Abstract
			
			Human fungal pathogens that cause invasive infections are
hidden killers, taking lives of one and a half million people
every year. However, research progress in this field has not
been rapid enough to effectively prevent or treat life-threatening
fungal diseases. To update recent research progress
and promote more active research in the field of human fungal
pathogens, eleven review articles concerning the virulence
mechanisms and host interactions of four major human fungal
pathogens–Candida albicans, Cryptococcus neoformans,
Aspergillus fumigatus, and Histoplasma capsulatum–are
presented in this special issue.			
						
						
					 
		
		
		 
		
			Citations
			Citations to this article as recorded by  

- Chemical profile, antioxidant, antifungal, and cytotoxic activities of propolis from the stingless bee Tetragona clavipes
 Ariane Pinheiro Cruz Bergamini, Brendo Victor Siqueira de Almeida Bergamini, Iana Soares Pessoa, Thiago Antônio de Sousa Cutrim, Tamires Cruz dos Santos, Matheus Campos dos Santos, Victor da Rocha Fonseca, Wanderson Romão, Rodrigo Scherer, Denise Coutinho
 Brazilian Journal of Microbiology.2025; 56(1): 251.     CrossRef
- The unfolded protein response is a potential therapeutic target in pathogenic fungi
 Hao Zhou, Jinping Zhang, Rong Wang, Ju Huang, Caiyan Xin, Zhangyong Song
 The FEBS Journal.2025; 292(19): 5008.     CrossRef
- Formulation Optimization and Characterization of Bifonazole-Loaded Transethosomal Gel by 32 Factorial Design for the Treatment of Topical Fungal Infection
 Umeshkumar Dinesh Patel, Vinayak Shivamurthi Mastiholimath
 BioNanoScience.2025;[Epub]     CrossRef
- Evaluation of Ultraviolet Light-Based Oxidative Systems for the Inactivation and Change in Susceptibility of a Fluconazole-Resistant Candida albicans Strain
 Luz Dary Caicedo-Bejarano, Adriana María Correa-Bermúdez, Sandra Patricia Castro-Narváez, Efraím A. Serna-Galvis
 Water.2025; 17(16): 2448.     CrossRef
- Reactive Halogen Species Boost Fungal Spore Inactivation in Seawater during UV/PMS Treatment
 Ye Chen, Muke Lin, Zhuoyun Tang, Yuqin Wang, Dehua Xia, Zhechao Hua, Jingyun Fang, Ran Yin
 Environmental Science & Technology.2025; 59(36): 19537.     CrossRef
- Transferosomes As A Promising Platform for Targeted Antifungal Drug Delivery
 Yashmi Jain, Geetika Jain, Dakshita Dutta, Manish Yadav
 Current Fungal Infection Reports.2025;[Epub]     CrossRef
- Torsade de Pointes and QT Prolongation Among Antifungal Triazoles: A Real-World, Retrospective, Observational, Pharmacovigilance Analysis of the FDA Adverse Event Reporting System (FAERS) Database
 Long Chen, Ming-Jia Liu, Song Wang, Dan Yang, Nan-Nan Ding, Ji Zhang
 Cardiovascular Toxicology.2025; 25(10): 1616.     CrossRef
- Humans vs. Fungi: An Overview of Fungal Pathogens against Humans
 Kasun M. Thambugala, Dinushani A. Daranagama, Danushka S. Tennakoon, Dona Pamoda W. Jayatunga, Sinang Hongsanan, Ning Xie
 Pathogens.2024; 13(5): 426.     CrossRef
- Active monitoring of antifungal adverse events in hospitalized patients based on Global Trigger Tool method
 Xiao Meng, Yaozhou Wu, Zixuan Liu, Yifan Chen, Zhizhou Dou, Li Wei
 Frontiers in Pharmacology.2024;[Epub]     CrossRef
- Interplay of host-immunity in fungal eye infections
 Piyush Baindara, Santi M. Mandal
 Fungal Biology Reviews.2024; 48: 100357.     CrossRef
