Skip Navigation
Skip to contents

Journal of Microbiology : Journal of Microbiology

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
1 "nucleoside analogues"
Filter
Filter
Article category
Keywords
Publication year
Review
MINIREVIEW] Bioactive Activities of Natural Products against Herpesvirus Infection
Myoungki Son , Minjung Lee , Gi-Ho Sung , Taeho Lee , Yu Su Shin , Hyosun Cho , Paul M. Lieberman , Hyojeung Kang
J. Microbiol. 2013;51(5):545-551.   Published online October 31, 2013
DOI: https://doi.org/10.1007/s12275-013-3450-9
  • 44 View
  • 0 Download
  • 33 Crossref
AbstractAbstract
More than 90% of adults have been infected with at least one human herpesvirus, which establish long-term latent infection for the life of the host. While anti-viral drugs exist that limit herpesvirus replication, many of these are ineffective against latent infection. Moreover, drug-resistant strains of herpesvirus emerge following chemotherapeutic treatment. For example, resistance to acyclovir and related nucleoside analogues can occur when mutations arise in either HSV thymidine kinase or DNA polymerases. Thus, there exists an unmet medical need to develop new anti-herpesvirus agents with different mechanisms of action. In this Review, we discuss the promise of anti-herpetic substances derived from natural products including extracts and pure compounds from potential herbal medicines. One example is Glycyrrhizic acid isolated from licorice that shows promising antiviral activity towards human gammaherpesviruses. Secondly, we discuss anti-herpetic mechanisms utilized by several natural products in molecular level. While nucleoside analogues inhibit replicating herpesviruses in lytic replication, some natural products can disrupt the herpesvirus latent infection in the host cell. In addition, natural products can stimulate immune responses against herpesviral infection. These findings suggest that natural products could be one of the best choices for development of new treatments for latent herpesvirus infection, and may provide synergistic anti-viral activity when supplemented with nucleoside analogues. Therefore, it is important to identify which natural products are more efficacious anti-herpetic agents, and to understand the molecular mechanism in detail for further advance in the anti-viral therapies.

