Journal of Microbiology

Journal Articles

Genome Sequencing Highlights the Plant Cell Wall Degrading Capacity of Edible Mushroom Stropharia rugosoannulata: Mengpei Guo , Xiaolong Ma , Yan Zhou , Yinbing Bian , Gaolei Liu , Yingli Cai , Tianji Huang , Hongxia Dong , Dingjun Cai , Xueji Wan , Zhihong Wang , Yang Xiao , Heng Kang; J. Microbiol. 2023;61(1):83-93. Published online February 1, 2023; DOI: https://doi.org/10.1007/s12275-022-00003-7

58 View
0 Download
5 Web of Science
4 Crossref

The basidiomycetous edible mushroom Stropharia rugosoannulata has excellent nutrition, medicine, bioremediation, and biocontrol properties. S. rugosoannulata has been widely and easily cultivated using agricultural by-products showing strong lignocellulose degradation capacity. However, the unavailable high-quality genome information has hindered the research on gene function and molecular breeding of S. rugosoannulata. This study provided a high-quality genome assembly and annotation from S. rugosoannulata monokaryotic strain QGU27 based on combined Illumina-Nanopore data. The genome size was about 47.97 Mb and consisted of 20 scaffolds, with an N50 of 3.73 Mb and a GC content of 47.9%. The repetitive sequences accounted for 17.41% of the genome, mostly long terminal repeats (LTRs). A total of 15,726 coding gene sequences were putatively identified with the BUSCO score of 98.7%. There are 142 genes encoding plant cell wall degrading enzymes (PCWDEs) in the genome, and 52, 39, 30, 11, 8, and 2 genes related to lignin, cellulose, hemicellulose, pectin, chitin, and cutin degradation, respectively. Comparative genomic analysis revealed that S. rugosoannulata is superior in utilizing aldehyde-containing lignins and is possible to utilize algae during the cultivation.

Citations

Citations to this article as recorded by

Analysis of Gene Regulatory Network and Transcription Factors in Different Tissues of the Stropharia rugosoannulata Fruiting Body
Jia Lu, Jing Yan, Na Lu, Jiling Song, Jiayao Lin, Xiaohua Zhou, Xuebing Ying, Zhen Li, Zufa Zhou, Fangjie Yao
Journal of Fungi.2025; 11(2): 123. CrossRef
Evaluation of Genetic Diversity and Agronomic Traits of Germplasm Resources of Stropharia rugosoannulata
Miao Gu, Qiang Chen, Yan Zhang, Yongchang Zhao, Li Wang, Xiangli Wu, Mengran Zhao, Wei Gao
Horticulturae.2024; 10(3): 213. CrossRef
Molecular Profiling of Rice Straw Degradability Discrepancy in Stropharia rugosoannulata Core Germplasm
Wenbing Gong, Yuyu Zeng, Xinru Li, Zhidong Zhao, Nan Shen, Yan Zhou, Yinbing Bian, Yang Xiao
Journal of Agricultural and Food Chemistry.2024; 72(45): 25379. CrossRef
Genome assembly of M. spongiola and comparative genomics of the genus Morchella provide initial insights into taxonomy and adaptive evolution
Qing Meng, Zhanling Xie, Hongyan Xu, Jing Guo, Qingqing Peng, Yanyan Li, Jiabao Yang, Deyu Dong, Taizhen Gao, Fan Zhang
BMC Genomics.2024;[Epub] CrossRef

Effects of digested Cheonggukjang on human microbiota assessed by in vitro fecal fermentation: Vineet Singh , Nakwon Hwang , Gwangpyo Ko , Unno Tatsuya; J. Microbiol. 2021;59(2):217-227. Published online February 1, 2021; DOI: https://doi.org/10.1007/s12275-021-0525-x

51 View
0 Download
13 Web of Science
13 Crossref

Abstract

In vitro fecal fermentation is an assay that uses fecal microbes to ferment foods, the results of which can be used to evaluate the potential of prebiotic candidates. To date, there have been various protocols used for in vitro fecal fermentation- based assessments of food substances. In this study, we investigated how personal gut microbiota differences and external factors affect the results of in vitro fecal fermentation assays. We used Cheonggukjang (CGJ), a Korean traditional fermented soybean soup that is acknowledged as healthy functional diet. CGJ was digested in vitro using acids and enzymes, and then fermented with human feces anaerobically. After fecal fermentation, the microbiota was analyzed using MiSeq, and the amount of short chain fatty acids (SCFAs) were measured using GC-MS. Our results suggest that CGJ was effectively metabolized by fecal bacteria to produce SCFAs, and this process resulted in an increase in the abundance of Coprococcus, Ruminococcus, and Bifidobacterium and a reduction in the growth of Sutterella, an opportunistic pathogen. The metabolic activities predicted from the microbiota shifts indicated enhanced metabolism linked to methionine biosynthesis and depleted chondroitin sulfate degradation. Moreover, the amount of SCFAs and microbiota shifts varied depending on personal microbiota differences. Our findings also suggest that in vitro fecal fermentation of CGJ for longer durations may partially affect certain fecal microbes. Overall, the study discusses the usability of in vitro gastrointestinal digestion and fecal fermentation (GIDFF) to imitate the effects of diet-induced microbiome modulation and its impact on the host.

Citations

Citations to this article as recorded by

Significance of Soy-Based Fermented Food and Their Bioactive Compounds Against Obesity, Diabetes, and Cardiovascular Diseases
Sushmita Dwivedi, Vineet Singh, Kritika Sharma, Amani Sliti, Mamta Baunthiyal, Jae-Ho Shin
Plant Foods for Human Nutrition.2024; 79(1): 1. CrossRef
Fermented foods: Harnessing their potential to modulate the microbiota-gut-brain axis for mental health
Ramya Balasubramanian, Elizabeth Schneider, Eoin Gunnigle, Paul D. Cotter, John F. Cryan
Neuroscience & Biobehavioral Reviews.2024; 158: 105562. CrossRef
The nutrition and therapeutic potential of millets: an updated narrative review
Jinu Jacob, Veda Krishnan, Chris Antony, Masimukka Bhavyasri, C. Aruna, Kiran Mishra, Thirunavukkarasu Nepolean, Chellapilla Tara Satyavathi, Kurella B. R. S. Visarada
Frontiers in Nutrition.2024;[Epub] CrossRef
Effects of OsomeFood Clean Label plant-based meals on the gut microbiome
Dwiyanto Jacky, Chia Bibi, Look Melvin Chee Meng, Fong Jason, Tan Gwendoline, Lim Jeremy, Chong Chun Wie
BMC Microbiology.2023;[Epub] CrossRef
Fermented soybean foods and diabetes
Yoshitaka Hashimoto, Masahide Hamaguchi, Michiaki Fukui
Journal of Diabetes Investigation.2023; 14(12): 1329. CrossRef
Early response of the gut microbiome and serum metabolites to Cheonggukjang intake in healthy Korean subjects
Eun-Ji Song, Min Jung Kim, Chang Hwa Jung, Won-Hyong Chung, Young-Do Nam, Mi Young Lim
Journal of Functional Foods.2023; 101: 105420. CrossRef
Role, relevance, and possibilities of in vitro fermentation models in human dietary, and gut‐microbial studies
Vineet Singh, HyunWoo Son, GyuDae Lee, Sunwoo Lee, Tatsuya Unno, Jae‐Ho Shin
Biotechnology and Bioengineering.2022; 119(11): 3044. CrossRef
Evaluation of Prebiotics through an In Vitro Gastrointestinal Digestion and Fecal Fermentation Experiment: Further Idea on the Implementation of Machine Learning Technique
Hokyung Song, Dabin Jeon, Tatsuya Unno
Foods.2022; 11(16): 2490. CrossRef
Anti-diabetic prospects of dietary bio-actives of millets and the significance of the gut microbiota: A case of finger millet
Vineet Singh, GyuDae Lee, HyunWoo Son, Sliti Amani, Mamta Baunthiyal, Jae-Ho Shin
Frontiers in Nutrition.2022;[Epub] CrossRef
Current Perspectives on the Physiological Activities of Fermented Soybean-Derived Cheonggukjang
Il-Sup Kim, Cher-Won Hwang, Woong-Suk Yang, Cheorl-Ho Kim
International Journal of Molecular Sciences.2021; 22(11): 5746. CrossRef
Alleviation of Neuronal Cell Death and Memory Deficit with Chungkookjang Made with Bacillus amyloliquefaciens and Bacillus subtilis Potentially through Promoting Gut–Brain Axis in Artery-Occluded Gerbils
Ting Zhang, Myeong-Seon Ryu, Xuangao Wu, Hee-Jong Yang, Su Ji Jeong, Ji-Won Seo, Do-Yeon Jeong, Sunmin Park
Foods.2021; 10(11): 2697. CrossRef
The final fate of food: On the establishment of in vitro colon models
Saartje Hernalsteens, Song Huang, Hai Hua Cong, Xiao Dong Chen
Food Research International.2021; 150: 110743. CrossRef
In Vitro Simulation of Human Colonic Fermentation: A Practical Approach towards Models’ Design and Analytical Tools
Elena Veintimilla-Gozalbo, Andrea Asensio-Grau, Joaquim Calvo-Lerma, Ana Heredia, Ana Andrés
Applied Sciences.2021; 11(17): 8135. CrossRef

