NOTE] Characterization of a Mutant Strain of a Filamentous Fungus Cladosporium phlei for the Mass Production of the Secondary Metabolite Phleichrome

Min-Hee Yi; Jung-Ae Kim; Jung-Mi Kim; Jin-Ah Park; Beom-Tae Kim; Seung-Moon Park; Moon-Sik Yang; Ki-Jun Hwang; Dae-Hyuk Kim

doi:10.1007/s12275-011-1022-4

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Research Support, Non-U.S. Gov't
NOTE] Characterization of a Mutant Strain of a Filamentous Fungus Cladosporium phlei for the Mass Production of the Secondary Metabolite Phleichrome: Min-Hee Yi ¹, Jung-Ae Kim ¹, Jung-Mi Kim ¹, Jin-Ah Park ¹, Beom-Tae Kim ², Seung-Moon Park ², Moon-Sik Yang ², Ki-Jun Hwang ³, Dae-Hyuk Kim ¹; Journal of Microbiology 2011;49(4):680-683
DOI: https://doi.org/10.1007/s12275-011-1022-4
Published online: September 2, 2011

¹Institute for Molecular Biology and Genetics, Center for Fungal Pathogenesis, Chonbuk National University, Chonbuk 561-756, Republic of Korea, ²Research Center of Bioactive Materials, Chonbuk National University, Chonbuk 561-756, Republic of Korea, ³Department of Chemistry, Chonbuk National University, Chonbuk 561-756, Republic of Korea¹Institute for Molecular Biology and Genetics, Center for Fungal Pathogenesis, Chonbuk National University, Chonbuk 561-756, Republic of Korea, ²Research Center of Bioactive Materials, Chonbuk National University, Chonbuk 561-756, Republic of Korea, ³Department of Chemistry, Chonbuk National University, Chonbuk 561-756, Republic of Korea

Corresponding author: Dae-Hyuk Kim , Tel: +82-63-270-3440,

Received: 12 January 2011 • Accepted: 11 April 2011

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Abstract

UV-mutagenesis was performed to obtain mutant strains that demonstrate altered production of phleichrome, a secondary metabolite of Cladosporium phlei. Among fifty mutants selected, based on the increased area and intensity of the purple pigment surrounding the colonies, the strain M0035 showed the highest production of phleichrome, more than seven fold over wild type. Plate cultures of the M0035 strain resulted in a total of 592 mg phleichrome consisting of 146 mg and 446 mg from the mycelia and agar media, respectively. The M0035 strain displayed a growth rate and a mycelial mass comparable to the parental strain but had significantly reduced asexual sporulation.

Keywords: Cladosporium phlei; UV-mutagenesis; perylenequinone; phleichrome

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NOTE] Characterization of a Mutant Strain of a Filamentous Fungus Cladosporium phlei for the Mass Production of the Secondary Metabolite Phleichrome

J. Microbiol. 2011;49(4):680-683. Published online September 2, 2011

DOI: https://doi.org/10.1007/s12275-011-1022-4

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