Journal of Microbiology

Research Support, Non-U.S. Gov't

Immunological Roles of Pasteurella multocida Toxin (PMT) Using a PMT Mutant Strain: Tae Jung Kim , Nguyen Tat Toan , Eun Jin Jang , Bock Gie Jung , Jae Il Lee , Bong Joo Lee; J. Microbiol. 2007;45(4):364-366.; DOI: https://doi.org/2559 [pii]

Abstract: The immunological role of the Pasteurella multocida toxin (PMT) in mice was examined using a PMT mutant strain. After a nasal inoculation, the mutant strain failed to induce interstitial pneumonia. Moreover, PMT had no significant effect on the populations of CD4+, CD8+, CD3+, and CD19+ immunocytes in blood or on the populations of CD4+ and CD8+ splenocytes (P<0.01). However, there was a significant increase in the total number of cells in the BAL samples obtained from the wild-type P. multocida-inoculated mice. On the other hand, the level of IL-1 expression decreased when the macrophages from the bronchio-alveolar lavage were stimulated with PMT. Overall, PMT appears to play some role (stimulating and/or inhibiting) in the immunological responses but further studies will be required to confirm this.

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