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Randomized Controlled Trial
Ulmus macrocarpa Hance extract modulates intestinal microbiota in healthy adults: a randomized, placebo-controlled clinical trial
Kwangmin Kim , Karpagam Veerappan , Nahyun Woo , Bohyeon Park , Sathishkumar Natarajan , Hoyong Chung , Cheolmin Kim , Junhyung Park
J. Microbiol. 2021;59(12):1150-1156.   Published online October 26, 2021
DOI: https://doi.org/10.1007/s12275-021-1329-8
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  • 6 Web of Science
  • 6 Crossref
AbstractAbstract
The stem and root bark of Ulmus macrocarpa Hance has been used as traditional pharmacological agent against inflammation related disorders. The objective of this study was to explore the impact of Ulmus macrocarpa Hance extract (UME) on human gut microbiota. A randomized placebo-controlled clinical study was conducted in healthy adults. The study subjects were given 500 mg/day of UME or placebo orally for 4 weeks. Eighty fecal samples were collected at baseline and 4 weeks of UME or placebo intervention. The gut microbiota variation was evaluated by 16S rRNA profiling. The microbial response was highly personalized, and no statistically significant differences was observed in both species richness and abundance. The number of bacterial species identified in study subjects ranged from 86 to 182 species. The analysis for taxonomical changes revealed an increase in Eubacterium ventriosum, Blautia faecis, Ruminococcus gnavus in the UME group. Functional enrichment of bacterial genes showed an increase in primary and secondary bile acid biosynthesis in UME group. Having known from previous studies Eubacterium regulated bile acid homeostasis in protecting gut microbial architecture and immunity, we suggest that UME supplementation might enhance host immunity by modulating gut microbiota. This is the first stage study and forthcoming clinical studies with larger participants are needed to confirm these findings.

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  • Catechin and flavonoid glycosides from the Ulmus genus: Exploring their nutritional pharmacology and therapeutic potential in osteoporosis and inflammatory conditions
    Chanhyeok Jeong, Chang Hyung Lee, Jiwon Seo, Jung Han Yoon Park, Ki Won Lee
    Fitoterapia.2024; 178: 106188.     CrossRef
  • Comparative transcriptomes of four Elm species provide insights into the genetic features and adaptive evolution of Ulmus spp.
    Shijie Wang, Lihui Zuo, Yichao Liu, Lianxiang Long, Jianghao Wu, Mengting Yuan, Jinmao Wang, Minsheng Yang
    Forest Ecology and Management.2024; 553: 121560.     CrossRef
  • Dietary Supplementation with Popped Amaranth Modulates the Gut Microbiota in Low Height-for-Age Children: A Nonrandomized Pilot Trial
    Oscar de Jesús Calva-Cruz, Cesaré Ovando-Vázquez, Antonio De León-Rodríguez, Fabiola Veana, Eduardo Espitia-Rangel, Samuel Treviño, Ana Paulina Barba-de la Rosa
    Foods.2023; 12(14): 2760.     CrossRef
  • Potential lipid-lowering effects of Ulmus macrocarpa Hance extract in adults with untreated high low-density lipoprotein cholesterol concentrations: A randomized double-blind placebo-controlled trial
    Ye Li Lee, Sang Yeoup Lee
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Research progress on the relationship between intestinal microecology and intestinal bowel disease
    Qianhui Fu, Tianyuan Song, Xiaoqin Ma, Jian Cui
    Animal Models and Experimental Medicine.2022; 5(4): 297.     CrossRef
  • The current status of old traditional medicine introduced from Persia to China
    Jinmin Shi, Yifan Yang, Xinxin Zhou, Lijun Zhao, Xiaohua Li, Abdullah Yusuf, Mohaddeseh S. M. Z. Hosseini, Fatemeh Sefidkon, Xuebo Hu
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
Journal Article
Instruction of microbiome taxonomic profiling based on 16S rRNA sequencing
Hyojung Kim , Sora Kim , Sungwon Jung
J. Microbiol. 2020;58(3):193-205.   Published online February 27, 2020
DOI: https://doi.org/10.1007/s12275-020-9556-y
  • 47 View
  • 0 Download
  • 23 Web of Science
  • 24 Crossref
AbstractAbstract
Recent studies on microbiome highlighted their importance in various environments including human, where they are involved in multiple biological contexts such as immune mechanism, drug response, and metabolism. The rapid increase of new findings in microbiome research is partly due to the technological advances in microbiome identification, including the next-generation sequencing technologies. Several applications of different next-generation sequencing platforms exist for microbiome identification, but the most popular method is using short-read sequencing technology to profile targeted regions of 16S rRNA genes of microbiome because of its low-cost and generally reliable performance of identifying overall microbiome compositions. The analysis of targeted 16S rRNA sequencing data requires multiple steps of data processing and systematic analysis, and many software tools have been proposed for such procedures. However, properly organizing and using such software tools still require certain level of expertise with computational environments. The purpose of this article is introducing the concept of computational analysis of 16S rRNA sequencing data to microbiologists and providing easy-to-follow and step-by-step instructions of using recent software tools of microbiome analysis. This instruction may be used as a quick guideline for general next-generation sequencing-based microbiome studies or a template of constructing own software pipelines for customized analysis.

