Dysregulation of KSHV Replication by Extracts from Carthamus tinctorius L.

Han Lee; Hyosun Cho; Myoungki Son; Gi-Ho Sung; Taeho Lee; Sang-Won Lee; Yong Woo Jung; Yu Su Shin; Hyojeung Kang

doi:10.1007/s12275-013-3282-7

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Dysregulation of KSHV Replication by Extracts from Carthamus tinctorius L.: Han Lee ¹, Hyosun Cho ², Myoungki Son ¹, Gi-Ho Sung ³, Taeho Lee ⁴, Sang-Won Lee ⁵, Yong Woo Jung ⁶, Yu Su Shin ⁵, Hyojeung Kang ¹; Journal of Microbiology 2013;51(4):490-498
DOI: https://doi.org/10.1007/s12275-013-3282-7
Published online: August 30, 2013

¹College of Pharmacy and Research Institute of Pharmaceutical Sciences, Institute for Microorganisms, Kyungpook National University, Daegu 702-701, Republic of Korea, ²College of Pharmacy, Duksung Women’s University, Seoul 132-714, Republic of Korea, ³Mushroom Research Division, National Institute of Horticultural and Herbal Science, Rural Development Administration, Suwon 440-706, Republic of Korea, ⁴Research Center, Dong-a Pharm. Co., LTD., Yongin 446-905, Republic of Korea, ⁵Department of Medicinal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong 369-873, Republic of Korea, ⁶College of Pharmacy, Korea University, Sejong 339-700, Republic of Korea¹College of Pharmacy and Research Institute of Pharmaceutical Sciences, Institute for Microorganisms, Kyungpook National University, Daegu 702-701, Republic of Korea, ²College of Pharmacy, Duksung Women’s University, Seoul 132-714, Republic of Korea, ³Mushroom Research Division, National Institute of Horticultural and Herbal Science, Rural Development Administration, Suwon 440-706, Republic of Korea, ⁴Research Center, Dong-a Pharm. Co., LTD., Yongin 446-905, Republic of Korea, ⁵Department of Medicinal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong 369-873, Republic of Korea, ⁶College of Pharmacy, Korea University, Sejong 339-700, Republic of Korea

Received: 15 May 2013 • Accepted: 7 August 2013

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Abstract

Carthamus tinctorius L. (CT) is traditionally used to reduce ailments from diseases of the musculoskeletal system and connective tissue and diseases of blood circulation and the cardiovascular system. Flower extracts from CT are known to have antibacterial activity, anti-inflammatory activity, and to inhibit tumor promotion in mouse skin carcinogenesis. In order to discover new antiviral agents from CT extracts, we tested whether CT extracts contain antiviral activity against gammaherpesvirus infection. This study demonstrated that treatment with CT extracts disrupted KSHV latency in the viral-infected host cells, iSLK-BAC16. n-Hexane and EtOH fractions of CT extracts critically affected at least two stages of the KHSV life-cycle by abnormally inducing KSHV lytic reactivation and by severely preventing KSHV virion release from the viral host cells. In addition to the effects on KSHV itself, CT extract treatments induced cellular modifications by dysregulating cell-cycle and producing strong cytotoxicity. This study demonstrated for the first time that CT extracts have antiviral activities that could be applied to development of new anti-gammaherpesviral agents.

Keywords: Carthamus tinctorius L.; Kaposi’s sarcoma-associated herpesvirus; extracts; latency; lytic reactivation

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Dysregulation of KSHV Replication by Extracts from Carthamus tinctorius L.

J. Microbiol. 2013;51(4):490-498. Published online August 30, 2013

DOI: https://doi.org/10.1007/s12275-013-3282-7

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