Journal of Microbiology

Journal Article

Propionate, together with triple antibiotics, inhibits the growth of Enterococci: Soyoung Jeong , Yunjae Lee , Cheol-Heui Yun , Ok-Jin Park , Seung Hyun Han; J. Microbiol. 2019;57(11):1019-1024. Published online October 28, 2019; DOI: https://doi.org/10.1007/s12275-019-9434-7

50 View
0 Download
15 Web of Science
14 Crossref

Enterococci are Gram-positive facultative anaerobic bacteria that colonize the oral cavity and gastrointestinal tract. Enterococcal infections, mainly caused by Enterococcus faecalis and Enterococcus faecium, include apical periodontitis, endocarditis, and bloodstream infections. Recently, vancomycinresistant Enterococci are considered major pathogens that are common but difficult to treat, especially in nosocomial settings. Moreover, E. faecalis is closely associated with recurrent endodontic infections and failed endodontic treatment. In this study, we investigated the effects of short-chain fatty acids (SCFAs), acetate, propionate, and butyrate, which are metabolites fermented by gut microbiota, on the growth of Enterococci. Enterococci were cultured in the presence or absence of acetate, propionate, or butyrate, and the optical density at 600 nm was measured to determine bacterial growth. The minimum inhibitory concentration/minimum bactericidal concentration test was conducted. Bacteria were treated with a SCFA, together with clinically used endodontic treatment methods such as triple antibiotics (metronidazole, minocycline, and ciprofloxacin) and chlorhexidine gluconate (CHX) to determine the effects of combination treatment. Of the SCFAs, propionate had a bacteriostatic effect, inhibiting the growth of E. faecalis in a dose-dependent manner and also that of clinical strains of E. faecalis isolated from dental plaques. Meanwhile, acetate and butyrate had minimal effects on E. faecalis growth. Moreover, propionate inhibited the growth of other Enterococci including E. faecium. In addition, combination treatment of propionate and triple antibiotics led to further growth inhibition, whereas no cooperative effect was observed at propionate plus CHX. These results indicate that propionate attenuates the growth of Enterococci, suggesting propionate as a potential agent to control Enterococcal infections, especially when combined with triple antibiotics.

