Abstract
Oxylipins are a class of molecules derived from the incorporation
of oxygen into polyunsaturated fatty acid substrates
through the action of oxygenases. While extensively investigated
in the context of mammalian immune responses, over
the last decade it has become apparent that oxylipins are a
common means of communication among and between plants,
animals, and fungi to control development and alter hostmicrobe
interactions. In fungi, some oxylipins are derived nonenzymatically
while others are produced by lipoxygenases,
cyclooxygenases, and monooxygenases with homology to
plant and human enzymes. Recent investigations of numerous
plant and human fungal pathogens have revealed oxylipins
to be involved in the establishment and progression of disease.
This review highlights oxylipin production by pathogenic
fungi and their role in fungal development and pathogen/
host interactions.
Citations
Citations to this article as recorded by
- Exploring Oxylipins in Host–Microbe Interactions and Their Impact on Infection and Immunity
Robert J. Neff, Christopher D. Radka
Current Issues in Molecular Biology.2025; 47(3): 190. CrossRef - Insights into PUFA and oxylipin production from incubation of Aspergillus novoparasiticus in sugarcane juice
Augusto Leonardo dos Santos, Marcelo José Pena Ferreira, Patricia Sartorelli, Josué José da Silva, Beatriz Thie Iamanaka, Jens Christian Frisvad, Marta Hiromi Taniwaki
Food Chemistry.2025; 473: 143051. CrossRef - Structural comparisons of bifunctional fatty acid dioxygenases with allene oxide, epoxy alcohol, or diol synthase activities
Ernst H. Oliw
Archives of Biochemistry and Biophysics.2025; 771: 110490. CrossRef - Glucose and HODEs regulate Aspergillus ochraceus quorum sensing through the GprC-AcyA pathway
Jing Gao, Huiqing Liu, Yuxin Jin, Yunbo Luo, Kunlun Huang, Zhihong Liang
Cellular and Molecular Life Sciences.2024;[Epub] CrossRef - Physiological response of Metarhizium rileyi with linoleic acid supplementation
Leidy Esther Sánchez-Rey, Nubia Moreno-Sarmiento, Erika Paola Grijalba-Bernal, Ginna Quiroga-Cubides
Fungal Biology.2024; 128(4): 1827. CrossRef - The gut-lung axis: the impact of the gut mycobiome on pulmonary diseases and infections
Emily A Sey, Adilia Warris
Oxford Open Immunology.2024;[Epub] CrossRef - The volatile components from Bacillus cereus N4 can restrain brown rot of peach fruit by inhibiting sporulation of Monilinia fructicola and inducing disease resistance
Yingying Shi, Song Zhang, Jinghan Zhang, Xiaorui Wang, Yuan He, Xiongde Han, Zunyang Song, Jingying Shi
Postharvest Biology and Technology.2024; 210: 112755. CrossRef - Inflammatory cytokine signalling in vulvovaginal candidiasis: a hot mess driving immunopathology
Kar On Cheng, Dolly E Montaño, Teresa Zelante, Axel Dietschmann, Mark S Gresnigt
Oxford Open Immunology.2024;[Epub] CrossRef - Trichoderma longibrachiatum’s Secondary Metabolite-A Review on Potential Compounds for Plant Growth and Biological Control for Plant Pathogens
Priya Ramasamy, Balachandar Subbu, Prabhakaran Narayanasamy
Asian Journal of Biological Sciences.2023; 16(3): 202. CrossRef - Mutational Analysis of Aspergillus fumigatus Volatile Oxylipins in a Drosophila Eclosion Assay
Hadeel S. Almaliki, Mengyao Niu, Nancy P. Keller, Guohua Yin, Joan W. Bennett
Journal of Fungi.2023; 9(4): 402. CrossRef - Plant Host Traits Mediated by Foliar Fungal Symbionts and Secondary Metabolites
