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Down-regulation of microRNA-155 suppressed Candida albicans induced acute lung injury by activating SOCS1 and inhibiting inflammation response
Xiaohua Li , Yuanzhong Gong , Xin Lin , Qiong Lin , Jianxiong Luo , Tianxing Yu , Junping Xu , Lifang Chen , Liyu Xu , Ying Hu
J. Microbiol. 2022;60(4):402-410.   Published online February 14, 2022
DOI: https://doi.org/10.1007/s12275-022-1663-5
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  • 5 Web of Science
  • 6 Crossref
AbstractAbstract
Acute lung injury caused by Candida albicans could result in high mortality and morbidity. MicroRNA-155 (miR-155) and suppressor of cytokine signaling 1 (SOCS1) have been believed to play a key in the regulation of inflammatory response. Whether miR-155/SOCS1 axis could regulate the acute lung injury caused by C. albicans has not been reported. The acute lung injury animal model was established with acute infection of C. albicans. miR-155 inhibitor, miR-155 mimic, and sh-SOCS1 were constructed. The binding site between miR- 155 and SOCS1 was identified with dual luciferase reporter assay. Knockdown of miR-155 markedly inhibited the germ tube formation of C. albicans. Knockdown of miR-155 significantly up-regulated the expression of SOCS1, and the binding site between miR-155 and SOCS1 was identified. Knockdown of miR-155 improved the acute lung injury, suppressed inflammatory factors and fungus loading through SOCS1. Knockdown of SOCS1 greatly reversed the influence of miR- 155 inhibitor on the cell apoptosis in vitro. The improvement of acute lung injury caused by C. albicans, suppression of inflammatory response and C. albicans infection, and inhibitor of cell apoptosis were achieved by knocking down miR-155 through SOCS1. This research might provide a new thought for the prevention and treatment of acute lung injury caused by C. albicans through targeting miR-155/SOCS1 axis.

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    Zsuzsanna Gaál
    International Journal of Molecular Sciences.2024; 25(3): 1942.     CrossRef
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    Yan Gao, Rui Wang, Luoying Li, Yumin He, Ding Yuan, Yifan Zhang, Yaqi Hu, Shuwen Wang, Chengfu Yuan
    Phytomedicine.2023; 115: 154827.     CrossRef
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    Osama Sweef, Elsayed Zaabout, Ahmed Bakheet, Mohamed Halawa, Ibrahim Gad, Mohamed Akela, Ehab Tousson, Ashraf Abdelghany, Saori Furuta
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Vertical distribution of bacterial community is associated with the degree of soil organic matter decomposition in the active layer of moist acidic tundra
Hye Min Kim , Min Jin Lee , Ji Young Jung , Chung Yeon Hwang , Mincheol Kim , Hee-Myong Ro , Jongsik Chun , Yoo Kyung Lee
J. Microbiol. 2016;54(11):713-723.   Published online October 29, 2016
DOI: https://doi.org/10.1007/s12275-016-6294-2
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  • 55 Crossref
AbstractAbstract
The increasing temperature in Arctic tundra deepens the active layer, which is the upper layer of permafrost soil that experiences repeated thawing and freezing. The increasing of soil temperature and the deepening of active layer seem to affect soil microbial communities. Therefore, information on soil microbial communities at various soil depths is essential to understand their potential responses to climate change in the active layer soil. We investigated the community structure of soil bacteria in the active layer from moist acidic tundra in Council, Alaska. We also interpreted their relationship with some relevant soil physicochemical characteristics along soil depth with a fine scale (5 cm depth interval). The bacterial community structure was found to change along soil depth. The relative abundances of Acidobacteria, Gammaproteobacteria, Planctomycetes, and candidate phylum WPS-2 rapidly decreased with soil depth, while those of Bacteroidetes, Chloroflexi, Gemmatimonadetes, and candidate AD3 rapidly increased. A structural shift was also found in the soil bacterial communities around 20 cm depth, where two organic (upper Oi and lower Oa) horizons are subdivided. The quality and the decomposition degree of organic matter might have influenced the bacterial community structure. Besides the organic matter quality, the vertical distribution of bacterial communities was also found to be related to soil pH and total phosphorus content. This study showed the vertical change of bacterial community in the active layer with a fine scale resolution and the possible influence of the quality of soil organic matter on shaping bacterial community structure.

Citations

Citations to this article as recorded by  
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