Cyclic Dipeptides from Lactic Acid Bacteria Inhibit Proliferation of the Influenza A Virus

Min-Kyu Kwak; Rui Liu; Jun-Oh Kwon; Min-Kyu Kim; Andrew HyoungJin Kim; Sa-Ouk Kang

doi:10.1007/s12275-013-3521-y

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Research Support, Non-U.S. Gov't
Cyclic Dipeptides from Lactic Acid Bacteria Inhibit Proliferation of the Influenza A Virus: Min-Kyu Kwak ¹, Rui Liu ¹, Jun-Oh Kwon ¹, Min-Kyu Kim ², Andrew HyoungJin Kim ¹, Sa-Ouk Kang ¹; Journal of Microbiology 2013;51(6):836-843
DOI: https://doi.org/10.1007/s12275-013-3521-y
Published online: December 19, 2013

¹Laboratory of Biophysics, School of Biological Sciences, and Institute of Microbiology, Seoul National University, Seoul 151-747, Republic of Korea, ²Marine Biotechnology Research Division, Korea Institute of Ocean Science and Technology, Ansan 426-744, Republic of Korea¹Laboratory of Biophysics, School of Biological Sciences, and Institute of Microbiology, Seoul National University, Seoul 151-747, Republic of Korea, ²Marine Biotechnology Research Division, Korea Institute of Ocean Science and Technology, Ansan 426-744, Republic of Korea

Corresponding author: Sa-Ouk Kang , Tel: +82-2-880-6703,

Received: 8 October 2013 • Accepted: 30 November 2013

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Abstract

We isolated Lactobacillus plantarum LBP-K10 from the traditional Korean fermented food kimchi. When organic acids were removed, the culture filtrate of this isolate showed high antiviral activity (measured using a plaque-forming assay) against the influenza A (H3N2) virus. Two fractions that were active against influenza A virus were purified from the culture filtrate using a C18 column with high-performance liquid chromatography. These active fractions were crystallized and identified to be the cyclic dipeptides cis-cyclo (L-Leu-L-Pro) and cis-cyclo(L-Phe-L-Pro) using gas chromatography-mass spectrometry; this identification was confirmed by X-ray crystallography. These cyclic dipeptides were identified in the culture filtrate of other lactic acid bacteria, including Lactobacillus spp., Leuconostoc spp., Weissella spp., and Lactococcus lactis.

Keywords: Lactobacillus plantarum LBP-K10; culture filtrate; cis-cyclo(L-Leu-L-Pro); cis-cyclo(L-Phe-L-Pro); influenza A virus; antiviral activity

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Cyclic Dipeptides from Lactic Acid Bacteria Inhibit Proliferation of the Influenza A Virus

J. Microbiol. 2013;51(6):836-843. Published online December 19, 2013

DOI: https://doi.org/10.1007/s12275-013-3521-y

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