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HOME > J. Microbiol > Volume 53(5); 2015 > Article
Review
MINIREVIEW] Two stress sensor proteins for the expression of sigmaE regulon: DegS and RseB
Dong Young Kim
Journal of Microbiology 2015;53(5):306-310.
DOI: https://doi.org/10.1007/s12275-015-5112-6
Published online: May 3, 2015
College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of KoreaCollege of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea
Corresponding author:  Dong Young Kim , Tel: +82-53-810-2832, 
Received: 2 March 2015   • Revised: 9 April 2015   • Accepted: 10 April 2015
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Abstract

In E. coli, sigmaE-dependent transcription is controlled by regulated-proteolysis of RseA. RseA, which holds sigmaE as an anti-sigma factor, is sequentially digested by DegS, RseP and cytoplasmic proteases to liberate sigmaE in response to dysfunction in outer-membrane biogenesis. Additionally, the sequential proteolysis is regulated by RseB binding to RseA (Fig. 1A). Direct interaction between RseA and RseB inhibits RseA-cleavage by DegS. Both proteolytic activation of DegS and binding disruption of RseB are thus required to initiate sigmaE-stress response. For the induction of sigmaEstress response, DegS and RseB recognize the states of OMP and LPS for outer-membrane biogenesis. DegS is activated by binding of unfolded OMPs and RseB binding to RseA is antagonized by LPS accumulated in periplasm. In this regard, DegS and RseB are proposed to be stress sensor proteins for sigmaE signal transduction. Interestingly, biogenesis of OMP and LPS appears to cross-talk with each other, indicating that dysfunction of either OMP or LPS can initiate RseA proteolysis. This review aims to briefly introduce two stress sensor proteins, DegS and RseB, which regulate sigmaEdependent transcription.

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    MINIREVIEW] Two stress sensor proteins for the expression of sigmaE regulon: DegS and RseB
    J. Microbiol. 2015;53(5):306-310.   Published online May 3, 2015
    DOI: https://doi.org/10.1007/s12275-015-5112-6
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