Review

Functional interplay between the oxidative stress response and DNA damage checkpoint signaling for genome maintenance in aerobic organisms: Ji Eun Choi , Woo-Hyun Chung; J. Microbiol. 2020;58(2):81-91. Published online December 23, 2019; DOI: https://doi.org/10.1007/s12275-020-9520-x

44 View
0 Download
10 Web of Science
9 Crossref

Abstract

The DNA damage checkpoint signaling pathway is a highly conserved surveillance mechanism that ensures genome integrity by sequential activation of protein kinase cascades. In mammals, the main pathway is orchestrated by two central sensor kinases, ATM and ATR, that are activated in response to DNA damage and DNA replication stress. Patients lacking functional ATM or ATR suffer from ataxia-telangiectasia (A-T) or Seckel syndrome, respectively, with pleiotropic degenerative phenotypes. In addition to DNA strand breaks, ATM and ATR also respond to oxidative DNA damage and reactive oxygen species (ROS), suggesting an unconventional function as regulators of intracellular redox status. Here, we summarize the multiple roles of ATM and ATR, and of their orthologs in Saccharomyces cerevisiae, Tel1 and Mec1, in DNA damage checkpoint signaling and the oxidative stress response, and discuss emerging ideas regarding the possible mechanisms underlying the elaborate crosstalk between those pathways. This review may provide new insights into the integrated cellular strategies responsible for maintaining genome stability in eukaryotes with a focus on the yeast model organism.

Citations

Citations to this article as recorded by

DSB-induced oxidative stress: Uncovering crosstalk between DNA damage response and cellular metabolism
Xinyu Li, Caini Yang, Hengyu Wu, Hongran Chen, Xing Gao, Sa Zhou, Tong-Cun Zhang, Wenjian Ma
DNA Repair.2024; 141: 103730. CrossRef
Effects of Stress on Biological Characteristics and Metabolism of Periodontal Ligament Stem Cells of Deciduous Teeth
Zhengyang Li, Jinyi Li, Shanshan Dai, Xuelong Su, Meiyue Ren, Shuyang He, Qingyu Guo, Fei Liu
International Dental Journal.2024;[Epub] CrossRef
Signification and Application of Mutator and Antimutator Phenotype-Induced Genetic Variations in Evolutionary Adaptation and Cancer Therapeutics
Woo-Hyun Chung
Journal of Microbiology.2023; 61(12): 1013. CrossRef
Metabolic Stress and Mitochondrial Dysfunction in Ataxia-Telangiectasia
Goutham Narayanan Subramanian, Abrey Jie Yeo, Magtouf Hnaidi Gatei, David John Coman, Martin Francis Lavin
Antioxidants.2022; 11(4): 653. CrossRef
The Rad9–Rad1–Hus1 DNA Repair Clamp is Found in Microsporidia
Anne Caroline Mascarenhas dos Santos, Alexander Thomas Julian, Jean-François Pombert, Emmanuelle Lerat
Genome Biology and Evolution.2022;[Epub] CrossRef
Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM)
Elias A. Tannous, Peter M. Burgers
Critical Reviews in Biochemistry and Molecular Biology.2021; 56(5): 441. CrossRef
DNA damage checkpoint and repair: From the budding yeast Saccharomyces cerevisiae to the pathogenic fungus Candida albicans
Shuangyan Yao, Yuting Feng, Yan Zhang, Jinrong Feng
Computational and Structural Biotechnology Journal.2021; 19: 6343. CrossRef
Acute Toxicity and DNA Instability Induced by Exposure to Low Doses of Triclosan and Phthalate DEHP, and Their Combinations, in vitro
Nathalia de Assis Aguilar Duarte, Lindiane Eloisa de Lima, Flora Troina Maraslis, Michael Kundi, Emilene Arusievicz Nunes, Gustavo Rafael Mazzaron Barcelos
Frontiers in Genetics.2021;[Epub] CrossRef
The mechanism and prevention of mitochondrial injury after exercise
Mingzhe Li, Baoan Ning, Tianhui Wang
Journal of Physiology and Biochemistry.2021; 77(2): 215. CrossRef

Journal Article

The NADPH oxidase AoNoxA in Arthrobotrys oligospora functions as an initial factor in the infection of Caenorhabditis elegans: Xin Li , Ying-Qian Kang , Yan-Lu Luo , Ke-Qin Zhang , Cheng-Gang Zou , Lian-Ming Liang; J. Microbiol. 2017;55(11):885-891. Published online October 27, 2017; DOI: https://doi.org/10.1007/s12275-017-7169-x

45 View
0 Download
15 Crossref

Abstract

Reactive oxygen species (ROS) produced by NADPH oxidases can serve as signaling molecules to regulate a variety of physiological processes in multi-cellular organisms. In the nematophagous fungus Arthrobotrys oligospora, we found that ROS were produced during conidial germination, hyphal extension, and trap formation in the presence of nematodes. Generation of an AoNoxA knockout strain demonstrated the crucial role of NADPH oxidase in the production of ROS in A. oligospora, with trap formation impaired in the AoNoxA mutant, even in the presence of the nematode host. In addition, the expression of virulence factor serine protease P186 was up-regulated in the wild-type strain, but not in the mutant strain, in the presence of Caenorhabditis elegans. These results indicate that ROS derived from AoNoxA are essential for full virulence of A. oligospora in nematodes.

