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Review
Host–microbial interactions in metabolic diseases: from diet to immunity
Ju-Hyung Lee , Joo-Hong Park
J. Microbiol. 2022;60(6):561-575.   Published online May 5, 2022
DOI: https://doi.org/10.1007/s12275-022-2087-y
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  • 5 Web of Science
  • 4 Crossref
AbstractAbstract
Growing evidence suggests that the gut microbiome is an important contributor to metabolic diseases. Alterations in microbial communities are associated with changes in lipid metabolism, glucose homeostasis, intestinal barrier functions, and chronic inflammation, all of which can lead to metabolic disorders. Therefore, the gut microbiome may represent a novel therapeutic target for obesity, type 2 diabetes, and nonalcoholic fatty liver disease. This review discusses how gut microbes and their products affect metabolic diseases and outlines potential treatment approaches via manipulation of the gut microbiome. Increasing our understanding of the interactions between the gut microbiome and host metabolism may help restore the healthy symbiotic relationship between them.

Citations

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  • Fecal Microbiota Transplantation: Indications, Methods, and Challenges
    Jee Young Lee, Yehwon Kim, Jiyoun Kim, Jiyeun Kate Kim
    Journal of Microbiology.2024; 62(12): 1057.     CrossRef
  • Galectin-4 increases the ability of M2 macrophages to enhance antiviral CD4+ T-cell responses
    In-Gu Lee, Yong-Hyun Joo, Hoyeon Jeon, Raehyuk Jeong, Eui Ho Kim, Hyunwoo Chung, Seong-il Eyun, Jeongkyu Kim, Young-Jin Seo, So-Hee Hong
    Journal of Leukocyte Biology.2023; 113(1): 71.     CrossRef
  • Microencapsulation of Bacteriophages for the Delivery to and Modulation of the Human Gut Microbiota through Milk and Cereal Products
    Christina Schubert, Sabina Fischer, Kathrin Dorsch, Lutz Teßmer, Jörg Hinrichs, Zeynep Atamer
    Applied Sciences.2022; 12(13): 6299.     CrossRef
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    Zhengzhong Luo, Li Ma, Tao Zhou, Yixin Huang, Liben Zhang, Zhenlong Du, Kang Yong, Xueping Yao, Liuhong Shen, Shumin Yu, Xiaodong Shi, Suizhong Cao
    Metabolites.2022; 12(8): 687.     CrossRef
Journal Articles
The velvet repressed vidA gene plays a key role in governing development in Aspergillus nidulans
Min-Ju Kim , Won-Hee Jung , Ye-Eun Son , Jae-Hyuk Yu , Mi-Kyung Lee , Hee-Soo Park
J. Microbiol. 2019;57(10):893-899.   Published online August 28, 2019
DOI: https://doi.org/10.1007/s12275-019-9214-4
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  • 14 Web of Science
  • 12 Crossref
AbstractAbstract
Fungal development is regulated by a variety of transcription factors in Aspergillus nidulans. Previous studies demonstrated that the NF-κB type velvet transcription factors regulate certain target genes that govern fungal differentiation and cellular metabolism. In this study, we characterize one of the VosA/VelB-inhibited developmental genes called vidA, which is predicted to encode a 581-amino acid protein with a C2H2 zinc finger domain at the C-terminus. Levels of vidA mRNA are high during the early and middle phases of asexual development and decrease during the late phase of asexual development and asexual spore (conidium) formation. Deletion of either vosA or velB results in increased vidA mRNA accumulation in conidia, suggesting that vidA transcript accumulation in conidia is repressed by VosA and VelB. Phenotypic analysis demonstrated that deletion of vidA causes decreased colony growth, reduced production of asexual spores, and abnormal formation of sexual fruiting bodies. In addition, the vidA deletion mutant conidia contain more trehalose and β-glucan than wild type. Overall, these results suggest that VidA is a putative transcription factor that plays a key role in governing proper fungal growth, asexual and sexual development, and conidia formation in A. nidulans.