- Cytotoxicity, antifungal and antioxidant properties of Lonchocarpus capassa leaf extracts
 Tambudzani C. Machaba, Salome Mahlo, Jacobus Eloff, Winston Nxumalo, Lyndy McGaw
 Journal of Medicinal Plants for Economic Development.2024;[Epub]     CrossRef
- Alternative and Classical Processes for Disinfection of Water Polluted by Fungi: A Systematic Review
 Luz Dary Caicedo-Bejarano, Alejandra Morante-Caicedo, Sandra Patricia Castro-Narváez, Efraím A. Serna-Galvis
 Water.2024; 16(7): 936.     CrossRef
- IRF7 Exacerbates Candida albicans Infection by Compromising CD209-Mediated Phagocytosis and Autophagy-Mediated Killing in Macrophages
 Furong Qing, Lina Sui, Wenji He, Yayun Chen, Li Xu, Liangmei He, Qiuxiang Xiao, Tianfu Guo, Zhiping Liu
 The Journal of Immunology.2024; 212(12): 1932.     CrossRef
- Verapamil enhances the activity of Caspofungin against Cryptococcus neoformans, coinciding with inhibited Ca2+/CN pathway and damage to cell wall integrity
 Xinyuan Peng, Qingtao Kong, Qian Wei, Shilin Guo, Qiying Chen, Min Peng, Binyi An, Xiaoyu Wang, Chen Zhang, Hong Sang
 International Journal of Antimicrobial Agents.2024; 64(4): 107303.     CrossRef
- 
            Cathelicidin boosts the antifungal activity of neutrophils and improves prognosis during
            Aspergillus fumigatus
            keratitis
          
 Xiaochen Hou, Cui Li, Jingyi Liu, Shanshan Yang, Xudong Peng, Qian Wang, Chengxiu Liu, Xing Liu, Junjie Luan, Guiqiu Zhao, Jing Lin, Mairi C. Noverr
 Infection and Immunity.2024;[Epub]     CrossRef
- Development, Optimization, and In Vitro/In Vivo Evaluation of Azelaic Acid Transethosomal Gel for Antidermatophyte Activity
 Ali M. Nasr, Noha M. Badawi, Yasmine H. Tartor, Nader M. Sobhy, Shady A. Swidan
 Antibiotics.2023; 12(4): 707.     CrossRef
- PU.1-CD23 signaling mediates pulmonary innate immunity against Aspergillus fumigatus infection by driving inflammatory response
 Min Wang, Ming Zhang, Jiayong Qiu, Chenyang Liu, Yao Lou, Tongsheng Wang, Yingmin Zhang, Yimin Mao
 BMC Immunology.2023;[Epub]     CrossRef
- Matrix-assisted laser desorption/ionisation-time of flight mass spectrometry azole susceptibility assessment in Candida and Aspergillus species
 Ana Luisa Perini Leme Giordano, Lais Pontes, Caio Augusto Gualtieri Beraquet, Luzia Lyra, Angelica Zaninelli Schreiber
 Memórias do Instituto Oswaldo Cruz.2023;[Epub]     CrossRef
- A parallel and silent emerging pandemic: Antimicrobial resistance (AMR) amid COVID-19 pandemic
 Suriya Rehman
 Journal of Infection and Public Health.2023; 16(4): 611.     CrossRef
- Current Insights in Fungal Importance—A Comprehensive Review
 Viorica Maria Corbu, Irina Gheorghe-Barbu, Andreea Ștefania Dumbravă, Corneliu Ovidiu Vrâncianu, Tatiana Eugenia Șesan
 Microorganisms.2023; 11(6): 1384.     CrossRef
- Clinical infections in neurosurgical oncology: An overview
 Tomaz Velnar, Nina Kocivnik, Roman Bosnjak
 World Journal of Clinical Cases.2023; 11(15): 3418.     CrossRef
- The effect of herbal medicine in innate immunity to Candida albicans
 Meng-Yuan Bao, Ming Li, Qing-Ru Bu, Yue Yang, Hang Song, Chang-Zhong Wang, Tian-Ming Wang, Ning Li
 Frontiers in Immunology.2023;[Epub]     CrossRef
- Betulinic acid and Drummondin E: Potential inhibitors of Unfolded Protein Response Pathway of Candida auris
