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- The putative sensor histidine kinase VadJ coordinates development and sterigmatocystin production in Aspergillus nidulans
- Yanxia Zhao , Mi-Kyung Lee , Jieyin Lim , Heungyun Moon , Hee-Soo Park , Weifa Zheng , Jae-Hyuk Yu
- J. Microbiol. 2021;59(8):746-752. Published online July 5, 2021
- DOI: https://doi.org/10.1007/s12275-021-1055-2
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- 7 Crossref
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Abstract
- The VosA-VelB heterocomplex governs expression of several genes associated with fungal development and secondary metabolism. In this study, we have investigated the functions of one of the VosA-VelB-activated developmental genes vadJ in development and production of the mycotoxin sterigmatocystin in the model fungus Aspergillus nidulans. The vadJ gene is predicted to encode a 957-amino acid length protein containing a highly conserved sensor histidine kinase domain. The deletion of vosA or velB resulted in decreased mRNA levels of vadJ throughout the life cycle, suggesting that VosA and VelB are necessary for proper expression of vadJ. Nullifying vadJ led to highly restricted colony growth, lowered formation of asexual spores, and about two-fold reduction in conidial viability. Conversely, the deletion of vadJ resulted in elevated production of sexual fruiting bodies and sterigmatocystin. These suggest that VadJ is necessary for proper coordination of asexual and sexual development, and sterigmatocystin production. In accordance with this idea, the deletion of vadJ led to elevated mRNA levels of the two key sexual developmental activators esdC and nsdD. In summary, the putative sensor histidine kinase VadJ represses sexual development and sterigmatocystin production, but activates asexual development in A. nidulans.
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Citations
Citations to this article as recorded by
- Velvet Family Protein FpVelB Affects Virulence in Association with Secondary Metabolism in Fusarium pseudograminearum
Yuxing Wu, Sen Han, Yajiao Wang, Qiusheng Li, Lingxiao Kong
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Xuwen Hou, Liyao Liu, Dan Xu, Daowan Lai, Ligang Zhou
Journal of Fungi.2024; 10(8): 561. CrossRef - Adaptative responses of Neurospora crassa by histidine kinases upon the attack of the arthropod Sinella curviseta
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Current Genetics.2024;[Epub] CrossRef - Implication of VelB in the development, pathogenicity, and secondary metabolism of Penicillium expansum
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Postharvest Biology and Technology.2023; 195: 112121. CrossRef - Regulators of the Asexual Life Cycle of Aspergillus nidulans
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Cells.2023; 12(11): 1544. CrossRef - Post‐translational modifications drive secondary metabolite biosynthesis in Aspergillus: a review
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Environmental Microbiology.2022; 24(7): 2857. CrossRef - The Putative C2H2 Transcription Factor VadH Governs Development, Osmotic Stress Response, and Sterigmatocystin Production in Aspergillus nidulans
Xiaoyu Li, Yanxia Zhao, Heungyun Moon, Jieyin Lim, Hee-Soo Park, Zhiqiang Liu, Jae-Hyuk Yu
Cells.2022; 11(24): 3998. CrossRef
- Velvet Family Protein FpVelB Affects Virulence in Association with Secondary Metabolism in Fusarium pseudograminearum
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