Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling

Praveen Rai; Drista Sharma; Rani Soni; Nazia Khatoon; Bhaskar Sharma; Tarun Kumar Bhatt

doi:10.1007/s12275-017-6525-1

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Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling: Praveen Rai , Drista Sharma , Rani Soni , Nazia Khatoon , Bhaskar Sharma , Tarun Kumar Bhatt; Journal of Microbiology 2017;55(4):231-236.
DOI: https://doi.org/10.1007/s12275-017-6525-1
Published online: March 1, 2017

School of Life Science, Department of Biotechnology, Central University of Rajasthan, BandarSindri, Ajmer, Rajasthan, 305817, IndiaSchool of Life Science, Department of Biotechnology, Central University of Rajasthan, BandarSindri, Ajmer, Rajasthan, 305817, India

Corresponding author: Tarun Kumar Bhatt , Tel: +919928920412,

Received: 13 October 2016 • Revised: 23 December 2016 • Accepted: 23 December 2016

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Abstract

Malaria has been present since ancient time and remains a major global health problem in developing countries. Plas-modium falciparum belongs to the phylum Apicomplexan, largely contain disease-causing parasites and characterized by the presence of apicoplast. It is a very essential organelle of P. falciparum responsible for the synthesis of key mole-cules required for the growth of the parasite. Indispensable nature of apicoplast makes it a potential drug target. Calcium signaling is important in the establishment of malaria para-site inside the host. It has been involved in invasion and egress of merozoites during the asexual life cycle of the parasite. Calcium signaling also regulates apicoplast metabolism. There-fore, in this review, we will focus on the role of apicoplast in malaria biology and its metabolic regulation through Ca++ signaling.

Keywords: malaria;Plasmodium falciparum;apicoplast;cal-cium signaling;transcription regulation

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Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling

J. Microbiol. 2017;55(4):231-236. Published online March 1, 2017

DOI: https://doi.org/10.1007/s12275-017-6525-1

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