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- Fresh Washed Microbiota Transplantation Alters Gut Microbiota Metabolites to Ameliorate Sleeping Disorder Symptom of Autistic Children
- Nai-Hua Liu , Hong-Qian Liu , Jia-Yi Zheng , Meng-Lu Zhu , Li-Hao Wu , Hua-Feng Pan , Xing-Xiang He
- J. Microbiol. 2023;61(8):741-753. Published online September 4, 2023
- DOI: https://doi.org/10.1007/s12275-023-00069-x
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- 7 Web of Science
- 6 Crossref
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Abstract
PDF - Accumulating studies have raised concerns about gut dysbiosis associating autism spectrum disorder (ASD) and its related symptoms. However, the effect of gut microbiota modification on the Chinese ASD population and its underlying mechanism were still elusive. Herein, we enrolled 24 ASD children to perform the first course of fresh washed microbiota transplantation (WMT), 18 patients decided to participate the second course, 13 of which stayed to participate the third course, and there were 8 patients at the fourth course. Then we evaluated the effects of fresh WMT on these patients and their related symptoms. Our results found that the sleeping disorder symptom was positively interrelated to ASD, fresh WMT significantly alleviated ASD and its sleeping disorder and constipation symptoms. In addition, WMT stably and continuously downregulated Bacteroides/ Flavonifractor/Parasutterella while upregulated Prevotella_9 to decrease toxic metabolic production and improve detoxification by regulating glycolysis/myo-inositol/D-glucuronide/D-glucarate degradation, L-1,2-propanediol degradation, fatty acid β-oxidation. Thus, our results suggested that fresh WMT moderated gut microbiome to improve the behavioral and sleeping disorder symptoms of ASD via decrease toxic metabolic production and improve detoxification. Which thus provides a promising gut ecological strategy for ASD children and its related symptoms treatments.
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Citations
Citations to this article as recorded by
- Effects of gastrointestinal symptoms on the efficacy of washed microbiota transplantation in patients with autism
Dong-Xia Hu, Cai-Mei Lu, Xin-Yu Si, Qing-Ting Wu, Li-Hao Wu, Hao-Jie Zhong, Xing-Xiang He
Frontiers in Pediatrics.2025;[Epub] CrossRef - The Impact of Fecal Microbiota Transplantation on Gastrointestinal and Behavioral Symptoms in Children and Adolescents with Autism Spectrum Disorder: A Systematic Review
Anna Liber, Małgorzata Więch
Nutrients.2025; 17(13): 2250. CrossRef - Pathogenic bacteria enriched in the oral microbiota might be associated with recurrent pulmonary infections in elderly individuals
Jingyi Xu, Ruyi Qu, Keke Yang, Yuezhu Wang, Meiyun Nie, Xiaodong Qi, Huajun Zheng, Ling Yang
Aging Clinical and Experimental Research.2025;[Epub] CrossRef - Does constipation affect the effectiveness of washed microbiota transplantation in treating autism spectrum disorders?
Zihao Pan, Zheng Gao, Junyi Chen, Yongxi Quan, Jiating Xu, Xiaofeng Liang, Wenrui Xie, Xingxiang He, Lihao Wu
Frontiers in Neuroscience.2025;[Epub] CrossRef - Untargeted urine metabolomics and machine learning provide potential metabolic signatures in children with autism spectrum disorder
Xian Liu, Xin Sun, Cheng Guo, Zhi-Fang Huang, Yi-Ru Chen, Fang-Mei Feng, Li-Jie Wu, Wen-Xiong Chen
Frontiers in Psychiatry.2024;[Epub] CrossRef - Washed Microbiota Transplantation Improves the Sleep Quality in Patients with Inflammatory Bowel Disease
Qianqian Li, Yujie Liu, Zulun Zhang, Sheng Zhang, Xiao Ding, Faming Zhang
Nature and Science of Sleep.2024; Volume 16: 1141. CrossRef
- Effects of gastrointestinal symptoms on the efficacy of washed microbiota transplantation in patients with autism
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