Inhibitory Effect of Lactobacillus reuteri on Periodontopathic and Cariogenic Bacteria

Mi-Sun Kang; Jong-Suk Oh; Hyun-Chul Lee; Hoi-Soon Lim; Seok-Woo Lee; Kyu-Ho Yang; Nam-Ki Choi; Seon-Mi Kim

doi:10.1007/s12275-011-0252-9

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Research Support, Non-U.S. Gov't
Inhibitory Effect of Lactobacillus reuteri on Periodontopathic and Cariogenic Bacteria: Mi-Sun Kang ¹, Jong-Suk Oh ¹, Hyun-Chul Lee ¹, Hoi-Soon Lim ², Seok-Woo Lee ^3,4, Kyu-Ho Yang ^2,5, Nam-Ki Choi ^2,6, Seon-Mi Kim ^2,6; Journal of Microbiology 2011;49(2):193-199
DOI: https://doi.org/10.1007/s12275-011-0252-9
Published online: May 3, 2011

¹Department of Microbiology, School of Medicine, Chonnam National University, Gwangju 501-746, Republic of Korea, ²Dental Science Research Institute, Chonnam National University, Gwangju 500-757, Republic of Korea, ³Department of Periodontics, Chonnam National University, Gwangju 500-757, Republic of Korea, ⁴Division of Periodontics, School of Dentistry, Marquette University, Milwaukee, WI, USA, ⁵Department of Pediatric Dentistry, Chonnam National University, Gwangju 500-757, Republic of Korea, ⁶Department of Pediatric Dentistry, Chonnam National University, Gwangju 500-757, Republic of Korea¹Department of Microbiology, School of Medicine, Chonnam National University, Gwangju 501-746, Republic of Korea, ²Dental Science Research Institute, Chonnam National University, Gwangju 500-757, Republic of Korea, ³Department of Periodontics, Chonnam National University, Gwangju 500-757, Republic of Korea, ⁴Division of Periodontics, School of Dentistry, Marquette University, Milwaukee, WI, USA, ⁵Department of Pediatric Dentistry, Chonnam National University, Gwangju 500-757, Republic of Korea, ⁶Department of Pediatric Dentistry, Chonnam National University, Gwangju 500-757, Republic of Korea

Corresponding author: Seon-Mi Kim , Tel: +82-62-530-5826,

Received: 7 July 2010 • Accepted: 1 December 2010

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Abstract

The interaction between Lactobacillus reuteri, a probiotic bacterium, and oral pathogenic bacteria have not been studied adequately. This study examined the effects of L. reuteri on the proliferation of periodontopathic bacteria including Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, and Tannerella forsythia, and on the formation of Streptococcus mutans biofilms. Human-derived L. reuteri strains (KCTC 3594 and KCTC 3678) and rat-derived L. reuteri KCTC 3679 were used. All strains exhibited significant inhibitory effects on the growth of periodontopathic bacteria and the formation of S. mutans biofilms. These antibacterial activities of L. reuteri were attributed to the production of organic acids, hydrogen peroxide, and a bacteriocin-like compound. Reuterin, an antimicrobial factor, was produced only by L. reuteri KCTC 3594. In addition, L. reuteri inhibited the production of methyl mercaptan by F. nucleatum and P. gingivalis. Overall, these results suggest that L. reuteri may be useful as a probiotic agent for improving oral health.

Keywords: Lactobacillus reuteri; periodontopathic bacteria; Streptococcus mutans; inhibitory effect; biofilms

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Inhibitory Effect of Lactobacillus reuteri on Periodontopathic and Cariogenic Bacteria

J. Microbiol. 2011;49(2):193-199. Published online May 3, 2011

DOI: https://doi.org/10.1007/s12275-011-0252-9

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