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[Minireview] Unraveling new functions of superoxide dismutase using yeast model system: Beyond its conventional role in superoxide radical scavenging
Woo-Hyun Chung1 , 2
Journal of Microbiology 2017;55(6):409-416.
DOI: https://doi.org/10.1007/s12275-017-6647-5
Published online: March 9, 2017
College of Pharmacy, Innovative Drug Center, Duksung Women’s University, Seoul 01369, Republic of KoreaCollege of Pharmacy, Innovative Drug Center, Duksung Women’s University, Seoul 01369, Republic of Korea
Corresponding author:  2 , Tel: +82-2-901-8737, 
Received: 17 December 2016   • Revised: 31 January 2017   • Accepted: 31 January 2017
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Abstract

To deal with chemically reactive oxygen molecules constantly threatening aerobic life, cells are readily equipped with elabo-rate biological antioxidant systems. Superoxide dismutase is a metalloenzyme catalytically eliminating superoxide radi-cal as a first-line defense mechanism against oxidative stress. Multiple different SOD isoforms have been developed through-out evolution to play distinct roles in separate subcellular com-partments. SOD is not essential for viability of most aerobic organisms and intriguingly found even in strictly anaerobic bacteria. Sod1 has recently been known to play important roles as a nuclear transcription factor, an RNA binding pro-tein, a synthetic lethal interactor, and a signal modulator in glucose metabolism, most of which are independent of its canonical function as an antioxidant enzyme. In this review, recent advances in understanding the unconventional role of Sod1 are highlighted and discussed with an emphasis on its genetic crosstalk with DNA damage repair/checkpoint path-ways. The budding yeast Saccharomyces cerevisiae has been successfully used as an efficient tool and a model organism to investigate a number of novel functions of Sod1.

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    [Minireview] Unraveling new functions of superoxide dismutase using yeast model system: Beyond its conventional role in superoxide radical scavenging
    J. Microbiol. 2017;55(6):409-416.   Published online March 9, 2017
    DOI: https://doi.org/10.1007/s12275-017-6647-5
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