Skip Navigation
Skip to contents

Journal of Microbiology : Journal of Microbiology

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Articles

Page Path
HOME > J. Microbiol > Volume 52(12); 2014 > Article
Research Support, Non-U.S. Gov't
Effect of Zinc on Growth Performance, Gut Morphometry, and Cecal Microbial Community in Broilers Challenged with Salmonella enterica serovar Typhimurium
Yuxin Shao , Zhao Lei , Jianmin Yuan , Ying Yang , Yuming Guo , Bingkun Zhang
Journal of Microbiology 2014;52(12):1002-1011.
DOI: https://doi.org/10.1007/s12275-014-4347-y
Published online: November 29, 2014
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Key Laboratory of Feed Safety and Bioavailability, Ministry of Agriculture, P.R. China, Beijing, 100193, P. R. ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Key Laboratory of Feed Safety and Bioavailability, Ministry of Agriculture, P.R. China, Beijing, 100193, P. R. China
Corresponding author:  Bingkun Zhang , Tel: +86-10-62734978, 
Received: 16 June 2014   • Revised: 24 September 2014   • Accepted: 14 October 2014
prev next
  • 54 Views
  • 0 Download
  • 65 Crossref
  • 76 Scopus
Full Article

Abstract

To evaluate the effects of supplemental zinc on growth performance, gut morphometry, and the cecal microbial community in broilers challenged with Salmonella typhimurium, 180, 1-day-old male Cobb 500 broiler chicks were randomly assigned to 3 treatments with ten replicates for a 42 day experiment. The 3 treatments were: unchallenged, S. typhimurium- challenged, and S. typhimurium-challenged with 120 mg/kg of zinc supplementation in the diet. Salmonella infection caused a reduction in body-weight gain and feed intake, disrupted the intestinal structure by decreasing the villus-height/crypt-depth ratio of the ileum and increasing the apoptotic index of ileal epithelial cells. Moreover, the cecal microbial community was altered by Salmonella infection, as demonstrated by a reduced number of Lactobacillus and total bacteria. Dietary zinc supplementation improved growth performance by increasing the body-weight gain and feed intake in the challenged broilers. In addition, zinc repaired intestinal injury by reducing the apoptotic index of ileal epithelial cells, enhancing villus height and the villusheight/ crypt-depth ratio of the ileum, and the proliferation index of ileal epithelial cells. Finally, zinc regulated the cecal microbial community by increasing the number of total bacteria and beneficial Lactobacillus bacteria, and reducing the number of Salmonella. The results indicated that dietary zinc supplementation improved growth performance, intestinal morphology, and intestinal microbiota in S. typhimurium- challenged broilers.

  • Cite this Article
    Cite this Article
    export Copy Download
    Close
    Download Citation
    Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
    Format:
    • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
    • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
    Include:
    • Citation for the content below
    Effect of Zinc on Growth Performance, Gut Morphometry, and Cecal Microbial Community in Broilers Challenged with Salmonella enterica serovar Typhimurium
    J. Microbiol. 2014;52(12):1002-1011.   Published online November 29, 2014
    DOI: https://doi.org/10.1007/s12275-014-4347-y
    Close
Related articles
Journal of Microbiology : Journal of Microbiology
© The Microbiological Society of Korea.
TOP