Citations

Citations to this article as recorded by

Serotype-Dependent Inhibition of Streptococcus pneumoniae Growth by Short-Chain Fatty Acids
Suwon Lim, Dongwook Lee, Sungho Jeong, Jeong Woo Park, Jintaek Im, Bokeum Choi, Donghyun Gwak, Cheol-Heui Yun, Ho Seong Seo, Seung Hyun Han
Journal of Microbiology and Biotechnology.2024; 34(1): 47. CrossRef
Microbiota signatures associated with invasive Candida albicans infection in the gastrointestinal tract of immunodeficient mice
Jia-Ying Yan, Tsung-Han Lin, Yu-Tang Jong, Jun-Wei Hsueh, Sze-Hsien Wu, Hsiu-Jung Lo, Yee-Chun Chen, Chien-Hsiung Pan
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef
Diet-induced changes in the jejunal microbiota of developing broilers reduce the abundance of Enterococcus hirae and Enterococcus faecium
Paul B. Stege, Dirkjan Schokker, Frank Harders, Soumya K. Kar, Norbert Stockhofe, Vera Perricone, Johanna M. J. Rebel, Ingrid C. de Jong, Alex Bossers
BMC Genomics.2024;[Epub] CrossRef
Enterococcus faecium: evolution, adaptation, pathogenesis and emerging therapeutics
Yahan Wei, Dennise Palacios Araya, Kelli L. Palmer
Nature Reviews Microbiology.2024; 22(11): 705. CrossRef
Mechanisms of probiotic Bacillus against enteric bacterial infections
Jiajia Zhu, Yunsheng Chen, Kálmán Imre, Damla Arslan-Acaroz, Fatih Ramazan Istanbullugil, Yuwen Fang, Gaspar Ros, Kui Zhu, Ulas Acaroz
One Health Advances.2023;[Epub] CrossRef
Structural features and anticancer mechanisms of pectic polysaccharides: A review
Fangfang Yue, Jiaxin Xu, Sitan Zhang, Xinyu Hu, Xin Wang, Xin Lü
International Journal of Biological Macromolecules.2022; 209: 825. CrossRef
Dual role of microbiota-derived short-chain fatty acids on host and pathogen
Rasoul Mirzaei, Elahe Dehkhodaie, Behnaz Bouzari, Mandana Rahimi, Abolfazl Gholestani, Seyed Reza Hosseini-Fard, Hossein Keyvani, Ali Teimoori, Sajad Karampoor
Biomedicine & Pharmacotherapy.2022; 145: 112352. CrossRef
RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus growth inhibition by propionate
Jintaek Im, Dongwook Lee, Ok-Jin Park, Sathishkumar Natarajan, Junhyung Park, Cheol-Heui Yun, Seung Hyun Han
Frontiers in Microbiology.2022;[Epub] CrossRef
Propionate Attenuates Growth of Oral Streptococci through Enhancing Methionine Biosynthesis
Taehwan Park, Jintaek Im, A Reum Kim, Dongwook Lee, Sungho Jeong, Cheol-Heui Yun, Seung Hyun Han
Journal of Microbiology and Biotechnology.2022; 32(10): 1234. CrossRef
Bacterial-Induced Blood Pressure Reduction: Mechanisms for the Treatment of Hypertension via the Gut
Tyler Alexander Cookson
Frontiers in Cardiovascular Medicine.2021;[Epub] CrossRef
Influence of operating conditions on the persistence of E. coli, enterococci, Clostridium perfringens and Clostridioides difficile in semi-continuous mesophilic anaerobic reactors
Derongs Lorine, Druilhe Céline, Le Maréchal Caroline, Barbut Frédéric, Heurtevent Lorette, Buffet Julie, Martin Laure, Ziebal Christine, Poezevara Typhaine, Rouxel Sandra, Houard Emmanuelle, Syed Zaidi Rabab, Couturier Jeanne, Pourcher Anne-Marie
Waste Management.2021; 134: 32. CrossRef
Short-Chain Fatty Acids as a Potential Treatment for Infections: a Closer Look at the Lungs
Marina Gomes Machado, Valentin Sencio, François Trottein, Andreas J. Bäumler
Infection and Immunity.2021;[Epub] CrossRef
The lung–gut axis during viral respiratory infections: the impact of gut dysbiosis on secondary disease outcomes
Valentin Sencio, Marina Gomes Machado, François Trottein
Mucosal Immunology.2021; 14(2): 296. CrossRef
Enhanced biofilm formation of Streptococcus gordonii with lipoprotein deficiency
Ok‐Jin Park, Solmin Jung, Taehwan Park, A Reum Kim, Dongwook Lee, Hyun Jung Ji, Ho Seong Seo, Cheol‐Heui Yun, Seung Hyun Han
Molecular Oral Microbiology.2020; 35(6): 271. CrossRef

Research Support, Non-U.S. Gov't

Lactobacillus paracasei subsp. paracasei LC01 Positively Modulates Intestinal Microflora in Healthy Young Adults: Hao Zhang , Jing Sun , Xianting Liu , Chuan Hong , Yuanbo Zhu , Aiping Liu , Siqi Li , Huiyuan Guo , Fazheng Ren; J. Microbiol. 2013;51(6):777-782. Published online December 19, 2013; DOI: https://doi.org/10.1007/s12275-013-3279-2

