Abstract
Organisms living in extreme environments have evolved a
wide range of survival strategies by changing biochemical and
physiological features depending on their biological niches.
Interestingly, organisms exhibiting high radiation resistance
have been discovered in the three domains of life (Bacteria,
Archaea, and Eukarya), even though a naturally radiationintensive
environment has not been found. To counteract
the deleterious effects caused by radiation exposure, radiation-
resistant organisms employ a series of defensive systems,
such as changes in intracellular cation concentration, excellent
DNA repair systems, and efficient enzymatic and non-enzymatic
antioxidant systems. Here, we overview past and recent
findings about radiation-resistance mechanisms in the
three domains of life for potential usage of such radiationresistant
microbes in the biotechnology industry.
Citations
Citations to this article as recorded by

- The planetary protection strategy of Mars Sample Return’s Earth Return Orbiter mission
Giuseppe Cataldo, Lorenz Affentranger, Brian G. Clement, Daniel P. Glavin, David W. Hughes, John Hall, Bruno Sarli, Christine E. Szalai
Journal of Space Safety Engineering.2024; 11(2): 374. CrossRef - Insights into the Impact of Physicochemical and Microbiological Parameters on the Safety Performance of Deep Geological Repositories
Mar Morales-Hidalgo, Cristina Povedano-Priego, Marcos F. Martinez-Moreno, Miguel A. Ruiz-Fresneda, Margarita Lopez-Fernandez, Fadwa Jroundi, Mohamed L. Merroun
Microorganisms.2024; 12(5): 1025. CrossRef - Wireless Battery-free and Fully Implantable Organ Interfaces
Aman Bhatia, Jessica Hanna, Tucker Stuart, Kevin Albert Kasper, David Marshall Clausen, Philipp Gutruf
Chemical Reviews.2024; 124(5): 2205. CrossRef - Editorial: Rising stars in fungal pathogenesis: 2023
Brian L. Wickes, Adriana Marcela Celis Ramírez, Michal A. Olszewski, Yong-Sun Bahn
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef - WP15 ConCorD state-of-the-art report (container corrosion under disposal conditions)
Andrés G. Muñoz, Abdesselam Abdelouas, Ursula Alonso, Ana María Fernández, Rizlan Bernier-Latmani, Andrea Cherkouk, Roberto Gaggiano, James Hesketh, Nick Smart, Cristiano Padovani, Kristel Mijnendonckx, Vanessa Montoya, Andrés Idiart, Arnau Pont, Olga Rib
Frontiers in Nuclear Engineering.2024;[Epub] CrossRef - Relationships between radiation, wildfire and the soil microbial communities in the Chornobyl Exclusion Zone
Alexandre Barretto de Menezes, Sergii Gashchak, Michael D. Wood, Nicholas A. Beresford
Science of The Total Environment.2024; 950: 175381. CrossRef -
UV-B Halotolerant Bacteria from Marakkanam Saltpan and Biology of UV-B Tolerant
Pontibacillus salipaludis
Based on Whole Genome Sequencing
Amit Kumar
Geomicrobiology Journal.2024; 41(2): 183. CrossRef - Unraveling radiation resistance strategies in two bacterial strains from the high background radiation area of Chavara-Neendakara: A comprehensive whole genome analysis
Sowptika Pal, Ramani Yuvaraj, Hari Krishnan, Balasubramanian Venkatraman, Jayanthi Abraham, Anilkumar Gopinathan, Hari S. Misra
PLOS ONE.2024; 19(6): e0304810. CrossRef - Optimization Function for Determining Optimal Dose Range for Beef and Seed Potato Irradiation
Elena Kozlova, Ulyana Bliznyuk, Alexander Chernyaev, Polina Borshchegovskaya, Arcady Braun, Victoria Ipatova, Sergey Zolotov, Alexander Nikitchenko, Natalya Chulikova, Anna Malyuga, Yana Zubritskaya, Timofey Bolotnik, Anastasia Oprunenko, Aleksandr Kozlov
Foods.2024; 13(23): 3729. CrossRef - Impact of microbial processes on the safety of deep geological repositories for radioactive waste
Miguel A. Ruiz-Fresneda, Marcos F. Martinez-Moreno, Cristina Povedano-Priego, Mar Morales-Hidalgo, Fadwa Jroundi, Mohamed L. Merroun
Frontiers in Microbiology.2023;[Epub] CrossRef - Ionizing radiation effects on microorganisms and its applications in the food industry
