Skip Navigation
Skip to contents

Journal of Microbiology : Journal of Microbiology

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Articles

Page Path
HOME > J. Microbiol > Volume 51(6); 2013 > Article
Review
MINIREVIEW] Overview: Replication of Porcine Reproductive and Respiratory Syndrome Virus
Sang-Im Yun , Young-Min Lee
Journal of Microbiology 2013;51(6):711-723.
DOI: https://doi.org/10.1007/s12275-013-3431-z
Published online: December 19, 2013
Department of Animal, Dairy, and Veterinary Sciences, Utah Science Technology and Research, College of Agriculture and Applied Sciences, Utah State University, Logan, UT 84322-4815, USADepartment of Animal, Dairy, and Veterinary Sciences, Utah Science Technology and Research, College of Agriculture and Applied Sciences, Utah State University, Logan, UT 84322-4815, USA
Corresponding author:  Young-Min Lee , Tel: +1-435-797-9667, 
Received: 12 August 2013   • Accepted: 7 October 2013
next
  • 40 Views
  • 0 Download
  • 47 Crossref
  • 48 Scopus
Full Article

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus that causes significant losses in the pig industry, is one of the most important animal pathogens of global significance. Since the discovery of the virus, significant progress has been made in understanding its epidemiology and transmission, but no adequate control measures are yet available to eliminate infection with this pathogen. The genome replication of PRRSV is required to reproduce, within a few hours of infection, the millions of progeny virions that establish, disseminate, and maintain infection. Replication of the viral RNA genome is a multistep process involving a replication complex that is formed not only from components of viral and cellular origin but also from the viral genomic RNA template; this replication complex is embedded within particular virus-induced membrane vesicles. PRRSV RNA replication is directed by at least 14 replicase proteins that have both common enzymatic activities, including viral RNA polymerase, and also unusual and poorly understood RNAprocessing functions. In this review, we summarize our current understanding of PRRSV replication, which is important for developing a successful strategy for the prevention and control of this pathogen.

  • Cite this Article
    Cite this Article
    export Copy Download
    Close
    Download Citation
    Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
    Format:
    • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
    • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
    Include:
    • Citation for the content below
    MINIREVIEW] Overview: Replication of Porcine Reproductive and Respiratory Syndrome Virus
    J. Microbiol. 2013;51(6):711-723.   Published online December 19, 2013
    DOI: https://doi.org/10.1007/s12275-013-3431-z
    Close
Related articles
Journal of Microbiology : Journal of Microbiology
© The Microbiological Society of Korea.
TOP