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Purification of an Immunosuppressor Produced by Penicillium urticae
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HOME > J. Microbiol > Volume 36(4); 1998 > Article
Purification of an Immunosuppressor Produced by Penicillium urticae
Lee, Jae Jung , Yoo, Seoung Ku , Kim, Eui Joong , Yu, Ju Hyun , Bai, Dong Hoon 1, Yoon, Sung Sik 2, Kim, Wook Sung 3
Journal of Microbiology 1998;36(4):280-282

Department of Biotechnology, College of Engineering and Bioproducts Research Center, Yonsei University; ¹Department of Food Engineering, Dankook University; ²Department of Biological Resources and Technology, Yonsei University; ³PULMUONE Co.Department of Biotechnology, College of Engineering and Bioproducts Research Center, Yonsei University; ¹Department of Food Engineering, Dankook University; ²Department of Biological Resources and Technology, Yonsei University; ³PULMUONE Co.
Corresponding author:  Yoo, Seoung Ku ,
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Abstract

An immunosuppressive chemical produced by Penicilium urticae (KFCC 11611) was purified from the supernatant of a culture broth by ethyl acetate extraction, silica gel column chromatography, and precipitation by adding cold n-hexane followed by crystalization. The chemical effectively inhibited the mouse mixed lymphocyte reaction (MLR) at a concentration of 1.25ⅹ10^3 ㎍/ml, which was lower than the effective concentration of cyclosporin A. The chemical was identified as the antibiotic patulin (MW 154.1 Da) by NMR and mass spectroscopy.

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    Purification of an Immunosuppressor Produced by Penicillium urticae
    J. Microbiol. 1998;36(4):280-282.
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