 Nahid Akhtar, Amit Joshi, Vikas Kaushik, Sangeetha Mohan, M. Amin-ul Mannan
 Research Journal of Pharmacy and Technology.2023; : 2867.     CrossRef
- Understanding the Roles of Host Defense Peptides in Immune Modulation: From Antimicrobial Action to Potential as Adjuvants
 Ju Kim, Byeol-Hee Cho, Yong-Suk Jang
 Journal of Microbiology and Biotechnology.2023; 33(3): 288.     CrossRef
- Bacillus Metabolites: Compounds, Identification and Anti-Candida albicans Mechanisms
 Weichen Wang, Jin Zhao, Zhizi Zhang
 Microbiology Research.2022; 13(4): 972.     CrossRef
- Uncommon case of histoplasmosis with oral manifestation: A case report of diagnosis in a South American patient
 Letícia Copatti Dogenski, Eduarda Mafaciolli Pasqualotto, Mateus José Dutra, Gisele Rovani, Micheline Sandini Trentin, João Paulo De Carli
 International Journal of Surgery Case Reports.2022; 93: 106920.     CrossRef
- Oral delivery of butoconazole nitrate nanoparticles for systemic treatment of chronic paracoccidioidomycosis: A future aspect
 Tasleem, Nithya Shanthi, Arun Kumar Mahato, Richa Bahuguna
 Journal of Drug Delivery Science and Technology.2022; 77: 103808.     CrossRef
- Time to Conquer Fungal Infectious Diseases: Employing Nanoparticles as Powerful and Versatile Antifungal Nanosystems against a Wide Variety of Fungal Species
 Ali Jangjou, Zahra Zareshahrabadi, Milad Abbasi, Amirreza Talaiekhozani, Hesam Kamyab, Shreeshivadasan Chelliapan, Ahmad Vaez, Ali Golchin, Lobat Tayebi, Ehsan Vafa, Ali Mohammad Amani, Hossein Faramarzi
 Sustainability.2022; 14(19): 12942.     CrossRef
- Does the technical methodology influence the quality attributes and the potential of skin permeation of Luliconazole loaded transethosomes?
 Mahmoud M. El-Sonbaty, Mohamed A. Akl, Khalid M. El-Say, Alaa A. Kassem
 Journal of Drug Delivery Science and Technology.2022; 68: 103096.     CrossRef
- Guanylated Hyperbranched Polylysines with High In Vitro and In Vivo Antifungal Activity
 Xiao Liu, Yilong Yang, Miaomiao Han, Jianwei Guo, Hui Liu, Yadong Liu, Junjie Xu, Shengxiang Ji, Xuesi Chen
 Advanced Healthcare Materials.2022;[Epub]     CrossRef
- The Role of the Glutathione System in Stress Adaptation, Morphogenesis and Virulence of Pathogenic Fungi
 Tanaporn Wangsanut, Monsicha Pongpom
 International Journal of Molecular Sciences.2022; 23(18): 10645.     CrossRef
- HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3
 Han Wu, Xiaofan Yin, Xibao Zhao, Zherui Wu, Yue Xiao, Qianqian Di, Ping Sun, Haimei Tang, Jiazheng Quan, Weilin Chen
 Redox Biology.2022; 56: 102461.     CrossRef
- Pre-Exposure With Extracellular Vesicles From Aspergillus fumigatus Attenuates Inflammatory Response and Enhances Fungal Clearance in a Murine Model Pulmonary Aspergillosis
 Jéssica Amanda Marques Souza, Isabella Luísa da Silva Gurgel, Nathália Luísa Sousa de Oliveira Malacco, Flávia Rayssa Braga Martins, Celso Martins Queiroz-Junior, Mauro Martins Teixeira, Frederico Marianetti Soriani
 Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
- The emerging role of neutrophil extracellular traps in fungal infection
 Chuting Liang, Ni Lian, Min Li
 Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
- Permanent, Antimicrobial Coating to Rapidly Kill and Prevent Transmission of Bacteria, Fungi, Influenza, and SARS-CoV-2