Citations

Citations to this article as recorded by  
  • Regulators of the Asexual Life Cycle of Aspergillus nidulans
    Ye-Eun Son, Jae-Hyuk Yu, Hee-Soo Park
    Cells.2023; 12(11): 1544.     CrossRef
  • The Forkhead Gene fkhB is Necessary for Proper Development in Aspergillus nidulans
    Seo-Yeong Jang, Ye-Eun Son, Dong-Soon Oh, Kap-Hoon Han, Jae-Hyuk Yu, Hee-Soo Park
    Journal of Microbiology and Biotechnology.2023; 33(11): 1420.     CrossRef
  • The function of a conidia specific transcription factor CsgA in Aspergillus nidulans
    He-Jin Cho, Hee-Soo Park
    Scientific Reports.2022;[Epub]     CrossRef
  • The Putative C2H2 Transcription Factor VadH Governs Development, Osmotic Stress Response, and Sterigmatocystin Production in Aspergillus nidulans
    Xiaoyu Li, Yanxia Zhao, Heungyun Moon, Jieyin Lim, Hee-Soo Park, Zhiqiang Liu, Jae-Hyuk Yu
    Cells.2022; 11(24): 3998.     CrossRef
  • The Role of Chromatin and Transcriptional Control in the Formation of Sexual Fruiting Bodies in Fungi
    Minou Nowrousian
    Microbiology and Molecular Biology Reviews.2022;[Epub]     CrossRef
  • Functions of PUF Family RNA-Binding Proteins in Aspergillus nidulans
    Sung-Hun Son, Seo-Yeong Jang, Hee-Soo Park
    Journal of Microbiology and Biotechnology.2021; 31(5): 676.     CrossRef
  • The putative sensor histidine kinase VadJ coordinates development and sterigmatocystin production in Aspergillus nidulans
    Yanxia Zhao, Mi-Kyung Lee, Jieyin Lim, Heungyun Moon, Hee-Soo Park, Weifa Zheng, Jae-Hyuk Yu
    Journal of Microbiology.2021; 59(8): 746.     CrossRef
  • Unveiling the Functions of the VosA-VelB Target GenevidDinAspergillus nidulans
    Ye-Eun Son, Hee-Soo Park
    Mycobiology.2021; 49(3): 258.     CrossRef
  • Velvet activated McrA plays a key role in cellular and metabolic development in Aspergillus nidulans
    Mi-Kyung Lee, Ye-Eun Son, Hee-Soo Park, Ahmad Alshannaq, Kap-Hoon Han, Jae-Hyuk Yu
    Scientific Reports.2020;[Epub]     CrossRef
  • The role of the VosA-repressed dnjA gene in development and metabolism in Aspergillus species
    Ye-Eun Son, He-Jin Cho, Wanping Chen, Sung-Hun Son, Mi-Kyung Lee, Jae-Hyuk Yu, Hee-Soo Park
    Current Genetics.2020; 66(3): 621.     CrossRef
  • Homeobox proteins are essential for fungal differentiation and secondary metabolism in Aspergillus nidulans
    Sung-Hun Son, Ye-Eun Son, He-Jin Cho, Wanping Chen, Mi-Kyung Lee, Lee-Han Kim, Dong-Min Han, Hee-Soo Park
    Scientific Reports.2020;[Epub]     CrossRef
  • The brlA Gene Deletion Reveals That Patulin Biosynthesis Is Not Related to Conidiation in Penicillium expansum
    Chrystian Zetina-Serrano, Ophélie Rocher, Claire Naylies, Yannick Lippi, Isabelle P. Oswald, Sophie Lorber, Olivier Puel
    International Journal of Molecular Sciences.2020; 21(18): 6660.     CrossRef
Characterization of the velvet regulators in Aspergillus flavus
Tae-Jin Eom , Heungyun Moon , Jae-Hyuk Yu , Hee-Soo Park
J. Microbiol. 2018;56(12):893-901.   Published online October 25, 2018
DOI: https://doi.org/10.1007/s12275-018-8417-4
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AbstractAbstract
Fungal development and secondary metabolism are closely associated via the activities of the fungal NK-kB-type velvet regulators that are highly conserved in filamentous fungi. Here, we investigated the roles of the velvet genes in the aflatoxigenic fungus Aspergillus flavus. Distinct from other Aspergillus species, the A. flavus genome contains five velvet genes, veA, velB, velC, velD, and vosA. The deletion of velD blocks the production of aflatoxin B1, but does not affect the formation of sclerotia. Expression analyses revealed that vosA and velB mRNAs accumulated at high levels during the late phase of asexual development and in conidia. The absence of vosA or velB decreased the content of conidial trehalose and the tolerance of conidia to the thermal and UV stresses. In addition, double mutant analyses demonstrated that VosA and VelB play an inter-dependent role in trehalose biosynthesis and conidial stress tolerance. Together with the findings of previous studies, the results of the present study suggest that the velvet regulators play the conserved and vital role in sporogenesis, conidial trehalose biogenesis, stress tolerance, and aflatoxin biosynthesis in A. flavus.

