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HOME > J. Microbiol > Volume 52(12); 2014 > Article
Research Support, Non-U.S. Gov't
Pseudomonas aeruginosa-induced IL-1β Production is Inhibited by Sophora flavescens via the NF-κB/inflammasome Pathways
Jung-Hoon Lee 1, Heesung Shin 1, Yong-Jae Kim 1, Se-Hwan Paek 1, Shouguang Jin 2, Un-Hwan Ha 1
Journal of Microbiology 2014;52(12):1044-1049.
DOI: https://doi.org/10.1007/s12275-014-4512-3
Published online: November 29, 2014
1Department of Biotechnology and Bioinformatics, Korea University, Sejong 339-700, Republic of Korea, 2Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, USA1Department of Biotechnology and Bioinformatics, Korea University, Sejong 339-700, Republic of Korea, 2Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, USA
Corresponding author:  Shouguang Jin , Tel: +82-44-860-1418, 
Un-Hwan Ha , Tel: +82-44-860-1418, 
Received: 16 September 2014   • Revised: 21 October 2014   • Accepted: 21 October 2014
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Abstract

The proinflammatory cytokine interleukin-1β plays an important role in protecting the host against airway infection; however, it can also trigger a massive influx of neutrophils into the airways, causing tissue damage. Anti-inflammatory treatments are particularly in demand for patients suffering from chronic inflammatory diseases. Sophora flavescens is a traditional herbal medicine used to reduce inflammation, but no study has examined its ability to block IL-1β production. Here, we show that S. flavescens reduced the Pseudomonas aeruginosa-induced expression of IL-1β by lung epithelial cells and macrophages. S. flavescens was also effective at reducing IL-1β production induced by either Staphylococcus aureus or phorbol 12-myristate 13-acetate, indicating that the effect is generalizable to diverse inflammatory stimuli. In addition, S. flavescens blocked the phosphorylation of IKKα/β, key upstream kinases involved in the degradation of IκBα, and the cleavage of caspase-1, a key component of the inflammasome. Thus, this study demonstrates that S. flavescens exerts its anti-inflammatory effects by blocking P. aeruginosa-mediated NF-κB/inflammasome activation and the subsequent production of IL-1β.

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    Pseudomonas aeruginosa-induced IL-1β Production is Inhibited by Sophora flavescens via the NF-κB/inflammasome Pathways
    J. Microbiol. 2014;52(12):1044-1049.   Published online November 29, 2014
    DOI: https://doi.org/10.1007/s12275-014-4512-3
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