Evidence That Vibrio vulnificus AhpC2 Is Essential for Survival Under High Salinity by Modulating Intracellular Level of ROS

Myung Jin Koh; Hyun Sung Lee; Jee Eun Rhee; Sang Ho Choi

doi:10.1007/s12275-009-0227-2

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Evidence That Vibrio vulnificus AhpC2 Is Essential for Survival Under High Salinity by Modulating Intracellular Level of ROS: Myung Jin Koh ¹, Hyun Sung Lee ¹, Jee Eun Rhee ², Sang Ho Choi ¹; Journal of Microbiology 2010;48(1):129-133.
DOI: https://doi.org/10.1007/s12275-009-0227-2
Published online: March 11, 2010

¹National Research Laboratory of Molecular Microbiology and Toxicology, Department of Agricultural Biotechnology, Center for Agricultural Biomaterials, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Republic of Korea, ²Division of AIDS, Center for Immunology and Pathology, Korea National Institute of Health, Seoul 122-701, Republic of Korea¹National Research Laboratory of Molecular Microbiology and Toxicology, Department of Agricultural Biotechnology, Center for Agricultural Biomaterials, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Republic of Korea, ²Division of AIDS, Center for Immunology and Pathology, Korea National Institute of Health, Seoul 122-701, Republic of Korea

Corresponding author: Sang Ho Choi , Tel: +82-2-880-4857,

Received: 27 July 2009 • Accepted: 9 September 2009

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Abstract

Expression of ahpC2 encoding an alkyl hydroperoxide reductase of Vibrio vulnificus, a foodborne pathogen, was incrementally induced depending on NaCl concentrations in the culture. Growth of the ahpC2 mutant was significantly impaired with longer lag phase and lower growth rate when cultured under high salinity. ROS was accumulated in V. vulnificus cells when stressed by exposure to high salinity, and the ahpC2 mutant accumulated higher level of ROS as compared with the parental wild type. Consequently, the combined results suggest that AhpC2 contributes to the growth of V. vulnificus under high salinity by scavenging ROS in cells.

Keywords: V. vulnificus ahpC2;salt stress;ROS

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Evidence That Vibrio vulnificus AhpC2 Is Essential for Survival Under High Salinity by Modulating Intracellular Level of ROS

J. Microbiol. 2010;48(1):129-133. Published online March 11, 2010

DOI: https://doi.org/10.1007/s12275-009-0227-2

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