Moriah Sandy, Tina I. Bui, Kenia Segura Abá, Nestor Ruiz, John Paszalek, Elise W. Connor, Christine V. Hawkes
Microbial Ecology.2023; 86(1): 408. CrossRef - Transcriptome analysis reveals infection strategies employed by Fusarium graminearum as a root pathogen
Yi Ding, Donald M. Gardiner, Kemal Kazan
Microbiological Research.2022; 256: 126951. CrossRef - Phenotypic plasticity of Monilinia spp. in response to light wavelengths: From in vitro development to virulence on nectarines
Lucía Verde-Yáñez, Núria Vall-llaura, Josep Usall, Neus Teixidó, Rosario Torres
International Journal of Food Microbiology.2022; 373: 109700. CrossRef - Light and mycelial injury influences the volatile and non-volatile metabolites and the biocontrol properties of Trichoderma atroviride
Hexon Angel Contreras-Cornejo, Omar Orozco-Granados, Arturo Ramírez-Ordorica, Perla García-Juárez, José López-Bucio, Lourdes Macías-Rodríguez
Rhizosphere.2022; 22: 100511. CrossRef - Editorial: Lipid metabolism and membrane structure in plant biotic interactions
Fiona L. Goggin, Jyoti Shah, Glenda Gillaspy
Frontiers in Plant Science.2022;[Epub] CrossRef - Biotic stress caused by in vitro co-inoculation enhances the expression of acetylcholinesterase inhibitors by fungi
Geane Pereira de Oliveira, Debora Luiza Costa Barreto, Mauro Ramalho Silva, Rodinei Augusti, Ivanildo Evódio Marriel, Ubiraci Gomes de Paula Lana, Jacqueline Aparecida Takahashi
Natural Product Research.2022; 36(16): 4266. CrossRef - Towards understanding of fungal biocontrol mechanisms of different yeasts antagonistic to Botrytis cinerea through exometabolomic analysis
Alicia Fernandez-San Millan, Jordi Gamir, Luis Larraya, Inmaculada Farran, Jon Veramendi
Biological Control.2022; 174: 105033. CrossRef - Malassezia: A Commensal, Pathogen, and Mutualist of Human and Animal Skin
Giuseppe Ianiri, Salomé LeibundGut-Landmann, Thomas L. Dawson
Annual Review of Microbiology.2022; 76(1): 757. CrossRef - Bacterial lipoxygenases: Biochemical characteristics, molecular structure and potential applications
Ruth Chrisnasari, Marie Hennebelle, Jean-Paul Vincken, Willem J.H. van Berkel, Tom A. Ewing
Biotechnology Advances.2022; 61: 108046. CrossRef - Mechanisms of Plant Natural Immunity and the Role of Selected Oxylipins as Molecular Mediators in Plant Protection
Piotr Barbaś, Dominika Skiba, Piotr Pszczółkowski, Barbara Sawicka
Agronomy.2022; 12(11): 2619. CrossRef - Iron and manganese lipoxygenases of plant pathogenic fungi and their role in biosynthesis of jasmonates
Ernst H. Oliw
Archives of Biochemistry and Biophysics.2022; 722: 109169. CrossRef - Eight-carbon volatiles: prominent fungal and plant interaction compounds
Kayla K Pennerman, Guohua Yin, Joan W Bennett, Maaria Rosenkranz
Journal of Experimental Botany.2022; 73(2): 487. CrossRef - Unfolded Protein Response and Scaffold Independent Pheromone MAP Kinase Signaling Control Verticillium dahliae Growth, Development, and Plant Pathogenesis
Jessica Starke, Rebekka Harting, Isabel Maurus, Miriam Leonard, Rica Bremenkamp, Kai Heimel, James W. Kronstad, Gerhard H. Braus
Journal of Fungi.2021; 7(4): 305. CrossRef - WITHDRAWN: Fatty acid dioxygenase-cytochrome P450 fusion enzymes of the top 10 fungal pathogens in molecular plant pathology and human-pathogenic fungi
Ernst H. Oliw
