Skip Navigation
Skip to contents

Journal of Microbiology : Journal of Microbiology

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Articles

Page Path
HOME > J. Microbiol > Volume 53(9); 2015 > Article
Research Support, Non-U.S. Gov't
The effect of dietary bovine colostrum on respiratory syncytial virus infection and immune responses following the infection in the mouse
Mei Ling Xu , Hyoung Jin Kim , Ga Ram Wi , Hong-Jin Kim
Journal of Microbiology 2015;53(9):661-666.
DOI: https://doi.org/10.1007/s12275-015-5353-4
Published online: August 27, 2015
Laboratory of Virology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of KoreaLaboratory of Virology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea
Corresponding author:  Hong-Jin Kim , Tel: +82-2-820-5613, 
Received: 16 July 2015   • Revised: 3 August 2015   • Accepted: 3 August 2015
prev
  • 63 Views
  • 0 Download
  • 20 Crossref
  • 19 Scopus
Full Article

Abstract

Human respiratory syncytial virus (hRSV) is the most common cause of respiratory tract infection among young children because of immature T cell immunity of them against hRSV. CD8 T cells play a pivotal role in clearing hRSV and preventing subsequent infection. We examined the effects of dietary bovine colostrum on virus infection and CD8 T cell responses following hRSV infection in the mouse model. Mice received bovine colostrum for 14 days prior to hRSV challenge, and lung indexes (severity of symptom) and lung virus titers were analyzed. In addition, the activation of CD8 T cells in the bronchoalveolar lavage fluids (BALFs) of mice receiving bovine colostrum were compared with those in the BALFs of mice receiving phosphate-buffered saline (PBS) or ribavirin, post virus challenge. The severity of infection and lung virus titers were reduced in the mice receiving bovine colostrum, compared to those receiving PBS. Moreover CD8 T cell responses were selectively enhanced in the former. Our results suggest that dietary bovine colostrum exerts the effects to inhibit hRSV and ameliorate the symptom by hRSV infection, and enhances the CD8 T cell response during the hRSV infection.

  • Cite this Article
    Cite this Article
    export Copy Download
    Close
    Download Citation
    Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
    Format:
    • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
    • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
    Include:
    • Citation for the content below
    The effect of dietary bovine colostrum on respiratory syncytial virus infection and immune responses following the infection in the mouse
    J. Microbiol. 2015;53(9):661-666.   Published online August 27, 2015
    DOI: https://doi.org/10.1007/s12275-015-5353-4
    Close
Related articles
Journal of Microbiology : Journal of Microbiology
© The Microbiological Society of Korea.
TOP