Emmanuel Kormla Danyo, Maria Ivantsova, Irina Selezneva
Foods and Raw Materials.2023; 12(1): 1. CrossRef - Impact of radioactive contamination of soils on the diversity of micropopulation and the transformation of organic substances
I. Gudkov, I. Volkohon, V. Illienko, M. Lazarev, A. Klepko
Agricultural Science and Practice.2023; 9(3): 3. CrossRef - Aging of fuel-containing materials (fuel debris) in the Chornobyl (Chernobyl) Nuclear Power Plant and its implication for the decommissioning of the Fukushima Daiichi Nuclear Power Station
Toru Kitagaki, Viktor A. Krasnov, Atsushi Ikeda-Ohno
Journal of Nuclear Materials.2023; 576: 154224. CrossRef - Impact of ionizing radiation on the environmental microbiomes of Chornobyl wetlands
Elin Videvall, Pablo Burraco, Germán Orizaola
Environmental Pollution.2023; 330: 121774. CrossRef - Geography and environmental pressure are predictive of class‐specific radioresistance in black fungi
Lorenzo Aureli, Claudia Coleine, Manuel Delgado‐Baquerizo, Dag Ahren, Alessia Cemmi, Ilaria Di Sarcina, Silvano Onofri, Laura Selbmann
Environmental Microbiology.2023; 25(12): 2931. CrossRef - Wort disinfection treatment with electron beam for bioethanol production
Rubens Perez Calegari, Eric Alberto da Silva, Ana Paula Maria da Silva, Marcelo Pego Gomes, Layna Amorim Mota, Valter Arthur, Antonio Sampaio Baptista
Scientia Agricola.2023;[Epub] CrossRef - Redox status and metabolomic profiling of thioredoxin reductase inhibitors and 4 kGy ionizing radiation-exposed Deinococcus radiodurans
M. Sudharsan, N. Rajendra Prasad, G. Kanimozhi, B.S. Rishiikeshwer, G.R. Brindha, Anindita Chakraborty
Microbiological Research.2022; 261: 127070. CrossRef -
Sphingomonas radiodurans sp. nov., a novel radiation-resistant bacterium isolated from the north slope of Mount Everest
Yang Liu, Tuo Chen, Xiaowen Cui, Yeteng Xu, Shixin Hu, Yidan Zhao, Wei Zhang, Guangxiu Liu, Gaosen Zhang
International Journal of Systematic and Evolutionary Microbiology
.2022;[Epub] CrossRef - Sequence, structure, and function of the Dps DNA-binding protein from Deinococcus wulumuqiensis R12
Yao Chen, Zhihan Yang, Xue Zhou, Mengmeng Jin, Zijie Dai, Dengming Ming, Zhidong Zhang, Liying Zhu, Ling Jiang
Microbial Cell Factories.2022;[Epub] CrossRef - PCNA from Thermococcus gammatolerans: A protein involved in chromosomal DNA metabolism intrinsically resistant at high levels of ionizing radiation
Yerli Marín‐Tovar, Hugo Serrano‐Posada, Adelaida Díaz‐Vilchis, Enrique Rudiño‐Piñera
Proteins: Structure, Function, and Bioinformatics.2022; 90(9): 1684. CrossRef - An insight into the mechanisms of homeostasis in extremophiles
Adithi Somayaji, Chetan Roger Dhanjal, Rathnamegha Lingamsetty, Ramesh Vinayagam, Raja Selvaraj, Thivaharan Varadavenkatesan, Muthusamy Govarthanan
Microbiological Research.2022; 263: 127115. CrossRef - Synthetic fungal melanin nanoparticles with excellent antioxidative property
Hengjie Zhang, Chuhao Huang, Jianhua Zhang, Chao Wang, Tianyou Wang, Shun Shi, Zhipeng Gu, Yiwen Li
Giant.2022; 12: 100120. CrossRef - Genomic Insights into the Radiation-Resistant Capability of Sphingomonas qomolangmaensis S5-59T and Sphingomonas glaciei S8-45T, Two Novel Bacteria from the North Slope of Mount Everest
Yang Liu, Xiaowen Cui, Ruiqi Yang, Yiyang Zhang, Yeteng Xu, Guangxiu Liu, Binglin Zhang, Jinxiu Wang, Xinyue Wang, Wei Zhang, Tuo Chen, Gaosen Zhang
Microorganisms.2022; 10(10): 2037. CrossRef - Response of soil microbial communities to natural radionuclides along specific-activity gradients
Guangwen Feng, Jinlong Yong, Qian Liu, Henglei Chen, Peihong Mao
Ecotoxicology and Environmental Safety.2022; 246: 114156. CrossRef - Questioning the radiation limits of life: Ignicoccus hospitalis between replication and VBNC
Dagmar Koschnitzki, Ralf Moeller, Stefan Leuko, Bartos Przybyla, Kristina Beblo-Vranesevic, Reinhard Wirth, Harald Huber, Reinhard Rachel, Petra Rettberg