Fungal Genetics and Biology.2021; : 103603. CrossRef - FgPKS7 is an essential player in mating‐type‐mediated regulatory pathway required for completing sexual cycle in Fusarium graminearum
Da‐Woon Kim, Yoo‐Kyoung Shin, Sang‐Won Lee, Kanphassorn Wimonmuang, Kyo Bin Kang, Young‐Sang Lee, Sung‐Hwan Yun
Environmental Microbiology.2021; 23(4): 1972. CrossRef - Dietary Polyunsaturated Fatty Acids (PUFAs): Uses and Potential Health Benefits
Bharat Kapoor, Dhriti Kapoor, Shristy Gautam, Rahul Singh, Savita Bhardwaj
Current Nutrition Reports.2021; 10(3): 232. CrossRef - Molecular insights into lipoxygenases for biocatalytic synthesis of diverse lipid mediators
Jung-Ung An, Seong-Eun Kim, Deok-Kun Oh
Progress in Lipid Research.2021; 83: 101110. CrossRef - Turning Inside Out: Filamentous Fungal Secretion and Its Applications in Biotechnology, Agriculture, and the Clinic
Timothy C. Cairns, Xiaomei Zheng, Ping Zheng, Jibin Sun, Vera Meyer
Journal of Fungi.2021; 7(7): 535. CrossRef - Emission of novel volatile biomarkers for wheat powdery mildew
Kamirán Áron Hamow, Zsuzsanna Ambrózy, Katalin Puskás, Imre Majláth, Mónika Cséplő, Réka Mátyus, Katalin Posta, Péter Lukács, László Sági
Science of The Total Environment.2021; 781: 146767. CrossRef - Fatty acid dioxygenase-cytochrome P450 fusion enzymes of filamentous fungal pathogens
Ernst H. Oliw
Fungal Genetics and Biology.2021; 157: 103623. CrossRef - Aflatoxin Biosynthesis, Genetic Regulation, Toxicity, and Control Strategies: A Review
Rahim Khan, Farinazleen Mohamad Ghazali, Nor Ainy Mahyudin, Nik Iskandar Putra Samsudin
Journal of Fungi.2021; 7(8): 606. CrossRef - Fungal G-Protein-Coupled Receptors: A Promising Mediator of the Impact of Extracellular Signals on Biosynthesis of Ochratoxin A
Jing Gao, Xinge Xu, Kunlun Huang, Zhihong Liang
Frontiers in Microbiology.2021;[Epub] CrossRef - Eicosapolyenoic fatty acids alter oxylipin gene expression and fatty acid hydroperoxide profiles in tomato and pepper roots
Sara M. Dye, Jun Yang, Richard M. Bostock
Physiological and Molecular Plant Pathology.2020; 109: 101444. CrossRef - Molecular crosstalk between the endophyte Paraconiothyrium variabile and the phytopathogen Fusarium oxysporum – Modulation of lipoxygenase activity and beauvericin production during the interaction
Margot Bärenstrauch, Stéphane Mann, Chloé Jacquemin, Sarra Bibi, Oum-Kalthoum Sylla, Emmanuel Baudouin, Didier Buisson, Soizic Prado, Caroline Kunz
Fungal Genetics and Biology.2020; 139: 103383. CrossRef - Fungal evolution: cellular, genomic and metabolic complexity
Miguel A. Naranjo‐Ortiz, Toni Gabaldón
Biological Reviews.2020; 95(5): 1198. CrossRef - Plant Antifungal Lectins: Mechanism of Action and Targets on Human Pathogenic Fungi
Marianela Del Rio, Laura de la Canal, Mariana Regente
Current Protein & Peptide Science.2020; 21(3): 284. CrossRef - Critical thresholds of 1-Octen-3-ol shape inter-species Aspergillus interactions modulating the growth and secondary metabolism
Digar Singh, Su Young Son, Choong Hwan Lee
Scientific Reports.2020;[Epub] CrossRef - Comparisons of the Sexual Cycles for the Coccidian Parasites Eimeria and Toxoplasma
Bruno Martorelli Di Genova, Laura J. Knoll
Frontiers in Cellular and Infection Microbiology.2020;[Epub] CrossRef - Laminariales Host Does Impact Lipid Temperature Trajectories of the Fungal Endophyte Paradendryphiella salina (Sutherland.)