Citations

Citations to this article as recorded by  
  • Exploring phytobiotics in aquaculture: sources, mode of action, effects, administration, and its bioavailability in fish
    Pandi Kalaiselvan, Kavitha Malarvizhi, Amit Ranjan
    Aquaculture International.2024; 32(5): 5737.     CrossRef
  • Tilapia lake virus: understanding incidence, enhancing resistance, and exploring seaweed therapies
    Sourabh Debbarma, Nitesh Kumar Yadav, Ng Chinglembi Devi, Bagthasingh Chrisolite, Yilbong Yirang, Dharmendra Kumar Meena, Soibam Khogen Singh, Naresh Kumar Mehta, Bhargavi Priyadarshini Mocherla
    Aquaculture International.2024; 32(7): 10313.     CrossRef
  • Causality between herpes virus infections and allograft dysfunction after tissue and organ transplantation: a two-sample bidirectional Mendelian randomization study
    Xiaojuan Qiu, Tianjiao Ma, Shishun Zhao, Zongyu Zheng
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Association between human herpesviruses and multiple sclerosis: A systematic review and meta-analysis
    Zohreh Khalesi, Vahid Tamrchi, Mohammad Hossein Razizadeh, Arash Letafati, Pouya Moradi, Arezoo Habibi, Negar Habibi, Jafar Heidari, Maryam Noori, Mahboubeh Nahid Samiei, Ziba Azarash, Mahdiyeh Hoseini, Hassan Saadati, Atefeh Bahavar, Maryam Farajzade, Se
    Microbial Pathogenesis.2023; 177: 106031.     CrossRef
  • Delivery of miR-34a-5p by Folic Acid-Modified β-Cyclodextrin-Grafted Polyethylenimine Copolymer Nanocarriers to Resist KSHV
    Fangling Li, Dongdong Cao, Wenyi Gu, Lin Cui, Zhongpeng Qiu, Zhiyong Liu, Dongmei Li, Xuhong Guo
    ACS Applied Nano Materials.2023; 6(12): 10826.     CrossRef
  • Exploration of natural compounds against the human mpox virus DNA-dependent RNA polymerase in silico
    Jameel M. Abduljalil, Abdo A. Elfiky, Alaa M. Elgohary
    Journal of Infection and Public Health.2023; 16(7): 996.     CrossRef
  • Tackling the Future Pandemics: Broad-Spectrum Antiviral Agents (BSAAs) Based on A-Type Proanthocyanidins
    Massimo E. Maffei, Cristiano Salata, Giorgio Gribaudo
    Molecules.2022; 27(23): 8353.     CrossRef
  • The Role of the Natural Antioxidant Mechanism in Sperm Cells
    Alicja Kowalczyk
    Reproductive Sciences.2022; 29(5): 1387.     CrossRef
  • Viral infections in cultured fish and shrimps: current status and treatment methods
    Haimanti Mondal, Natarajan Chandrasekaran, Amitava Mukherjee, John Thomas
    Aquaculture International.2022; 30(1): 227.     CrossRef
  • Microalgal drugs: A promising therapeutic reserve for the future
    Ankesh Ahirwar, Khushboo Kesharwani, Rahul Deka, Shreya Muthukumar, Mohd. Jahir Khan, Anshuman Rai, Vandana Vinayak, Sunita Varjani, Khashti Ballabh Joshi, Shruti Morjaria
    Journal of Biotechnology.2022; 349: 32.     CrossRef
  • Palmitic Amide Triggers Virus Life Cycle via Enhancing Host Energy Metabolism
    Xinyi Zhang, Jianjian Zhuang, Liquan Huang, Xiaobo Zhang
    Frontiers in Microbiology.2022;[Epub]     CrossRef
  • 2-Methoxy-6-Acetyl-7-Methyljuglone: A Bioactive Phytochemical with Potential Pharmacological Activities
    Atif Ali Khan Khalil, Asma Saleem Qazi, Abdul Nasir, Mi-Jeong Ahn, Muhammad Ajmal Shah, Muhammad Saad Ahmad, Wasim Sajjad, Tahir Ali, Muhammad Naeem, Fawad Ali Shah, Muhammad Tufail Ahmed Khan, Muhammad Romman, Shahfiq Ur Rehman, Adnan Haider, Raishma
    Anti-Cancer Agents in Medicinal Chemistry.2022; 22(4): 687.     CrossRef
  • Natural Products and Their Derivatives against Human Herpesvirus Infection
    Chattarin Ruchawapol, Man Yuan, Si-Min Wang, Wen-Wei Fu, Hong-Xi Xu
    Molecules.2021; 26(20): 6290.     CrossRef
  • Antiviral activity of sulfated polysaccharides from Sargassum ilicifolium against fish Betanodavirus infection
    Jyotsna, Parameswaran Vijayakumar, Tharmathass Stalin Dhas, Ravi Mani, Vasantharaja Raguraman
    Aquaculture International.2021; 29(3): 1049.     CrossRef
  • Effects of Apigenin and Astragalus Polysaccharide on the Cryopreservation of Bull Semen
    Hongtao Wang, Ping Lu, Chongshan Yuan, Jing Zhao, Hongyu Liu, Wenfa Lu, Jun Wang
    Animals.2021; 11(6): 1506.     CrossRef
  • Viral UL8 Is Involved in the Antiviral Activity of Oleanolic Acid Against HSV-1 Infection
    Tianhao Shan, Ju Ye, Jiaoyan Jia, Zhaoyang Wang, Yuzhou Jiang, Yiliang Wang, Yifei Wang, Kai Zheng, Zhe Ren
    Frontiers in Microbiology.2021;[Epub]     CrossRef
  • Allicin and Glycyrrhizic Acid Display Antiviral Activity Against Latent and Lytic Kaposi Sarcoma-associated Herpesvirus
    Yirui Xie, Ying Chen, Yongzheng Guo, Ying Huang, Biao Zhu