Citations

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  • Data-Independent Acquisition Proteome Technology for Analysis of Antifungal and Anti-aflatoxigenic Properties of Eugenol to Aspergillus flavus
    Xinyue Zhang, Wenjing Peng, Mumin Zheng, Bolei Yang, Bowen Tai, Xu Li, Fuguo Xing
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    Toxins.2024; 16(7): 285.     CrossRef
  • Involvement of LaeA and Velvet Proteins in Regulating the Production of Mycotoxins and Other Fungal Secondary Metabolites
    Xuwen Hou, Liyao Liu, Dan Xu, Daowan Lai, Ligang Zhou
    Journal of Fungi.2024; 10(8): 561.     CrossRef
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    Ye-Eun Son, Hee-Soo Park
    International Journal of Food Microbiology.2024; 413: 110607.     CrossRef
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    International Journal of Food Microbiology.2024; 417: 110693.     CrossRef
  • The Velvet transcription factor PnVeA regulates necrotrophic effectors and secondary metabolism in the wheat pathogen Parastagonospora nodorum
    Shota Morikawa, Callum Verdonk, Evan John, Leon Lenzo, Nicolau Sbaraini, Chala Turo, Hang Li, David Jiang, Yit-Heng Chooi, Kar-Chun Tan
    BMC Microbiology.2024;[Epub]     CrossRef
  • Beyond morphogenesis and secondary metabolism: function of Velvet proteins and LaeA in fungal pathogenesis
    Ana M. Calvo, Apoorva Dabholkar, Elizabeth M. Wyman, Jessica M. Lohmar, Jeffrey W. Cary, Yvonne Nygård
    Applied and Environmental Microbiology.2024;[Epub]     CrossRef
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    Ye-Eun Son, Jae-Hyuk Yu, Hee-Soo Park, Gustavo H. Goldman
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    Wenbin Yu, Rongqiang Pei, Yufei Zhang, Yayi Tu, Bin He
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    Zongting Huang, Dandan Wu, Sile Yang, Wangzhuo Fu, Dongmei Ma, Yanfang Yao, Hong Lin, Jun Yuan, Yanling Yang, Zhenhong Zhuang
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    Journal of Microbiology.2021; 59(8): 746.     CrossRef
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    Ye-Eun Son, He-Jin Cho, Wanping Chen, Sung-Hun Son, Mi-Kyung Lee, Jae-Hyuk Yu, Hee-Soo Park
    Current Genetics.2020; 66(3): 621.     CrossRef
  • The velvet Regulator VosA Governs Survival and Secondary Metabolism of Sexual Spores in Aspergillus nidulans
    Min-Ju Kim, Mi-Kyung Lee, Huy Quang Pham, Myeong Ju Gu, Bohan Zhu, Sung-Hun Son, Dongyup Hahn, Jae-Ho Shin, Jae-Hyuk Yu, Hee-Soo Park, Kap-Hoon Han
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Review
REVIEW] Transcriptional Regulatory Elements in Fungal Secondary Metabolism
Wenbing Yin , Nancy P. Keller
J. Microbiol. 2011;49(3):329-339.   Published online June 30, 2011
DOI: https://doi.org/10.1007/s12275-011-1009-1
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  • 112 Crossref
AbstractAbstract
Filamentous fungi produce a variety of secondary metabolites of diverse beneficial and detrimental activities to humankind. The genes required for a given secondary metabolite are typically arranged in a gene cluster. There is considerable evidence that secondary metabolite gene regulation is, in part, by transcriptional control through hierarchical levels of transcriptional regulatory elements involved in secondary metabolite cluster regulation. Identification of elements regulating secondary metabolism could potentially provide a means of increasing production of beneficial metabolites, decreasing production of detrimental metabolites, aid in the identification of ‘silent’ natural products and also contribute to a broader understanding of molecular mechanisms by which secondary metabolites are produced. This review summarizes regulation of secondary metabolism associated with transcriptional regulatory elements from a broad view as well as the tremendous advances in discovery of cryptic or novel secondary metabolites by genomic mining.

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