model of Chronic Mycobacterium abscessus Lung Infection in Immunocompetent Mice
Camilla Riva, Enrico Tortoli, Federica Cugnata, Francesca Sanvito, Antonio Esposito, Marco Rossi, Anna Colarieti, Tamara Canu, Cristina Cigana, Alessandra Bragonzi, Nicola Ivan Loré, Paolo Miotto, Daniela Maria Cirillo
International Journal of Molecular Sciences.2020; 21(18): 6590. CrossRef - Mycobacterium abscessus Morphotype Comparison in a Murine Model
Lindsay J. Caverly, Silvia M. Caceres, Cori Fratelli, Carrie Happoldt, Kelley M. Kidwell, Kenneth C. Malcolm, Jerry A. Nick, David P. Nichols, Nades Palaniyar
PLOS ONE.2015; 10(2): e0117657. CrossRef - Increasing nontuberculous mycobacteria infection in cystic fibrosis
Ophir Bar-On, Huda Mussaffi, Meir Mei-Zahav, Dario Prais, Guy Steuer, Patrick Stafler, Shai Hananya, Hannah Blau
Journal of Cystic Fibrosis.2015; 14(1): 53. CrossRef - Differential Immune Responses to Segniliparus rotundus and Segniliparus rugosus Infection and Analysis of Their Comparative Virulence Profiles
Jong-Seok Kim, Woo Sik Kim, Keehoon Lee, Choul-Jae Won, Jin Man Kim, Seok-Yong Eum, Won-Jung Koh, Sung Jae Shin, Yung-Fu Chang
PLoS ONE.2013; 8(3): e59646. CrossRef - Mycobacterium abscessus Bacteremia After Receipt of Intravenous Infusate of Cytokine-Induced Killer Cell Therapy for Body Beautification and Health Boosting
Raymond Liu, Kelvin K. W. To, Jade L. L. Teng, Garnet K. Y. Choi, Ka-Yi Mok, Kin-Ip Law, Eugene Y. K. Tso, Kitty S. C. Fung, Tak-Chiu Wu, Alan K. L. Wu, Shing-Hoi Fung, Sally C. Y. Wong, Nigel J. Trendell-Smith, Kwok-Yung Yuen
Clinical Infectious Diseases.2013; 57(7): 981. CrossRef - Current Understanding ofMycobacterium abscessusInfection
Go-Eun Choi, Youngsuk Jo, Sung Jae Shin
Journal of Bacteriology and Virology.2012; 42(1): 17. CrossRef
- Mycobacterium abscessus biofilm cleared from murine lung by monoclonal antibody against bacterial DNABII proteins
First
Prev
TOP
