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- Manganese Transporter Proteins in Salmonella enterica serovar Typhimurium
- Nakyeong Ha , Eun-Jin Lee
- J. Microbiol. 2023;61(3):289-296. Published online March 2, 2023
- DOI: https://doi.org/10.1007/s12275-023-00027-7
- 75 View
- 0 Download
- 8 Web of Science
- 8 Crossref
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Abstract
- The metal cofactors are essential for the function of many enzymes. The host restricts the metal acquisition of pathogens for their immunity and the pathogens have evolved many ways to obtain metal ions for their survival and growth. Salmonella enterica serovar Typhimurium also needs several metal cofactors for its survival, and manganese has been found to contribute to Salmonella pathogenesis. Manganese helps Salmonella withstand oxidative and nitrosative stresses. In addition, manganese affects glycolysis and the reductive TCA, which leads to the inhibition of energetic and biosynthetic metabolism. Therefore, manganese homeostasis is crucial for full virulence of Salmonella. Here, we summarize the current information about three importers and two exporters of manganese that have been identified in Salmonella. MntH, SitABCD, and ZupT have been shown to participate in manganese uptake. mntH and sitABCD are upregulated by low manganese concentration, oxidative stress, and host NRAMP1 level. mntH also contains a Mn2+- dependent riboswitch in its 5′ UTR. Regulation of zupT expression requires further investigation. MntP and YiiP have been identified as manganese efflux proteins. mntP is transcr!ptionally activated by MntR at high manganese levels and repressed its activity by MntS at low manganese levels. Regulation of yiiP requires further analysis, but it has been shown that yiiP expression is not dependent on MntS. Besides these five transporters, there might be additional transporters that need to be identified.
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Citations
Citations to this article as recorded by
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Functional characterization of a TerC family protein of
Riemerella anatipestifer
in manganese detoxification and virulence
Qinyuan Chen, Fang Guo, Li Huang, Mengying Wang, Chunfeng Shi, Shutong Zhang, Yizhou Yao, Mingshu Wang, Dekang Zhu, Renyong Jia, Shun Chen, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Bin Tian, Juan Huang, Xumin Ou, Qun Gao, Di Sun, Ling Zhang, Yanling
Applied and Environmental Microbiology.2024;[Epub] CrossRef - NO enhances the adaptability to high-salt environments by regulating osmotic balance, antioxidant defense, and ion homeostasis in eelgrass based on transcriptome and metabolome analysis
Xianyan Wang, Tongtong Wang, Pei Yu, Yuchun Li, Xinfang Lv
Frontiers in Plant Science.2024;[Epub] CrossRef - High-throughput fitness experiments reveal specific vulnerabilities of human-adapted Salmonella during stress and infection
Benjamin X. Wang, Dmitry Leshchiner, Lijuan Luo, Miles Tuncel, Karsten Hokamp, Jay C. D. Hinton, Denise M. Monack
Nature Genetics.2024; 56(6): 1288. CrossRef -
Biological characteristics of manganese transporter MntP in
Klebsiella pneumoniae
Wei Peng, Yafei Xu, Yilin Yin, Jichen Xie, Renhui Ma, Guoyuan Song, Zhiqiang Zhang, Qiuhang Quan, Qinggen Jiang, Moran Li, Bei Li, Michael David Leslie Johnson
mSphere.2024;[Epub] CrossRef -
Exploring resource competition by protective lactic acid bacteria cultures to control
Salmonella
in food: an Achilles’ heel to target?