    Infectious Microbes and Diseases.2020; 2(1): 30.     CrossRef
  • Anti-herpes simplex type-1 (HSV-1) activity from the roots of Jatropha multifida L
    Ratchanaporn Chokchaisiri, Jaranwit Srijun, Waraluck Chaichompoo, Sarot Cheenpracha, Lucksagoon Ganranoo, Apichart Suksamrarn
    Medicinal Chemistry Research.2020; 29(2): 328.     CrossRef
  • In Vitro Anti-HSV-1 Activity of Polyphenol-Rich Extracts and Pure Polyphenol Compounds Derived from Pistachios Kernels (Pistacia vera L.)
    Maria Musarra-Pizzo, Rosamaria Pennisi, Ichrak Ben-Amor, Antonella Smeriglio, Giuseppina Mandalari, Maria Teresa Sciortino
    Plants.2020; 9(2): 267.     CrossRef
  • Oleandrin: A bioactive phytochemical and potential cancer killer via multiple cellular signaling pathways
    Nazia Kanwal, Azhar Rasul, Ghulam Hussain, Haseeb Anwar, Muhammad Ajmal Shah, Iqra Sarfraz, Ammara Riaz, Rabia Batool, Muhammad Shahbaz, Arif Hussain, Zeliha Selamoglu
    Food and Chemical Toxicology.2020; 143: 111570.     CrossRef
  • A pilot study of oral tranexamic acid and Glycyrrhizin compound in the treatment of recalcitrant Riehl’s melanosis
    Zhongyi Xu, Xiaoxue Xing, Chengfeng Zhang, Li Chen, Leihong Flora Xiang
    Journal of Cosmetic Dermatology.2019; 18(1): 286.     CrossRef
  • Using glycyrrhizic acid to target sumoylation processes during Epstein-Barr virus latency
    Gretchen L. Bentz, Angela J. Lowrey, Dustin C. Horne, Vy Nguyen, Austin R. Satterfield, Tabithia D. Ross, Abigail E. Harrod, Olga N. Uchakina, Robert J. McKallip, Luwen Zhang
    PLOS ONE.2019; 14(5): e0217578.     CrossRef
  • The Antimicrobial and Antiviral Activity of Polyphenols from Almond (Prunus dulcis L.) Skin
    Maria Musarra-Pizzo, Giovanna Ginestra, Antonella Smeriglio, Rosamaria Pennisi, Maria Teresa Sciortino, Giuseppina Mandalari
    Nutrients.2019; 11(10): 2355.     CrossRef
  • Virucidal, antiviral and immunomodulatory activities of β-escin and Aesculus hippocastanum extract
    Flavia M Michelini, Laura E Alché, Carlos A Bueno
    Journal of Pharmacy and Pharmacology.2018; 70(11): 1561.     CrossRef
  • Perspective on Biotransformation and De Novo Biosynthesis of Licorice Constituents
    Yujia Zhao, Bo Lv, Xudong Feng, Chun Li
    Journal of Agricultural and Food Chemistry.2017; 65(51): 11147.     CrossRef
  • Fraxinus: A Plant with Versatile Pharmacological and Biological Activities
    Iqra Sarfraz, Azhar Rasul, Farhat Jabeen, Tahira Younis, Muhammad Kashif Zahoor, Muhammad Arshad, Muhammad Ali, Rainer W. Bussmann
    Evidence-Based Complementary and Alternative Medicine.2017;[Epub]     CrossRef
  • In vitro cytotoxicity and biological activities of Genipa americana (Rubiaceae) ethanolic extracts
    Silva Campos Codignoto Paola, Batista de Araújo Shirley, Munhoz Bastos Natan, de Oliveira Fernandes Thais, Arielle Santana Barbosa Tamiris, Eduardo Dias Igidio Carlos, Faustino Fernando, Judite Bittencourt Fernandes Maria, Oliveira da Conceição Aline
    African Journal of Microbiology Research.2017; 11(9): 385.     CrossRef
  • Apigenin inhibits African swine fever virus infection in vitro
    Astghik Hakobyan, Erik Arabyan, Aida Avetisyan, Liana Abroyan, Lina Hakobyan, Hovakim Zakaryan
    Archives of Virology.2016; 161(12): 3445.     CrossRef
  • Genipin Enhances Kaposi’s Sarcoma-Associated Herpesvirus Genome Maintenance
    Miyeon Cho, Seok Won Jung, Soomin Lee, Kuwon Son, Gyu Hwan Park, Jong-Wha Jung, Yu Su Shin, Taegun Seo, Hyosun Cho, Hyojeung Kang, Shou-Jiang Gao
    PLOS ONE.2016; 11(10): e0163693.     CrossRef
  • Genipin as a novel chemical activator of EBV lytic cycle
    Myoungki Son, Minjung Lee, Eunhyun Ryu, Aree Moon, Choon-Sik Jeong, Yong Woo Jung, Gyu Hwan Park, Gi-Ho Sung, Hyosun Cho, Hyojeung Kang
    Journal of Microbiology.2015; 53(2): 155.     CrossRef
  • Seaweed extracts as antimicrobial agents in aquaculture
    Ioannis N Vatsos, Celine Rebours
    Journal of Applied Phycology.2015; 27(5): 2017.     CrossRef
  • Bioactive natural products with anti-herpes simplex virus properties
    Sherif T S Hassan, Radka Masarčíková, Kateřina Berchová
    Journal of Pharmacy and Pharmacology.2015; 67(10): 1325.     CrossRef
  • A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide
    Manabu Kaneko, Koichi Watashi, Shinji Kamisuki, Hiroki Matsunaga, Masashi Iwamoto, Fumihiro Kawai, Hirofumi Ohashi, Senko Tsukuda, Satomi Shimura, Ryosuke Suzuki, Hideki Aizaki, Masaya Sugiyama, Sam-Yong Park, Takayoshi Ito, Naoko Ohtani, Fumio Sugawara,
    Journal of Virology.2015; 89(23): 11945.     CrossRef

Journal of Microbiology : Journal of Microbiology
TOP