 Sreyan Ghosh, Riya Mukherjee, Vinay S. Mahajan, Julie Boucau, Shiv Pillai, Jayanta Haldar
 ACS Applied Materials & Interfaces.2022; 14(37): 42483.     CrossRef
- Antifungal Activity of the Frog Skin Peptide Temporin G and Its Effect on Candida albicans Virulence Factors
 Felicia Diodata D’Auria, Bruno Casciaro, Marta De Angelis, Maria Elena Marcocci, Anna Teresa Palamara, Lucia Nencioni, Maria Luisa Mangoni
 International Journal of Molecular Sciences.2022; 23(11): 6345.     CrossRef
- WITHDRAWN: Fatty acid dioxygenase-cytochrome P450 fusion enzymes of the top 10 fungal pathogens in molecular plant pathology and human-pathogenic fungi
 Ernst H. Oliw
 Fungal Genetics and Biology.2021; : 103603.     CrossRef
- MYO1F regulates antifungal immunity by regulating acetylation of microtubules
 Wanwei Sun, Xiaojian Ma, Heping Wang, Yanyun Du, Jianwen Chen, Huijun Hu, Ru Gao, Ruirui He, Qianwen Peng, Zhihui Cui, Huazhi Zhang, Junhan Wang, Xinming Jia, Bradley N. Martin, Cun-Jin Zhang, Xiaoxia Li, Chenhui Wang
 Proceedings of the National Academy of Sciences.2021;[Epub]     CrossRef
- Solubility enhancement, formulation development and antifungal activity of luliconazole niosomal gel-based system
 Ashish Kumar Garg, Balaji Maddiboyina, Mohammed Hamed Saeed Alqarni, Aftab Alam, Hibah M. Aldawsari, Pinki Rawat, Sima Singh, Prashant Kesharwani
 Journal of Biomaterials Science, Polymer Edition.2021; 32(8): 1009.     CrossRef
- Preclinical safety evaluation of amphotericin A21: A novel antifungal
 Ivan Ortega‐Blake, Mario Fernández‐Zertuche, Ignacio Regla, Walfred Sánchez‐Peña, Antonieta Gómez‐Solis, Paola Jaimes‐Chavez, Arturo Galván‐Hernández, Erika Tovar‐Garduño, Lourdes Rodríguez‐Fragoso
 Basic & Clinical Pharmacology & Toxicology.2021; 129(1): 72.     CrossRef
- Antimicrobial Peptides: The Promising Therapeutics for Cutaneous Wound Healing
 Fengze Miao, Ying Li, Zongguang Tai, Yong Zhang, Yue Gao, Menghong Hu, Quangang Zhu
 Macromolecular Bioscience.2021;[Epub]     CrossRef
- The transcription factor Cas5 suppresses hyphal morphogenesis during yeast-form growth in Candida albicans
 Jong-Myeong Kim, Hye Yun Moon, Dong Wook Lee, Hyun Ah Kang, Jeong-Yoon Kim
 Journal of Microbiology.2021; 59(10): 911.     CrossRef
- Antifungal activity of thiosemicarbazones, bis(thiosemicarbazones), and their metal complexes
 Kritika Bajaj, Robert M. Buchanan, Craig A. Grapperhaus
 Journal of Inorganic Biochemistry.2021; 225: 111620.     CrossRef
- Fatty acid dioxygenase-cytochrome P450 fusion enzymes of filamentous fungal pathogens
 Ernst H. Oliw
 Fungal Genetics and Biology.2021; 157: 103623.     CrossRef
- Membrane-Interacting Antifungal Peptides
 Caroline Struyfs, Bruno P. A. Cammue, Karin Thevissen
 Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
- Aspergillus fumigatus In-Host HOG Pathway Mutation for Cystic Fibrosis Lung Microenvironment Persistence
 Brandon S. Ross, Lotus A. Lofgren, Alix Ashare, Jason E. Stajich, Robert A. Cramer, J. Andrew Alspaugh
 mBio.2021;[Epub]     CrossRef
- Nanomaterial-Based Antifungal Therapies to Combat Fungal Diseases Aspergillosis, Coccidioidomycosis, Mucormycosis, and Candidiasis
 Angel León-Buitimea, Javier A. Garza-Cervantes, Diana Y. Gallegos-Alvarado, Macario Osorio-Concepción, José Ruben Morones-Ramírez
 Pathogens.2021; 10(10): 1303.     CrossRef