Marine Vallet, Tarik Meziane, Najet Thiney, Soizic Prado, Cédric Hubas
Marine Drugs.2020; 18(8): 379. CrossRef - Understanding Host–Pathogen Interactions in Brassica napus in the Omics Era
Ting Xiang Neik, Junrey Amas, Martin Barbetti, David Edwards, Jacqueline Batley
Plants.2020; 9(10): 1336. CrossRef - The novel bZIP transcription factor Fpo1 negatively regulates perithecial development by modulating carbon metabolism in the ascomycete fungus Fusarium graminearum
Jiyoung Shin, Duc‐Cuong Bui, Sieun Kim, So Yun Jung, Hye Jin Nam, Jae Yun Lim, Gyung Ja Choi, Yin‐Won Lee, Jung‐Eun Kim, Hokyoung Son
Environmental Microbiology.2020; 22(7): 2596. CrossRef - Co‐opting oxylipin signals in microbial disease
Mengyao Niu, Nancy P. Keller
Cellular Microbiology.2019; 21(6): e13025. CrossRef - Fathoming Aspergillus oryzae metabolomes in formulated growth matrices
Digar Singh, Sunmin Lee, Choong Hwan Lee
Critical Reviews in Biotechnology.2019; 39(1): 35. CrossRef - Metabolomic variation in wild and cultured cordyceps and mycelia of Isaria cicadae
Yaqiong He, Wancun Zhang, Fan Peng, Ruili Lu, Hong Zhou, Guanhu Bao, Bin Wang, Bo Huang, Zengzhi Li, Fenglin Hu
Biomedical Chromatography.2019;[Epub] CrossRef - An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere
Svetlana Pakhomova, William E. Boeglin, David B. Neau, Sue G. Bartlett, Alan R. Brash, Marcia E. Newcomer
Protein Science.2019; 28(5): 920. CrossRef - Differential expression analysis of Trichoderma virens RNA reveals a dynamic transcriptome during colonization of Zea mays roots
Elizabeth A. Malinich, Ken Wang, Prasun K. Mukherjee, Michael Kolomiets, Charles M. Kenerley
BMC Genomics.2019;[Epub] CrossRef - Carbohydrate, glutathione, and polyamine metabolism are central to Aspergillus flavus oxidative stress responses over time
Jake C. Fountain, Liming Yang, Manish K. Pandey, Prasad Bajaj, Danny Alexander, Sixue Chen, Robert C. Kemerait, Rajeev K. Varshney, Baozhu Guo
BMC Microbiology.2019;[Epub] CrossRef - How Histone Deacetylase Inhibitors Alter the Secondary Metabolites of Botryosphaeria mamane, an Endophytic Fungus Isolated from Bixa orellana
Asih Triastuti, Marieke Vansteelandt, Fatima Barakat, Manon Trinel, Patricia Jargeat, Nicolas Fabre, Carlos A. Amasifuen Guerra, Kember Mejia, Alexis Valentin, Mohamed Haddad
Chemistry & Biodiversity.2019;[Epub] CrossRef - Disturbance in biosynthesis of arachidonic acid impairs the sexual development of the onion blight pathogen Stemphylium eturmiunum
Yanxia Zhao, Qun Wang, Shi Wang, Xiaoman Liu, Jae-HyuK Yu, Weifa Zheng, Xiuguo Zhang
Current Genetics.2019; 65(3): 759. CrossRef - Recombinant Lipoxygenases and Hydroperoxide Lyases for the Synthesis of Green Leaf Volatiles
Holly Stolterfoht, Claudia Rinnofner, Margit Winkler, Harald Pichler
Journal of Agricultural and Food Chemistry.2019; 67(49): 13367. CrossRef - Riboflavin and pantothenic acid biosynthesis are crucial for iron homeostasis and virulence in the pathogenic mold Aspergillus fumigatus
Anna-Maria Dietl, Zohar Meir, Yona Shadkchan, Nir Osherov, Hubertus Haas
Virulence.2018; 9(1): 1036. CrossRef - Deciphering drought‐induced metabolic responses and regulation in developing maize kernels
Liming Yang, Jake C. Fountain, Pingsheng Ji, Xinzhi Ni, Sixue Chen, Robert D. Lee, Robert C. Kemerait, Baozhu Guo
Plant Biotechnology Journal.2018; 16(9): 1616. CrossRef - Fungal Cytochrome P450s and the P450 Complement (CYPome) of Fusarium graminearum
