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Providencia Isolates Carrying blaPER-1 and blaVIM-2 Genes: Biofilm-Forming Capacity and Biofilm Inhibitory Concentrations for Carbapenem Antibiotics
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Research Support, Non-U.S. Gov't
Providencia Isolates Carrying blaPER-1 and blaVIM-2 Genes: Biofilm-Forming Capacity and Biofilm Inhibitory Concentrations for Carbapenem Antibiotics
Jungmin Kim , Shukho Kim , Hee Woo Lee , Sung Min Kim , Sung Yong Seol
Journal of Microbiology 2011;49(3):512-515
DOI: https://doi.org/10.1007/s12275-011-1221-z
Published online: June 30, 2011
Department of Microbiology, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of KoreaDepartment of Microbiology, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea
Corresponding author:  Sung Yong Seol , Tel: +82-53-420-4842, 
Received: 28 April 2011   • Accepted: 8 June 2011
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Multidrug-resistant clinical isolates of Providencia carrying blaPER-1 and blaVIM-2 were evaluated for the abilities to form biofilm and high biofilm forming capacity was demonstrated in them. Minimum biofilm inhibitory concentrations (MBICs), minimum biofilm eradication concentrations (MBECs), and minimum inhibitory concentrations (MICs) for imipenem and meropenem were also determined. In all tested strains, the MBICs were higher than the MICs for both drugs. Interestingly, the MBICs and the MBEC50 for meropenem were lower than those for imipenem in the isolates producing high amounts of biofilm, suggesting that meropenem is superior to imipenem in the growth inhibition and eradication of biofilm forming Providencia strains.

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    Providencia Isolates Carrying blaPER-1 and blaVIM-2 Genes: Biofilm-Forming Capacity and Biofilm Inhibitory Concentrations for Carbapenem Antibiotics
    J. Microbiol. 2011;49(3):512-515.   Published online June 30, 2011
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