Md Bashir Uddin , Byeong-Hoon Lee , Chamilani Nikapitiya , Jae-Hoon Kim , Tae-Hwan Kim , Hyun-Cheol Lee , Choul Goo Kim , Jong-Soo Lee , Chul-Joong Kim
J. Microbiol. 2016;54(12):853-866. Published online November 26, 2016
Bee venom (BV) from honey bee (Apis Melifera L.) contains
at least 18 pharmacologically active components including
melittin (MLT), phospholipase A2 (PLA2), and apamin etc.
BV is safe for human treatments dose dependently and proven
to possess different healing properties including antibacterial
and antiparasitidal properties. Nevertheless, antiviral
properties of BV have not well investigated. Hence, we
identified the potential antiviral properties of BV and its
component against a broad panel of viruses. Co-incubation
of non-cytotoxic amounts of BV and MLT, the main component
of BV, significantly inhibited the replication of enveloped
viruses such as Influenza A virus (PR8), Vesicular
Stomatitis Virus (VSV), Respiratory Syncytial Virus (RSV),
and Herpes Simplex Virus (HSV). Additionally, BV and MLT
also inhibited the replication of non-enveloped viruses such
as Enterovirus-71 (EV-71) and Coxsackie Virus (H3). Such
antiviral properties were mainly explained by virucidal mechanism.
Moreover, MLT protected mice which were challenged
with lethal doses of pathogenic influenza A H1N1
viruses. Therefore, these results provides the evidence that BV
and MLT could be a potential source as a promising antiviral
agent, especially to develop as a broad spectrum antiviral
agent.
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