Citations

Citations to this article as recorded by

AoPrdx2 Regulates Oxidative Stress, Reactive Oxygen Species, Trap Formation, and Secondary Metabolism in Arthrobotrys oligospora
Na Zhao, Meichen Zhu, Qianqian Liu, Yanmei Shen, Shipeng Duan, Lirong Zhu, Jinkui Yang
Journal of Fungi.2024; 10(2): 110. CrossRef
Tools and basic procedures of gene manipulation in nematode-trapping fungi
Shunxian Wang, Xingzhong Liu
Mycology.2023; 14(2): 75. CrossRef
Caenorhabditis elegansLIN‐24, a homolog of bacterial pore‐forming toxin, protects the host from microbial infection
Huijie Zhang, Weirong Zeng, Ming‐Ming Zhao, Jiali Wang, Qiquan Wang, Ting Chen, Yuyan Zhang, Wenhui Lee, Shenghan Chen, Yun Zhang, Xinqiang Lan, Yang Xiang
The FASEB Journal.2023;[Epub] CrossRef
Key processes required for the different stages of fungal carnivory by a nematode-trapping fungus
Hung-Che Lin, Guillermo Vidal-Diez de Ulzurrun, Sheng-An Chen, Ching-Ting Yang, Rebecca J. Tay, Tomoyo Iizuka, Tsung-Yu Huang, Chih-Yen Kuo, A. Pedro Gonçalves, Siou-Ying Lin, Yu-Chu Chang, Jason E. Stajich, Erich M. Schwarz, Yen-Ping Hsueh, Aaron P. Mitc
PLOS Biology.2023; 21(11): e3002400. CrossRef
Recent Advances in Life History Transition with Nematode-Trapping Fungus Arthrobotrys oligospora and Its Application in Sustainable Agriculture
Da Wang, Nan Ma, Wanqin Rao, Ying Zhang
Pathogens.2023; 12(3): 367. CrossRef
Aolatg1 and Aolatg13 Regulate Autophagy and Play Different Roles in Conidiation, Trap Formation, and Pathogenicity in the Nematode-Trapping Fungus Arthrobotrys oligospora
Duanxu Zhou, Yingmei Zhu, Na Bai, Meihua Xie, Ke-Qin Zhang, Jinkui Yang
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
Regulatory Mechanism of Trap Formation in the Nematode-Trapping Fungi
Mei-Chen Zhu, Xue-Mei Li, Na Zhao, Le Yang, Ke-Qin Zhang, Jin-Kui Yang
Journal of Fungi.2022; 8(4): 406. CrossRef
Transcriptomic Analysis Reveals That Rho GTPases Regulate Trap Development and Lifestyle Transition of the Nematode-Trapping Fungus Arthrobotrys oligospora
Le Yang, Xuemei Li, Na Bai, Xuewei Yang, Ke-Qin Zhang, Jinkui Yang, Christina A. Cuomo
Microbiology Spectrum.2022;[Epub] CrossRef
Prey sensing and response in a nematode-trapping fungus is governed by the MAPK pheromone response pathway
Sheng-An Chen, Hung-Che Lin, Frank C Schroeder, Yen-Ping Hsueh, A Gladfelter
Genetics.2021;[Epub] CrossRef
Forward genetic screens identified mutants with defects in trap morphogenesis in the nematode-trapping fungus Arthrobotrys oligospora
Tsung-Yu Huang, Yi-Yun Lee, Guillermo Vidal-Diez de Ulzurrun, Yen-Ping Hsueh, J Dunlap
G3 Genes|Genomes|Genetics.2021;[Epub] CrossRef
The NADPH Oxidase A of Verticillium dahliae Is Essential for Pathogenicity, Normal Development, and Stress Tolerance, and It Interacts with Yap1 to Regulate Redox Homeostasis
Vasileios Vangalis, Ioannis A. Papaioannou, Emmanouil A. Markakis, Michael Knop, Milton A. Typas
Journal of Fungi.2021; 7(9): 740. CrossRef
DdaSTE12 is involved in trap formation, ring inflation, conidiation, and vegetative growth in the nematode-trapping fungus Drechslerella dactyloides
Yani Fan, Weiwei Zhang, Yue Chen, Meichun Xiang, Xingzhong Liu
Applied Microbiology and Biotechnology.2021; 105(19): 7379. CrossRef
Azaphilones biosynthesis complements the defence mechanism of Trichoderma guizhouense against oxidative stress
Guan Pang, Tingting Sun, Zhenzhong Yu, Tao Yuan, Wei Liu, Hong Zhu, Qi Gao, Dongqing Yang, Christian P. Kubicek, Jian Zhang, Qirong Shen
Environmental Microbiology.2020; 22(11): 4808. CrossRef
Natural diversity in the predatory behavior facilitates the establishment of a robust model strain for nematode-trapping fungi
Ching-Ting Yang, Guillermo Vidal-Diez de Ulzurrun, A. Pedro Gonçalves, Hung-Che Lin, Ching-Wen Chang, Tsung-Yu Huang, Sheng-An Chen, Cheng-Kuo Lai, Isheng J. Tsai, Frank C. Schroeder, Jason E. Stajich, Yen-Ping Hsueh
Proceedings of the National Academy of Sciences.2020; 117(12): 6762. CrossRef
Guttation capsules containing hydrogen peroxide: an evolutionarily conserved NADPH oxidase gains a role in wars between related fungi
Jian Zhang, Youzhi Miao, Mohammad Javad Rahimi, Hong Zhu, Andrei Steindorff, Sabine Schiessler, Feng Cai, Guan Pang, Komal Chenthamara, Yu Xu, Christian P. Kubicek, Qirong Shen, Irina S. Druzhinina
Environmental Microbiology.2019; 21(8): 2644. CrossRef

Reviews

Minireview] Microbial radiation-resistance mechanisms: Kwang-Woo Jung , Sangyong Lim , Yong-Sun Bahn; J. Microbiol. 2017;55(7):499-507. Published online June 30, 2017; DOI: https://doi.org/10.1007/s12275-017-7242-5

52 View
0 Download
40 Crossref

Abstract

Organisms living in extreme environments have evolved a wide range of survival strategies by changing biochemical and physiological features depending on their biological niches. Interestingly, organisms exhibiting high radiation resistance have been discovered in the three domains of life (Bacteria, Archaea, and Eukarya), even though a naturally radiationintensive environment has not been found. To counteract the deleterious effects caused by radiation exposure, radiation- resistant organisms employ a series of defensive systems, such as changes in intracellular cation concentration, excellent DNA repair systems, and efficient enzymatic and non-enzymatic antioxidant systems. Here, we overview past and recent findings about radiation-resistance mechanisms in the three domains of life for potential usage of such radiationresistant microbes in the biotechnology industry.