Ludovico Screpanti, Nathalie Desmasures, Margot Schlusselhuber
Critical Reviews in Food Science and Nutrition.2024; : 1. CrossRef - Substrate-Induced Structural Dynamics and Evolutionary Linkage of Siderophore-Iron ABC Transporters of Mycobacterium tuberculosis
Aisha Farhana, Abdullah Alsrhani, Hasan Ejaz, Muharib Alruwaili, Ayman A. M. Alameen, Emad Manni, Zafar Rasheed, Yusuf Saleem Khan
Medicina.2024; 60(11): 1891. CrossRef - Structures and coordination chemistry of transporters involved in manganese and iron homeostasis
Shamayeeta Ray, Rachelle Gaudet
Biochemical Society Transactions.2023; 51(3): 897. CrossRef - Bacterial Regulatory Mechanisms for the Control of Cellular Processes: Simple Organisms’ Complex Regulation
Jin-Won Lee
Journal of Microbiology.2023; 61(3): 273. CrossRef
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Functional characterization of a TerC family protein of
Riemerella anatipestifer
in manganese detoxification and virulence
Journal Articles
- Chitosan-chelated zinc modulates cecal microbiota and attenuates inflammatory response in weaned rats challenged with Escherichia coli
- Dan Feng , Minyang Zhang , Shiyi Tian , Jing Wang , Weiyun Zhu
- J. Microbiol. 2020;58(9):780-792. Published online September 1, 2020
- DOI: https://doi.org/10.1007/s12275-020-0056-x
- 51 View
- 0 Download
- 10 Web of Science
- 9 Crossref
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Abstract
- Escherichia coli (E. coli) infection is very common among young growing animals, and zinc supplementation is often used to alleviate inflammation induced by this disease. Therefore, the objective of this study was to evaluate whether chitosan- chelated zinc (CS-Zn) supplementation could attenuate gut injury induced by E. coli challenge and to explore how CSZn modulates cecal microbiota and alleviates intestinal inflammation in weaned rats challenged with E. coli. 36 weaned rats (55.65 ± 2.18 g of BW, n = 12) were divided into three treatment groups consisting of unchallenged rats fed a basal diet (Control) and two groups of rats challenged with E. coli and fed a basal diet or a diet containing 640 mg/kg CS-Zn (E. coli + CS-Zn, containing 50 mg/kg Zn) for a 14-day experiment. On days 10 to 12, each rat was given 4 ml of E. coli solution with a total bacteria count of 1010 CFU by oral gavage daily or normal saline of equal dosage. CS-Zn supplementation mitigated intestinal morphology impairment (e.g. higher crypt depth and lower macroscopic damage index) induced by E. coli challenge (P < 0.05), and alleviated the increase of Myeloperoxidase (MPO) activity after E. coli challenge (P < 0.05). 16S rRNA sequencing analyses revealed that E. coli challenge significantly increased the abundance of Verrucomicrobia and E. coli (P < 0.05). However, CS-Zn supplementation increased the abundance of Lactobacillus and decreased the relative abundance of Proteobacteria, Desulfovibrio and E. coli (P < 0.05). The concentrations of butyrate in the cecal digesta, which decreased due to the challenge, were higher in the E. coli + CS-Zn group (P < 0.05). In addition, CS-Zn supplementation significantly prevented the elevation of pro-inflammatory cytokines IL-6 concentration and upregulated the level of anti-inflammatory cytokines IL-10 in cecal mucosa induced by E. coli infection (P < 0.05). In conclusion, these results indicate that CS-Zn produces beneficial effects in alleviating gut mucosal injury of E. coli challenged rats by enhancing the intestinal morphology and modulating cecal bacterial composition, as well as attenuating inflammatory response.
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Citations
Citations to this article as recorded by- Organic zinc glycine chelate is better than inorganic zinc in improving growth performance of cherry valley ducks by regulating intestinal morphology, barrier function, and the gut microbiome
Yaqi Chang, Ke Wang, Min Wen, Bing Wu, Guangmang Liu, Hua Zhao, Xiaoling Chen, Jingyi Cai, Gang Jia
Journal of Animal Science.2023;[Epub] CrossRef - Effects on the intestinal morphology, inflammatory response and microflora in piglets challenged with enterotoxigenic Escherichia coli K88
Kun Zhang, Xiaoyang Shen, Lu Han, Mengyun Wang, Shaoqiang Lian, Kejun Wang, Chunli Li
