Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis

Ji-Chan Jang; Yong-Gyun Jung; Jungil Choi; Hyunju Jung; Sungweon Ryoo

doi:10.1007/s12275-017-6630-1

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Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis: Ji-Chan Jang ^1,2, Yong-Gyun Jung ^3,4,5, Jungil Choi ⁶, Hyunju Jung ⁷, Sungweon Ryoo ^7,8; Journal of Microbiology 2017;55(6):483-487
DOI: https://doi.org/10.1007/s12275-017-6630-1
Published online: April 20, 2017

¹Molecular Mechanisms of Antibiotics, Division of Life Science, ²Research Institute of Life Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea, ³Interdisciplinary Program of Biomodulation, College of Natural Science, ⁴Myongji Bioefficiency Research Centre, ⁵Center for Nutraceutical and Pharmaceutical Materials, Myongji University, Yongin 17058, Republic of Korea, ⁶Department of Materials Science and Engineering Northwestern University Evanston, IL 60208, USA, ⁷Korean Institute of Tuberculosis, Osong 28158, Republic of Korea, ⁸Korean National Tuberculosis Association, Seoul 06763, Republic of Korea¹Molecular Mechanisms of Antibiotics, Division of Life Science, ²Research Institute of Life Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea, ³Interdisciplinary Program of Biomodulation, College of Natural Science, ⁴Myongji Bioefficiency Research Centre, ⁵Center for Nutraceutical and Pharmaceutical Materials, Myongji University, Yongin 17058, Republic of Korea, ⁶Department of Materials Science and Engineering Northwestern University Evanston, IL 60208, USA, ⁷Korean Institute of Tuberculosis, Osong 28158, Republic of Korea, ⁸Korean National Tuberculosis Association, Seoul 06763, Republic of Korea

Corresponding author: Sungweon Ryoo , Tel: +82-10-3068-1815,

Received: 13 December 2016 • Revised: 26 January 2017 • Accepted: 27 February 2017

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Abstract

This study aimed to provide information that bedaquilline is significantly effective for treatment of totally drug resistant (TDR) Mycobacterium tuberculosis that shows resistant to all first- and second-line drugs-using an innovative disc agarose channel (DAC) system. Time-lapse images of single bacterial cells under culture conditions with different concentrations of bedaquiline were analysed by image processing software to determine minimum inhibitory concentrations (MICs). Bedaquiline inhibited the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L. The results of the present study demonstrate that bedaquiline, newly approved by the United States Food and Drug Admi-nistration (FDA), may offer therapeutic solutions for TDR -TB.

Keywords: bedaquiline; Mycobacterium tuberculosis; totally drug resistant Mycobacterium tuberculosis

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Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis

J. Microbiol. 2017;55(6):483-487. Published online April 20, 2017

DOI: https://doi.org/10.1007/s12275-017-6630-1

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