50 View
0 Download
21 Crossref

Abstract

Lactobacillus paracasei subsp. paracasei LC01 (LC01) can tolerate intestinal stresses and has antioxidant activity. To evaluate the effect of the bacterium on human intestinal microflora, a randomized, double-blind, placebo-controlled human trial was carried out. Fifty-two healthy adult volunteers were randomized equally to two groups. One group consumed 12% (wt/vol) skimmed milk supplemented with 1010 CFU of LC01 each day for the 4-week treatment period, and then consumed placebo in the next treatment period, separated by a 2-week washout. The other group followed the reverse order. Group-specific real-time PCR and biochemical analyses was used to determine the intestinal bacterial composition of fecal samples collected at the end of every period, and the concentration of short-chain fatty acids and ammonia. A significant inhibition in fecal Escherichia coli and increase in Lactobacillus, Bifidobacterium, and Roseburia intestinalis were observed after consumption of LC01. Acetic acid and butyric acid were significantly higher in the probiotic stage and fecal ammonia was significantly lower. The results indicated a modulation effect of LC01 on the intestinal microflora of young adults, suggesting a beneficial effect on bowel health. LC01 may have potential value as a probiotic.

Citations

Citations to this article as recorded by

Targeting maternal gut microbiome to improve mental health outcomes—a pilot feasibility trial
Faith Gallant, Kieran Cooley, Sophie Grigoriadis, Neda Ebrahimi
Frontiers in Psychiatry.2024;[Epub] CrossRef
Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease
Zhi Zhang, Jiajia Sun, Yanxia Li, Kexin Yang, Gang Wei, Shenglong Zhang
Experimental Gerontology.2023; 183: 112308. CrossRef
Dietary Lactobacillus fermentum and Lactobacillus paracasei improve the intestinal health of broilers challenged with coccidia and Clostridium perfringens
Peng Li, Liyun Zheng, Ya Qi, Zhipeng Liu, Encun Du, Jintao Wei, Zhengfan Zhang, Shuangshuang Guo, Binying Ding
Frontiers in Veterinary Science.2022;[Epub] CrossRef
Chemical composition and sensory properties of fermented citrus juice using probiotic lactic acid bacteria
Masahiro Yuasa, Ami Shimada, Ayumi Matsuzaki, Ayaka Eguchi, Mihoko Tominaga
Food Bioscience.2021; 39: 100810. CrossRef
The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health
Ana Nogal, Ana M. Valdes, Cristina Menni
Gut Microbes.2021;[Epub] CrossRef
Differences in Manifestations and Gut Microbiota Composition Between Patients With Different Henoch-Schonlein Purpura Phenotypes
Yuanzhen Zhang, Guizhi Xia, Xiaojing Nie, Yugui Zeng, Yi Chen, Yifang Qian, Guangming Chen, Jun Huang, Chengfeng Wang, Chuanyin Zhang, Xiaoli Huang, Yuen Yang, Xiaojian Qiu, Fang Yang, Jie Chen, Jun Hu
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef
Lactobacillus casei LC01 Regulates Intestinal Epithelial Permeability through miR-144 Targeting of OCLN and ZO1
Qiuke Hou, Yongquan Huang, Yan Wang, Liu Liao, Zhaoyang Zhu, Wenjie Zhang, Yongshang Liu, Peiwu Li, Xinlin Chen, Fengbin Liu
Journal of Microbiology and Biotechnology.2020; 30(10): 1480. CrossRef
Gut microbiota is associated with adiposity markers and probiotics may impact specific genera
Aline Corado Gomes, Christian Hoffmann, João Felipe Mota
European Journal of Nutrition.2020; 59(4): 1751. CrossRef
Microbiota and Lifestyle: A Special Focus on Diet