Jiyoung Shin, Jung-Eun Kim, Yin-Won Lee, Hokyoung Son
Toxins.2018; 10(3): 112. CrossRef - De novo assembly and comparative transcriptome analysis of Monilinia fructicola, Monilinia laxa and Monilinia fructigena, the causal agents of brown rot on stone fruits
Rita M. De Miccolis Angelini, Domenico Abate, Caterina Rotolo, Donato Gerin, Stefania Pollastro, Francesco Faretra
BMC Genomics.2018;[Epub] CrossRef - Root Exudates of Stressed Plants Stimulate and AttractTrichodermaSoil Fungi
Nadia Lombardi, Stefania Vitale, David Turrà, Massimo Reverberi, Corrado Fanelli, Francesco Vinale, Roberta Marra, Michelina Ruocco, Alberto Pascale, Giada d’Errico, Sheridan L. Woo, Matteo Lorito
Molecular Plant-Microbe Interactions®.2018; 31(10): 982. CrossRef - Comprehensive Secondary Metabolite Profiling Toward Delineating the Solid and Submerged-State Fermentation of Aspergillus oryzae KCCM 12698
Su Y. Son, Sunmin Lee, Digar Singh, Na-Rae Lee, Dong-Yup Lee, Choong H. Lee
Frontiers in Microbiology.2018;[Epub] CrossRef - Cyclooxygenases and lipoxygenases are used by the fungus Podospora anserina to repel nematodes
Roselyne Ferrari, Isabelle Lacaze, Pauline Le Faouder, Justine Bertrand-Michel, Camille Oger, Jean-Marie Galano, Thierry Durand, Stéphane Moularat, Laetitia Chan Ho Tong, Charlie Boucher, Jaafar Kilani, Yohann Petit, Océane Vanparis, César Trannoy, Sylvai
Biochimica et Biophysica Acta (BBA) - General Subjects.2018; 1862(10): 2174. CrossRef - Fungal Morphogenesis, from the Polarized Growth of Hyphae to Complex Reproduction and Infection Structures
Meritxell Riquelme, Jesús Aguirre, Salomon Bartnicki-García, Gerhard H. Braus, Michael Feldbrügge, Ursula Fleig, Wilhelm Hansberg, Alfredo Herrera-Estrella, Jörg Kämper, Ulrich Kück, Rosa R. Mouriño-Pérez, Norio Takeshita, Reinhard Fischer
Microbiology and Molecular Biology Reviews.2018;[Epub] CrossRef - Eicosanoid biosynthesis influences the virulence of Candida parapsilosis
Tanmoy Chakraborty, Ernst Thuer, Marieke Heijink, Renáta Tóth, László Bodai, Csaba Vágvölgyi, Martin Giera, Toni Gabaldón, Attila Gácser
Virulence.2018; 9(1): 1019. CrossRef - Lipoxygenase Activity Accelerates Programmed Spore Germination in Aspergillus fumigatus
Gregory J. Fischer, William Bacon, Jun Yang, Jonathan M. Palmer, Taylor Dagenais, Bruce D. Hammock, Nancy P. Keller
Frontiers in Microbiology.2017;[Epub] CrossRef - Oxylipins and oxylipin synthesis pathways in fungi
N. N. Gessler, S. Yu. Filippovich, G. P. Bachurina, E. A. Kharchenko, N. V. Groza, T. A. Belozerskaya
Applied Biochemistry and Microbiology.2017; 53(6): 628. CrossRef - Fungal manipulation of hormone-regulated plant defense
Rajesh N. Patkar, Naweed I. Naqvi, Cyril Zipfel
PLOS Pathogens.2017; 13(6): e1006334. CrossRef - Functional characterization of cytochrome P450 monooxygenases in the cereal head blight fungus Fusarium graminearum
Ji Young Shin, Duc‐Cuong Bui, Yoonji Lee, Hyejin Nam, Soyun Jung, Miao Fang, Jin‐Cheol Kim, Theresa Lee, Hun Kim, Gyung Ja Choi, Hokyoung Son, Yin‐Won Lee
Environmental Microbiology.2017; 19(5): 2053. CrossRef - Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef - Secondary metabolism in Trichoderma – Chemistry meets genomics
Susanne Zeilinger, Sabine Gruber, Ravindra Bansal, Prasun K. Mukherjee
Fungal Biology Reviews.2016; 30(2): 74. CrossRef
MSK
Cite this Article
