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- 1Medical Convergence Materials Commercialization Center, Gyeongsan
- JaeJin An , Eun-Mi Ha
- J. Microbiol. 2020;58(11):967-977. Published online October 30, 2020
- DOI: https://doi.org/10.1007/s12275-020-0375-y
- 59 View
- 0 Download
- 20 Web of Science
- 17 Crossref
-
Abstract
-
Lactobacillus plantarum-derived metabolites (LDMs) increase
drug sensitivity to 5-FU and antimetastatic effects in 5-FUresistant
colorectal cancer cells (HCT-116/5FUR). In this
study, we evaluated the effects of LDMs on the regulation of
genes and proteins involved in HCT-116/5-FUR cell proliferation
and metastasis. HCT-116/5-FUR cells showed high
metastatic potential, significantly reduced tight junction (TJ)
integrity, including increased migration and paracellular permeability,
and upregulation of claudin-1 (CLDN-1). The genetic
silencing of CLDN-1 increased the sensitivity of HCT-
116/5FUR to 5-FU and inhibited its metastatic potential by
regulating the expression of epithelial-mesenchymal transition
(EMT) related genes. Co-treatment of HCT-116/5FUR
with LDMs and 5-FU suppressed chemoresistant and metastatic
behavior by downregulating CLDN-1 expression. Finally,
we designed LDMs-based therapeutic strategies to treatment
for metastatic 5-FU-resistant colorectal cancer cells. These
results
suggested that LDMs and 5-FU cotreatments can synergistically target 5-FU-resistant cells, making it a candidate strategy to overcome 5-FU chemoresistance improve anticancer drug efficacy. -
Citations
Citations to this article as recorded by
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Research Support, U.S. Gov't, Non-P.H.S.
- Identification of Enriched Conjugated Linoleic Acid Isomers in Cultures of Ruminal Microorganisms after Dosing with 1-13C-Linoleic Acid
- Yong-Jae Lee , Thomas C. Jenkins
- J. Microbiol. 2011;49(4):622-627. Published online September 2, 2011
- DOI: https://doi.org/10.1007/s12275-011-0415-8
- 43 View
- 0 Download
- 9 Scopus
-
Abstract
- Most studies of linoleic acid biohydrogenation propose that it converts to stearic acid through the production of cis-9 trans-11 CLA and trans-11 C18:1. However, several other CLA have been identified in ruminal contents, suggesting additional pathways may exist. To explore this possibility, this research investigated the linoleic acid biohydrogenation pathway to identify CLA isomers in cultures of ruminal microorganisms after dosing with a 13C stable isotope. The 13C enrichment was calculated as [(M+1/M)×100] in labeled minus unlabeled cultures. After 48 h incubation, significant 13C enrichment was observed in seven CLA isomers, indicating their formation from linoleic acid. All enriched CLA isomers had double bonds in either the 9,11 or 10,12 position except for trans-9 cis-11 CLA. The cis-9 trans-11 CLA exhibited the highest enrichment (30.65%), followed by enrichments from 21.06 to 23.08% for trans-10 cis-12, cis-10 trans-12, trans-9 trans-11, and trans-10 trans-12 CLA. The remaining two CLA (cis-9 cis-11 and cis-10 cis-12 CLA) exhibited enrichments of 18.38 and 19.29%, respectively. The results of this study verified the formation of cis-9 trans-11 and trans-10 cis-12 CLA isomers from linoleic acid biohydrogenation. An additional five CLA isomers also contained carbons originating from linoleic acid, indicating that pathways of linoleic acid biohydrogenation are more complex than previously described.
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