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- Rab27b regulates extracellular vesicle production in cells infected with Kaposi’s sarcoma–associated herpesvirus to promote cell survival and persistent infection
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Hyungtaek Jeon , Su-Kyung Kang , Myung-Ju Lee , Changhoon Park , Seung-Min Yoo , Yun Hee Kang , Myung-Shin Lee
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J. Microbiol. 2021;59(5):522-529. Published online April 20, 2021
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DOI: https://doi.org/10.1007/s12275-021-1108-6
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Abstract
- Extracellular vesicles (EVs) play a crucial role in cell-to-cell
communication. EVs and viruses share several properties
related to their structure and the biogenesis machinery in
cells. EVs from virus-infected cells play a key role in virus
spread and suppression using various loading molecules,
such as viral proteins, host proteins, and microRNAs. However,
it remains unclear how and why viruses regulate EV
production inside host cells. The purpose of this study is to
investigate the molecular mechanisms underlying EV production
and their roles in Kaposi’s sarcoma-associated herpesvirus
(KSHV)-infected cells. Here, we found that KSHV
induced EV production in human endothelial cells via Rab-
27b upregulation. The suppression of Rab27b expression in
KSHV-infected cells enhanced cell death by increasing autophagic
flux and autolysosome formation. Our results indicate
that Rab27b regulates EV biogenesis to promote cell survival
and persistent viral infection during KSHV infection,
thereby providing novel insights into the crucial role of Rab-
27b in the KSHV life cycle.
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