Abstract
The incidence of fluconazole-resistant Candida albicans has been increasing worldwide. Both biofilm and fungal morphogenesis are main virulence factors of C. albicans cells. Extracellular fungal prostaglandins are synthesized during biofilm adhesion and development and through yeast-hypha conversion. Hence, we targeted prostaglandin synthesis with various cyclooxygenase (COX) inhibitors (aspirin, diclofenac, ketoprofen, tenoxicam, and ketorolac) and assessed their effect on fungal adhesion, biofilm formation, and yeast-hypha conversion in clinical isolates of Fluconazole resistant C. albicans. Significant reduction in fungal adhesion and detachment of mature biofilm was attained down to 1 mM concentrations of anti-inflammatory agents. Microscopical examination of fungal cells in the presence of the tested drugs showed significant reduction of germ tube formation. Therefore, COX inhibitors have a significant effect on reduction of Candida adhesion and biofilm development in correlation with fungal morphogenesis. Moreover, inhibition of C. albicans by COX inhibitors gave synergistic activity with fluconazole suggesting that combination therapeutic strategies may be fruitful for management of infection of Fluconazole resistant C. albicans.
Citations
Citations to this article as recorded by
- Hyphal‐associated protein expression is crucial for Candida albicans‐induced eicosanoid biosynthesis in immune cells
Jana Schimanski, Mark S. Gresnigt, Elena Brunner, Oliver Werz, Bernhard Hube, Ulrike Garscha
European Journal of Immunology.2024;[Epub] CrossRef - Can nonsteroidal anti-inflammatory drugs (NSAIDs) be repurposed for fungal infection?
Fatemeh Babaei, Mohammadreza Mirzababaei, Alireza Tavakkoli, Marjan Nassiri-Asl, Hossein Hosseinzadeh
Naunyn-Schmiedeberg's Archives of Pharmacology.2024; 397(1): 59. CrossRef - Elucidation of the mechanisms of fluconazole resistance and repurposing treatment options against urinary Candida spp. isolated from hospitalized patients in Alexandria, Egypt
Hend Zeitoun, Rawan A. Salem, Nadia M. El-Guink, Nesrin S. Tolba, Nelly M. Mohamed
BMC Microbiology.2024;[Epub] CrossRef - An integrated transcriptomic and metabolomic approach to investigate the heterogeneous Candida albicans biofilm phenotype
Christopher Delaney, Bryn Short, Ranjith Rajendran, Ryan Kean, Karl Burgess, Craig Williams, Carol A. Munro, Gordon Ramage
Biofilm.2023; 5: 100112. CrossRef -
Targeting Adhesion in Fungal Pathogen
Candida Albicans
Harlei Martin, Kevin Kavanagh, Trinidad Velasco-Torrijos
Future Medicinal Chemistry.2021; 13(3): 313. CrossRef - Design, synthesis and biological evaluation of a series of iron and copper chelating deferiprone derivatives as new agents active against Candida albicans
Martina Bortolami, Fabiana Pandolfi, Antonella Messore, Daniele Rocco, Marta Feroci, Roberto Di Santo, Daniela De Vita, Roberta Costi, Paola Cascarino, Giovanna Simonetti, Luigi Scipione
Bioorganic & Medicinal Chemistry Letters.2021; 42: 128087. CrossRef - Aspirin as an Antifungal-Lock Agent in Inhibition of Candidal Biofilm Formation in Surgical Catheters
Alice Kit Ying Chan, Yiu Cheung Tsang, Chun Hung Chu, Chiu Shun Peter Tsang
Infection and Drug Resistance.2021; Volume 14: 1427. CrossRef - Drug repurposing strategies in the development of potential antifungal agents
Qian Zhang, Fangyan Liu, Meng Zeng, Yingyu Mao, Zhangyong Song
Applied Microbiology and Biotechnology.2021; 105(13): 5259. CrossRef - Anti-biofilm effect by the combined action of fluconazole and acetylsalicylic acid against species of Candida parapsilosis complex
Franz de Assis Graciano dos Santos, Melyna Chaves Leite-Andrade, Ildnay de Sousa Brandão, Adryelle Idalina da Silva Alves, Maria Daniela Silva Buonafina, Michellangelo Nunes, Luiz Nascimento de Araújo-Neto, Maria Audilene de Freitas, Fábio André Brayner,
Infection, Genetics and Evolution.2020; 84: 104378. CrossRef - Diclofenac exhibits synergism with azoles against planktonic cells and biofilms of Candida tropicalis
Raimunda Sâmia Nogueira Brilhante, Jaiane Alves Brasil, Jonathas Sales de Oliveira, Vandbergue Santos Pereira, Waldemiro de Aquino Pereira-Neto, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha
Biofouling.2020; 36(5): 528. CrossRef - Drug Repurposing Strategy against Fungal Biofilms
Thaís Pereira de Mello, Laura Nunes Silva, Lívia de Souza Ramos, Heloísa Freire Frota, Marta Helena Branquinha, André Luis Souza dos Santos
Current Topics in Medicinal Chemistry.2020; 20(7): 509. CrossRef - Aspirin alleviates orthopedic implant‑associated infection
Yi Jiang, Sheng‑Nan Wang, Hang‑Tian Wu, Han‑Jun Qin, Ming‑Liang Ren, Jian‑Chun Lin, Bin Yu
International Journal of Molecular Medicine.2019;[Epub] CrossRef - Metabolomic analysis of low and high biofilm-forming Helicobacter pylori strains
Eric Hong Jian Wong, Chow Goon Ng, Khean Lee Goh, Jamuna Vadivelu, Bow Ho, Mun Fai Loke
Scientific Reports.2018;[Epub] CrossRef - Effects of Rhodomyrtus tomentosa extract on virulence factors of Candida albicans and human neutrophil function
Jutharat Hmoteh, Khadar Syed Musthafa, Supayang Piyawan Voravuthikunchai
Archives of Oral Biology.2018; 87: 35. CrossRef -
Prostaglandin E
2
Receptor Antagonist with Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus
Mélanie A. C. Ikeh, Paul L. Fidel, Mairi C. Noverr
Antimicrobial Agents and Chemotherapy.2018;[Epub] CrossRef - Oral hygiene might prevent cancer
Oscar J. Cordero, Rubén Varela-Calviño
Heliyon.2018; 4(10): e00879. CrossRef - Characterization of a novel antibiofilm effect of nitric oxide-releasing aspirin (NCX-4040) on Candida albicans isolates from denture stomatitis patients
Francisco Madariaga-Venegas, Roberto Fernández-Soto, Luisa Fernanda Duarte, Nicole Suarez, Daniela Delgadillo, José A. Jara, Ricardo Fernández-Ramires, Blanca Urzúa, Alfredo Molina-Berríos, Sompop Bencharit
PLOS ONE.2017; 12(5): e0176755. CrossRef - Potential Antifungal Targets against a Candida Biofilm Based on an Enzyme in the Arachidonic Acid Cascade—A Review
Xinning Liu, Decai Wang, Cuixiang Yu, Tao Li, Jianqiao Liu, Shujuan Sun
Frontiers in Microbiology.2016;[Epub] CrossRef - Neutrophils influx and proinflammatory cytokines inhibition by sodium salicylate, unlike aspirin, in Candida albicans-induced peritonitis model
Priscilla Aparecida Tártari Pereira, Daniel Bini, Fernanda Bovo, Lucia Helena Faccioli, Marta Chagas Monteiro
Folia Microbiologica.2016; 61(4): 337. CrossRef - New frontiers for anti-biofilm drug development
Suzana M. Ribeiro, Mário R. Felício, Esther Vilas Boas, Sónia Gonçalves, Fabrício F. Costa, Ramar Perumal Samy, Nuno C. Santos, Octávio L. Franco
Pharmacology & Therapeutics.2016; 160: 133. CrossRef - Effect of tyrosol on Staphylococcus aureus antimicrobial susceptibility, biofilm formation and virulence factors
H Abdel Rhman Shaymaa, E Rizk Dina
African Journal of Microbiology Research.2016; 10(20): 687. CrossRef - Effect of non-steroidal anti-inflammatory drugs and dexamethazone on the biofilm formation and expression of some adhesion-related genes of Candida albicans and Staphylococcus aureus
Mahmoud Abd El Baky Rehab, G El Gendy Sherein
African Journal of Microbiology Research.2016; 10(20): 694. CrossRef - The roles of CDR1, CDR2, and MDR1 in kaempferol-induced suppression with fluconazole-resistant Candida albicans
Jing Shao, MengXiang Zhang, TianMing Wang, Yue Li, ChangZhong Wang
Pharmaceutical Biology.2016; 54(6): 984. CrossRef - Potent Synergy between Spirocyclic Pyrrolidinoindolinones and Fluconazole against Candida albicans
Ilandari Dewage Udara Anulal Premachandra, Kevin A. Scott, Chengtian Shen, Fuqiang Wang, Shelley Lane, Haoping Liu, David L. Van Vranken
ChemMedChem.2015; 10(10): 1672. CrossRef - Th17 response and its regulation in inflammatory upper airway diseases
Y. Liu, M. Zeng, Z. Liu
Clinical & Experimental Allergy.2015; 45(3): 602. CrossRef -
Role of Pathogen-Derived Cell Wall Carbohydrates and Prostaglandin E
2
in Immune Response and Suppression of Fish Immunity by the Oomycete Saprolegnia parasitica
Rodrigo Belmonte, Tiehui Wang, Gary J. Duncan, Ida Skaar, Hugo Mélida, Vincent Bulone, Pieter van West, Christopher J. Secombes, J. A. Appleton
Infection and Immunity.2014; 82(11): 4518. CrossRef
MSK
Cite this Article