Research in Veterinary Science.2023; 157: 50. CrossRef - Surface engineering of chitosan nanosystems and the impact of functionalized groups on the permeability of model drug across intestinal tissue
Sadaf Ejaz, Syed Muhammad Afroz Ali, Bina Zarif, Ramla Shahid, Ayesha Ihsan, Tayyaba Noor, Muhammad Imran
International Journal of Biological Macromolecules.2023; 242: 124777. CrossRef - Chitosan Protects Immunosuppressed Mice Against Cryptosporidium parvum Infection Through TLR4/STAT1 Signaling Pathways and Gut Microbiota Modulation
Sajid Ur Rahman, Haiyan Gong, Rongsheng Mi, Yan Huang, Xiangan Han, Zhaoguo Chen
Frontiers in Immunology.2022;[Epub] CrossRef - Effect of Dietary Zinc Methionine Supplementation on Growth Performance, Immune Function and Intestinal Health of Cherry Valley Ducks Challenged With Avian Pathogenic Escherichia coli
Yaqi Chang, Jia Mei, Ting Yang, Zhenyu Zhang, Guangmang Liu, Hua Zhao, Xiaoling Chen, Gang Tian, Jingyi Cai, Bing Wu, Fali Wu, Gang Jia
Frontiers in Microbiology.2022;[Epub] CrossRef - Chitosan-chelated zinc modulates ileal microbiota, ileal microbial metabolites, and intestinal function in weaned piglets challenged with Escherichia coli K88
Guojun Hou, Minyang Zhang, Jing Wang, Weiyun Zhu
Applied Microbiology and Biotechnology.2021; 105(19): 7529. CrossRef - Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues
Anatoly V. Skalny, Michael Aschner, Xin Gen Lei, Viktor A. Gritsenko, Abel Santamaria, Svetlana I. Alekseenko, Nagaraja Tejo Prakash, Jung-Su Chang, Elena A. Sizova, Jane C. J. Chao, Jan Aaseth, Alexey A. Tinkov
International Journal of Molecular Sciences.2021; 22(23): 13074. CrossRef - Potential Applications of Chitosan-Based Nanomaterials to Surpass the Gastrointestinal Physiological Obstacles and Enhance the Intestinal Drug Absorption
Nutthapoom Pathomthongtaweechai, Chatchai Muanprasat
Pharmaceutics.2021; 13(6): 887. CrossRef - Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19
Jiezhong Chen, Luis Vitetta
Journal of Clinical Medicine.2021; 10(13): 2903. CrossRef
- Organic zinc glycine chelate is better than inorganic zinc in improving growth performance of cherry valley ducks by regulating intestinal morphology, barrier function, and the gut microbiome
- Garden microbiomes of Apterostigma dentigerum and Apterostigma pilosum fungus-growing ants (Hymenoptera: Formicidae)
- Cely T. González , Kristin Saltonstall , Hermógenes Fernández-Marín
- J. Microbiol. 2019;57(10):842-851. Published online August 3, 2019
- DOI: https://doi.org/10.1007/s12275-019-8639-0
- 44 View
- 0 Download
- 5 Web of Science
- 5 Crossref
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Abstract
- Fungus-growing ants share a complex symbiosis with microbes, including fungal mutualists, antibiotic-producing bacteria, and fungal pathogens. The bacterial communities associated with this symbiosis are poorly understood but likely play important roles in maintaining the health and function of fungal gardens. We studied bacterial communities in gardens of two Apterostigma species, A. dentigerum, and A. pilosum, using next-generation sequencing to evaluate differences between the two ant species, their veiled and no-veiled fungal garden types, and across three collection locations. We also compared different parts of nests to test for homogeneity within nests. Enterobacteriaceae dominated gardens of both species and common OTUs were shared across both species and nest types. However, differences in community diversity were detected between ant species, and in the communities of A. dentigerum veiled and no-veiled nests within sites. Apterostigma pilosum had a higher proportion of Phyllobacteriaceae and differed from A. dentigerum in the proportions of members of the order Clostridiales. Within A. dentigerum, nests with veiled and no-veiled fungus gardens had similar taxonomic profiles but differed in the relative abundance of some groups, with veiled gardens having more Rhodospirillaceae and Hyphomicrobiaceae, and no-veiled having more Xanthomonadaceae and certain genera in the Enterobacteriaceae C. However, bacterial communities in Apterostigma fungal gardens are highly conserved and resemble those of the nests of other attine ants with dominant taxa likely playing a role in biomass degradation and defense. Further work is required to understand and explain how bacterial community composition of fungus-growing nests is maintained.
