NOTE] GFP-Expressing Influenza A Virus for Evaluation of the Efficacy of Antiviral Agents

Jin Il Kim; Sehee Park; Ilseob Lee; Sangmoo Lee; Saem Shin; Yongkwan Won; Min-Woong Hwang; Joon-Yong Bae; Jun Heo; Hye-Eun Hyun; Hyejin Jun; Soon Sung Lim; Man-Seong Park

doi:10.1007/s12275-012-2163-9

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Research Support, Non-U.S. Gov't
NOTE] GFP-Expressing Influenza A Virus for Evaluation of the Efficacy of Antiviral Agents: Jin Il Kim ^1,2, Sehee Park ^1,2, Ilseob Lee ^1,2, Sangmoo Lee ^1,2, Saem Shin ^1,2, Yongkwan Won ^1,2, Min-Woong Hwang ^1,2, Joon-Yong Bae ^1,2, Jun Heo ^1,2, Hye-Eun Hyun ^1,2, Hyejin Jun ^1,2, Soon Sung Lim ³, Man-Seong Park ^1,2; Journal of Microbiology 2012;50(2):359-362
DOI: https://doi.org/10.1007/s12275-012-2163-9
Published online: April 27, 2012

¹Department of Microbiology, Hallym University, Chuncheon 200-702, Republic of Korea, ²Center for Medical Science Research, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea, ³Department of Food Science and Nutrition, College of Natural Sciences, Hallym University, Chuncheon 200-702, Republic of Korea¹Department of Microbiology, Hallym University, Chuncheon 200-702, Republic of Korea, ²Center for Medical Science Research, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea, ³Department of Food Science and Nutrition, College of Natural Sciences, Hallym University, Chuncheon 200-702, Republic of Korea

Corresponding author: Man-Seong Park , Tel: +82-33-248-2632,

Received: 22 March 2012 • Accepted: 17 April 2012

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Abstract

To address its value as a screening tool in the development of antiviral drugs, a recombinant influenza virus expressing green fluorescent protein (rPR8-GFP virus) was investigated in vitro and in vivo. The inhibition of viral growth by a neuraminidase inhibitor in the cells or lower respiratory tracts of mice could be visualized by the level of fluorescence. In addition, the rPR8-GFP virus exhibited high pathogenicity in mice. Taken together, these results suggest that the rPR8-GFP virus can be a useful tool for the rapid identification of antiviral drugs active against influenza viruses.

Keywords: influenza; green fluorescent protein; antiviral drug

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NOTE] GFP-Expressing Influenza A Virus for Evaluation of the Efficacy of Antiviral Agents

J. Microbiol. 2012;50(2):359-362. Published online April 27, 2012

DOI: https://doi.org/10.1007/s12275-012-2163-9

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