Citations

Citations to this article as recorded by

The planetary protection strategy of Mars Sample Return’s Earth Return Orbiter mission
Giuseppe Cataldo, Lorenz Affentranger, Brian G. Clement, Daniel P. Glavin, David W. Hughes, John Hall, Bruno Sarli, Christine E. Szalai
Journal of Space Safety Engineering.2024; 11(2): 374. CrossRef
Insights into the Impact of Physicochemical and Microbiological Parameters on the Safety Performance of Deep Geological Repositories
Mar Morales-Hidalgo, Cristina Povedano-Priego, Marcos F. Martinez-Moreno, Miguel A. Ruiz-Fresneda, Margarita Lopez-Fernandez, Fadwa Jroundi, Mohamed L. Merroun
Microorganisms.2024; 12(5): 1025. CrossRef
Wireless Battery-free and Fully Implantable Organ Interfaces
Aman Bhatia, Jessica Hanna, Tucker Stuart, Kevin Albert Kasper, David Marshall Clausen, Philipp Gutruf
Chemical Reviews.2024; 124(5): 2205. CrossRef
Editorial: Rising stars in fungal pathogenesis: 2023
Brian L. Wickes, Adriana Marcela Celis Ramírez, Michal A. Olszewski, Yong-Sun Bahn
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef
WP15 ConCorD state-of-the-art report (container corrosion under disposal conditions)
Andrés G. Muñoz, Abdesselam Abdelouas, Ursula Alonso, Ana María Fernández, Rizlan Bernier-Latmani, Andrea Cherkouk, Roberto Gaggiano, James Hesketh, Nick Smart, Cristiano Padovani, Kristel Mijnendonckx, Vanessa Montoya, Andrés Idiart, Arnau Pont, Olga Rib
Frontiers in Nuclear Engineering.2024;[Epub] CrossRef
Relationships between radiation, wildfire and the soil microbial communities in the Chornobyl Exclusion Zone
Alexandre Barretto de Menezes, Sergii Gashchak, Michael D. Wood, Nicholas A. Beresford
Science of The Total Environment.2024; 950: 175381. CrossRef
UV-B Halotolerant Bacteria from Marakkanam Saltpan and Biology of UV-B Tolerant Pontibacillus salipaludis Based on Whole Genome Sequencing
Amit Kumar
Geomicrobiology Journal.2024; 41(2): 183. CrossRef
Unraveling radiation resistance strategies in two bacterial strains from the high background radiation area of Chavara-Neendakara: A comprehensive whole genome analysis
Sowptika Pal, Ramani Yuvaraj, Hari Krishnan, Balasubramanian Venkatraman, Jayanthi Abraham, Anilkumar Gopinathan, Hari S. Misra
PLOS ONE.2024; 19(6): e0304810. CrossRef
Optimization Function for Determining Optimal Dose Range for Beef and Seed Potato Irradiation
Elena Kozlova, Ulyana Bliznyuk, Alexander Chernyaev, Polina Borshchegovskaya, Arcady Braun, Victoria Ipatova, Sergey Zolotov, Alexander Nikitchenko, Natalya Chulikova, Anna Malyuga, Yana Zubritskaya, Timofey Bolotnik, Anastasia Oprunenko, Aleksandr Kozlov
Foods.2024; 13(23): 3729. CrossRef
Impact of microbial processes on the safety of deep geological repositories for radioactive waste
Miguel A. Ruiz-Fresneda, Marcos F. Martinez-Moreno, Cristina Povedano-Priego, Mar Morales-Hidalgo, Fadwa Jroundi, Mohamed L. Merroun
Frontiers in Microbiology.2023;[Epub] CrossRef
Ionizing radiation effects on microorganisms and its applications in the food industry
Emmanuel Kormla Danyo, Maria Ivantsova, Irina Selezneva
Foods and Raw Materials.2023; 12(1): 1. CrossRef
Impact of radioactive contamination of soils on the diversity of micropopulation and the transformation of organic substances
I. Gudkov, I. Volkohon, V. Illienko, M. Lazarev, A. Klepko
Agricultural Science and Practice.2023; 9(3): 3. CrossRef
Aging of fuel-containing materials (fuel debris) in the Chornobyl (Chernobyl) Nuclear Power Plant and its implication for the decommissioning of the Fukushima Daiichi Nuclear Power Station
Toru Kitagaki, Viktor A. Krasnov, Atsushi Ikeda-Ohno
Journal of Nuclear Materials.2023; 576: 154224. CrossRef
Impact of ionizing radiation on the environmental microbiomes of Chornobyl wetlands
Elin Videvall, Pablo Burraco, Germán Orizaola
Environmental Pollution.2023; 330: 121774. CrossRef
Geography and environmental pressure are predictive of class‐specific radioresistance in black fungi
Lorenzo Aureli, Claudia Coleine, Manuel Delgado‐Baquerizo, Dag Ahren, Alessia Cemmi, Ilaria Di Sarcina, Silvano Onofri, Laura Selbmann
Environmental Microbiology.2023; 25(12): 2931. CrossRef
Wort disinfection treatment with electron beam for bioethanol production
Rubens Perez Calegari, Eric Alberto da Silva, Ana Paula Maria da Silva, Marcelo Pego Gomes, Layna Amorim Mota, Valter Arthur, Antonio Sampaio Baptista
Scientia Agricola.2023;[Epub] CrossRef
Redox status and metabolomic profiling of thioredoxin reductase inhibitors and 4 kGy ionizing radiation-exposed Deinococcus radiodurans
M. Sudharsan, N. Rajendra Prasad, G. Kanimozhi, B.S. Rishiikeshwer, G.R. Brindha, Anindita Chakraborty
Microbiological Research.2022; 261: 127070. CrossRef
Sphingomonas radiodurans sp. nov., a novel radiation-resistant bacterium isolated from the north slope of Mount Everest
Yang Liu, Tuo Chen, Xiaowen Cui, Yeteng Xu, Shixin Hu, Yidan Zhao, Wei Zhang, Guangxiu Liu, Gaosen Zhang
International Journal of Systematic and Evolutionary Microbiology .2022;[Epub] CrossRef
Sequence, structure, and function of the Dps DNA-binding protein from Deinococcus wulumuqiensis R12
Yao Chen, Zhihan Yang, Xue Zhou, Mengmeng Jin, Zijie Dai, Dengming Ming, Zhidong Zhang, Liying Zhu, Ling Jiang
Microbial Cell Factories.2022;[Epub] CrossRef
PCNA from Thermococcus gammatolerans: A protein involved in chromosomal DNA metabolism intrinsically resistant at high levels of ionizing radiation
Yerli Marín‐Tovar, Hugo Serrano‐Posada, Adelaida Díaz‐Vilchis, Enrique Rudiño‐Piñera
Proteins: Structure, Function, and Bioinformatics.2022; 90(9): 1684. CrossRef
An insight into the mechanisms of homeostasis in extremophiles
Adithi Somayaji, Chetan Roger Dhanjal, Rathnamegha Lingamsetty, Ramesh Vinayagam, Raja Selvaraj, Thivaharan Varadavenkatesan, Muthusamy Govarthanan
Microbiological Research.2022; 263: 127115. CrossRef
Synthetic fungal melanin nanoparticles with excellent antioxidative property
Hengjie Zhang, Chuhao Huang, Jianhua Zhang, Chao Wang, Tianyou Wang, Shun Shi, Zhipeng Gu, Yiwen Li
Giant.2022; 12: 100120. CrossRef
Genomic Insights into the Radiation-Resistant Capability of Sphingomonas qomolangmaensis S5-59T and Sphingomonas glaciei S8-45T, Two Novel Bacteria from the North Slope of Mount Everest
Yang Liu, Xiaowen Cui, Ruiqi Yang, Yiyang Zhang, Yeteng Xu, Guangxiu Liu, Binglin Zhang, Jinxiu Wang, Xinyue Wang, Wei Zhang, Tuo Chen, Gaosen Zhang
Microorganisms.2022; 10(10): 2037. CrossRef
Response of soil microbial communities to natural radionuclides along specific-activity gradients
Guangwen Feng, Jinlong Yong, Qian Liu, Henglei Chen, Peihong Mao
Ecotoxicology and Environmental Safety.2022; 246: 114156. CrossRef
Questioning the radiation limits of life: Ignicoccus hospitalis between replication and VBNC
Dagmar Koschnitzki, Ralf Moeller, Stefan Leuko, Bartos Przybyla, Kristina Beblo-Vranesevic, Reinhard Wirth, Harald Huber, Reinhard Rachel, Petra Rettberg
Archives of Microbiology.2021; 203(4): 1299. CrossRef
Global Warming, Climate Change, and Environmental Pollution: Recipe for a Multifactorial Stress Combination Disaster
Sara I. Zandalinas, Felix B. Fritschi, Ron Mittler
Trends in Plant Science.2021; 26(6): 588. CrossRef
The Transcriptomic and Phenotypic Response of the Melanized Yeast Exophiala dermatitidis to Ionizing Particle Exposure
Zachary Schultzhaus, Amy Chen, Igor Shuryak, Zheng Wang
Frontiers in Microbiology.2021;[Epub] CrossRef
Genomic characterization and proteomic analysis of the halotolerant Micrococcus luteus SA211 in response to the presence of lithium
Fabiana Lilian Martínez, Verónica Beatriz Rajal, Verónica Patricia Irazusta
Science of The Total Environment.2021; 785: 147290. CrossRef
Helical and linear morphotypes ofArthrospirasp. PCC 8005 display genomic differences and respond differently to60Co gamma irradiation
Anu Yadav, Pieter Monsieurs, Agnieszka Misztak, Krzysztof Waleron, Natalie Leys, Ann Cuypers, Paul J. Janssen
European Journal of Phycology.2020; 55(2): 129. CrossRef
Gamma Radiation Tolerance and Protein Carbonylation Caused by Irradiation of Resting Cysts in the Free-living Ciliated Protist Colpoda cucullus
Ryota Saito, Ryota Koizumi, Tatsuya Sakai, Taiga Shimizu, Taiki Ono, Yoichiro Sogame
Acta Protozoologica.2020; 59(2): 67. CrossRef
Carotenoids as a Protection Mechanism against Oxidative Stress in Haloferax mediterranei
Micaela Giani, Rosa María Martínez-Espinosa
Antioxidants.2020; 9(11): 1060. CrossRef
Active Galactic Nuclei: Boon or Bane for Biota?
Manasvi Lingam, Idan Ginsburg, Shmuel Bialy
The Astrophysical Journal.2019; 877(1): 62. CrossRef
Computational search for UV radiation resistance strategies in Deinococcus swuensis isolated from Paramo ecosystems
Jorge Díaz-Riaño, Leonardo Posada, Iván Camilo Acosta, Carlos Ruíz-Pérez, Catalina García-Castillo, Alejandro Reyes, María Mercedes Zambrano, Hari S. Misra
PLOS ONE.2019; 14(12): e0221540. CrossRef
GATA-type transcription factors play a vital role in radiation sensitivity of Cryptococcus neoformans by regulating the gene expression of specific amino acid permeases
Wanchang Cui, XiangHong Li, Lisa Hull, Mang Xiao
Scientific Reports.2019;[Epub] CrossRef
Reducing the ionizing radiation background does not significantly affect the evolution of Escherichia coli populations over 500 generations
Nathanael Lampe, Pierre Marin, Marianne Coulon, Pierre Micheau, Lydia Maigne, David Sarramia, Fabrice Piquemal, Sébastien Incerti, David G. Biron, Camille Ghio, Télesphore Sime-Ngando, Thomas Hindre, Vincent Breton
Scientific Reports.2019;[Epub] CrossRef
Covalent Modification of Amino Acids and Peptides Induced by Ionizing Radiation from an Electron Beam Linear Accelerator Used in Radiotherapy
Benjamin B. Minkoff, Steven T. Bruckbauer, Grzegorz Sabat, Michael M. Cox, Michael R. Sussman
Radiation Research.2019; 191(5): 447. CrossRef
Genome analysis of Rubritalea profundi SAORIC-165T, the first deep-sea verrucomicrobial isolate, from the northwestern Pacific Ocean
Jaeho Song, Ilnam Kang, Yochan Joung, Susumu Yoshizawa, Ryo Kaneko, Kenshiro Oshima, Masahira Hattori, Koji Hamasaki, Kazuhiro Kogure, Soochan Kim, Kangseok Lee, Jang-Cheon Cho
Journal of Microbiology.2019; 57(5): 413. CrossRef
Shifts in microbial community composition in tannery-contaminated soil in response to increased gamma radiation
Mohammad A. A. Al-Najjar, Majed M. Albokari
Annals of Microbiology.2019; 69(13): 1567. CrossRef
Colloquium: Physical constraints for the evolution of life on exoplanets
Manasvi Lingam, Abraham Loeb
Reviews of Modern Physics.2019;[Epub] CrossRef
Enhanced biodegradation and kinetics of anthraquinone dye by laccase from an electron beam irradiated endophytic fungus
Kavitha Keshava Navada, Ganesh Sanjeev, Ananda Kulal
International Biodeterioration & Biodegradation.2018; 132: 241. CrossRef