Archives of Microbiology.2021; 203(4): 1299. CrossRef - Global Warming, Climate Change, and Environmental Pollution: Recipe for a Multifactorial Stress Combination Disaster
Sara I. Zandalinas, Felix B. Fritschi, Ron Mittler
Trends in Plant Science.2021; 26(6): 588. CrossRef - The Transcriptomic and Phenotypic Response of the Melanized Yeast Exophiala dermatitidis to Ionizing Particle Exposure
Zachary Schultzhaus, Amy Chen, Igor Shuryak, Zheng Wang
Frontiers in Microbiology.2021;[Epub] CrossRef - Genomic characterization and proteomic analysis of the halotolerant Micrococcus luteus SA211 in response to the presence of lithium
Fabiana Lilian Martínez, Verónica Beatriz Rajal, Verónica Patricia Irazusta
Science of The Total Environment.2021; 785: 147290. CrossRef - Helical and linear morphotypes ofArthrospirasp. PCC 8005 display genomic differences and respond differently to60Co gamma irradiation
Anu Yadav, Pieter Monsieurs, Agnieszka Misztak, Krzysztof Waleron, Natalie Leys, Ann Cuypers, Paul J. Janssen
European Journal of Phycology.2020; 55(2): 129. CrossRef - Gamma Radiation Tolerance and Protein Carbonylation Caused by Irradiation of Resting Cysts in the Free-living Ciliated Protist Colpoda cucullus
Ryota Saito, Ryota Koizumi, Tatsuya Sakai, Taiga Shimizu, Taiki Ono, Yoichiro Sogame
Acta Protozoologica.2020; 59(2): 67. CrossRef - Carotenoids as a Protection Mechanism against Oxidative Stress in Haloferax mediterranei
Micaela Giani, Rosa María Martínez-Espinosa
Antioxidants.2020; 9(11): 1060. CrossRef - Active Galactic Nuclei: Boon or Bane for Biota?
Manasvi Lingam, Idan Ginsburg, Shmuel Bialy
The Astrophysical Journal.2019; 877(1): 62. CrossRef - Computational search for UV radiation resistance strategies in Deinococcus swuensis isolated from Paramo ecosystems
Jorge Díaz-Riaño, Leonardo Posada, Iván Camilo Acosta, Carlos Ruíz-Pérez, Catalina García-Castillo, Alejandro Reyes, María Mercedes Zambrano, Hari S. Misra
PLOS ONE.2019; 14(12): e0221540. CrossRef - GATA-type transcription factors play a vital role in radiation sensitivity of Cryptococcus neoformans by regulating the gene expression of specific amino acid permeases
Wanchang Cui, XiangHong Li, Lisa Hull, Mang Xiao
Scientific Reports.2019;[Epub] CrossRef - Reducing the ionizing radiation background does not significantly affect the evolution of Escherichia coli populations over 500 generations
Nathanael Lampe, Pierre Marin, Marianne Coulon, Pierre Micheau, Lydia Maigne, David Sarramia, Fabrice Piquemal, Sébastien Incerti, David G. Biron, Camille Ghio, Télesphore Sime-Ngando, Thomas Hindre, Vincent Breton
Scientific Reports.2019;[Epub] CrossRef - Covalent Modification of Amino Acids and Peptides Induced by Ionizing Radiation from an Electron Beam Linear Accelerator Used in Radiotherapy
Benjamin B. Minkoff, Steven T. Bruckbauer, Grzegorz Sabat, Michael M. Cox, Michael R. Sussman
Radiation Research.2019; 191(5): 447. CrossRef - Genome analysis of Rubritalea profundi SAORIC-165T, the first deep-sea verrucomicrobial isolate, from the northwestern Pacific Ocean
Jaeho Song, Ilnam Kang, Yochan Joung, Susumu Yoshizawa, Ryo Kaneko, Kenshiro Oshima, Masahira Hattori, Koji Hamasaki, Kazuhiro Kogure, Soochan Kim, Kangseok Lee, Jang-Cheon Cho
Journal of Microbiology.2019; 57(5): 413. CrossRef - Shifts in microbial community composition in tannery-contaminated soil in response to increased gamma radiation
Mohammad A. A. Al-Najjar, Majed M. Albokari
Annals of Microbiology.2019; 69(13): 1567. CrossRef - Colloquium: Physical constraints for the evolution of life on exoplanets
Manasvi Lingam, Abraham Loeb
Reviews of Modern Physics.2019;[Epub] CrossRef - Enhanced biodegradation and kinetics of anthraquinone dye by laccase from an electron beam irradiated endophytic fungus
Kavitha Keshava Navada, Ganesh Sanjeev, Ananda Kulal
International Biodeterioration & Biodegradation.2018; 132: 241. CrossRef