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Citations
Citations to this article as recorded by- The mobilome landscape of biocide-resistance in Brazilian ESKAPE isolates
Elias Eduardo Barbosa da Rosa, Frederico Schmitt Kremer
Brazilian Journal of Microbiology.2024;[Epub] CrossRef - Pharmacological potential of ants and their symbionts – a review
Surbhi Agarwal, Garima Sharma, Kavita Verma, Narayanan Latha, Vartika Mathur
Entomologia Experimentalis et Applicata.2022; 170(12): 1032. CrossRef - Disease management in two sympatric Apterostigma fungus‐growing ants for controlling the parasitic fungus Escovopsis
Yuliana Christopher, William T. Wcislo, Sergio Martínez‐Luis, William O.H. Hughes, Nicole M. Gerardo, Hermógenes Fernández‐Marín
Ecology and Evolution.2021; 11(11): 6041. CrossRef - The Microbiome of Neotropical Water Striders and Its Potential Role in Codiversification
Anakena M. Castillo, Kristin Saltonstall, Carlos F. Arias, Karina A. Chavarria, Luis A. Ramírez-Camejo, Luis C. Mejía, Luis F. De León
Insects.2020; 11(9): 578. CrossRef - Bacteria Contribute to Plant Secondary Compound Degradation in a Generalist Herbivore System
Charlotte B. Francoeur, Lily Khadempour, Rolando D. Moreira-Soto, Kirsten Gotting, Adam J. Book, Adrián A. Pinto-Tomás, Ken Keefover-Ring, Cameron R. Currie, Margaret J. McFall-Ngai
mBio.2020;[Epub] CrossRef
- The mobilome landscape of biocide-resistance in Brazilian ESKAPE isolates
Research Support, Non-U.S. Gov't
- Profiling of the Bacteria Responsible for Pyogenic Liver Abscess by 16S rRNA Gene Pyrosequencing
- Yun Gyu Song , Sang Gun Shim , Kwang Min Kim , Dong-Hae Lee , Dae-Soo Kim , Sang-Haeng Choi , Jae-Young Song , Hyung-Lyun Kang , Seung-Chul Baik , Woo-Kon Lee , Myung-Je Cho , Kwang-Ho Rhee
- J. Microbiol. 2014;52(6):504-509. Published online May 29, 2014
- DOI: https://doi.org/10.1007/s12275-014-4241-7
- 49 View
- 0 Download
- 22 Crossref
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Abstract
- Pyogenic liver abscess (PLA) is a severe disease with considerable mortality and is often polymicrobial. Understanding the pathogens that cause PLA is the basis for PLA treatment. Here, we profiled the bacterial composition in PLA fluid by pyrosequencing the 16S ribosomal RNA (rRNA) gene based on next-generation sequencing (NGS) technology to identify etiological agents of PLA and to provide information of their 16S rRNA sequences for application to DNA-based techniques in the hospital. Twenty patients with PLA who underwent percutaneous catheter drainage, abscess culture, and blood culture for isolates were included. Genomic DNAs from abscess fluids were subjected to polymerase chain reaction and pyrosequencing of the 16S rRNA gene with a 454 GS Junior System. The abscess and blood cultures were positive in nine (45%) and four (20%) patients, respectively. Pyrosequencing of 16S rRNA gene showed that 90% of the PLA fluid samples contained single or multiple genera of known bacteria such as Klebsiella, Fusobacterium, Streptococcus, Bacteroides, Prevotella, Peptostreptococcus, unassigned Enterobacteriaceae, and Dialister. Klebsiella was predominantly found in the PLA fluid samples. All samples that carried unassigned bacteria had 26.8% reads on average. We demonstrated that the occurrence of PLA was associated with eight known bacterial genera as well as unassigned bacteria and that 16S rRNA gene sequencing was more useful than conventional culture methods for accurate identification of bacterial pathogens from PLA.
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Citations
Citations to this article as recorded by- Alterations of Gut Microbiota in Pyogenic Liver Abscess Patients with and without Type 2 Diabetes Mellitus
Shanshan Liu, Xiaomeng Ge, Xizhan Xu, Kang Zhang, Xinxin Lu
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G. Rossi, M. Ronot, V. Zarrouk, A. Lefort
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Frontiers in Immunology.2022;[Epub] CrossRef - Liver abscesses in the Western pediatric population
L Grossar, I Hoffman, E Sokal, X Stéphenne, P Witters
Acta Gastro Enterologica Belgica.2022; 85(3): 439. CrossRef - Characterization of abscesses from liver, pancreas and kidney using deep sequencing of the 16S rRNA gene
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N.K. Abd El‐Aziz, A.A Gharib, E.A.A. Mohamed, A.H. Hussein
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Annals of Surgical Oncology.2021; 28(1): 560. CrossRef - Glycan cross-feeding supports mutualism between Fusobacterium and the vaginal microbiota
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