[Minireview] Unraveling new functions of superoxide dismutase using yeast model system: Beyond its conventional role in superoxide radical scavenging: Woo-Hyun Chung ,; J. Microbiol. 2017;55(6):409-416. Published online March 9, 2017; DOI: https://doi.org/10.1007/s12275-017-6647-5

46 View
0 Download
39 Crossref

Abstract

To deal with chemically reactive oxygen molecules constantly threatening aerobic life, cells are readily equipped with elabo-rate biological antioxidant systems. Superoxide dismutase is a metalloenzyme catalytically eliminating superoxide radi-cal as a first-line defense mechanism against oxidative stress. Multiple different SOD isoforms have been developed through-out evolution to play distinct roles in separate subcellular com-partments. SOD is not essential for viability of most aerobic organisms and intriguingly found even in strictly anaerobic bacteria. Sod1 has recently been known to play important roles as a nuclear transcription factor, an RNA binding pro-tein, a synthetic lethal interactor, and a signal modulator in glucose metabolism, most of which are independent of its canonical function as an antioxidant enzyme. In this review, recent advances in understanding the unconventional role of Sod1 are highlighted and discussed with an emphasis on its genetic crosstalk with DNA damage repair/checkpoint path-ways. The budding yeast Saccharomyces cerevisiae has been successfully used as an efficient tool and a model organism to investigate a number of novel functions of Sod1.

