Neutralization Potential of the Plasma of HIV-1 Infected Indian Patients in the Context of Anti-V3 Antibody Content and Antiretroviral Theraphy

Alok Kumar Choudhary; Raiees Andrabi; Somi Sankaran Prakash; Rajesh Kumar; Shubhasree Dutta Choudhury Choudhury; Naveet Wig; Ashutosh Biswas; Anjali Hazarika; Kalpana Luthra

doi:10.1007/s12275-012-1246-y

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Neutralization Potential of the Plasma of HIV-1 Infected Indian Patients in the Context of Anti-V3 Antibody Content and Antiretroviral Theraphy: Alok Kumar Choudhary ¹, Raiees Andrabi ¹, Somi Sankaran Prakash ¹, Rajesh Kumar ¹, Shubhasree Dutta Choudhury Choudhury ¹, Naveet Wig ², Ashutosh Biswas ², Anjali Hazarika ³, Kalpana Luthra ¹; Journal of Microbiology 2012;50(1):149-154
DOI: https://doi.org/10.1007/s12275-012-1246-y
Published online: February 27, 2012

¹Department of Biochemistry, CN Centre, All India Institute of Medical Sciences, 110029, New Delhi, India, ²Department of Medicine, CN Centre, All India Institute of Medical Sciences, 110029, New Delhi, India, ³Department of Blood Bank, CN Centre, All India Institute of Medical Sciences, 110029, New Delhi, India¹Department of Biochemistry, CN Centre, All India Institute of Medical Sciences, 110029, New Delhi, India, ²Department of Medicine, CN Centre, All India Institute of Medical Sciences, 110029, New Delhi, India, ³Department of Blood Bank, CN Centre, All India Institute of Medical Sciences, 110029, New Delhi, India

Corresponding author: Kalpana Luthra , Tel: +91-11-26546431,

Received: 16 May 2011 • Accepted: 19 October 2011

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Abstract

We assessed the anti-V3 antibody content and viral neutralization potential of the plasma of 63 HIV-1-infected patients (antiretroviral naïve=39, treated=24) against four primary isolates (PIs) of clade C and a tier 1 clade B isolate SF162. Depletion and inhibition of anti-V3 antibodies in the plasma of five patients with high titers of anti-V3 antibodies led to modest change in the neutralization percentage against two PIs (range 0–21%). The plasma of antiretroviral-treated patients exhibited higher neutralization potential than that of the drug-naïve plasmas against the four PIs tested which was further evidenced by a follow-up study.

Keywords: HIV-1; India; neutralizing antibodies; anti-V3 antibodies; antiretroviral therapy

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Neutralization Potential of the Plasma of HIV-1 Infected Indian Patients in the Context of Anti-V3 Antibody Content and Antiretroviral Theraphy

J. Microbiol. 2012;50(1):149-154. Published online February 27, 2012

DOI: https://doi.org/10.1007/s12275-012-1246-y

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