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[Minireview] Antibiotic resistance of pathogenic Acinetobacter species and emerging combination therapy
Bora Shin , Woojun Park
Journal of Microbiology 2017;55(11):837-849.
DOI: https://doi.org/10.1007/s12275-017-7288-4
Published online: October 27, 2017
Laboratory of Molecular Environmental Microbiology, Department of Environmental Science and Ecological Engineering, Korea University, Seoul 02841, Republic of KoreaLaboratory of Molecular Environmental Microbiology, Department of Environmental Science and Ecological Engineering, Korea University, Seoul 02841, Republic of Korea
Corresponding author:  Woojun Park , Tel: +82-2-3290-3067, 
Received: 17 July 2017   • Revised: 19 September 2017   • Accepted: 20 September 2017
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Abstract

The increasing antibiotic resistance of Acinetobacter species in both natural and hospital environments has become a serious problem worldwide in recent decades. Because of both intrinsic and acquired antimicrobial resistance (AMR) against last-resort antibiotics such as carbapenems, novel therapeutics are urgently required to treat Acinetobacter-associated infectious diseases. Among the many pathogenic Acinetobacter species, A. baumannii has been reported to be resistant to all classes of antibiotics and contains many AMR genes, such as blaADC (Acinetobacter-derived cephalosporinase). The AMR of pathogenic Acinetobacter species is the result of several different mechanisms, including active efflux pumps, mutations in antibiotic targets, antibiotic modification, and low antibiotic membrane permeability. To overcome the limitations of existing drugs, combination theraphy that can increase the activity of antibiotics should be considered in the treatment of Acinetobacter infections. Understanding the molecular mechanisms behind Acinetobacter AMR resistance will provide vital information for drug development and therapeutic strategies using combination treatment. Here, we summarize the classic mechanisms of Acinetobacter AMR, along with newly-discovered genetic AMR factors and currently available antimicrobial adjuvants that can enhance drug efficacy in the treatment of A. baumannii infections.

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    [Minireview] Antibiotic resistance of pathogenic Acinetobacter species and emerging combination therapy
    J. Microbiol. 2017;55(11):837-849.   Published online October 27, 2017
    DOI: https://doi.org/10.1007/s12275-017-7288-4
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