Citations

Citations to this article as recorded by

The combined application of rutin and silicon alleviates osmotic stress in maize seedlings by triggering accumulation of osmolytes and antioxidants’ defense mechanisms
Namuun Altansambar, Asiye Sezgin Muslu, Asim Kadıoglu
Physiology and Molecular Biology of Plants.2024; 30(3): 513. CrossRef
Role of Extracellular Vesicles in the Progression of Brain Tumors
Gabriella Schiera, Carlo Maria Di Liegro, Francesco Vento, Italia Di Liegro
Biology.2024; 13(8): 586. CrossRef
Sodium transport and redox regulation in Saccharomyces cerevisiae under osmotic stress depending on oxygen availability
A. Shirvanyan, K. Trchounian
Scientific Reports.2024;[Epub] CrossRef
Estresse oxidativo em Oenocarpus bacaba e Oenocarpus mapora submetidas à deficiência hídrica
Karollyne Renata Silva De Paula Baptista, Milena Pantoja De Moraes, Tamirys Marcelina da Silva, Kamilla Melo De Jesus, Glauco André Dos Santos Nogueira, Antonia Benedita Da Silva Bronze, Cândido Ferreira De Oliveira Neto
Scientific Electronic Archives.2024;[Epub] CrossRef
Exogenous application of sulfur-rich thiourea (STU) to alleviate the adverse effects of cobalt stress in wheat
Aiman Zahid, Kaleem ul din, Muhamad Ahmad, Umer Hayat, Usman Zulfiqar, Syed Muhammad Hassan Askri, Muhammad Zohaib Anjum, Muhammad Faisal Maqsood, Nazish Aijaz, Talha Chaudhary, Hayssam M. Ali
BMC Plant Biology.2024;[Epub] CrossRef
Silicon-Mediated Improvement in Drought and Salinity Stress Tolerance of Black Gram (Vigna mungo L.) by Modulating Growth, Physiological, Biochemical, and Root Attributes
Waheed Ahmad, Ejaz Ahmad Waraich, Arslan Haider, Nasir Mahmood, Tahrim Ramzan, Saud Alamri, Manzer H. Siddiqui, Mohd. Sayeed Akhtar
ACS Omega.2024; 9(35): 37231. CrossRef
Capsaicin toxicity to the yeast Saccharomyces cerevisiae is not due to oxidative stress but to disruption of membrane structure
Klaudia Kuczera, Katarzyna Naparło, Mirosław Soszyński, Grzegorz Bartosz, Izabela Sadowska-Bartosz
Chemico-Biological Interactions.2023; 374: 110407. CrossRef
The essential liaison of two copper proteins: the Cu-sensing transcription factor Mac1 and the Cu/Zn superoxide dismutase Sod1 in Saccharomyces cerevisiae
Dimitra Dialynaki, Athanasia Stavropoulou, Maria Laskou, Despina Alexandraki
Current Genetics.2023; 69(1): 41. CrossRef
Quinoa Response to Application of Phosphogypsum and Plant Growth-Promoting Rhizobacteria under Water Stress Associated with Salt-Affected Soil
Moshira A. El-Shamy, Tarek Alshaal, Hossam Hussein Mohamed, Asmaa M. S. Rady, Emad M. Hafez, Abdullah S. Alsohim, Diaa Abd El-Moneim
Plants.2022; 11(7): 872. CrossRef
The Stimulation of Superoxide Dismutase Enzyme Activity and Its Relation with the Pyrenophora teres f. teres Infection in Different Barley Genotypes
Viola Kunos, Mónika Cséplő, Diána Seress, Adnan Eser, Zoltán Kende, Andrea Uhrin, Judit Bányai, József Bakonyi, Magda Pál, Klára Mészáros
Sustainability.2022; 14(5): 2597. CrossRef
Transcriptome Analysis of Glutathione Response: RNA-Seq Provides Insights into Balance between Antioxidant Response and Glucosinolate Metabolism
Biao Zhu, Kuanhong Wang, Zhile Liang, Zhujun Zhu, Jing Yang
Antioxidants.2022; 11(7): 1322. CrossRef
Effects of Chitosan-Coated Microdiet on Dietary Physical Properties, Growth Performance, Digestive Enzyme Activities, Antioxidant Capacity, and Inflammation Response of Large Yellow Croaker (Larimichthys crocea) Larvae
Jiahui Liu, Wenxuan Xu, Yongtao Liu, Yuntao Wang, Jianmin Zhang, Zhen Wang, Kangsen Mai, Qinghui Ai, Zhen-Yu Du
Aquaculture Nutrition.2022; 2022: 1. CrossRef
Genetic Potential and Inheritance Patterns of Physiological, Agronomic and Quality Traits in Bread Wheat under Normal and Water Deficit Conditions
Mohamed Kamara, Medhat Rehan, Amany Mohamed, Rania El Mantawy, Ahmed Kheir, Diaa Abd El-Moneim, Fatmah Safhi, Salha ALshamrani, Emad Hafez, Said Behiry, Mohamed Ali, Elsayed Mansour
Plants.2022; 11(7): 952. CrossRef
Capsaicin Toxicity to the Yeast Saccharomyces Cerevisiae: Membrane Disturbance, Not Oxidative Stress
Grzegorz Bartosz, Katarzyna Naparło, Klaudia Kuczera, Mirosław Soszyński, Izabela Sadowska-Bartosz
SSRN Electronic Journal .2022;[Epub] CrossRef
Collaborative Impact of Compost and Beneficial Rhizobacteria on Soil Properties, Physiological Attributes, and Productivity of Wheat Subjected to Deficit Irrigation in Salt Affected Soil
Alaa El-Dein Omara, Emad M. Hafez, Hany S. Osman, Emadeldeen Rashwan, Mohamed A. A. El-Said, Khadiga Alharbi, Diaa Abd El-Moneim, Salah M. Gowayed
Plants.2022; 11(7): 877. CrossRef
Effects of diet-induced hypercholesterolemia and gold nanoparticles treatment on peripheral tissues
MATHEUS S. RODRIGUES, JULIA N. MARTINS, GABRIELA C. DE PAULA, LIGIA M. VENTURINI, GUSTAVO DE B. SILVEIRA, EMÍLIO L. STRECK, JOSIANI BUDNI, RICARDO A. MACHADO DE ÁVILA, ANDREZA F. DE BEM, PAULO C.L. SILVEIRA, JADE DE OLIVEIRA
Anais da Academia Brasileira de Ciências.2022;[Epub] CrossRef
Stimulating the Growth, Anabolism, Antioxidants, and Yield of Rice Plants Grown under Salt Stress by Combined Application of Bacterial Inoculants and Nano-Silicon
Khadiga Alharbi, Hany S. Osman, Emadeldeen Rashwan, Emad M. Hafez, Alaa El-Dein Omara
Plants.2022; 11(24): 3431. CrossRef
Oxidative Stress and Antioxidant Metabolism under Adverse Environmental Conditions: a Review
Pedro García-Caparrós, Luigi De Filippis, Alvina Gul, Mirza Hasanuzzaman, Munir Ozturk, Volkan Altay, María Teresa Lao
The Botanical Review.2021; 87(4): 421. CrossRef
Evaluation of Silicon and Proline Application on the Oxidative Machinery in Drought-Stressed Sugar Beet
Muneera D. F. AlKahtani, Yaser M. Hafez, Kotb Attia, Emadeldeen Rashwan, Latifa Al Husnain, Hussah I. M. AlGwaiz, Khaled A. A. Abdelaal
Antioxidants.2021; 10(3): 398. CrossRef
Pre treatment with Bacillus subtilis mitigates drought induced photo-oxidative damages in okra by modulating antioxidant system and photochemical activity
Pravisya Puthiyottil, Yusuf Akkara
Physiology and Molecular Biology of Plants.2021; 27(5): 945. CrossRef
Soil Amendment Using Biochar and Application of K-Humate Enhance the Growth, Productivity, and Nutritional Value of Onion (Allium cepa L.) under Deficit Irrigation Conditions
Khaled G. Abdelrasheed, Yasser Mazrou, Alaa El-Dein Omara, Hany S. Osman, Yasser Nehela, Emad M. Hafez, Asmaa M. S. Rady, Diaa Abd El-Moneim, Bassam F. Alowaiesh, Salah M. Gowayed
Plants.2021; 10(12): 2598. CrossRef
Redox-Sensitive VDAC: A Possible Function as an Environmental Stress Sensor Revealed by Bioinformatic Analysis
Andonis Karachitos, Wojciech Grabiński, Martyna Baranek, Hanna Kmita
Frontiers in Physiology.2021;[Epub] CrossRef
Seed Priming Boost Adaptation in Pea Plants under Drought Stress
Sally A. Arafa, Kotb A. Attia, Gniewko Niedbała, Magdalena Piekutowska, Salman Alamery, Khaled Abdelaal, Talal K. Alateeq, Mohamed A. M. Ali, Amr Elkelish, Shreen Y. Attallah
Plants.2021; 10(10): 2201. CrossRef
SOD1, more than just an antioxidant
Elis Cristina Araujo Eleutherio, Rayne Stfhany Silva Magalhães, Aline de Araújo Brasil, José Raphael Monteiro Neto, Luan de Holanda Paranhos
Archives of Biochemistry and Biophysics.2021; 697: 108701. CrossRef
Reactive oxygen species detection-approaches in plants: Insights into genetically encoded FRET-based sensors
Naser A. Anjum, Amreen, Aadil Y. Tantray, Nafees A. Khan, Altaf Ahmad
Journal of Biotechnology.2020; 308: 108. CrossRef
The role of Rsv1 in the transcriptional regulation of genes involved in sugar metabolism for long‐term survival
Eun‐Jung Kim, Yong‐Joon Cho, Woo‐Hyun Chung, Jung‐Hye Roe
The FEBS Journal.2020; 287(5): 878. CrossRef
Functional interplay between the oxidative stress response and DNA damage checkpoint signaling for genome maintenance in aerobic organisms
Ji Eun Choi, Woo-Hyun Chung
Journal of Microbiology.2020; 58(2): 81. CrossRef
SOD1 deficiency: a novel syndrome distinct from amyotrophic lateral sclerosis
Julien H Park, Christiane Elpers, Janine Reunert, Michael L McCormick, Julia Mohr, Saskia Biskup, Oliver Schwartz, Stephan Rust, Marianne Grüneberg, Anja Seelhöfer, Ulrike Schara, Eugen Boltshauser, Douglas R Spitz, Thorsten Marquardt
Brain.2019; 142(8): 2230. CrossRef
Insight Into the Salivary Secretome of Varroa destructor and Salivary Toxicity to Apis cerana
Yi Zhang, Richou Han
Journal of Economic Entomology.2019; 112(2): 505. CrossRef
Roles of the Two-MnSOD System of Stenotrophomonas maltophilia in the Alleviation of Superoxide Stress
Herng-Woei Jair, Hsu-Feng Lu, Yi-Wei Huang, Sz-Yun Pan, I-Ling Lin, Hsin-Hui Huang, Tsuey-Ching Yang
International Journal of Molecular Sciences.2019; 20(7): 1770. CrossRef
Structural Properties and Interaction Partners of Familial ALS-Associated SOD1 Mutants
Jisen Huai, Zhongjian Zhang
Frontiers in Neurology.2019;[Epub] CrossRef
Inhibition of Aflatoxin Production by Paraquat and External Superoxide Dismutase in Aspergillus flavus
Tomohiro Furukawa, Shohei Sakuda
Toxins.2019; 11(2): 107. CrossRef
Cross talk between SOD1 and the mitochondrial UPR in cancer and neurodegeneration
Maria Gomez, Doris Germain
Molecular and Cellular Neuroscience.2019; 98: 12. CrossRef
Synthetic lethal interaction between oxidative stress response and DNA damage repair in the budding yeast and its application to targeted anticancer therapy
Ji Eun Choi, Woo-Hyun Chung
Journal of Microbiology.2019; 57(1): 9. CrossRef
Lack of superoxide dismutase in a rad51 mutant exacerbates genomic instability and oxidative stress-mediated cytotoxicity in Saccharomyces cerevisiae
Ji Eun Choi, Seo-Hee Heo, Myung Ju Kim, Woo-Hyun Chung
Free Radical Biology and Medicine.2018; 129: 97. CrossRef
The 70-kDa Heat-shock Protein as a Potential Biomarker of Quality of the Parapenaeus longirostris Shrimp Flesh
Annalisa Pinsino, Rosa Bonaventura, Caterina Costa, Roberta Russo, Francesca Zito, Valeria Guarrasi, Valeria Matranga
Journal of Aquatic Food Product Technology.2018; 27(1): 122. CrossRef
Consequences of cytochrome c oxidase assembly defects for the yeast stationary phase
Alicia F. Dubinski, Raffaele Camasta, Tyler G.B. Soule, Bruce H. Reed, D. Moira Glerum
Biochimica et Biophysica Acta (BBA) - Bioenergetics.2018; 1859(6): 445. CrossRef
Preventive and Therapeutic Effects of Thymol in a Lipopolysaccharide-Induced Acute Lung Injury Mice Model
Limei Wan, Dongmei Meng, Hong Wang, Shanhe Wan, Shunjun Jiang, Shanshan Huang, Li Wei, Pengjiu Yu
Inflammation.2018; 41(1): 183. CrossRef
Extracellular Vesicle‐Associated RNA as a Carrier of Epigenetic Information
Carlo Maria Di Liegro, Gabriella Schiera, Italia Di Liegro
Genes.2017; 8(10): 240. CrossRef

