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- Assembly of Bacterial Surface Glycopolymers as an Antibiotic Target
- Hongbaek Cho
- J. Microbiol. 2023;61(3):359-367. Published online March 23, 2023
- DOI: https://doi.org/10.1007/s12275-023-00032-w
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- 4 Web of Science
- 4 Crossref
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Abstract
- Bacterial cells are covered with various glycopolymers such as peptidoglycan (PG), lipopolysaccharides (LPS), teichoic acids, and capsules. Among these glycopolymers, PG assembly is the target of some of our most effective antibiotics, consistent with its essentiality and uniqueness to bacterial cells. Biosynthesis of other surface glycopolymers have also been acknowledged as potential targets for developing therapies to control bacterial infections, because of their importance for bacterial survival in the host environment. Moreover, biosynthesis of most surface glycopolymers are closely related to PG assembly because the same lipid carrier is shared for glycopolymer syntheses. In this review, I provide an overview of PG assembly and antibiotics that target this pathway. Then, I discuss the implications of a common lipid carrier being used for assembly of PG and other surface glycopolymers in antibiotic development.
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Citations
Citations to this article as recorded by
- Diversity of sugar-diphospholipid-utilizing glycosyltransferase families
Ida K. S. Meitil, Garry P. Gippert, Kristian Barrett, Cameron J. Hunt, Bernard Henrissat
Communications Biology.2024;[Epub] CrossRef - Metalation of Extracytoplasmic Proteins and Bacterial Cell Envelope Homeostasis
Bixi He, John D. Helmann
Annual Review of Microbiology .2024; 78(1): 83. CrossRef - A hierarchical approach towards identification of novel inhibitors against L, D-transpeptidase YcbB as an anti-bacterial therapeutic target
Abdullah S. Alawam, Lina M. Alneghery, Maher S. Alwethaynani, Mubarak A. Alamri
Journal of Biomolecular Structure and Dynamics.2024; : 1. CrossRef - Bacterial Regulatory Mechanisms for the Control of Cellular Processes: Simple Organisms’ Complex Regulation
Jin-Won Lee
Journal of Microbiology.2023; 61(3): 273. CrossRef
- Diversity of sugar-diphospholipid-utilizing glycosyltransferase families
Research Support, Non-U.S. Gov't
- Estrogenic Reduction of Styrene Monomer Degraded by Phanerochaete chrysosporium KFRI 20742
- Jae-Won Lee , Soo-Min Lee , Eui-Ju Hong , Eui-Bae Jeung , Ha-Young Kang , Myung-Kil Kim , In-Gyu Choi
- J. Microbiol. 2006;44(2):177-184.
- DOI: https://doi.org/2367 [pii]
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Abstract
- The characteristic biodegradation of monomeric styrene by Phanerochaete chrysosporium KFRI 20742, Trametes versicolor KFRI 20251 and Daldinia concentrica KFRI 40-1 was carried out to examine the resistance, its degradation efficiency and metabolites analysis. The estrogenic reduction effect of styrene by the fungi was also evaluated. The mycelium growth of fungi differentiated depending on the concentration levels of styrene. Additionally P. chrysosporium KFRI 20742 showed superior mycelium growth at less than 200 mg/l, while D. concentrica KFRI 40-1 was more than 200 mg/l. The degradation efficiency reached 99% during one day of incubation for all the fungi. Both manganese-dependent peroxidase and laccase activities in liquid medium were the highest at the initial stage of incubation, whereas the lowest was after the addition of styrene. However, both activities were gradually recovered after. The major metabolites of styrene by P. chrysosporium KFRI 20742 were 2-phenyl ethanol, benzoic acid, cyclohexadiene-1,4-dione, butanol and succinic acid. From one to seven days of incubating the fungi, the expression of pS2 mRNA widely known as an estrogen response gene was decreased down to the level of baseline after one day. Also, the estrogenic effect of styrene completely disappeared after treatment with supernatant of P. chrysosporium KFRI 20742 from one week of culture down to the levels of vehicle.
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