- Cathelicidin-inspired antimicrobial peptides as novel antifungal compounds
 Martin van Eijk, Stephanie Boerefijn, Lida Cen, Marisela Rosa, Marnix J H Morren, Cornelis K van der Ent, Bart Kraak, Jan Dijksterhuis, Ivan D Valdes, Henk P Haagsman, Hans de Cock
 Medical Mycology.2020; 58(8): 1073.     CrossRef
- Broad-Spectrum Antimicrobial and Antibiofilm Activity of a Natural Clay Mineral from British Columbia, Canada
 Shekooh Behroozian, Sarah L. Svensson, Loretta Y. Li, Julian E. Davies, Pascale F. Cossart
 mBio.2020;[Epub]     CrossRef
- Antimicrobial host defence peptides: functions and clinical potential
 Neeloffer Mookherjee, Marilyn A. Anderson, Henk P. Haagsman, Donald J. Davidson
 Nature Reviews Drug Discovery.2020; 19(5): 311.     CrossRef
- Alteration of Fermentative Metabolism Enhances Mucor circinelloides Virulence
 Sharel P. Díaz-Pérez, J. Alberto Patiño-Medina, Marco I. Valle-Maldonado, Adolfo López-Torres, Irvin E. Jácome-Galarza, Verónica Anaya-Martínez, Verónica Gómez-Ruiz, Jesús Campos-García, Rosa E. Nuñez-Anita, Rafael Ortiz-Alvarado, Martha I. Ramírez-Díaz,
 Infection and Immunity.2020;[Epub]     CrossRef
- Fungal evolution: major ecological adaptations and evolutionary transitions
 Miguel A. Naranjo‐Ortiz, Toni Gabaldón
 Biological Reviews.2019; 94(4): 1443.     CrossRef
- 
            Acute Lung Injury and Repair Induced by Single Exposure of
            Aspergillus Fumigatus
            in Immunocompetent Mice
          
 Nathália L S O Malacco, Jéssica A M Souza, Aline C Mendes, Milene A Rachid, Lucas R Kraemer, Matheus S Mattos, Graziele N Lima, Lirlândia P Sousa, Daniele G Souza, Vanessa Pinho, Mauro M Teixeira, Remo C Russo, Frederico M Soriani
 Future Microbiology.2019; 14(17): 1511.     CrossRef
- Aspergillus fumigatus phosphoethanolamine transferase gene gpi7 is required for proper transportation of the cell wall GPI-anchored proteins and polarized growth
 Haomiao Ouyang, Ting Du, Hui Zhou, Iain B. H. Wilson, Jinghua Yang, Jean-Paul Latgé, Cheng Jin
 Scientific Reports.2019;[Epub]     CrossRef
- Characterization of fungal biodiversity and communities associated with the reef macroalga Sargassum ilicifolium reveals fungal community differentiation according to geographic locality and algal structure
 Benjamin J. Wainwright, Andrew G. Bauman, Geoffrey L. Zahn, Peter A. Todd, Danwei Huang
 Marine Biodiversity.2019; 49(6): 2601.     CrossRef
- Glycobiology of Human Fungal Pathogens: New Avenues for Drug Development
 Danielle J. Lee, Holly O’Donnell, Françoise H. Routier, Joe Tiralongo, Thomas Haselhorst
 Cells.2019; 8(11): 1348.     CrossRef
- Fungal dissemination is limited by liver macrophage filtration of the blood
 Donglei Sun, Peng Sun, Hongmei Li, Mingshun Zhang, Gongguan Liu, Ashley B. Strickland, Yanli Chen, Yong Fu, Juan Xu, Mohammed Yosri, Yuchen Nan, Hong Zhou, Xiquan Zhang, Meiqing Shi
 Nature Communications.2019;[Epub]     CrossRef
- Intracellular cAMP Measurements in Candida albicans Biofilms
 Liuliu Jiang, Shengyan Chen, Kairui Sun, Peng Zhou, Xin Wei
 BIO-PROTOCOL.2019;[Epub]     CrossRef
- Linolenic Acid-Modified MPEG-PEI Micelles for Encapsulation of Amphotericin B
 Hongmei Xu, Fangfang Teng, Feilong Zhou, Li Zhu, Yi Wen, Runliang Feng, Zhimei Song
 Future Medicinal Chemistry.2019; 11(20): 2647.     CrossRef
