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HOME > J. Microbiol > Volume 52(11); 2014 > Article
Journal Article
Use of Selected Lactic Acid Bacteria in the Eradication of Helicobacter pylori Infection
Jin-Eung Kim , Min-Soo Kim , Yeo-Sang Yoon , Myung-Jun Chung , Do-Young Yum
Journal of Microbiology 2014;52(11):955-962.
DOI: https://doi.org/10.1007/s12275-014-4355-y
Published online: October 3, 2014
R&D Center, Cell Biotech, Co. Ltd., Gimpo 415-871, Republic of KoreaR&D Center, Cell Biotech, Co. Ltd., Gimpo 415-871, Republic of Korea
Corresponding author:  Do-Young Yum , Tel: +82-31-987-6205, 
Received: 19 June 2014   • Revised: 17 July 2014   • Accepted: 19 August 2014
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Abstract

Helicobacter pylori is among the major pathogenic bacteria that cause chronic gastritis and peptic ulcer disease and is related to the development of gastric cancer. Several chemicals, including antibiotics, have been used to eradicate H. pylori; however, they do not always curb the infection. Ten representative type strains of lactic acid bacteria (LAB) were screened for antagonism toward H. pylori via inhibition of urease activity. Strains inhibiting the binding of H. pylori to human gastric cell line cells and suppressing H. pylori-induced interleukin-8 (IL-8) production were also screened. Of these, Pediococcus pentosaseus (SL4), which inhibited the adhesion of H. pylori to MKN-45 gastric cancer cells, Bifidobacterium longum (BG7), with urease inhibiting activity, and Lactococcus lactis (SL3), and Enterococcus faecalis (SL5), which suppressed H. pylori-induced IL-8 production within MKN-45 and AGS cells, were selected. In mouse model, these LAB stains in combination significantly suppressed IL-8 levels in serum. Gastric pH also recovered to normal values after the administration of these LAB. These stains effectively suppressed H. pylori viability, although not to the extent of antibiotic treatment. When used as probiotics, LAB may help decrease the occurrence of gastritis and reduce the risk of H. pylori infection without, inducing side effects.

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    Use of Selected Lactic Acid Bacteria in the Eradication of Helicobacter pylori Infection
    J. Microbiol. 2014;52(11):955-962.   Published online October 3, 2014
    DOI: https://doi.org/10.1007/s12275-014-4355-y
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