Noemí Redondo-Useros, Esther Nova, Natalia González-Zancada, Ligia E. Díaz, Sonia Gómez-Martínez, Ascensión Marcos
Nutrients.2020; 12(6): 1776. CrossRef
Hematobiochemical and Immunological Responses of Rats Treated with Multi-strain Probiotics and Infected with Trypanosoma brucei
Chukwuemeka Calistus Okolo, Nwakaego Ernestina Nweze, Ifeanyi James Eze
Probiotics and Antimicrobial Proteins.2020; 12(3): 952. CrossRef
Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study
Ezgi BELLIKCI-KOYU, Banu Pınar SARER-YUREKLI, Yakut AKYON, Fadime AYDIN-KOSE, Cem KARAGOZLU, Ahmet Gokhan OZGEN, Annika BRINKMANN, Andreas NITSCHE, Koray ERGUNAY, Engin YILMAZ, Zehra BUYUKTUNCER
Nutrients.2019; 11(9): 2089. CrossRef
“Physicochemical, immunomodulatory and safety aspects of milks fermented with Lactobacillus paracasei isolated from kefir”
Ana A. Bengoa, Carolina Iraporda, Leonardo B. Acurcio, Sávio H. de Cicco Sandes, Karen Costa, Gabriele Moreira Guimarães, Rosa M. Esteves Arantes, Elisabeth Neumann, Álvaro Cantini Nunes, Jaques R. Nicoli, Graciela L. Garrote, Analía G. Abraham
Food Research International.2019; 123: 48. CrossRef
Use of Gas Chromatography to Quantify Short Chain Fatty Acids in the Serum, Colonic Luminal Content and Feces of Mice
Willian Ribeiro, Marco Vinolo, Leandro Calixto, Caroline Ferreira
BIO-PROTOCOL.2018;[Epub] CrossRef
Roseburia Spp.: A Marker of Health?
Zohreh Tamanai-Shacoori, Imen Smida, Latifa Bousarghin, Olivier Loreal, Vincent Meuric, Shao Bing Fong, Martine Bonnaure-Mallet, Anne Jolivet-Gougeon
Future Microbiology.2017; 12(2): 157. CrossRef
An overview of advanced technologies for selection of probiotics and their expediency: A review
Ruby Yadav, Pratyoosh Shukla
Critical Reviews in Food Science and Nutrition.2017; 57(15): 3233. CrossRef
RNA and a cell wall component of Enterococcus faecalis IC-1 are required for phagocytosis and interleukin 12 production by the mouse macrophage cell line J774.1
Junpei Nakase, Yuuichi Ukawa, Syoji Takemoto, Takayoshi Kubo, Yuko M Sagesaka, Ayako Aoki-Yoshida, Mamoru Totsuka
Bioscience, Biotechnology, and Biochemistry.2017; 81(6): 1099. CrossRef
The Role of Probiotics on the Microbiota
Esther Nova, Fátima Pérez de Heredia, Sonia Gómez‐Martínez, Ascensión Marcos
Nutrition in Clinical Practice.2016; 31(3): 387. CrossRef
The growth potential for dairy probiotics
Gregor Reid
International Dairy Journal.2015; 49: 16. CrossRef
Fate, activity, and impact of ingested bacteria within the human gut microbiota
Muriel Derrien, Johan E.T. van Hylckama Vlieg
Trends in Microbiology.2015; 23(6): 354. CrossRef
Cellular model to assess the antioxidant activity of lactobacilli
Jiali Xing, Gang Wang, Zhennan Gu, Xiaoming Liu, Qiuxiang Zhang, Jianxin Zhao, Hao Zhang, Yong Q. Chen, Wei Chen
RSC Advances.2015; 5(47): 37626. CrossRef
Antiviral effects of Lactobacillus ruminis SPM0211 and Bifidobacterium longum SPM1205 and SPM1206 on rotavirus-infected Caco-2 cells and a neonatal mouse model
Joo Yeon Kang, Do Kyung Lee, Nam Joo Ha, Hea Soon Shin
Journal of Microbiology.2015; 53(11): 796. CrossRef

Published Erratum

Erratum] The transcription factor Cas5 suppresses hyphal morphogenesis during yeast-form growth in Candida albicans: Jong-Myeong Kim , Hye Yun Moon , Dong Wook Lee , Hyun Ah Kang , Jeong-Yoon Kim; J. Microbiol. 2021;59(11):1063-1063.; DOI: https://doi.org/10.1007/s12275-021-0326-2

40 View
0 Download

First
Prev
Page of 1
Next
Last

Search