Citations

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  • PreLect: Prevalence leveraged consistent feature selection decodes microbial signatures across cohorts
    Yin-Cheng Chen, Yin-Yuan Su, Tzu-Yu Chu, Ming-Fong Wu, Chieh-Chun Huang, Chen-Ching Lin
    npj Biofilms and Microbiomes.2025;[Epub]     CrossRef
  • Microbial Population Analysis Based on 16S rRNA Detection and Its Application in Epidemic Disease Warning
    逸欣 王
    Advances in Microbiology.2024; 13(03): 216.     CrossRef
  • The microbial composition of pancreatic ductal adenocarcinoma: a systematic review of 16S rRNA gene sequencing
    Nabeel Merali, Tarak Chouari, Casie Sweeney, James Halle-Smith, Maria-Danae Jessel, Bing Wang, James O’ Brien, Satoshi Suyama, José I. Jiménez, Keith J. Roberts, Eirini Velliou, Shivan Sivakumar, Timothy A. Rockall, Ayse Demirkan, Virginia Pedicord, Dongm
    International Journal of Surgery.2024; 110(10): 6771.     CrossRef
  • Effect of the 16S rRNA Gene Hypervariable Region on the Microbiome Taxonomic Profile and Diversity in the Endangered Fish Totoaba macdonaldi
    Itzel Soledad Pérez-Bustamante, Roberto Cruz-Flores, Jesús Antonio López-Carvallo, Samuel Sánchez-Serrano
    Microorganisms.2024; 12(11): 2119.     CrossRef
  • The Synergistic Impact of a Novel Plant Growth-Promoting Rhizobacterial Consortium and Ascophyllum nodosum Seaweed Extract on Rhizosphere Microbiome Dynamics and Growth Enhancement in Oryza sativa L. RD79
    Pisit Thamvithayakorn, Cherdchai Phosri, Louisa Robinson-Boyer, Puenisara Limnonthakul, John H. Doonan, Nuttika Suwannasai
    Agronomy.2024; 14(11): 2698.     CrossRef
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    Hamidreza Taherkhani, Azadeh KavianFar, Sargol Aminnezhad, Hossein Lanjanian, Ali Ahmadi, Sadegh Azimzadeh, Ali Masoudi-Nejad
    Heliyon.2024; 10(4): e24775.     CrossRef
  • Patent Mining on the Use of Antioxidant Phytochemicals in the Technological Development for the Prevention and Treatment of Periodontitis
    Paulo José Lima Juiz, Luiza Teles Barbalho Ferreira, Edilson Araújo Pires, Cristiane Flora Villarreal
    Antioxidants.2024; 13(5): 566.     CrossRef
  • Periodontal Hastalıklar: Başlıca Risk Faktörleri
    Tuba USTAOĞLU, Deniz MIHÇIOĞLU
    Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi.2023; 8(3): 501.     CrossRef
  • Potential effects of gut microbiota on host cancers: focus on immunity, DNA damage, cellular pathways, and anticancer therapy
    Jiaao Sun, Feng Chen, Guangzhen Wu
    The ISME Journal.2023; 17(10): 1535.     CrossRef
  • Using microbiome information to understand and improve animal performance
    Jeferson Menezes Lourenco, Christina Breanne Welch
    Italian Journal of Animal Science.2022; 21(1): 899.     CrossRef
  • The Influence of Periodontal Disease on Oral Health Quality of Life in Patients with Cardiovascular Disease: A Cross-Sectional Observational Single-Center Study
    Pompilia Camelia Lazureanu, Florina Georgeta Popescu, Laura Stef, Mircea Focsa, Monica Adriana Vaida, Romeo Mihaila
    Medicina.2022; 58(5): 584.     CrossRef
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    Kridtapat Sirisereephap, Tomoki Maekawa, Hikaru Tamura, Takumi Hiyoshi, Hisanori Domon, Toshihito Isono, Yutaka Terao, Takeyasu Maeda, Koichi Tabeta
    International Journal of Molecular Sciences.2022; 23(10): 5540.     CrossRef
  • Effects of oral health intervention strategies on cognition and microbiota alterations in patients with mild Alzheimer's disease: A randomized controlled trial
    Lili Chen, Huizhen Cao, Xiaoqi Wu, Xinhua Xu, Xinli Ji, Bixia Wang, Ping Zhang, Hong Li
    Geriatric Nursing.2022; 48: 103.     CrossRef
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    Yun Zhang, Haonan Ning, Wenyu Zheng, Jing Liu, Fuhai Li, Junfei Chen
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Defining the baseline of pulmonary microbiota in healthy populations and influencing factors
    Zhuoning Tang, Sen Yang, Zilong He
    Highlights in Science, Engineering and Technology.2022; 11: 38.     CrossRef
  • Beware to ignore the rare: how imputing zero-values can improve the quality of 16S rRNA gene studies results
    Giacomo Baruzzo, Ilaria Patuzzi, Barbara Di Camillo
    BMC Bioinformatics.2022;[Epub]     CrossRef
  • Periodontal Disease: The Good, The Bad, and The Unknown
    Lea M. Sedghi, Margot Bacino, Yvonne Lorraine Kapila
    Frontiers in Cellular and Infection Microbiology.2021;[Epub]     CrossRef
  • Omics-based microbiome analysis in microbial ecology: from sequences to information
    Jang-Cheon Cho
    Journal of Microbiology.2021; 59(3): 229.     CrossRef
  • Microbiome-immune interactions in tuberculosis
    Giorgia Mori, Mark Morrison, Antje Blumenthal, N.Luisa Hiller
    PLOS Pathogens.2021; 17(4): e1009377.     CrossRef
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    Lauren E. Eldred, R. Greg Thorn, David Roy Smith
    Frontiers in Genetics.2021;[Epub]     CrossRef
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    PLOS ONE.2021; 16(9): e0257681.     CrossRef
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    Dokyun Na
    Journal of Microbiology.2020; 58(3): 173.     CrossRef
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    Journal of Microbiology.2020; 58(11): 893.     CrossRef
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    Janet L. H. Sperling, Daniel Fitzgerald, Felix A. H. Sperling, Katharine E. Magor
    Tropical Medicine and Infectious Disease.2020; 5(4): 173.     CrossRef

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