Journal Article

Latent Kaposi’s sarcoma-associated herpesvirus infection in bladder cancer cells promotes drug resistance by reducing reactive oxygen species: Suhyuk Lee , Jaehyuk Jang , Hyungtaek Jeon , Jisu Lee , Seung-Min Yoo , Jinsung Park , Myung-Shin Lee; J. Microbiol. 2016;54(11):782-788. Published online October 29, 2016; DOI: https://doi.org/10.1007/s12275-016-6388-x

44 View
0 Download
7 Crossref

Abstract

Kaposi’s sarcoma-associated herpesvirus (KSHV) is the major etiologic agent of Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. Recent studies have indicated that KSHV can be detected at high frequency in patient-derived bladder cancer tissue and might be associated with the pathogenesis of bladder cancer. Bladder cancer is the second most common cancer of the genitourinary tract, and it has a high rate of recurrence. Because drug resistance is closely related to chemotherapy failure and cancer recurrence, we investigated whether KSHV infection is associated with drug resistance of bladder cancer cells. Some KSHV-infected bladder cancer cell lines showed resistance to an anti-cancer drug, cisplatin, possibly as a result of downregulation of reactive oxygen species. Additionally, drug resistance acquired from KSHV infection could partly be overcome by HDAC1 inhibitors. Taken together, the data suggest the possible role of KSHV in chemo-resistant bladder cancer, and indicate the therapeutic potential of HDAC1 inhibitors in drug-resistant bladder cancers associated with KSHV infection.

Citations

Citations to this article as recorded by

Development of KSHV vaccine platforms and chimeric MHV68-K-K8.1 glycoprotein for evaluating the in vivo immunogenicity and efficacy of KSHV vaccine candidates
Wan-Shan Yang, Dokyun Kim, Soowon Kang, Chih-Jen Lai, Inho Cha, Pei-Ching Chang, Jae U. Jung, Satya Dandekar
mBio.2024;[Epub] CrossRef
Genomic analysis of schistosomiasis-associated colorectal cancer reveals a unique mutational landscape and therapeutic implications
Dong Yu, Anqi Wang, Jing Zhang, Xinxing Li, Caifeng Jiang, Haiyang Zhou
Genes & Diseases.2023; 10(3): 657. CrossRef
Revisiting Histone Deacetylases in Human Tumorigenesis: The Paradigm of Urothelial Bladder Cancer
Aikaterini F. Giannopoulou, Athanassios D. Velentzas, Eumorphia G. Konstantakou, Margaritis Avgeris, Stamatia A. Katarachia, Nikos C. Papandreou, Nikolas I. Kalavros, Vassiliki E. Mpakou, Vassiliki Iconomidou, Ema Anastasiadou, Ioannis K. Kostakis, Issido
International Journal of Molecular Sciences.2019; 20(6): 1291. CrossRef
Hepatitis C Virus-Induced FUT8 Causes 5-FU Drug Resistance in Human Hepatoma Huh7.5.1 Cells
Shu Li, Xiao-Yu Liu, Qiu Pan, Jian Wu, Zhi-Hao Liu, Yong Wang, Min Liu, Xiao-Lian Zhang
Viruses.2019; 11(4): 378. CrossRef
Mechanistic Insights into Chemoresistance Mediated by Oncogenic Viruses in Lymphomas
Jungang Chen, Samantha Kendrick, Zhiqiang Qin
Viruses.2019; 11(12): 1161. CrossRef
Primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas
Sangmin Kang, Jinjong Myoung
Journal of Microbiology.2017; 55(5): 319. CrossRef
Chitin Oligosaccharide (COS) Reduces Antibiotics Dose and Prevents Antibiotics-Caused Side Effects in Adolescent Idiopathic Scoliosis (AIS) Patients with Spinal Fusion Surgery
Yang Qu, Jinyu Xu, Haohan Zhou, Rongpeng Dong, Mingyang Kang, Jianwu Zhao
Marine Drugs.2017; 15(3): 70. CrossRef

