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HOME > J. Microbiol > Volume 49(4); 2011 > Article
Research Support, N.I.H., Extramural
The Activity of a Small Lytic Peptide PTP-7 on Staphylococcus aureus Biofilms
Riddhi Kharidia , Jun F. Liang
Journal of Microbiology 2011;49(4):663-668.
DOI: https://doi.org/10.1007/s12275-011-1013-5
Published online: September 2, 2011
Department of Chemistry, Chemical Biology, and Biomedical Engineering, Charles V. Schaefer School of Engineering and Sciences, Stevens Institute of Technology, Hoboken, NJ 07030, USA
Corresponding author:  Jun F. Liang , Tel: +1-201-216-5640, 
Received: 10 January 2011   • Accepted: 29 March 2011
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Abstract

One of the most important features of bacterial biofilms is their resistance to antibiotics and to the host immune system. In this study, we have found that a small lytic peptide, PTP-7, is very potent to Gram-positive bacteria and is able to kill antibiotic sensitive and resistant Staphylococcus aureus indiscriminately. Further studies have revealed that despite being a cationic peptide, the antibacterial activity of PTP-7 was not affected by the negatively charged extracellular polymeric substance (EPS) of biofilms. PTP-7 could diffuse into the deep layer of S. aureus biofilms to kill bacteria inside biofilms efficiently and effectively. Neither the high concentrations of metal ions nor the acidic pH in biofilms affected the activity of peptide PTP-7. It seems that the unique sequence/structure together with the resistant bacteria killing ability of peptide PTP-7 confers its anti-biofilm activity. This study sheds new light on the treatment of bacterial biofilms, especially various biofilm related infections.

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    The Activity of a Small Lytic Peptide PTP-7 on Staphylococcus aureus Biofilms
    J. Microbiol. 2011;49(4):663-668.   Published online September 2, 2011
    DOI: https://doi.org/10.1007/s12275-011-1013-5
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