- Design, synthesis, and evaluation of novel 2-substituted 1,4-benzenediol library as antimicrobial agents against clinically relevant pathogens
 Daiane Flores Dalla Lana, Bruna Gerardon Batista, Gabriella da Rosa Machado, Mário Lettieri Teixeira, Luís Flávio Souza de Oliveira, Michel Mansur Machado, Saulo Fernandes de Andrade, William Lopes, Marilene Henning Vainstein, Alejandro Peixoto de Abreu L
 Saudi Pharmaceutical Journal.2019; 27(8): 1064.     CrossRef
- Vesicular nanocarrier based treatment of skin fungal infections: Potential and emerging trends in nanoscale pharmacotherapy
 Shivani Verma, Puneet Utreja
 Asian Journal of Pharmaceutical Sciences.2019; 14(2): 117.     CrossRef
- Comparison of Two Molecular Assays for Detection and Characterization of Aspergillus fumigatus Triazole Resistance and Cyp51A Mutations in Clinical Isolates and Primary Clinical Samples of Immunocompromised Patients
 Patricia Postina, Julian Skladny, Tobias Boch, Oliver A. Cornely, Axel Hamprecht, Peter-Michael Rath, Jörg Steinmann, Oliver Bader, Thomas Miethke, Anne Dietz, Natalia Merker, Wolf-Karsten Hofmann, Dieter Buchheidt, Birgit Spiess
 Frontiers in Microbiology.2018;[Epub]     CrossRef
- Cryptic Aspergillus from clinical samples in the USA and description of a new species in section Flavipedes
 João P. Z. Siqueira, Nathan Wiederhold, Josepa Gené, Dania García, Margarete T. G. Almeida, Josep Guarro
 Mycoses.2018; 61(11): 814.     CrossRef
- Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
 Ewa Bielska, Marta Arch Sisquella, Maha Aldeieg, Charlotte Birch, Eloise J. O’Donoghue, Robin C. May
 Nature Communications.2018;[Epub]     CrossRef
- Fungi-Induced Upper and Lower Respiratory Tract Allergic Diseases: One Entity
 Aleksandra Barac, David S. Y. Ong, Ljiljana Jovancevic, Aleksandar Peric, Pavol Surda, Vesna Tomic Spiric, Salvatore Rubino
 Frontiers in Microbiology.2018;[Epub]     CrossRef
- Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity
 Dayanira Alsina‐Beauchamp, Alejandra Escós, Pilar Fajardo, Diego González‐Romero, Ester Díaz‐Mora, Ana Risco, Miguel A Martín‐Serrano, Carlos del Fresno, Jorge Dominguez‐Andrés, Noelia Aparicio, Rafal Zur, Natalia Shpiro, Gordon D Brown, Carlos Ardavín, M
 EMBO Molecular Medicine.2018;[Epub]     CrossRef
- The Interaction of Human Pathogenic Fungi With C-Type Lectin Receptors
 Surabhi Goyal, Juan Camilo Castrillón-Betancur, Esther Klaile, Hortense Slevogt
 Frontiers in Immunology.2018;[Epub]     CrossRef
- JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression
 Xueqiang Zhao, Yahui Guo, Changying Jiang, Qing Chang, Shilei Zhang, Tianming Luo, Bin Zhang, Xinming Jia, Mien-Chie Hung, Chen Dong, Xin Lin
 Nature Medicine.2017; 23(3): 337.     CrossRef
- Identification of Fungal Species in Brain Tissue from Alzheimer’s Disease by Next-Generation Sequencing
 Ruth Alonso, Diana Pisa, Begoña Aguado, Luis Carrasco
 Journal of Alzheimer's Disease.2017; 58(1): 55.     CrossRef
- Nanoparticles as safe and effective delivery systems of antifungal agents: Achievements and challenges
 Ghareb M. Soliman
 International Journal of Pharmaceutics.2017; 523(1): 15.     CrossRef
- Conclusion and future perspectives on antifungal stewardship
 Jose María Aguado, Jose Tiago Silva, Emilio Bouza
 Journal of Antimicrobial Chemotherapy.2016; 71(suppl 2): ii43.     CrossRef