Research Support, Non-U.S. Gov'ts

Lithium Inhibits Growth of Intracellular Mycobacterium kansasii through Enhancement of Macrophage Apoptosis: Hosung Sohn , Kwangwook Kim , Kil-Soo Lee , Han-Gyu Choi , Kang-In Lee , A-Rum Shin , Jong-Seok Kim , Sung Jae Shin , Chang-Hwa Song , Jeong-Kyu Park , Hwa-Jung Kim; J. Microbiol. 2014;52(4):299-306. Published online February 17, 2014; DOI: https://doi.org/10.1007/s12275-014-3469-6

53 View
0 Download
7 Crossref

Abstract

Mycobacterium kansasii (Mk) is an emerging pathogen that causes a pulmonary disease similar to tuberculosis. Macrophage apoptosis contributes to innate host defense against mycobacterial infection. Recent studies have suggested that lithium significantly enhances the cytotoxic activity of death stimuli in many cell types. We examined the effect of lithium on the viability of host cells and intracellular Mk in infected macrophages. Lithium treatment resulted in a substantial reduction in the viability of intracellular Mk in macrophages. Macrophage cell death was significantly enhanced after adding lithium to Mk-infected cells but not after adding to uninfected macrophages. Lithium-enhanced cell death was due to an apoptotic response, as evidenced by augmented DNA fragmentation and caspase activation. Reactive oxygen species were essential for lithium-induced apoptosis. Intracellular scavenging by N-acetylcysteine abrogated the lithiummediated decrease in intracellular Mk growth as well as apoptosis. These data suggest that lithium is associated with control of intracellular Mk growth through modulation of the apoptotic response in infected macrophages.

Citations

Citations to this article as recorded by

Recombinant Rv0753c Protein of Mycobacterium tuberculosis Induces Apoptosis Through Reactive Oxygen Species-JNK Pathway in Macrophages
Kang-In Lee, Seunga Choi, Han-Gyu Choi, Sintayehu Gurmessa Kebede, Thi Binh Dang, Yong Woo Back, Hye-Soo Park, Hwa-Jung Kim
Journal of Bacteriology and Virology.2020; 50(4): 246. CrossRef
Investigating the Role of Everolimus in mTOR Inhibition and Autophagy Promotion as a Potential Host-Directed Therapeutic Target in Mycobacterium tuberculosis Infection
Stephen Cerni, Dylan Shafer, Kimberly To, Vishwanath Venketaraman
Journal of Clinical Medicine.2019; 8(2): 232. CrossRef
Mycobacterium abscessus glycopeptidolipids inhibit macrophage apoptosis and bacterial spreading by targeting mitochondrial cyclophilin D
Jake Whang, Yong Woo Back, Kang-In Lee, Nagatoshi Fujiwara, Seungwha Paik, Chul Hee Choi, Jeong-Kyu Park, Hwa-Jung Kim
Cell Death & Disease.2017; 8(8): e3012. CrossRef
Invasion of Mammalian Cells by Rough Variant ofMycobacterium abscessus
Jake Whang, Young Woo Back, Gang-In Lee, Hwa-Jung Kim
Journal of Bacteriology and Virology.2016; 46(4): 193. CrossRef
Mycobacterium tuberculosis effectors interfering host apoptosis signaling
Minqiang Liu, Wu Li, Xiaohong Xiang, Jianping Xie
Apoptosis.2015; 20(7): 883. CrossRef
Targeting Batf2 for infectious diseases and cancer
Reto Guler, Sugata Roy, Harukazu Suzuki, Frank Brombacher
Oncotarget.2015; 6(29): 26575. CrossRef
Extended stability of cyclin D1 contributes to limited cell cycle arrest at G1-phase in BHK-21 cells with Japanese encephalitis virus persistent infection
Ji Young Kim, Soo Young Park, Hey Rhyoung Lyoo, Eung Seo Koo, Man Su Kim, Yong Seok Jeong
Journal of Microbiology.2015; 53(1): 77. CrossRef

Food-Borne Enterococci and Their Resistance to Oxidative Stress: Barbora Vlková , Tomá&# , Gabriel Minárik , Lubomíra Tóthová , Hana Drahovská , Ján Tur&# , Peter Celec; J. Microbiol. 2011;49(4):657-662. Published online September 2, 2011; DOI: https://doi.org/10.1007/s12275-011-0296-x

27 View
0 Download
4 Scopus

Abstract: Enterococci are important food-borne pathogens that cause serious infections. Several virulence factors have been described including aggregation substance, gelatinase, cytolysin, and enterococcal surface protein. The ability to cause infections is mainly dependent on the response to oxidative stress due to the production of reactive oxygen species by immune cells. The aim of our study was to analyze the resistance of enterococcal strains from food to clinically relevant antiseptic agents with regard to the presence of selected virulence factors, and to uncover potential mechanisms of the antioxidative resistance. Eighty-two enterococcal isolates from Bryndza cheese were tested using in vitro growth assays to study the ability of these isolates to survive exposure to antiseptic agents – hydrogen peroxide, hypochlorite, and chlorhexidine. Virulence genotypes of the isolates were determined by PCR, and RT real time PCR was used for gene expression under oxidative stress. Resistance against antiseptic agents depends on the concentration of applied chemicals, on the time of exposure, but also on virulence factors of the enterococcal strains. Oxidative stress induces the expression of antioxidative enzymes and down-regulates the expression of prooxidative enzymes. These effects are dependent on the virulence genotype of the enterococcal strains. These findings are important for future research, especially concerning the role of enterococci in oral diseases.

Decomposition of Biological Macromolecules by Plasma Generated with Helium and Oxygen: Seong-Mi Kim , Jong-Il Kim; J. Microbiol. 2006;44(4):466-471.; DOI: https://doi.org/2403 [pii]

36 View
0 Download

Abstract: In this study, we attempted to characterize the biomolecular effects of an atmospheric pressure cold plasma (APCP) system which utilizes helium/oxygen (He/O2). APCP using He/O2 generates a low level of UV while generating reactive oxygen radicals which probably serve as the primary factor in sterilization; these reactive oxygen radicals have the advantage of being capable to access the interiors of the structures of microbial cells. The damaging effects of plasma exposure on polypeptides, DNA, and enzyme proteins in the cell were assessed usiing biochemical methods.

Purification and Characterization of Catalase-3 of Deinococcus radiophilus: Lee, In Jeong , Lee, Young Nam; J. Microbiol. 1995;33(3):239-243.

34 View
0 Download

Abstract: Deinococcus radiophilus, an UV resistant bacterium seemed to contain three issoenzymes of catalase. Among them, the samllest and most abundant species in cell-free extract, catalase-3 which also exhibited peroxidase activity was purified to electrophoretic homogeneity (145-fold purification) by chromatographic procedures. Its molecular weight was 155 kDa composed of four 38 kDa subunits. The K_m value of catalase-3 for H₂O₂was approximately 0.5 mM. This enzyme showed a typical ferric heme spectrum with maximum absorption at 405 nm. Upon binding to cyanide, the 405 nm peak shifted to 420 nm. Catalase-3 was very sensitive to inhibitors of heme proteins, such as cyanide, azide and hydroxylamine. A ratio of A_405/A_28O was 0.5 Catalase-3 was active over a wide range of pH, between pH 7 and 10. The enzyme was rather heat-labile and partially sensitive to ethanol-chloroform treatment, but resistant to 3-amino-1, 2, 4-triazole. Catalase-3 of D. radiophilus, which is a bifunction catalatic peroxidatic enzyme seemed to share certain molecular properties with the typical catalase and the catalase-peroxidase along with its own unique features.

First
Prev
Page of 1
Next
Last

Search