For a long time, antibiotics have been ‘magical weapons’ to
combat pathogenic microbes. The success of antibiotics is
now greatly threatened by resistance to antibiotics and many
scientists have already talked about the coming of the postantibiotic
era. This special issue is prepared to understand
recent research findings and new concepts about antibiotic
resistance. Above all, this special issue explores mechanisms
for the generation, selection, and spread of antibiotic resistance,
and gives insight into what to target to prevent the development
of antibiotic resistance. Just as antibiotics came
from the concept of “magic bullet”, a breakthrough will come
from a new concept based on a profound understanding of
antibiotic resistance.