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HOME > J. Microbiol > Volume 53(2); 2015 > Article
Review
Minireview] The molecular mechanism of azole resistance in Aspergillus fumigatus: from bedside to bench and back
Xiaolei Wei , Yuanwei Zhang Zhang , Ling Lu
Journal of Microbiology 2015;53(2):91-99.
DOI: https://doi.org/10.1007/s12275-015-5014-7
Published online: January 28, 2015
Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology; College of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. ChinaJiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology; College of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China
Corresponding author:  Ling Lu , Tel: +86-25-85891791, 
Received: 12 January 2015   • Accepted: 13 January 2015
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Abstract

The growing use of immunosuppressive therapies has resulted in a dramatic increased incidence of invasive fungal infections (IFIs) caused by Aspergillus fumigatus, a common pathogen, and is also associated with a high mortality rate. Azoles are the primary guideline-recommended therapy agents for first-line treatment and prevention of IFIs. However, increased azole usage in medicinal and agricultural settings has caused azole-resistant isolates to repeatedly emerge in the environment, resulting in a significant threat to human health. In this review, we present and summarize current research on the resistance mechanisms of azoles in A. fumigatus as well as efficient susceptibility testing methods. Moreover, we analyze and discuss the putative clinical (bedside) indication of these findings from bench work.

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    Minireview] The molecular mechanism of azole resistance in Aspergillus fumigatus: from bedside to bench and back
    J. Microbiol. 2015;53(2):91-99.   Published online January 28, 2015
    DOI: https://doi.org/10.1007/s12275-015-5014-7
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